Slc2a2

Summary

Gene Symbol: Slc2a2
Description: solute carrier family 2 (facilitated glucose transporter), member 2
Alias: AI266973, Glut-2, Glut2, solute carrier family 2, facilitated glucose transporter member 2, glucose transporter type 2, liver, liver-type glucose transporter
Species: mouse
Products:     Slc2a2

Top Publications

  1. Asano T, Shibasaki Y, Lin J, Akanuma Y, Takaku F, Oka Y. The nucleotide sequence of cDNA for a mouse liver-type glucose transporter protein. Nucleic Acids Res. 1989;17:6386 pubmed
  2. Gouyon F, Caillaud L, Carriere V, Klein C, Dalet V, Citadelle D, et al. Simple-sugar meals target GLUT2 at enterocyte apical membranes to improve sugar absorption: a study in GLUT2-null mice. J Physiol. 2003;552:823-32 pubmed
    The physiological significance of the presence of GLUT2 at the food-facing pole of intestinal cells is addressed by a study of fructose absorption in GLUT2-null and control mice submitted to different sugar diets...
  3. Tobin V, Le Gall M, Fioramonti X, Stolarczyk E, Blazquez A, Klein C, et al. Insulin internalizes GLUT2 in the enterocytes of healthy but not insulin-resistant mice. Diabetes. 2008;57:555-62 pubmed
    ..sugar uptake to match dietary load, resulting from a rapid transient translocation of the fructose/glucose GLUT2 transporter to the brush border membrane (BBM) of enterocytes...
  4. Yang Y, Thorel F, Boyer D, Herrera P, Wright C. Context-specific ?- to-?-cell reprogramming by forced Pdx1 expression. Genes Dev. 2011;25:1680-5 pubmed publisher
    ..Our findings reveal that Pdx1 can work single-handedly as a potent context-dependent autonomous reprogramming agent, and suggest a postnatal differentiation evaluation stage involved in normal endocrine maturation. ..
  5. Stolarczyk E, Guissard C, Michau A, Even P, Grosfeld A, Serradas P, et al. Detection of extracellular glucose by GLUT2 contributes to hypothalamic control of food intake. Am J Physiol Endocrinol Metab. 2010;298:E1078-87 pubmed publisher
    The sugar transporter GLUT2, present in several tissues of the gut-brain axis, has been reported to be involved in the control of food intake...
  6. Artner I, Blanchi B, Raum J, Guo M, Kaneko T, Cordes S, et al. MafB is required for islet beta cell maturation. Proc Natl Acad Sci U S A. 2007;104:3853-8 pubmed
    ..However, Pdx1, Nkx6.1, and GLUT2 were selectively lost in these insulin-deficient cells between E15.5 and E18.5...
  7. Fujitani Y, Fujitani S, Boyer D, Gannon M, Kawaguchi Y, Ray M, et al. Targeted deletion of a cis-regulatory region reveals differential gene dosage requirements for Pdx1 in foregut organ differentiation and pancreas formation. Genes Dev. 2006;20:253-66 pubmed
  8. Guillam M, Hummler E, Schaerer E, Yeh J, Birnbaum M, Beermann F, et al. Early diabetes and abnormal postnatal pancreatic islet development in mice lacking Glut-2. Nat Genet. 1997;17:327-30 pubmed
    ..Glut-2 is thus required to maintain normal glucose homeostasis and normal function and development of the endocrine pancreas. Its absence leads to symptoms characteristic of non-insulin-dependent diabetes mellitus. ..
  9. Stiles B, Kuralwalla Martinez C, Guo W, Gregorian C, Wang Y, Tian J, et al. Selective deletion of Pten in pancreatic beta cells leads to increased islet mass and resistance to STZ-induced diabetes. Mol Cell Biol. 2006;26:2772-81 pubmed
    ..Our data demonstrate that PTEN loss in beta cells is not tumorigenic but beneficial. This suggests that modulating the PTEN-controlled signaling pathway is a potential approach for beta-cell protection and regeneration therapies. ..

More Information

Publications91

  1. Bady I, Marty N, Dallaporta M, Emery M, Gyger J, Tarussio D, et al. Evidence from glut2-null mice that glucose is a critical physiological regulator of feeding. Diabetes. 2006;55:988-95 pubmed
    ..Here, we evaluated feeding behavior in glut2-null mice, which express a transgenic glucose transporter in their beta-cells to rescue insulin secretion (..
  2. Wang S, Jensen J, Seymour P, Hsu W, Dor Y, Sander M, et al. Sustained Neurog3 expression in hormone-expressing islet cells is required for endocrine maturation and function. Proc Natl Acad Sci U S A. 2009;106:9715-20 pubmed publisher
    ..These findings demonstrate that Neurog3 is required not only for initiating endocrine cell differentiation, but also for promoting islet cell maturation and maintaining islet function. ..
  3. Offield M, Jetton T, Labosky P, Ray M, Stein R, Magnuson M, et al. PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum. Development. 1996;122:983-95 pubmed
    ..a local absence of the normal columnar epithelial lining, villi, and Brunner's glands, which are replaced by a GLUT2-positive cuboidal epithelium resembling the bile duct lining...
  4. Gannon M, Ray M, Van Zee K, Rausa F, Costa R, Wright C. Persistent expression of HNF6 in islet endocrine cells causes disrupted islet architecture and loss of beta cell function. Development. 2000;127:2883-95 pubmed
    ..several mature beta cell markers were expressed in beta cells of transgenic islets, the glucose transporter GLUT2 was absent or severely reduced...
  5. Hu He K, Lorenzo P, Brun T, Jimenez Moreno C, Aeberhard D, Vallejo Ortega J, et al. In vivo conditional Pax4 overexpression in mature islet ?-cells prevents stress-induced hyperglycemia in mice. Diabetes. 2011;60:1705-15 pubmed publisher
    ..Bcl-2, Cdk4, and c-myc expression levels were increased in Pax4 islets while MafA, insulin, and GLUT2 transcript levels were suppressed in both animal models...
  6. Cani P, Holst J, Drucker D, Delzenne N, Thorens B, Burcelin R, et al. GLUT2 and the incretin receptors are involved in glucose-induced incretin secretion. Mol Cell Endocrinol. 2007;276:18-23 pubmed
    ..We determined the role of GLUT2, GLP-1 or GIP receptors in glucose-induced incretins secretion, in the corresponding knockout mice...
  7. Hou J, Williams D, Vicogne J, Pessin J. The glucose transporter 2 undergoes plasma membrane endocytosis and lysosomal degradation in a secretagogue-dependent manner. Endocrinology. 2009;150:4056-64 pubmed publisher
    ..We observed that expressed GLUT2 protein in the cultured Min6B1 cell line undergoes enhanced endocytosis at high extracellular glucose ..
  8. Thorens B, Guillam M, Beermann F, Burcelin R, Jaquet M. Transgenic reexpression of GLUT1 or GLUT2 in pancreatic beta cells rescues GLUT2-null mice from early death and restores normal glucose-stimulated insulin secretion. J Biol Chem. 2000;275:23751-8 pubmed
    b>GLUT2-null mice are hyperglycemic, hypoinsulinemic, hyperglucagonemic, and glycosuric and die within the first 3 weeks of life...
  9. Guillam M, Dupraz P, Thorens B. Glucose uptake, utilization, and signaling in GLUT2-null islets. Diabetes. 2000;49:1485-91 pubmed
    We previously reported that pancreatic islet beta-cells from GLUT2-null mice lost the first phase but preserved the second phase of glucose-stimulated insulin secretion (GSIS)...
  10. Ait Omar A, Monteiro Sepulveda M, Poitou C, Le Gall M, Cotillard A, Gilet J, et al. GLUT2 accumulation in enterocyte apical and intracellular membranes: a study in morbidly obese human subjects and ob/ob and high fat-fed mice. Diabetes. 2011;60:2598-607 pubmed publisher
    In healthy rodents, intestinal sugar absorption in response to sugar-rich meals and insulin is regulated by GLUT2 in enterocyte plasma membranes. Loss of insulin action maintains apical GLUT2 location...
  11. Härndahl L, Wierup N, Enerback S, Mulder H, Manganiello V, Sundler F, et al. Beta-cell-targeted overexpression of phosphodiesterase 3B in mice causes impaired insulin secretion, glucose intolerance, and deranged islet morphology. J Biol Chem. 2004;279:15214-22 pubmed
    ..Furthermore, morphological examinations demonstrated deranged islet cytoarchitecture. In conclusion, these results are consistent with an essential role for PDE3B in cAMP-mediated regulation of insulin release and glucose homeostasis. ..
  12. Henseleit K, Nelson S, Kuhlbrodt K, Hennings J, Ericson J, Sander M. NKX6 transcription factor activity is required for alpha- and beta-cell development in the pancreas. Development. 2005;132:3139-49 pubmed
    ..We demonstrate that expression of Myt1 depends on overall Nkx6 gene dose, and therefore identify Myt1 as a possible downstream target of Nkx6 genes in the endocrine differentiation pathway. ..
  13. Mazur M, Winkler M, Ganic E, Colberg J, Johansson J, Bennet H, et al. Microphthalmia transcription factor regulates pancreatic ?-cell function. Diabetes. 2013;62:2834-42 pubmed publisher
    ..Pax6 is an essential regulator of ?-cell-specific factors like insulin and Glut2. Studies in the developing eye suggest that Pax6 interacts with Mitf to regulate pigment cell differentiation...
  14. Perez S, Cano D, Dao Pick T, Rougier J, Werb Z, Hebrok M. Matrix metalloproteinases 2 and 9 are dispensable for pancreatic islet formation and function in vivo. Diabetes. 2005;54:694-701 pubmed
    ..However, islet formation is unaffected in transgenic mice with modified tissue inhibitor of metalloproteinase-1 (TIMP1) levels, suggesting that MMP activity may contribute little to islet morphogenesis in vivo. ..
  15. Doyle M, Loomis Z, Sussel L. Nkx2.2-repressor activity is sufficient to specify alpha-cells and a small number of beta-cells in the pancreatic islet. Development. 2007;134:515-23 pubmed
    ..insulin-positive cells that do form in the rescued mice do not express the mature beta-cell markers MafA or Glut2 (Slc2a2), suggesting that additional activator functions of Nkx2.2 are required for beta-cell maturation...
  16. Thorens B. GLUT2 in pancreatic and extra-pancreatic gluco-detection (review). Mol Membr Biol. 2001;18:265-73 pubmed
    ..This signalling mechanism depends on glucose metabolism and requires the presence of specific molecules such as GLUT2, glucokinase and the K(ATP) channel subunits Kir6.2 and SUR1...
  17. Yamashita H, Shao J, Qiao L, Pagliassotti M, Friedman J. Effect of spontaneous gestational diabetes on fetal and postnatal hepatic insulin resistance in Lepr(db/+) mice. Pediatr Res. 2003;53:411-8 pubmed
  18. Zahn C, Jaschke A, Weiske J, Hommel A, Hesse D, Augustin R, et al. ADP-ribosylation factor-like GTPase ARFRP1 is required for trans-Golgi to plasma membrane trafficking of E-cadherin. J Biol Chem. 2008;283:27179-88 pubmed publisher
    ..These data indicate that knock-out of Arfrp1 disrupts the trafficking of E-cadherin through the Golgi and suggest an essential role of the GTPase in trans-Golgi network function. ..
  19. Waeber G, Thompson N, Nicod P, Bonny C. Transcriptional activation of the GLUT2 gene by the IPF-1/STF-1/IDX-1 homeobox factor. Mol Endocrinol. 1996;10:1327-34 pubmed
    ..As the glucose transporter type 2 (GLUT2) gene expression is selectively decreased in the beta-pancreatic cells of experimental models of diabetes, we ..
  20. Burcelin R, Del Carmen Munoz M, Guillam M, Thorens B. Liver hyperplasia and paradoxical regulation of glycogen metabolism and glucose-sensitive gene expression in GLUT2-null hepatocytes. Further evidence for the existence of a membrane-based glucose release pathway. J Biol Chem. 2000;275:10930-6 pubmed
    We investigated the impact of GLUT2 gene inactivation on the regulation of hepatic glucose metabolism during the fed to fast transition...
  21. Sakar Y, Nazaret C, Letteron P, Ait Omar A, Avenati M, Viollet B, et al. Positive regulatory control loop between gut leptin and intestinal GLUT2/GLUT5 transporters links to hepatic metabolic functions in rodents. PLoS ONE. 2009;4:e7935 pubmed publisher
    ..In this study, we determine the effects of luminal leptin on activity/expression of GLUT2 and GLUT5 transporters in response to sugars intake and analyse their physiological consequences...
  22. Jung J, Wang X, Loeken M. Mouse embryonic stem cells established in physiological-glucose media express the high KM Glut2 glucose transporter expressed by normal embryos. Stem Cells Transl Med. 2013;2:929-34 pubmed publisher
    b>Glut2 is one of the facilitative glucose transporters expressed by preimplantation and early postimplantation embryos. Glut2 is important for survival before embryonic day 10.5...
  23. Chesnut K, She J, Cheng I, Muralidharan K, Wakeland E. Characterizations of candidate genes for IDD susceptibility from the diabetes-prone NOD mouse strain. Mamm Genome. 1993;4:549-54 pubmed
    ..The distribution of these Il-2 alleles among inbred strains correlated with the detection of Chr 3 as an interval effecting diabetes susceptibility in three separate genetic crosses.(ABSTRACT TRUNCATED AT 250 WORDS) ..
  24. Wang S, Zhang J, Zhao A, Hipkens S, Magnuson M, Gu G. Loss of Myt1 function partially compromises endocrine islet cell differentiation and pancreatic physiological function in the mouse. Mech Dev. 2007;124:898-910 pubmed
    ..In addition, they also had reduced Glut2 expression, and attenuated glucose-induced insulin secretion in the adult islets...
  25. Ahn Y, Kim J, Han G, Lee B, Kim Y. Cloning and characterization of rat pancreatic beta-cell/liver type glucose transporter gene: a unique exon/intron organization. Arch Biochem Biophys. 1995;323:387-96 pubmed
    Four overlapping lambda genomic clones encoding rat pancreatic beta-cell/liver type glucose transporter (GLUT2) have been isolated and characterized. The gene is about 35 kb long and contains 14 exons and 13 introns...
  26. Heller R, Stoffers D, Liu A, Schedl A, Crenshaw E, Madsen O, et al. The role of Brn4/Pou3f4 and Pax6 in forming the pancreatic glucagon cell identity. Dev Biol. 2004;268:123-34 pubmed
    ..2 cells. The pancreatic phenotype of the pax6 mutants can be rescued with a YAC clone containing the human Pax6 gene. ..
  27. Broad T, Burkin D, Cambridge L, Lewis P, Maher D, Ansari H, et al. Four human chromosome 3q and four human chromosome 21 loci map onto sheep chromosome 1q. Mamm Genome. 1995;6:202-5 pubmed
    ..to the distal region of human Chr 3q, are ceruloplasmin (CP), sucrase isomaltase (SI), glucose transporter 2 (GLUT2), and ectopic viral integration site 1 (EVI1)...
  28. Röder P, Geillinger K, Zietek T, Thorens B, Koepsell H, Daniel H. The role of SGLT1 and GLUT2 in intestinal glucose transport and sensing. PLoS ONE. 2014;9:e89977 pubmed publisher
    Intestinal glucose absorption is mediated by SGLT1 whereas GLUT2 is considered to provide basolateral exit...
  29. Mounien L, Marty N, Tarussio D, Metref S, Genoux D, Preitner F, et al. Glut2-dependent glucose-sensing controls thermoregulation by enhancing the leptin sensitivity of NPY and POMC neurons. FASEB J. 2010;24:1747-58 pubmed publisher
    ..and leptin sensitivity of hypothalamic arcuate neurons in mice with inactivation of glucose transporter type 2 (Glut2)-dependent glucose sensing...
  30. Kawahira H, Ma N, Tzanakakis E, McMahon A, Chuang P, Hebrok M. Combined activities of hedgehog signaling inhibitors regulate pancreas development. Development. 2003;130:4871-9 pubmed
    ..Reduction of Fgf10 expression in Hhip homozygous mutants suggests that at least some of the observed phenotypes result from hedgehog-mediated inhibition of Fgf signaling at early stages. ..
  31. Heiser P, Lau J, Taketo M, Herrera P, Hebrok M. Stabilization of beta-catenin impacts pancreas growth. Development. 2006;133:2023-32 pubmed
    ..Taken together, these data suggest a previously unappreciated temporal/spatial role for beta-catenin signaling in the regulation of pancreas organ growth. ..
  32. Park S, Haase V, Johnson R. von Hippel Lindau tumor suppressor regulates hepatic glucose metabolism by controlling expression of glucose transporter 2 and glucose 6-phosphatase. Int J Oncol. 2007;30:341-8 pubmed
    ..from significantly reduced expression of two key liver-specific glucose metabolism genes, glucose transporter-2 (GLUT2) and glucose-6-phosphatase (G-6-Pase)...
  33. Muglia L, Jenkins N, Gilbert D, Copeland N, Majzoub J. Expression of the mouse corticotropin-releasing hormone gene in vivo and targeted inactivation in embryonic stem cells. J Clin Invest. 1994;93:2066-72 pubmed
    ..Mice chimeric for each of two ES clones with an inactivated CRH allele are being used to generate animals with complete CRH deficiency. ..
  34. Suzue K, Lodish H, Thorens B. Sequence of the mouse liver glucose transporter. Nucleic Acids Res. 1989;17:10099 pubmed
  35. Evans S, Doblado M, Chi M, Corbett J, Moley K. Facilitative glucose transporter 9 expression affects glucose sensing in pancreatic beta-cells. Endocrinology. 2009;150:5302-10 pubmed publisher
    ..Studies in GLUT2-deficient mice suggested the existence of another GLUT in the mammalian beta-cell responsible for glucose sensing...
  36. Zukerman S, Ackroff K, Sclafani A. Post-oral appetite stimulation by sugars and nonmetabolizable sugar analogs. Am J Physiol Regul Integr Comp Physiol. 2013;305:R840-53 pubmed publisher
    ..However, adding phloretin (a GLUT2 antagonist) to the glucose+phloridzin infusion blocked glucose appetition...
  37. Bonny C, Thompson N, Nicod P, Waeber G. Pancreatic-specific expression of the glucose transporter type 2 gene: identification of cis-elements and islet-specific trans-acting factors. Mol Endocrinol. 1995;9:1413-26 pubmed
    ..of type II diabetes and has been correlated with a reduced gene expression of the glucose transporter type 2 (Glut2)...
  38. Collombat P, Hecksher Sørensen J, Broccoli V, Krull J, Ponte I, Mundiger T, et al. The simultaneous loss of Arx and Pax4 genes promotes a somatostatin-producing cell fate specification at the expense of the alpha- and beta-cell lineages in the mouse endocrine pancreas. Development. 2005;132:2969-80 pubmed
    ..Finally, our data provide evidence that both Arx and Pax4 act as transcriptional repressors that control the expression level of one another, thereby mediating proper endocrine fate allocation. ..
  39. Souza Menezes J, Morales M, Tukaye D, Guggino S, Guggino W. Absence of ClC5 in knockout mice leads to glycosuria, impaired renal glucose handling and low proximal tubule GLUT2 protein expression. Cell Physiol Biochem. 2007;20:455-64 pubmed
    ..05). By western blot, we observed a significant decrease in GLUT2 protein expression levels in isolated PT ((n=10, p<0.01)) of KO mice...
  40. Lin J, Yan Y, Hsieh W, Peng P, Su C, Tarn W. RBM4 promotes pancreas cell differentiation and insulin expression. Mol Cell Biol. 2013;33:319-27 pubmed publisher
    ..These results suggest that RBM4 may have role in promoting pancreas cell differentiation and endocrine function, essentially via alternative splicing regulation. ..
  41. Medina M, Molina J, Gadea Y, Fachado A, Murillo M, Simovic G, et al. The thyroid hormone-inactivating type III deiodinase is expressed in mouse and human beta-cells and its targeted inactivation impairs insulin secretion. Endocrinology. 2011;152:3717-27 pubmed publisher
    ..An analogous role is likely in humans, given the similar D3 expression pattern. ..
  42. Jacquemin P, Durviaux S, Jensen J, Godfraind C, Gradwohl G, Guillemot F, et al. Transcription factor hepatocyte nuclear factor 6 regulates pancreatic endocrine cell differentiation and controls expression of the proendocrine gene ngn3. Mol Cell Biol. 2000;20:4445-54 pubmed
    ..They also suggest that HNF-6 is a candidate gene for diabetes mellitus in humans. ..
  43. Metzger D, Liu C, Ziaie A, Naji A, Zaret K. Grg3/TLE3 and Grg1/TLE1 induce monohormonal pancreatic ?-cells while repressing ?-cell functions. Diabetes. 2014;63:1804-16 pubmed publisher
    ..Ectopic expression of Grg3 in ?-cells represses glucagon and Arx, and the addition of Pdx1 induces Glut2 expression and glucose-responsive insulin secretion...
  44. Sussel L, Kalamaras J, Hartigan O Connor D, Meneses J, Pedersen R, Rubenstein J, et al. Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic beta cells. Development. 1998;125:2213-21 pubmed
    ..1. We propose that Nkx2.2 is required for the final differentiation of pancreatic beta cells, and in its absence, beta cells are trapped in an incompletely differentiated state. ..
  45. Kosfeld A, Kreuzer M, Daniel C, Brand F, Schäfer A, Chadt A, et al. Whole-exome sequencing identifies mutations of TBC1D1 encoding a Rab-GTPase-activating protein in patients with congenital anomalies of the kidneys and urinary tract (CAKUT). Hum Genet. 2016;135:69-87 pubmed publisher
  46. Santer R, Schneppenheim R, Dombrowski A, Gotze H, Steinmann B, Schaub J. Mutations in GLUT2, the gene for the liver-type glucose transporter, in patients with Fanconi-Bickel syndrome. Nat Genet. 1997;17:324-6 pubmed
    ..Here we report mutations in the gene encoding the facilitative glucose transporter 2 (GLUT2) in three FBS families, including the original patient described in 1949 by Fanconi and Bickel...
  47. Lamotte L, Jackerott M, Bucchini D, Jami J, Joshi R, Deltour L. Knock-in of diphteria toxin A chain gene at Ins2 locus: effects on islet development and localization of Ins2 expression in the brain. Transgenic Res. 2004;13:463-73 pubmed
    ..Transcripts for other key beta-cell markers, with the notable exception of Pdx-1, were also found in CP RNAs. These results must revive interest in studies focused on extrapancreatic insulin gene expression. ..
  48. Smith D, Gridley T. Differential screening of a PCR-generated mouse embryo cDNA library: glucose transporters are differentially expressed in early postimplantation mouse embryos. Development. 1992;116:555-61 pubmed
    ..Expression of Glut-1 was fairly widespread in the embryo at 8.5 dpc, but by 10.5 dpc expression was down-regulated and was observed in the eye and the spinal cord.(ABSTRACT TRUNCATED AT 250 WORDS) ..
  49. Dotimas J, Lee A, Schmider A, Carroll S, Shah A, Bilen J, et al. Diabetes regulates fructose absorption through thioredoxin-interacting protein. elife. 2016;5: pubmed publisher
    ..Our results indicate that Txnip is a critical regulator of fructose metabolism and suggest that a diabetic state can promote fructose uptake. ..
  50. Plank J, Mundell N, Frist A, Legrone A, Kim T, Musser M, et al. Influence and timing of arrival of murine neural crest on pancreatic beta cell development and maturation. Dev Biol. 2011;349:321-30 pubmed publisher
    ..that without neural crest, there was a reduction in the percentage of insulin-positive cells that co-expressed Glut2 and Pdx1 compared to controls...
  51. Zhang H, Ables E, Pope C, Washington M, Hipkens S, Means A, et al. Multiple, temporal-specific roles for HNF6 in pancreatic endocrine and ductal differentiation. Mech Dev. 2009;126:958-73 pubmed publisher
    ..These data confirm that HNF6 has both early and late functions in the developing pancreas and is essential for maintenance of Ngn3 expression and proper pancreatic duct morphology. ..
  52. Brouwers B, de Faudeur G, Osipovich A, Goyvaerts L, Lemaire K, Boesmans L, et al. Impaired islet function in commonly used transgenic mouse lines due to human growth hormone minigene expression. Cell Metab. 2014;20:979-90 pubmed publisher
    ..In addition, islets of Pdx1-Cre(Late) mice have lower GLUT2 expression and reduced glucose-induced insulin release and are protected against the β cell toxin ..
  53. Mellitzer G, Beucher A, Lobstein V, Michel P, Robine S, Kedinger M, et al. Loss of enteroendocrine cells in mice alters lipid absorption and glucose homeostasis and impairs postnatal survival. J Clin Invest. 2010;120:1708-21 pubmed publisher
    ..Our data help unravel the role of enteroendocrine cells and hormones in lipid absorption and maintenance of the intestinal epithelium. ..
  54. Clark P, Flores G, Evdokimov N, McCracken M, Chai T, Nair Gill E, et al. Positron emission tomography probe demonstrates a striking concentration of ribose salvage in the liver. Proc Natl Acad Sci U S A. 2014;111:E2866-74 pubmed publisher
    ..We demonstrate that solute carrier family 2, member 2 (also known as GLUT2), a glucose transporter expressed in the liver, is one ribose transporter, but we do not know if others exist...
  55. Nishimura W, Kondo T, Salameh T, El Khattabi I, Dodge R, Bonner Weir S, et al. A switch from MafB to MafA expression accompanies differentiation to pancreatic beta-cells. Dev Biol. 2006;293:526-39 pubmed
    ..Thus, this redundancy in the function and expression of the large-Maf factors may explain the normal islet morphology observed in the MafA knockout mice at birth. ..
  56. Cano D, Murcia N, Pazour G, Hebrok M. Orpk mouse model of polycystic kidney disease reveals essential role of primary cilia in pancreatic tissue organization. Development. 2004;131:3457-67 pubmed
    ..Thus, polaris and primary cilia function are required for the maturation and maintenance of proper tissue organization in the pancreas. ..
  57. Sund N, Ang S, Sackett S, Shen W, Daigle N, Magnuson M, et al. Hepatocyte nuclear factor 3beta (Foxa2) is dispensable for maintaining the differentiated state of the adult hepatocyte. Mol Cell Biol. 2000;20:5175-83 pubmed
    ..This is the first example of such functional dichotomy for a tissue specification transcription factor. ..
  58. Gould G, Holman G. The glucose transporter family: structure, function and tissue-specific expression. Biochem J. 1993;295 ( Pt 2):329-41 pubmed
  59. Ida Yonemochi H, Nakatomi M, Harada H, Takata H, Baba O, Ohshima H. Glucose uptake mediated by glucose transporter 1 is essential for early tooth morphogenesis and size determination of murine molars. Dev Biol. 2012;363:52-61 pubmed publisher
    ..and an in vitro organ culture experiment with an inhibitor of GLUTs1/2, phloretin, and Glut1 and Glut2 short interfering RNA (siRNA)...
  60. Seymour P, Freude K, Dubois C, Shih H, Patel N, Sander M. A dosage-dependent requirement for Sox9 in pancreatic endocrine cell formation. Dev Biol. 2008;323:19-30 pubmed publisher
    ..Our findings therefore suggest that defective endocrine specification might underlie the pancreatic phenotype of individuals with CD. ..
  61. Lindahl M, Danilova T, Palm E, Lindholm P, Voikar V, Hakonen E, et al. MANF is indispensable for the proliferation and survival of pancreatic ? cells. Cell Rep. 2014;7:366-75 pubmed publisher
    ..We demonstrate that MANF specifically promotes ? cell proliferation and survival, thereby constituting a therapeutic candidate for ? cell protection and regeneration. ..
  62. Chankiewitz E, Peschke D, Herberg L, Bazwinsky I, Muhlbauer E, Bromme H, et al. Did the gradual loss of GLUT2 cause a shift to diabetic disorders in the New Zealand obese mouse (NZO/Hl)?. Exp Clin Endocrinol Diabetes. 2006;114:262-9 pubmed
    ..In other diabetic models, it has been revealed that the proper functioning of the glucose transporter isoform 2 (GLUT2) is essential for adequate secretion of insulin...
  63. Gu Y, Lindner J, Kumar A, Yuan W, Magnuson M. Rictor/mTORC2 is essential for maintaining a balance between beta-cell proliferation and cell size. Diabetes. 2011;60:827-37 pubmed publisher
    ..The phosphorylation of AKT-S473, by negatively regulating that of AKT-T308, is essential for maintaining a balance between ?-cell proliferation and cell size in response to proliferative stimuli. ..
  64. Mueckler M, Kruse M, Strube M, Riggs A, Chiu K, Permutt M. A mutation in the Glut2 glucose transporter gene of a diabetic patient abolishes transport activity. J Biol Chem. 1994;269:17765-7 pubmed
    b>Glut2, the facilitative glucose transporter isoform expressed in pancreatic beta cells, is believed to play a role in glucose-stimulated insulin secretion...
  65. Wei F, Suzuki T, Watanabe S, Kimura S, Kaitsuka T, Fujimura A, et al. Deficit of tRNA(Lys) modification by Cdkal1 causes the development of type 2 diabetes in mice. J Clin Invest. 2011;121:3598-608 pubmed publisher
    ..These findings suggest that glucose-stimulated translation of proinsulin may require fully modified tRNA(Lys)(UUU), which could potentially explain the molecular pathogenesis of T2D in patients carrying cdkal1 risk alleles. ..
  66. Burcelin R, Dolci W, Thorens B. Glucose sensing by the hepatoportal sensor is GLUT2-dependent: in vivo analysis in GLUT2-null mice. Diabetes. 2000;49:1643-8 pubmed
    ..In this study, we tested whether GLUT2 plays a role in the portal glucose-sensing system that is similar to its involvement in pancreatic beta-cells...
  67. Valera A, Solanes G, Fernandez Alvarez J, Pujol A, Ferrer J, Asins G, et al. Expression of GLUT-2 antisense RNA in beta cells of transgenic mice leads to diabetes. J Biol Chem. 1994;269:28543-6 pubmed
    ..These results suggest that the reduction of GLUT-2 in the pancreas could be a crucial step in the development of diabetes mellitus. ..
  68. Wilcox C, Terry N, MAY C. Arx polyalanine expansion in mice leads to reduced pancreatic ?-cell specification and increased ?-cell death. PLoS ONE. 2013;8:e78741 pubmed publisher
    ..Overall, our analysis of an Arx polyalanine expansion mutation on pancreatic development suggests that impaired ?-cell function might also occur in ISSX patients. ..
  69. Yang Y, Magnuson M, Stein R, Wright C. The mammal-specific Pdx1 Area II enhancer has multiple essential functions in early endocrine cell specification and postnatal β-cell maturation. Development. 2017;144:248-257 pubmed publisher
    ..Therefore, trans-regulatory integration through Area II mediates a surprisingly extensive range of progenitor and β-cell-specific Pdx1 functions. ..
  70. Spaeth J, Gupte M, Perelis M, Yang Y, CYPHERT H, Guo S, et al. Defining a Novel Role for the Pdx1 Transcription Factor in Islet β-Cell Maturation and Proliferation During Weaning. Diabetes. 2017;66:2830-2839 pubmed publisher
    ..We discuss the impact of these novel findings to Pdx1 gene regulation and islet β-cell maturation postnatally. ..
  71. Coppieters K, Wiberg A, Amirian N, Kay T, Von Herrath M. Persistent glucose transporter expression on pancreatic beta cells from longstanding type 1 diabetic individuals. Diabetes Metab Res Rev. 2011;27:746-54 pubmed publisher
    ..It remains questionable, however, whether these surviving cells can physiologically sense and respond to glucose stimuli...
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    ..Of the latter, several facilitated transporters have been identified, including GLUT1 (erythrocyte/brain), GLUT2 (liver) and GLUT4 (adipose/muscle) isoforms...
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    ..Using Xenopus oocyte expression, we investigated whether facilitative glucose transporters GLUT2 and GLUT5-12 transported DHA...
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    ..Quantification of glucose transporter 2 (GLUT2) protein content by Western blot using an antibody with an epitope in the extracellular loop showed no significant ..
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    ..In addition, islet cells, which are produced from ductal tissue, were immunostained by the anti-panNb antibody. Our present results will contribute to the understanding of the mechanisms of islet development from ductal tissue. ..
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    ..We conclude that beta cell neogenesis occurred in adult islets and that the outcome of this process was regulated by the insulin-mediated normalization of circulating blood glucose levels. ..
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    ..Thus, dorsally Hlxb9 is required for specifying the gut epithelium to a pancreatic fate and ventrally for ensuring proper endocrine cell differentiation. ..
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    ..In this study, we report that GLUT2 is a target molecule for MLD-STZ toxicity...
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    ..The glycosuria of ArcPOMC-deficient mice was due to decreased levels of renal GLUT 2 (rGLUT2) but not sodium-glucose cotransporter 2 and was associated with reduced renal catecholamine content...
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