Slc2a1

Summary

Gene Symbol: Slc2a1
Description: solute carrier family 2 (facilitated glucose transporter), member 1
Alias: Glut-1, Glut1, solute carrier family 2, facilitated glucose transporter member 1, GT1, glucose transporter type 1, erythrocyte/brain, solute carrier family 2, member 1
Species: mouse
Products:     Slc2a1

Top Publications

  1. Saito K, Dubreuil V, Arai Y, Wilsch Bräuninger M, Schwudke D, Saher G, et al. Ablation of cholesterol biosynthesis in neural stem cells increases their VEGF expression and angiogenesis but causes neuron apoptosis. Proc Natl Acad Sci U S A. 2009;106:8350-5 pubmed publisher
    ..Moreover, our data reveal a hitherto unknown compensatory process by which the neural stem and progenitor cells of the developing mammalian brain evade the detrimental consequences of impaired endogenous cholesterol biosynthesis. ..
  2. Young C, Lewis A, Rudolph M, Ruehle M, Jackman M, Yun U, et al. Modulation of glucose transporter 1 (GLUT1) expression levels alters mouse mammary tumor cell growth in vitro and in vivo. PLoS ONE. 2011;6:e23205 pubmed publisher
    ..Of the 12 GLUT family glucose transporters expressed in mice, GLUT1 was the most abundantly expressed at the RNA level in the mouse mammary tumors from MMTV-c-ErbB2 mice and cell ..
  3. Heilig C, Saunders T, Brosius F, Moley K, Heilig K, Baggs R, et al. Glucose transporter-1-deficient mice exhibit impaired development and deformities that are similar to diabetic embryopathy. Proc Natl Acad Sci U S A. 2003;100:15613-8 pubmed
    The hyperglycemia of maternal diabetes suppresses the glucose transporter-1 (GLUT1) facilitative glucose transporter 49-66% in preimplantation embryos. Glucose uptake is reduced and apoptosis is activated...
  4. Wang D, Pascual J, Yang H, Engelstad K, Mao X, Cheng J, et al. A mouse model for Glut-1 haploinsufficiency. Hum Mol Genet. 2006;15:1169-79 pubmed
    ..This GLUT-1+/- mouse model creates an opportunity to investigate Glut-1 function, to examine the pathophysiology of Glut-1 DS in vivo and to evaluate new treatment strategies. ..
  5. Luptak I, Yan J, Cui L, Jain M, Liao R, Tian R. Long-term effects of increased glucose entry on mouse hearts during normal aging and ischemic stress. Circulation. 2007;116:901-9 pubmed
    ..and utilization in the heart by cardiac-specific overexpression of the insulin-independent glucose transporter GLUT1 (GLUT1-TG)...
  6. Schmidt S, Hommel A, Gawlik V, Augustin R, Junicke N, Florian S, et al. Essential role of glucose transporter GLUT3 for post-implantation embryonic development. J Endocrinol. 2009;200:23-33 pubmed publisher
    ..5. GLUT3 was detected in placental cone, in the visceral ectoderm and in the mesoderm of 7.5-day-old wild-type embryos. Our data indicate that GLUT3 is essential for the development of early post-implanted embryos. ..
  7. Liao R, Jain M, Cui L, D Agostino J, Aiello F, Luptak I, et al. Cardiac-specific overexpression of GLUT1 prevents the development of heart failure attributable to pressure overload in mice. Circulation. 2002;106:2125-31 pubmed
    ..We generated transgenic (TG) mice with cardiac-specific overexpression of insulin-independent glucose transporter GLUT1 to recapitulate the increases in basal glucose uptake rate observed in hypertrophied hearts...
  8. Hellstrom M, Gerhardt H, Kalén M, Li X, Eriksson U, Wolburg H, et al. Lack of pericytes leads to endothelial hyperplasia and abnormal vascular morphogenesis. J Cell Biol. 2001;153:543-53 pubmed
  9. Pantaleon M, Harvey M, Pascoe W, James D, Kaye P. Glucose transporter GLUT3: ontogeny, targeting, and role in the mouse blastocyst. Proc Natl Acad Sci U S A. 1997;94:3795-800 pubmed
    ..In contrast, GLUT1 was restricted to basolateral membranes of the outer TE cells in both compacted morulae and blastocysts...

More Information

Publications91

  1. Daneman R, Zhou L, Kebede A, Barres B. Pericytes are required for blood-brain barrier integrity during embryogenesis. Nature. 2010;468:562-6 pubmed publisher
    ..These data indicate that pericyte-endothelial cell interactions are critical to regulate the BBB during development, and disruption of these interactions may lead to BBB dysfunction and neuroinflammation during CNS injury and disease...
  2. Buller C, Heilig C, Brosius F. GLUT1 enhances mTOR activity independently of TSC2 and AMPK. Am J Physiol Renal Physiol. 2011;301:F588-96 pubmed publisher
    Enhanced GLUT1 expression in mesangial cells plays an important role in the development of diabetic nephropathy by stimulating signaling through several pathways resulting in increased glomerular matrix accumulation...
  3. FROLOVA A, Moley K. Quantitative analysis of glucose transporter mRNAs in endometrial stromal cells reveals critical role of GLUT1 in uterine receptivity. Endocrinology. 2011;152:2123-8 pubmed publisher
    ..b>GLUT1 mRNA is the most abundant and critical transporter in ESCs of both species, because knocking down this GLUT with ..
  4. Aghayan M, Rao L, Smith R, Jarett L, Charron M, Thorens B, et al. Developmental expression and cellular localization of glucose transporter molecules during mouse preimplantation development. Development. 1992;115:305-12 pubmed
    ..Of the latter, several facilitated transporters have been identified, including GLUT1 (erythrocyte/brain), GLUT2 (liver) and GLUT4 (adipose/muscle) isoforms...
  5. Hogan A, Heyner S, Charron M, Copeland N, Gilbert D, Jenkins N, et al. Glucose transporter gene expression in early mouse embryos. Development. 1991;113:363-72 pubmed
    The glucose transporter (GLUT) isoforms responsible for glucose uptake in early mouse embryos have been identified. GLUT 1, the isoform present in nearly every tissue examined including adult brain and erythrocytes, is expressed ..
  6. Bentley J, Itchayanan D, Barnes K, McIntosh E, Tang X, Downes C, et al. Interleukin-3-mediated cell survival signals include phosphatidylinositol 3-kinase-dependent translocation of the glucose transporter GLUT1 to the cell surface. J Biol Chem. 2003;278:39337-48 pubmed
    ..Immunocytochemistry and photoaffinity labeling revealed that IL-3 caused translocation of intracellular GLUT1 transporters to the cell surface, whereas a second transporter isoform, GLUT3, remained predominantly ..
  7. Nagamatsu S, Kornhauser J, Burant C, Seino S, Mayo K, Bell G. Glucose transporter expression in brain. cDNA sequence of mouse GLUT3, the brain facilitative glucose transporter isoform, and identification of sites of expression by in situ hybridization. J Biol Chem. 1992;267:467-72 pubmed
    ..Antisera to mouse GLUT3 immunoblotted a series of proteins of 45-50 kDa in mouse brain plasma membranes. These results are consistent with GLUT3 being a neuronal glucose transporter. ..
  8. Moley K, Chi M, Mueckler M. Maternal hyperglycemia alters glucose transport and utilization in mouse preimplantation embryos. Am J Physiol. 1998;275:E38-47 pubmed
    ..These findings suggest that, in response to a maternal diabetic state, preimplantation mouse embryos experience a decrease in glucose utilization directly related to a decrease in glucose transport at both the mRNA and protein levels. ..
  9. Daneman R, Agalliu D, Zhou L, Kuhnert F, Kuo C, Barres B. Wnt/beta-catenin signaling is required for CNS, but not non-CNS, angiogenesis. Proc Natl Acad Sci U S A. 2009;106:641-6 pubmed publisher
    ..Taken together these experiments reveal an essential role for Wnt/beta-catenin signaling in driving CNS-specific angiogenesis and provide molecular evidence that angiogenesis and BBB formation are in part linked. ..
  10. Ganguly A, McKnight R, Raychaudhuri S, Shin B, Ma Z, Moley K, et al. Glucose transporter isoform-3 mutations cause early pregnancy loss and fetal growth restriction. Am J Physiol Endocrinol Metab. 2007;292:E1241-55 pubmed
    ..This loss occurred despite the presence of other related isoforms, particularly GLUT1. In contrast, when a single allele was mutated, despite increased embryonic cell apoptosis, adaptive changes in ..
  11. Kaestner K, Christy R, McLenithan J, Braiterman L, Cornelius P, Pekala P, et al. Sequence, tissue distribution, and differential expression of mRNA for a putative insulin-responsive glucose transporter in mouse 3T3-L1 adipocytes. Proc Natl Acad Sci U S A. 1989;86:3150-4 pubmed
    ..One of these cDNAs encodes the murine homolog of the human hepG2/erythrocyte glucose transporter, termed GT1. GT1 mRNA is most abundant in mouse brain and is expressed in both 3T3-L1 preadipocytes and adipocytes...
  12. Roach W, Plomann M. PACSIN3 overexpression increases adipocyte glucose transport through GLUT1. Biochem Biophys Res Commun. 2007;355:745-50 pubmed
    ..These processes are known to be involved in trafficking of GLUT1 and GLUT4 in adipocytes...
  13. Kosfeld A, Kreuzer M, Daniel C, Brand F, Schäfer A, Chadt A, et al. Whole-exome sequencing identifies mutations of TBC1D1 encoding a Rab-GTPase-activating protein in patients with congenital anomalies of the kidneys and urinary tract (CAKUT). Hum Genet. 2016;135:69-87 pubmed publisher
  14. Bahary N, Leibel R, Joseph L, Friedman J. Molecular mapping of the mouse db mutation. Proc Natl Acad Sci U S A. 1990;87:8642-6 pubmed
    ..length polymorphisms to generate a gene order of: centromere-brown (Mt4)-P lambda Mm3(2)-Ifa (Inta)-Cjun-db-D4Rp1-Glut1-Mtv-13-Lck...
  15. Zhang C, Liu J, Liang Y, Wu R, Zhao Y, Hong X, et al. Tumour-associated mutant p53 drives the Warburg effect. Nat Commun. 2013;4:2935 pubmed publisher
    ..Mutp53 stimulates the Warburg effect through promoting GLUT1 translocation to the plasma membrane, which is mediated by activated RhoA and its downstream effector ROCK...
  16. Hölscher M, Silter M, Krull S, von Ahlen M, Hesse A, Schwartz P, et al. Cardiomyocyte-specific prolyl-4-hydroxylase domain 2 knock out protects from acute myocardial ischemic injury. J Biol Chem. 2011;286:11185-94 pubmed publisher
    ..This correlated with a decreased number of apoptotic cells in the infarcted myocardium in the cPhd2(-/-) mice and significantly improved cardiac function 3 weeks after myocardial infarction. ..
  17. Hooijmans C, Graven C, Dederen P, Tanila H, van Groen T, Kiliaan A. Amyloid beta deposition is related to decreased glucose transporter-1 levels and hippocampal atrophy in brains of aged APP/PS1 mice. Brain Res. 2007;1181:93-103 pubmed
    ..A certain level of Abeta must be reached in the hippocampus, before it affects GLUT-1 amount/capillary density leading to further impairment of energy metabolism and hippocampal atrophy. ..
  18. Ma S, Santhosh D, Kumar T P, Huang Z. A Brain-Region-Specific Neural Pathway Regulating Germinal Matrix Angiogenesis. Dev Cell. 2017;41:366-381.e4 pubmed publisher
    ..They also identify tissue-specific molecular targets for GM hemorrhage intervention. ..
  19. Koch A, Lang S, Wild P, Gantner S, Mahli A, Spanier G, et al. Glucose transporter isoform 1 expression enhances metastasis of malignant melanoma cells. Oncotarget. 2015;6:32748-60 pubmed publisher
    The glucose transporter isoform 1 (GLUT1; SLC2A1) is a key rate-limiting factor in the transport of glucose into cancer cells...
  20. Gutiérrez Torres D, González Horta C, Del Razo L, Infante Ramírez R, Ramos Martínez E, Levario Carrillo M, et al. Prenatal Exposure to Sodium Arsenite Alters Placental Glucose 1, 3, and 4 Transporters in Balb/c Mice. Biomed Res Int. 2015;2015:175025 pubmed publisher
    ..The aim of this study was to analyze the effect of sodium arsenite (NaAsO2) exposure on GLUT1, GLUT3, and GLUT4 protein expression and on placental morphology...
  21. Hyun C, Kim E, Flowers M, Liu X, Kim E, Strable M, et al. Adipose-specific deletion of stearoyl-CoA desaturase 1 up-regulates the glucose transporter GLUT1 in adipose tissue. Biochem Biophys Res Commun. 2010;399:480-6 pubmed publisher
    ..generated mice with an adipose-specific knockout of Scd1 (AKO), and report here that SCD1 deficiency increases GLUT1 expression in adipose tissue of AKO mice, but not global SCD1 knockout (GKO) mice...
  22. Busk M, Toustrup K, Sørensen B, Alsner J, Horsman M, Jakobsen S, et al. In vivo identification and specificity assessment of mRNA markers of hypoxia in human and mouse tumors. BMC Cancer. 2011;11:63 pubmed publisher
    ..comparing FAZA retention with patterns of gene expression in individual tissue fragments revealed that CA9, GLUT1 and LOX mRNA levels were equally and strongly correlated to hypoxic extent in FaDudd...
  23. Plum L, Giesen K, Kluge R, Junger E, Linnartz K, Schurmann A, et al. Characterisation of the mouse diabetes susceptibilty locus Nidd/SJL: islet cell destruction, interaction with the obesity QTL Nob1, and effect of dietary fat. Diabetologia. 2002;45:823-30 pubmed
    ..g. Nob1) and islet cell failure ( Nidd/SJL). The combined diabetogenic effects of Nidd/SJL and Nob1 were markedly enhanced by a high-fat diet, whereas that of Nidd/SJL alone was independent of the dietary fat content. ..
  24. Ortiz P, Honkanen R, Klingman D, Haspel H. Regulation of the functional expression of hexose transporter GLUT-1 by glucose in murine fibroblasts: role of lysosomal degradation. Biochemistry. 1992;31:5386-93 pubmed
    ..abstract truncated at 250 words) ..
  25. Cok A, Plaisier C, Salie M, Oram D, Chenge J, Louters L. Berberine acutely activates the glucose transport activity of GLUT1. Biochimie. 2011;93:1187-92 pubmed publisher
    ..of the acute affects of berberine on the transport activity of the insulin-insensitive glucose transporter, GLUT1. Therefore, we examined the acute effects of berberine on glucose uptake in L929 fibroblast cells, a cell line ..
  26. Shah K, Boreddy P, Abbruscato T. Nicotine pre-exposure reduces stroke-induced glucose transporter-1 activity at the blood-brain barrier in mice. Fluids Barriers CNS. 2015;12:10 pubmed publisher
    ..Specifically, the present study investigates glucose transporter-1 (GLUT1) function and expression at the BBB in a focal brain ischemia model of mice pre-exposed to nicotine...
  27. Bahary N, McGraw D, Shilling R, Friedman J. Microdissection and microcloning of mid-chromosome 4: genetic mapping of 41 microdissection clones. Genomics. 1993;16:113-22 pubmed
  28. Puchades M, Sogn C, Maehlen J, Bergersen L, Gundersen V. Unaltered lactate and glucose transporter levels in the MPTP mouse model of Parkinson's disease. J Parkinsons Dis. 2013;3:371-85 pubmed publisher
    ..to study whether there are altered levels of the transporters for monocarboxylates (MCT1 and MCT2) and glucose (GLUT1) in the MPTP mouse model of PD...
  29. Nomura Kitabayashi A, Anderson G, Sleep G, Mena J, Karabegovic A, Karamath S, et al. Endoglin is dispensable for angiogenesis, but required for endocardial cushion formation in the midgestation mouse embryo. Dev Biol. 2009;335:66-77 pubmed publisher
  30. Ferland R, Batiz L, Neal J, Lian G, Bundock E, Lu J, et al. Disruption of neural progenitors along the ventricular and subventricular zones in periventricular heterotopia. Hum Mol Genet. 2009;18:497-516 pubmed publisher
    ..Our current findings suggest that PH formation arises from a final common pathway involving disruption of vesicle trafficking, leading to impaired cell adhesion and loss of neuroependymal integrity. ..
  31. Chagnon Y, Bouchard C. Genetics of obesity: advances from rodent studies. Trends Genet. 1996;12:441-4 pubmed
  32. Bermejo Alvarez P, Rosenfeld C, Roberts R. Effect of maternal obesity on estrous cyclicity, embryo development and blastocyst gene expression in a mouse model. Hum Reprod. 2012;27:3513-22 pubmed publisher
    ..Does maternal obesity affect estrous cyclicity, embryo development and blastocyst gene expression in mice?..
  33. Gao S, Chung Y, Williams J, Riley J, Moley K, Latham K. Somatic cell-like features of cloned mouse embryos prepared with cultured myoblast nuclei. Biol Reprod. 2003;69:48-56 pubmed
    ..Myoblast clones also exhibit precocious enrichment of GLUT1 at the cell surface. Both myoblast and cumulus cell cloned embryos exhibit enhanced rates of glucose uptake...
  34. Shaheen F, Grammatopoulos D, Muller J, Zammit V, Lehnert H. Extra-nuclear telomerase reverse transcriptase (TERT) regulates glucose transport in skeletal muscle cells. Biochim Biophys Acta. 2014;1842:1762-9 pubmed publisher
    ..Collectively, these findings identified a novel extra-nuclear function of TERT that regulates an insulin-insensitive pathway involved in glucose uptake in human and mouse skeletal muscle cells. ..
  35. Joyner N, Smoak I. In vivo hyperglycemia and its effect on Glut-1 expression in the embryonic heart. Birth Defects Res A Clin Mol Teratol. 2004;70:438-48 pubmed
    ..Hyperglycemia-induced alterations in Glut-1 expression likely interfere with balance of glucose available to the embryonic heart that may affect cardiac morphogenesis. ..
  36. Choeiri C, Staines W, Messier C. Immunohistochemical localization and quantification of glucose transporters in the mouse brain. Neuroscience. 2002;111:19-34 pubmed
    A family of seven facilitative glucose transporters (Glut1-5, 7 and 8) mediates the cellular uptake of glucose...
  37. Malone C, Fromm J, Maertens O, DeRaedt T, Ingraham R, Cichowski K. Defining key signaling nodes and therapeutic biomarkers in NF1-mutant cancers. Cancer Discov. 2014;4:1062-73 pubmed publisher
    ..We unexpectedly found that the glucose transporter GLUT1 was potently suppressed, but only when both pathways were inhibited...
  38. Szpirer C, Riviere M, Szpirer J, Genet M, Dreze P, Islam M, et al. Assignment of 12 loci to rat chromosome 5: evidence that this chromosome is homologous to mouse chromosome 4 and to human chromosomes 9 and 1 (1p arm). Genomics. 1990;6:679-84 pubmed
    ..natriuretic factor (ANF = pronatriodilatin, PND), D4RP1, DSI1, galactosyltransferase (GGTB2), glucose transporter (GLUT1), interferon alpha 1 and related interferon alpha (INFA), interferon beta (INFB), lymphocyte-specific protein-..
  39. Riley J, Moley K. Glucose utilization and the PI3-K pathway: mechanisms for cell survival in preimplantation embryos. Reproduction. 2006;131:823-35 pubmed
    ..In addition, data demonstrating that PI3-K activity is important for glucose metabolism during this early developmental period will be discussed. ..
  40. Morita Y, Tsutsumi O, Oka Y, Taketani Y. Glucose transporter GLUT1 mRNA expression in the ontogeny of glucose incorporation in mouse preimplantation embryos. Biochem Biophys Res Commun. 1994;199:1525-31 pubmed
    ..chain reaction (RT-PCR) was applied to quantitatively determine the levels of glucose transporter GLUT1 mRNA in preimplantation mouse embryos...
  41. Jiang X, Kenerson H, Aicher L, Miyaoka R, Eary J, Bissler J, et al. The tuberous sclerosis complex regulates trafficking of glucose transporters and glucose uptake. Am J Pathol. 2008;172:1748-56 pubmed publisher
    ..Together, these data show that mTORC1 activity is insufficient for increased glycolysis in tumors and that constitutive mTOR activity negatively regulates glucose transporter trafficking. ..
  42. Tu T, Kim C, Nam Goong I, Nam C, Kim Y, Goto T, et al. 4-1BBL signaling promotes cell proliferation through reprogramming of glucose metabolism in monocytes/macrophages. FEBS J. 2015;282:1468-80 pubmed publisher
    ..The 4-1BBL signaling pathway may be a valid target for controlling macrophage-mediated chronic inflammation in obesity and metabolic diseases. ..
  43. Aerni Flessner L, Abi Jaoude M, Koenig A, Payne M, Hruz P. GLUT4, GLUT1, and GLUT8 are the dominant GLUT transcripts expressed in the murine left ventricle. Cardiovasc Diabetol. 2012;11:63 pubmed publisher
    ..the transport of glucose into the heart has primarily focused on the roles of the classical glucose transporters GLUT1 and GLUT4, little is known about the functions of more newly identified GLUT isoforms in the myocardium...
  44. Phoenix T, Patmore D, Boop S, Boulos N, Jacus M, Patel Y, et al. Medulloblastoma Genotype Dictates Blood Brain Barrier Phenotype. Cancer Cell. 2016;29:508-522 pubmed publisher
    ..Thus, medulloblastoma genotype dictates tumor vessel phenotype, explaining in part the disparate prognoses among medulloblastoma subtypes and suggesting an approach to enhance the chemoresponsiveness of other brain tumors. ..
  45. Lee M, Han H. Galectin-1 upregulates glucose transporter-1 expression level via protein kinase C, phosphoinositol-3 kinase, and mammalian target of rapamycin pathways in mouse embryonic stem cells. Int J Biochem Cell Biol. 2008;40:2421-30 pubmed publisher
    ..In conclusion, galectin-1 upregulates glucose uptake through Ca2+/protein kinase C/extracellular signal regulated kinase1/2, phosphoinositol-3-kinase/Akt, and mammalian target of rapamycin pathways in mouse ES cells. ..
  46. Singh R, Franke K, Kalucka J, Mamlouk S, Muschter A, Gembarska A, et al. HIF prolyl hydroxylase 2 (PHD2) is a critical regulator of hematopoietic stem cell maintenance during steady-state and stress. Blood. 2013;121:5158-66 pubmed publisher
  47. Kratsios P, Catela C, Salimova E, Huth M, Berno V, Rosenthal N, et al. Distinct roles for cell-autonomous Notch signaling in cardiomyocytes of the embryonic and adult heart. Circ Res. 2010;106:559-72 pubmed publisher
  48. Becker H, Mohebbi N, Perna A, Ganapathy V, Capasso G, Wagner C. Localization of members of MCT monocarboxylate transporter family Slc16 in the kidney and regulation during metabolic acidosis. Am J Physiol Renal Physiol. 2010;299:F141-54 pubmed publisher
  49. Shiota C, Woo J, Lindner J, Shelton K, Magnuson M. Multiallelic disruption of the rictor gene in mice reveals that mTOR complex 2 is essential for fetal growth and viability. Dev Cell. 2006;11:583-9 pubmed
    ..Taken together, these findings indicate that both rictor and mTORC2 are essential for the development of both embryonic and extraembryonic tissues. ..
  50. Vannucci S, Rutherford T, Wilkie M, Simpson I, Lauder J. Prenatal expression of the GLUT4 glucose transporter in the mouse. Dev Neurosci. 2000;22:274-82 pubmed
    ..These findings suggest that GLUT4-mediated glucose transport may play important roles during development of the brain and nonneuronal tissues in the mouse embryo. ..
  51. Stephens J, Pekala P. Transcriptional repression of the C/EBP-alpha and GLUT4 genes in 3T3-L1 adipocytes by tumor necrosis factor-alpha. Regulations is coordinate and independent of protein synthesis. J Biol Chem. 1992;267:13580-4 pubmed
    ..In addition to the transcriptional effect, we report that TNF-induced destabilization of these mRNAs contributes to decreased expression of all three genes. ..
  52. Guillam M, Dupraz P, Thorens B. Glucose uptake, utilization, and signaling in GLUT2-null islets. Diabetes. 2000;49:1485-91 pubmed
    ..We show that in the absence of GLUT2, no compensatory expression of either GLUT1 or GLUT3 is observed and that glucokinase is expressed at normal levels...
  53. Ryder J, Kawano Y, Chibalin A, Rincon J, Tsao T, Stenbit A, et al. In vitro analysis of the glucose-transport system in GLUT4-null skeletal muscle. Biochem J. 1999;342 ( Pt 2):321-8 pubmed
    ..We have characterized the glucose-transport system in soleus muscle from female GLUT4-null mice to determine whether GLUT1, 3 or 5 account for insulin-stimulated glucose-transport activity. Insulin increased 2-deoxyglucose uptake 2...
  54. Sakata M, Yamaguchi M, Imai T, Tadokoro C, Yoshimoto Y, Oka Y, et al. 8-Bromo-cAMP inhibits glucose transport activity in mouse placental cells in culture. J Endocrinol. 1996;150:319-27 pubmed
    Glucose plays an important role in fetal development and energy metabolism. Facilitative glucose transporter-1 (GLUT1) has been found in placenta. However, little is known about GLUT1 modulation in placental cells...
  55. Vannucci S, Gibbs E, Simpson I. Glucose utilization and glucose transporter proteins GLUT-1 and GLUT-3 in brains of diabetic (db/db) mice. Am J Physiol. 1997;272:E267-74 pubmed
    ..The results of this study indicate that the db/db mouse has markedly decelerated brain growth accompanied by global reductions in glucose metabolism that are not due to reductions in glucose transport capacity. ..
  56. Andrianifahanana M, Hernandez D, Yin X, Kang J, Jung M, Wang Y, et al. Profibrotic up-regulation of glucose transporter 1 by TGF-? involves activation of MEK and mammalian target of rapamycin complex 2 pathways. FASEB J. 2016;30:3733-3744 pubmed
    ..Here, we show that expression of the facilitative glucose transporter 1 (GLUT1) is induced by TGF-? in fibroblast lines and primary cells and is required for the profibrotic effects of TGF-?...
  57. Nayak B, Shanmugasundaram K, Friedrichs W, Cavaglierii R, Patel M, Barnes J, et al. HIF-1 Mediates Renal Fibrosis in OVE26 Type 1 Diabetic Mice. Diabetes. 2016;65:1387-97 pubmed publisher
    ..Through a series of genetic silencing and adenoviral overexpression studies, we have defined GLUT1 as a critical downstream target of HIF-1α mediating high glucose-induced matrix expression through the NADPH ..
  58. Morita Y, Tsutsumi O, Hosoya I, Taketani Y, Oka Y, Kato T. Expression and possible function of glucose transporter protein GLUT1 during preimplantation mouse development from oocytes to blastocysts. Biochem Biophys Res Commun. 1992;188:8-15 pubmed
    A micro-Western analysis method both sensitive and quantitative enough to analyze oocytes and embryos is developed. GLUT1 protein is present in mouse oocytes and preimplantation embryos and levels are increased by fertilization and with ..
  59. Siegenthaler J, Choe Y, Patterson K, Hsieh I, Li D, Jaminet S, et al. Foxc1 is required by pericytes during fetal brain angiogenesis. Biol Open. 2013;2:647-59 pubmed publisher
    ..Collectively these data point towards an important role for Foxc1 in certain brain pericyte functions (e.g. vessel morphogenesis) but not others (e.g. barriergenesis). ..
  60. Soans R, Lim D, Keenan B, Pack A, Shackleford J. Automated Protein Localization of Blood Brain Barrier Vasculature in Brightfield IHC Images. PLoS ONE. 2016;11:e0148411 pubmed publisher
    ..which is designed to automatically identify and segment microvessels containing the protein glucose transporter 1 (GLUT1)...
  61. Ge X, Chen C, Hui X, Wang Y, Lam K, Xu A. Fibroblast growth factor 21 induces glucose transporter-1 expression through activation of the serum response factor/Ets-like protein-1 in adipocytes. J Biol Chem. 2011;286:34533-41 pubmed publisher
    ..It enhances glucose uptake by inducing the expression of glucose transporter-1 (GLUT1) in adipocytes...
  62. Kim K, Kingsmore S, Han H, Yang Feng T, Godinot N, Seldin M, et al. Cloning of the human glycine transporter type 1: molecular and pharmacological characterization of novel isoform variants and chromosomal localization of the gene in the human and mouse genomes. Mol Pharmacol. 1994;45:608-17 pubmed
    ..These variants point to regions of the glycine transporter that might be important in the processing or transport function of this protein. ..
  63. Sakakura Y, Shibui T, Irie K, Yajima T. Metabolic mode peculiar to Meckel's cartilage: immunohistochemical comparisons of hypoxia-inducible factor-1alpha and glucose transporters in developing endochondral bones in mice. Eur J Oral Sci. 2008;116:341-52 pubmed publisher
    ..E14-E16) using immunohistochemistry for hypoxia-inducible factor-1alpha (HIF-1alpha), glucose transporter 1 (GLUT1), glucose transporter 3 (GLUT3), and glucose transporter 5 (GLUT5), and using enzyme histochemistry for glucose-6-..
  64. KC S, Carcamo J, Golde D. Vitamin C enters mitochondria via facilitative glucose transporter 1 (Glut1) and confers mitochondrial protection against oxidative injury. FASEB J. 2005;19:1657-67 pubmed
    ..form of vitamin C, dehydroascorbic acid (DHA), enters mitochondria via facilitative glucose transporter 1 (Glut1) and accumulates mitochondrially as ascorbic acid (mtAA)...
  65. Khan J, Rajakumar R, McKnight R, Devaskar U, Devaskar S. Developmental regulation of genes mediating murine brain glucose uptake. Am J Physiol. 1999;276:R892-900 pubmed
  66. Ida Yonemochi H, Nakatomi M, Harada H, Takata H, Baba O, Ohshima H. Glucose uptake mediated by glucose transporter 1 is essential for early tooth morphogenesis and size determination of murine molars. Dev Biol. 2012;363:52-61 pubmed publisher
    ..using immunohistochemistry and an in vitro organ culture experiment with an inhibitor of GLUTs1/2, phloretin, and Glut1 and Glut2 short interfering RNA (siRNA)...
  67. Arsenault P, Song D, Chung Y, Khurana T, Lee F. The Zinc Finger of Prolyl Hydroxylase Domain Protein 2 Is Essential for Efficient Hydroxylation of Hypoxia-Inducible Factor α. Mol Cell Biol. 2016;36:2328-43 pubmed publisher
    ..Thus, these findings have important implications for understanding both the molecular mechanism of the hypoxic response and human adaptation to high altitude. ..
  68. Gould G, Holman G. The glucose transporter family: structure, function and tissue-specific expression. Biochem J. 1993;295 ( Pt 2):329-41 pubmed
  69. Wieman H, Horn S, Jacobs S, Altman B, Kornbluth S, Rathmell J. An essential role for the Glut1 PDZ-binding motif in growth factor regulation of Glut1 degradation and trafficking. Biochem J. 2009;418:345-67 pubmed publisher
    Cell surface localization of the Glut (glucose transporter), Glut1, is a cytokine-controlled process essential to support the metabolism and survival of haemopoietic cells...
  70. Gunnink L, Alabi O, Kuiper B, Gunnink S, Schuiteman S, Strohbehn L, et al. Curcumin directly inhibits the transport activity of GLUT1. Biochimie. 2016;125:179-85 pubmed publisher
    ..Therefore, this study investigates the effects of curcumin in cell lines where the major transporter is GLUT1. We report that curcumin has an immediate inhibitory effect on basal glucose uptake in L929 fibroblast cells with ..
  71. Seidner G, Alvarez M, Yeh J, O Driscoll K, Klepper J, Stump T, et al. GLUT-1 deficiency syndrome caused by haploinsufficiency of the blood-brain barrier hexose carrier. Nat Genet. 1998;18:188-91 pubmed
    ..b>GLUT1 has been cloned and positionally mapped to the short arm of chromosome 1 (1p35-p31.3; refs 6-8)...
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    Glucose transporter 1 (GLUT1) plays a critical role in tumorigenesis and tumor progression in multiple cancer types. However, the specific function and clinical significance of GLUT1 in prostate cancer (PCa) are still unclear...
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    Transgenic mice that overexpress GLUT1 or GLUT4 in skeletal muscle were studied; the former but not the latter develop insulin resistance...
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    ..in endothelium to regulate sprouting, migration, and developmental expression of the blood-brain barrier marker Glut1, whereas in vitro, GPR124 mediated Cdc42-dependent directional migration to forebrain-derived, vascular ..
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    ..Our data suggest that restriction of fetal growth in 11beta-HSD2(-/-) mice is mediated, at least in part, via altered placental transport of nutrients and reduction in placental vascularization. ..
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    ..These findings identify Mfsd2a as a key regulator of BBB function that may act by suppressing transcytosis in CNS endothelial cells. Furthermore, our findings may aid in efforts to develop therapeutic approaches for CNS drug delivery...
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    ..These results support the hypothesis that redox status-associated changes in the host environment of tumor-bearing mice may contribute to cancer progression. ..
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    ..Expression of Glut-1 was fairly widespread in the embryo at 8.5 dpc, but by 10.5 dpc expression was down-regulated and was observed in the eye and the spinal cord.(ABSTRACT TRUNCATED AT 250 WORDS) ..
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    We identified a novel interaction between myosin VI and the GLUT1 transporter binding protein GLUT1CBP(GIPC1) and first proposed that as an adapter molecule it might function to couple vesicle-bound proteins to myosin VI movement...
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    ..apoptosis induced in both model systems correlates with a decrease in the expression of the glucose transporter GLUT1 at the plasma membrane...
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    Increased expression of the facilitative glucose transporter, GLUT1, leads to glomerulopathy that resembles diabetic nephropathy, whereas prevention of enhanced GLUT1 expression retards nephropathy...
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    ..GLUT1 (SLC2A1) is expressed in breast cancer cells and is likely responsible for avid glucose uptake observed in established ..