Gene Symbol: Slc29a2
Description: solute carrier family 29 (nucleoside transporters), member 2
Alias: Der12, Ent2, Hnp36, equilibrative nucleoside transporter 2, 36 kDa hydrophobic nucleolar protein, 36 kDa nucleolar protein HNP36, delayed early response gene 12, delayed-early response protein 12, equilibrative NBMPR-insensitive nucleoside transporter, equilibrative nitrobenzylmercaptopurine riboside-insensitive nucleoside transporter, nucleoside transporter, ei-type, solute carrier family 29 member 2
Species: mouse
Products:     Slc29a2

Top Publications

  1. Lanahan A, Williams J, Sanders L, Nathans D. Growth factor-induced delayed early response genes. Mol Cell Biol. 1992;12:3919-29 pubmed
    ..In 3T3 cells, the delayed early gene response to growth factors appears to be at least as complex as the immediate-early gene response previously described. ..
  2. Song A, Zhang Y, Han L, Yegutkin G, Liu H, Sun K, et al. Erythrocytes retain hypoxic adenosine response for faster acclimatization upon re-ascent. Nat Commun. 2017;8:14108 pubmed publisher
    ..Our findings suggest that targeting identified purinergic-signalling network would enhance the hypoxia adenosine response to counteract hypoxia-induced maladaptation. ..
  3. Williams J, Lanahan A. A mammalian delayed-early response gene encodes HNP36, a novel, conserved nucleolar protein. Biochem Biophys Res Commun. 1995;213:325-33 pubmed
    ..Both sequences encoded a hydrophobic 36 kD protein (HNP36) that was related to the yeast protein, FUN26...
  4. Griffiths M, Beaumont N, Yao S, Sundaram M, Boumah C, Davies A, et al. Cloning of a human nucleoside transporter implicated in the cellular uptake of adenosine and chemotherapeutic drugs. Nat Med. 1997;3:89-93 pubmed
  5. Handa M, Choi D, Caldeiro R, Messing R, Gordon A, Diamond I. Cloning of a novel isoform of the mouse NBMPR-sensitive equilibrative nucleoside transporter (ENT1) lacking a putative phosphorylation site. Gene. 2001;262:301-7 pubmed
    ..2 show similar dose response curves for NBMPR and dipyridamole inhibition of [(3)H]adenosine uptake as well as exhibiting comparable selectivity for both purine and pyrimidine nucleosides but not the corresponding nucleobases. ..
  6. Kiss A, Farah K, Kim J, Garriock R, Drysdale T, Hammond J. Molecular cloning and functional characterization of inhibitor-sensitive (mENT1) and inhibitor-resistant (mENT2) equilibrative nucleoside transporters from mouse brain. Biochem J. 2000;352 Pt 2:363-72 pubmed
    Mammalian cells express at least two subtypes of equilibrative nucleoside transporters, i.e. ENT1 and ENT2, which can be distinguished functionally by their sensitivity and resistance respectively to inhibition by nitrobenzylthioinosine...
  7. Acimovic Y, Coe I. Molecular evolution of the equilibrative nucleoside transporter family: identification of novel family members in prokaryotes and eukaryotes. Mol Biol Evol. 2002;19:2199-210 pubmed
    ..Finally, we propose an evolutionary history for the ENT family which clarifies the origin(s) of multiple isoforms in different taxa. ..
  8. Morote Garcia J, Kohler D, Roth J, Mirakaj V, Eldh T, Eltzschig H, et al. Repression of the equilibrative nucleoside transporters dampens inflammatory lung injury. Am J Respir Cell Mol Biol. 2013;49:296-305 pubmed publisher
    ..After inflammatory in vitro experiments, we observed a repression of ENT1 and ENT2 that was associated with an attenuation of extracellular adenosine uptake...
  9. Naydenova Z, Rose J, Coe I. Inosine and equilibrative nucleoside transporter 2 contribute to hypoxic preconditioning in the murine cardiomyocyte HL-1 cell line. Am J Physiol Heart Circ Physiol. 2008;294:H2687-92 pubmed publisher
    ..and inosine, across cardiomyocyte membranes is dependent on equilibrative nucleoside transporters 1 and 2 (ENT1 and ENT2)...

More Information


  1. Morote Garcia J, Rosenberger P, Nivillac N, Coe I, Eltzschig H. Hypoxia-inducible factor-dependent repression of equilibrative nucleoside transporter 2 attenuates mucosal inflammation during intestinal hypoxia. Gastroenterology. 2009;136:607-18 pubmed publisher
    ..Subsequent transcriptional studies suggested high expression levels of the equilibrative nucleoside transporter-2 (ENT2) in human epithelial cells and revealed ENT2 repression during hypoxia...
  2. Cheng X, Klaassen C. Tissue distribution, ontogeny, and hormonal regulation of xenobiotic transporters in mouse kidneys. Drug Metab Dispos. 2009;37:2178-85 pubmed publisher
    ..One exception is Ent2, which is highly expressed before birth and gradually decreases after birth until reaching adult levels at 15 days ..
  3. Eckle T, Hughes K, Ehrentraut H, Brodsky K, Rosenberger P, Choi D, et al. Crosstalk between the equilibrative nucleoside transporter ENT2 and alveolar Adora2b adenosine receptors dampens acute lung injury. FASEB J. 2013;27:3078-89 pubmed publisher
    ..Initial studies demonstrated time-dependent repression of ENT1 and ENT2 transcript and protein levels during ALI...