Slc26a6

Summary

Gene Symbol: Slc26a6
Description: solute carrier family 26, member 6
Alias: B930010B04Rik, CFEX, Pat-1, Pat1, solute carrier family 26 member 6, anion exchange transporter, chloride-formate exchanger, pendrin-L1, pendrin-like protein 1
Species: mouse
Products:     Slc26a6

Top Publications

  1. Wang Y, Soyombo A, Shcheynikov N, Zeng W, Dorwart M, Marino C, et al. Slc26a6 regulates CFTR activity in vivo to determine pancreatic duct HCO3- secretion: relevance to cystic fibrosis. EMBO J. 2006;25:5049-57 pubmed
    ..We show here that the Cl(-)/HCO(3)(-) exchanger slc26a6 controls CFTR activity and ductal fluid and HCO(3)(-) secretion...
  2. Petrovic S, Barone S, Wang Z, McDonough A, Amlal H, Soleimani M. Slc26a6 (PAT1) deletion downregulates the apical Na+/H+ exchanger in the straight segment of the proximal tubule. Am J Nephrol. 2008;28:330-8 pubmed
    b>Slc26a6 (PAT1, CFEX) is a major chloride/base exchanger located on the apical membrane of the kidney proximal tubule...
  3. Singh A, Riederer B, Chen M, Xiao F, Krabbenhöft A, Engelhardt R, et al. The switch of intestinal Slc26 exchangers from anion absorptive to HCOFormula secretory mode is dependent on CFTR anion channel function. Am J Physiol Cell Physiol. 2010;298:C1057-65 pubmed publisher
    ..The duodena of anesthetized CFTR-, NHE3-, Slc26a6-, and Scl26a3-deficient mice and wild-type (WT) littermates were perfused, and duodenal bicarbonate (HCO(3)(-)) ..
  4. Knauf F, Yang C, Thomson R, Mentone S, Giebisch G, Aronson P. Identification of a chloride-formate exchanger expressed on the brush border membrane of renal proximal tubule cells. Proc Natl Acad Sci U S A. 2001;98:9425-30 pubmed
    ..Sequence analysis indicated that CFEX very likely represents the mouse ortholog of human SLC26A6. Immunolocalization studies detected expression of CFEX, but not pendrin, on the brush border membrane of ..
  5. Whittamore J, Freel R, Hatch M. Sulfate secretion and chloride absorption are mediated by the anion exchanger DRA (Slc26a3) in the mouse cecum. Am J Physiol Gastrointest Liver Physiol. 2013;305:G172-84 pubmed publisher
    ..With DRA linked to the pathogenesis of other gastrointestinal diseases extending its functional characterization offers a more complete picture of its role in the intestine. ..
  6. Chavez J, Hernández González E, Wertheimer E, Visconti P, Darszon A, Trevino C. Participation of the Cl-/HCO(3)- exchangers SLC26A3 and SLC26A6, the Cl- channel CFTR, and the regulatory factor SLC9A3R1 in mouse sperm capacitation. Biol Reprod. 2012;86:1-14 pubmed publisher
    ..Alternatively, the [Cl(-)](i) increase might be mediated by anion exchangers. Among them, SLC26A3 and SLC26A6 are good candidates, since, in several cell types, they increase [Cl(-)](i) and interact with cystic fibrosis ..
  7. Clark J, Vandorpe D, Chernova M, Heneghan J, Stewart A, Alper S. Species differences in Cl- affinity and in electrogenicity of SLC26A6-mediated oxalate/Cl- exchange correlate with the distinct human and mouse susceptibilities to nephrolithiasis. J Physiol. 2008;586:1291-306 pubmed publisher
    ..However, recent studies have identified slc26a6 as an oxalate nephrolithiasis gene in the mouse...
  8. Wang Z, Petrovic S, Mann E, Soleimani M. Identification of an apical Cl(-)/HCO3(-) exchanger in the small intestine. Am J Physiol Gastrointest Liver Physiol. 2002;282:G573-9 pubmed
    ..downregulated in adenoma (DRA or SLC26A3), pendrin (PDS or SLC26A4), and the putative anion transporter (PAT1 or SLC26A6) has recently been identified...
  9. Ohana E, Shcheynikov N, Moe O, Muallem S. SLC26A6 and NaDC-1 transporters interact to regulate oxalate and citrate homeostasis. J Am Soc Nephrol. 2013;24:1617-26 pubmed publisher
    ..Here, we examined the relationship between the oxalate transporter SLC26A6 and the citrate transporter NaDC-1 in citrate and oxalate homeostasis...

More Information

Publications50

  1. Alper S, Stewart A, Vandorpe D, Clark J, Horack R, Simpson J, et al. Native and recombinant Slc26a3 (downregulated in adenoma, Dra) do not exhibit properties of 2Cl-/1HCO3- exchange. Am J Physiol Cell Physiol. 2011;300:C276-86 pubmed publisher
  2. Kato A, Chang M, Kurita Y, Nakada T, Ogoshi M, Nakazato T, et al. Identification of renal transporters involved in sulfate excretion in marine teleost fish. Am J Physiol Regul Integr Comp Physiol. 2009;297:R1647-59 pubmed publisher
    ..Among 14 clones examined, the expression of a Slc26a6 paralog (mfSlc26a6A) was the most upregulated (30-fold) in the kidney of SW mefugu...
  3. Ishiguro H, Namkung W, Yamamoto A, Wang Z, Worrell R, Xu J, et al. Effect of Slc26a6 deletion on apical Cl-/HCO3- exchanger activity and cAMP-stimulated bicarbonate secretion in pancreatic duct. Am J Physiol Gastrointest Liver Physiol. 2007;292:G447-55 pubmed
    The role of Slc26a6 (PAT1) on apical Cl-/HCO3- exchange and bicarbonate secretion in pancreatic duct cells was investigated using Slc26a6 null and wild-type (WT) mice...
  4. Sirish P, Ledford H, Timofeyev V, Thai P, Ren L, Kim H, et al. Action Potential Shortening and Impairment of Cardiac Function by Ablation of Slc26a6. Circ Arrhythm Electrophysiol. 2017;10: pubmed publisher
    ..Our previous studies identified several isoforms of a solute carrier Slc26a6 to be highly expressed in cardiomyocytes...
  5. Yang D, Shcheynikov N, Zeng W, Ohana E, So I, Ando H, et al. IRBIT coordinates epithelial fluid and HCO3- secretion by stimulating the transporters pNBC1 and CFTR in the murine pancreatic duct. J Clin Invest. 2009;119:193-202 pubmed publisher
    ..These findings define IRBIT as a key coordinator of epithelial fluid and HCO3- secretion and may have implications to all CFTR-expressing epithelia and to cystic fibrosis...
  6. Wang Z, Wang T, Petrovic S, Tuo B, Riederer B, Barone S, et al. Renal and intestinal transport defects in Slc26a6-null mice. Am J Physiol Cell Physiol. 2005;288:C957-65 pubmed
    b>SLC26A6 (PAT1, CFEX) is an anion exchanger that is expressed on the apical membrane of the kidney proximal tubule and the small intestine...
  7. Yin K, Lei Y, Wen X, Lacruz R, Soleimani M, Kurtz I, et al. SLC26A Gene Family Participate in pH Regulation during Enamel Maturation. PLoS ONE. 2015;10:e0144703 pubmed publisher
    The bicarbonate transport activities of Slc26a1, Slc26a6 and Slc26a7 are essential to physiological processes in multiple organs...
  8. Park S, Shcheynikov N, Hong J, Zheng C, Suh S, Kawaai K, et al. Irbit mediates synergy between ca(2+) and cAMP signaling pathways during epithelial transport in mice. Gastroenterology. 2013;145:232-241 pubmed publisher
    ..We created mice with disruptions in genes encoding the solute carrier family 26, member 6 (Slc26a6(-/-) mice) and inositol 1,4,5-triphosphate (InsP3) receptor-binding protein released with InsP3 (Irbit(-/-)) mice...
  9. Freel R, Hatch M, Green M, Soleimani M. Ileal oxalate absorption and urinary oxalate excretion are enhanced in Slc26a6 null mice. Am J Physiol Gastrointest Liver Physiol. 2006;290:G719-28 pubmed
    ..To assess the contribution of the putative anion transporter (PAT)1 (Slc26a6) to transepithelial oxalate transport, we compared the unidirectional and net fluxes of oxalate across isolated, ..
  10. Alvarez B, Kieller D, Quon A, Markovich D, Casey J. Slc26a6: a cardiac chloride-hydroxyl exchanger and predominant chloride-bicarbonate exchanger of the mouse heart. J Physiol. 2004;561:721-34 pubmed
    ..In neonatal and adult myocardium, AE1 (Slc4a1), AE2 (Slc4a2), AE3 (Slc4a3) (AE3fl and AE3c variants), Slc26a3 and Slc26a6 were expressed...
  11. Thomson R, Wang T, Thomson B, Tarrats L, Girardi A, Mentone S, et al. Role of PDZK1 in membrane expression of renal brush border ion exchangers. Proc Natl Acad Sci U S A. 2005;102:13331-6 pubmed
    Na-H exchanger NHE3 and Cl-anion exchanger CFEX (SLC26A6, PAT1) play principal roles in the reabsorption of Na and Cl in the proximal tubule of the mammalian kidney...
  12. Whittamore J, Hatch M. Loss of the anion exchanger DRA (Slc26a3), or PAT1 (Slc26a6), alters sulfate transport by the distal ileum and overall sulfate homeostasis. Am J Physiol Gastrointest Liver Physiol. 2017;313:G166-G179 pubmed publisher
    ..see text]) exchangers downregulated in adenoma (DRA; Slc26a3), and putative anion transporter 1 (PAT1; Slc26a6), to the underlying transport mechanism...
  13. Aronson P. Ion exchangers mediating NaCl transport in the renal proximal tubule. Cell Biochem Biophys. 2002;36:147-53 pubmed
    ..Finally, we cloned and functionally expressed CFEX, an anion transporter expressed on the apical surface of proximal tubule cells and capable of mediating Cl(-)-..
  14. Petrovic S, Wang Z, Ma L, Seidler U, Forte J, Shull G, et al. Colocalization of the apical Cl-/HCO3- exchanger PAT1 and gastric H-K-ATPase in stomach parietal cells. Am J Physiol Gastrointest Liver Physiol. 2002;283:G1207-16 pubmed
    The apical Cl-/HCO exchanger called the putative anion transporter (PAT1; SLC26A6) is expressed on apical membranes of villus cells in the duodenum, but its location in the stomach remains unknown...
  15. Jiang Z, Grichtchenko I, Boron W, Aronson P. Specificity of anion exchange mediated by mouse Slc26a6. J Biol Chem. 2002;277:33963-7 pubmed
    Recently, CFEX, the mouse orthologue of human SLC26A6, was localized to the brush border membrane of proximal tubule cells and was demonstrated to mediate Cl(-)-formate exchange when expressed in Xenopus oocytes...
  16. Jiang Z, Asplin J, Evan A, Rajendran V, Velazquez H, Nottoli T, et al. Calcium oxalate urolithiasis in mice lacking anion transporter Slc26a6. Nat Genet. 2006;38:474-8 pubmed
    ..b>SLC26A6 is an anion exchanger expressed on the apical membrane in many epithelial tissues, including kidney and intestine...
  17. Dilsizoglu Senol A, Tagliafierro L, Huguet L, Gorisse Hussonnois L, Chasseigneaux S, Allinquant B. PAT1 inversely regulates the surface Amyloid Precursor Protein level in mouse primary neurons. BMC Neurosci. 2015;16:10 pubmed publisher
    ..In this respect, by having homologies with kinesin light chain domains and because of its capacity to bind APP, PAT1 represents a good candidate...
  18. Song Y, Yamamoto A, Steward M, Ko S, Stewart A, Soleimani M, et al. Deletion of Slc26a6 alters the stoichiometry of apical Cl-/HCO-3 exchange in mouse pancreatic duct. Am J Physiol Cell Physiol. 2012;303:C815-24 pubmed publisher
    ..luminal pH and volume were measured simultaneously in interlobular pancreatic ducts isolated from wild-type and Slc26a6-null mice...
  19. Kim H, Myers R, Sihn C, Rafizadeh S, Zhang X. Slc26a6 functions as an electrogenic Cl-/HCO3- exchanger in cardiac myocytes. Cardiovasc Res. 2013;100:383-91 pubmed publisher
    ..A member of the solute carrier (SLC) family, Slc26a6, has been shown to be a chloride-hydroxyl exchanger and the predominant chloride-bicarbonate exchanger in the ..
  20. Garcia Perez I, Villaseñor A, Wijeyesekera A, Posma J, Jiang Z, Stamler J, et al. Urinary metabolic phenotyping the slc26a6 (chloride-oxalate exchanger) null mouse model. J Proteome Res. 2012;11:4425-35 pubmed publisher
    ..The chloride-oxalate exchanger slc26a6 (also known as CFEX or PAT-1), located in the renal proximal tubule, was originally thought to have an important ..
  21. Xie Q, Welch R, Mercado A, Romero M, Mount D. Molecular characterization of the murine Slc26a6 anion exchanger: functional comparison with Slc26a1. Am J Physiol Renal Physiol. 2002;283:F826-38 pubmed
    We report the molecular and functional characterization of murine Slc26a6, the putative apical chloride-formate exchanger of the proximal tubule. The Slc26a6 transcript is expressed in several tissues, including kidney...
  22. Walker N, Simpson J, Brazill J, Gill R, Dudeja P, Schweinfest C, et al. Role of down-regulated in adenoma anion exchanger in HCO3- secretion across murine duodenum. Gastroenterology. 2009;136:893-901 pubmed publisher
    ..Dra Cl(-)/HCO(3)(-) exchange should be considered in efforts to normalize HCO(3)(-) secretion in duodenal disorders such as ulcer disease and cystic fibrosis. ..
  23. Aronson P. Role of SLC26-mediated Cl-/base exchange in proximal tubule NaCl transport. Novartis Found Symp. 2006;273:148-58; discussion 158-63, 261-4 pubmed
    ..We did find expression of SLC26A6 (CFEX, PAT1) on the apical membrane of proximal tubule cells, and demonstrated that SLC26A6 is capable of ..
  24. Walker N, Simpson J, Hoover E, Brazill J, Schweinfest C, Soleimani M, et al. Functional activity of Pat-1 (Slc26a6) Cl(?)/HCO?(?) exchange in the lower villus epithelium of murine duodenum. Acta Physiol (Oxf). 2011;201:21-31 pubmed publisher
    ..The inhibitory effects of membrane depolarization on Pat-1 Cl(?)(IN) /HCO?(?) (OUT) exchange may require concurrent membrane association with Cftr. ..
  25. Shcheynikov N, Yang D, Wang Y, Zeng W, Karniski L, So I, et al. The Slc26a4 transporter functions as an electroneutral Cl-/I-/HCO3- exchanger: role of Slc26a4 and Slc26a6 in I- and HCO3- secretion and in regulation of CFTR in the parotid duct. J Physiol. 2008;586:3813-24 pubmed publisher
    ..In the present work we used the parotid gland duct which expressed Slc26a4 and Slc26a6 and the model systems of Slc26a4(-/-) and Slc26a6(-/-) mice to study the role and regulation of these SLC26 ..
  26. Singh A, Amlal H, Haas P, Dringenberg U, Fussell S, Barone S, et al. Fructose-induced hypertension: essential role of chloride and fructose absorbing transporters PAT1 and Glut5. Kidney Int. 2008;74:438-47 pubmed publisher
    ..jejunal NaCl and water absorption which was significantly decreased in mice whose apical chloride/base exchanger Slc26a6 (PAT1, CFEX) was knocked out...
  27. Walker N, Simpson J, Yen P, Gill R, Rigsby E, Brazill J, et al. Down-regulated in adenoma Cl/HCO3 exchanger couples with Na/H exchanger 3 for NaCl absorption in murine small intestine. Gastroenterology. 2008;135:1645-1653.e3 pubmed publisher
    ..mice with gene-targeted knockout (KO) of Cl(-)/HCO(3)(-) exchangers: Slc26a3, down-regulated in adenoma (Dra) or Slc26a6, putative anion transporter-1 (Pat-1)...
  28. Xia W, Yu Q, Riederer B, Singh A, Engelhardt R, Yeruva S, et al. The distinct roles of anion transporters Slc26a3 (DRA) and Slc26a6 (PAT-1) in fluid and electrolyte absorption in the murine small intestine. Pflugers Arch. 2014;466:1541-56 pubmed
    ..We investigated the role of the small intestinal apical anion exchangers PAT-1 (Slc26a6) and DRA (Slc26a3) in basal and CO2/HCO3 ?-stimulated jejunal fluid absorption...
  29. Tuo B, Riederer B, Wang Z, Colledge W, Soleimani M, Seidler U. Involvement of the anion exchanger SLC26A6 in prostaglandin E2- but not forskolin-stimulated duodenal HCO3- secretion. Gastroenterology. 2006;130:349-58 pubmed
    b>SLC26A6 is a recently identified apical Cl(-)/HCO(3)(-) exchanger with strong expression in murine duodenum...
  30. Seidler U, Rottinghaus I, Hillesheim J, Chen M, Riederer B, Krabbenhöft A, et al. Sodium and chloride absorptive defects in the small intestine in Slc26a6 null mice. Pflugers Arch. 2008;455:757-66 pubmed
    PAT1 (Slc26a6) is located on the apical membrane of the small intestinal villi, but its role for salt absorption has not been studied...
  31. Singh A, Liu Y, Riederer B, Engelhardt R, Thakur B, Soleimani M, et al. Molecular transport machinery involved in orchestrating luminal acid-induced duodenal bicarbonate secretion in vivo. J Physiol. 2013;591:5377-91 pubmed publisher
    ..several ion transporters and/or channels, including the solute carrier 26 anion transporters Slc26a3 (DRA) and Slc26a6 (PAT-1), the Na(+)/H(+) exchanger isoform 3 (NHE3), as well as the anion channels cystic fibrosis transmembrane ..
  32. Knauf F, Ko N, Jiang Z, Robertson W, Van Itallie C, Anderson J, et al. Net intestinal transport of oxalate reflects passive absorption and SLC26A6-mediated secretion. J Am Soc Nephrol. 2011;22:2247-55 pubmed publisher
    Mice lacking the oxalate transporter SLC26A6 develop hyperoxalemia, hyperoxaluria, and calcium-oxalate stones as a result of a defect in intestinal oxalate secretion, but what accounts for the absorptive oxalate flux remains unknown...
  33. Hassan H, Mentone S, Karniski L, Rajendran V, Aronson P. Regulation of anion exchanger Slc26a6 by protein kinase C. Am J Physiol Cell Physiol. 2007;292:C1485-92 pubmed
    b>SLC26A6 (CFEX, PAT1) is an anion exchanger expressed in several tissues including renal proximal tubule, pancreatic duct, small intestine, liver, stomach, and heart...
  34. Thomson R, Thomson C, Aronson P. N-glycosylation critically regulates function of oxalate transporter SLC26A6. Am J Physiol Cell Physiol. 2016;311:C866-C873 pubmed publisher
    The brush border Cl--oxalate exchanger SLC26A6 plays an essential role in mediating intestinal secretion of oxalate and is crucial for the maintenance of oxalate homeostasis and the prevention of hyperoxaluria and calcium ..
  35. Alper S, Stewart A, Chernova M, Zolotarev A, Clark J, Vandorpe D. Anion exchangers in flux: functional differences between human and mouse SLC26A6 polypeptides. Novartis Found Symp. 2006;273:107-19; discussion 119-25, 261-4 pubmed
    ..than is found among the SLC4 bicarbonate transporters, and among SLC26 transporters is most marked among SLC26A6 orthologues...
  36. Simpson J, Walker N, Supuran C, Soleimani M, Clarke L. Putative anion transporter-1 (Pat-1, Slc26a6) contributes to intracellular pH regulation during H+-dipeptide transport in duodenal villous epithelium. Am J Physiol Gastrointest Liver Physiol. 2010;298:G683-91 pubmed publisher
    ..In conclusion, Pat-1 Cl(-)/HCO(3)(-) exchange contributes to pH(i) regulation in the villous epithelium during H(+)-dipeptide absorption, possibly by providing a HCO(3)(-) import pathway. ..
  37. Dawson P, Rakoczy J, Simmons D. Placental, renal, and ileal sulfate transporter gene expression in mouse gestation. Biol Reprod. 2012;87:43 pubmed publisher
    ..5 or E6.5, whereas lower levels of Slc26a2, Slc26a6, and Slc26a7 mRNA increased by ?3- to 6-fold from E4.5...
  38. Simpson J, Schweinfest C, Shull G, Gawenis L, Walker N, Boyle K, et al. PAT-1 (Slc26a6) is the predominant apical membrane Cl-/HCO3- exchanger in the upper villous epithelium of the murine duodenum. Am J Physiol Gastrointest Liver Physiol. 2007;292:G1079-88 pubmed
    ..exchangers localized to the apical membrane of murine duodenal villi: Slc26a3 [down-regulated in adenoma (DRA)], Slc26a6 [putative anion transporter 1 (PAT-1)], and Slc4a9 [anion exchanger 4 (AE4)]...
  39. Ko N, Knauf F, Jiang Z, Markovich D, Aronson P. Sat1 is dispensable for active oxalate secretion in mouse duodenum. Am J Physiol Cell Physiol. 2012;303:C52-7 pubmed publisher
    Mice deficient for the apical membrane oxalate transporter SLC26A6 develop hyperoxalemia, hyperoxaluria, and calcium oxalate stones due to a defect in intestinal oxalate secretion...
  40. Jalali R, Zandieh Doulabi B, DenBesten P, Seidler U, Riederer B, Wedenoja S, et al. Slc26a3/Dra and Slc26a6 in Murine Ameloblasts. J Dent Res. 2015;94:1732-9 pubmed publisher
    ..carrier (Slc) family 26A encodes different anion exchangers that exchange Cl(-)/HCO3 (-), including Slc26a3/Dra, Slc26a6/Pat-1, and Slc26a4/pendrin...
  41. Chernova M, Jiang L, Friedman D, Darman R, Lohi H, Kere J, et al. Functional comparison of mouse slc26a6 anion exchanger with human SLC26A6 polypeptide variants: differences in anion selectivity, regulation, and electrogenicity. J Biol Chem. 2005;280:8564-80 pubmed
    The unusually low 78% amino acid identity between the orthologous human SLC26A6 and mouse slc26a6 polypeptides prompted systematic comparison of their anion transport functions in Xenopus oocytes...