Gene Symbol: Slc25a5
Description: solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 5
Alias: Ant2, ADP/ATP translocase 2, ADP, ATP carrier protein 2, adenine nucleotide translocase, adenine nucleotide translocator 2, fibroblast
Species: mouse
Products:     Slc25a5

Top Publications

  1. Shabalina I, Kramarova T, Nedergaard J, Cannon B. Carboxyatractyloside effects on brown-fat mitochondria imply that the adenine nucleotide translocator isoforms ANT1 and ANT2 may be responsible for basal and fatty-acid-induced uncoupling respectively. Biochem J. 2006;399:405-14 pubmed
    ..However, in liver, only Ant2 mRNA was found, whereas in brown adipose tissue, Ant1 and Ant2 mRNA levels were equal...
  2. Osmundsen H, Landin M, From S, Kolltveit K, Risnes S. Changes in gene-expression during development of the murine molar tooth germ. Arch Oral Biol. 2007;52:803-13 pubmed
    ..Such data is therefore useful in directing attention towards genes, or cellular activities, which likely are worthy of further studies as regards their involvement in odontogenesis...
  3. Cho J, Zhang Y, Park S, Joseph A, Han C, Park H, et al. Mitochondrial ATP transporter depletion protects mice against liver steatosis and insulin resistance. Nat Commun. 2017;8:14477 pubmed publisher
    Non-alcoholic fatty liver disease (NAFLD) is a common metabolic disorder in obese individuals. Adenine nucleotide translocase (ANT) exchanges ADP/ATP through the mitochondrial inner membrane, and Ant2 is the predominant isoform expressed ..
  4. Cozens A, Runswick M, Walker J. DNA sequences of two expressed nuclear genes for human mitochondrial ADP/ATP translocase. J Mol Biol. 1989;206:261-80 pubmed
    ..The two DNA sequence also contain many short interspersed repetitive sequences including 11 Alu repeats, and a novel element about 236 base-pairs in length, which is repeated in a six-fold tandem array in intron B of the T2 gene. ..
  5. Hubackova S, Kucerová A, Michlits G, Kyjacova L, Reinis M, Korolov O, et al. IFNγ induces oxidative stress, DNA damage and tumor cell senescence via TGFβ/SMAD signaling-dependent induction of Nox4 and suppression of ANT2. Oncogene. 2016;35:1236-49 pubmed publisher
    ..Furthermore, the expression of adenine nucleotide translocase 2 (ANT2) was suppressed by IFNγ contributing to elevation of ROS and DNA damage...
  6. van Wietmarschen N, Moradian A, Morin G, Lansdorp P, Uringa E. The mammalian proteins MMS19, MIP18, and ANT2 are involved in cytoplasmic iron-sulfur cluster protein assembly. J Biol Chem. 2012;287:43351-8 pubmed publisher
    ..Furthermore, we show that ADP/ATP translocase 2 (ANT2) interacts with Fe-S apoproteins and MMS19 in the CIA complex but not with the individual proteins...
  7. Parker N, Affourtit C, Vidal Puig A, Brand M. Energization-dependent endogenous activation of proton conductance in skeletal muscle mitochondria. Biochem J. 2008;412:131-9 pubmed publisher
    ..for UCPs (uncoupling proteins)], carboxyatractylate and bongkrekate (considered specific for the adenine nucleotide translocase) was examined in skeletal muscle mitochondria from wild-type and Ucp3-knockout mice...
  8. Kokoszka J, Waymire K, Levy S, Sligh J, Cai J, Jones D, et al. The ADP/ATP translocator is not essential for the mitochondrial permeability transition pore. Nature. 2004;427:461-5 pubmed
    ..Moreover, hepatocytes without ANT remained competent to respond to various initiators of cell death. Therefore, ANTs are non-essential structural components of the mtPTP, although they do contribute to its regulation. ..
  9. Liu X, Oliver F, Brown S, Denny P, Keightley P. High-resolution quantitative trait locus mapping for body weight in mice by recombinant progeny testing. Genet Res. 2001;77:191-7 pubmed

More Information


  1. Ellison J, Salido E, Shapiro L. Genetic mapping of the adenine nucleotide translocase-2 gene (Ant2) to the mouse proximal X chromosome. Genomics. 1996;36:369-71 pubmed
    ..We have previously cloned cDNAs derived from the mouse adenine nucleotide translocase-1 and -2 genes (Ant1 and Ant2) and assigned the loci to mouse chromosomes 8 and X, respectively...
  2. Levy S, Chen Y, Graham B, Wallace D. Expression and sequence analysis of the mouse adenine nucleotide translocase 1 and 2 genes. Gene. 2000;254:57-66 pubmed
    Only two isoforms of the adenine nucleotide translocase (Ant) protein have been identified in mouse, as opposed to the three in humans...
  3. Singh U, Sun T, Shi W, Schulz R, Nuber U, Varanou A, et al. Expression and functional analysis of genes deregulated in mouse placental overgrowth models: Car2 and Ncam1. Dev Dyn. 2005;234:1034-45 pubmed
    ..This strongly suggested that altered expression of Car2 and Ncam1 is a downstream event in placental hyperplasia. ..
  4. Matsuki Y, Kaname T, Suematsu S, Yamaguchi Y, Abe K, Yamamura K. Mouse K-glypican gene, gpc4, maps to chromosome X. Genomics. 1998;54:358-9 pubmed
  5. Sutton K, Wilkinson M. The rapidly evolving Pem homeobox gene and Agtr2, Ant2, and Lamp2 are closely linked in the proximal region of the mouse X chromosome. Genomics. 1997;45:447-50 pubmed
    ..spretus backcross panels, we established the order of markers within this segment of the Hprt region as: Agtr2-Pem-Ant2-DXMit50-Lamp2-DXMit49...
  6. Graham B, Waymire K, Cottrell B, Trounce I, MacGregor G, Wallace D. A mouse model for mitochondrial myopathy and cardiomyopathy resulting from a deficiency in the heart/muscle isoform of the adenine nucleotide translocator. Nat Genet. 1997;16:226-34 pubmed
    ..Significantly, mutant adults manifested severe exercise intolerance. Therefore, Ant1 mutant mice have the biochemical, histological, metabolic and physiological characteristics of mitochondrial myopathy and cardiomyopathy. ..
  7. Ellison J, Li X, Francke U, Shapiro L. Rapid evolution of human pseudoautosomal genes and their mouse homologs. Mamm Genome. 1996;7:25-30 pubmed
    ..Attempts to clone the mouse homolog of the human pseudoautosomal adenine nucleotide translocase-3 (ANT3) gene resulted in the isolation of the murine homologs of the human ANT1 and ANT2 genes...
  8. Ho L, Titus A, Banerjee K, George S, Lin W, Deota S, et al. SIRT4 regulates ATP homeostasis and mediates a retrograde signaling via AMPK. Aging (Albany NY). 2013;5:835-49 pubmed
    ..We find that Sirt4 affects mitochondrial uncoupling via the adenine nucleotide translocator 2 (ANT2)...
  9. Markkanen M, Karhunen T, Llano O, Ludwig A, Rivera C, Uvarov P, et al. Distribution of neuronal KCC2a and KCC2b isoforms in mouse CNS. J Comp Neurol. 2014;522:1897-914 pubmed publisher
    ..The results, together with those of previous studies, suggest that KCC2a and KCC2b have overlapping roles in neonatal neurons but presumably different roles in mature neurons. ..
  10. Cho J, Seo J, Lim C, Yang L, Shiratsuchi T, Lee M, et al. Mitochondrial ATP transporter Ant2 depletion impairs erythropoiesis and B lymphopoiesis. Cell Death Differ. 2015;22:1437-50 pubmed publisher
    ..Mice have three ANT paralogs, Ant1 (Slc25a4), Ant2 (Slc25a5) and Ant4 (Slc25a31), which are expressed in a tissue-dependent manner...
  11. Kokoszka J, Waymire K, Flierl A, Sweeney K, Angelin A, MacGregor G, et al. Deficiency in the mouse mitochondrial adenine nucleotide translocator isoform 2 gene is associated with cardiac noncompaction. Biochim Biophys Acta. 2016;1857:1203-1212 pubmed publisher
    ..The predominant isoform is the heart-muscle-brain ANT-isoform gene 1 (Ant1) while the other is the systemic Ant2 gene...
  12. Gormally E, Boyd Y. Faint lined (Fnl): a novel X-linked coat mutant in the mouse. Genet Res. 1998;72:211-6 pubmed 3H1 males and haplotype analysis positioned Fnl in the proximal region of the mouse X chromosome distal to Ant2 and proximal to Hprt...
  13. Fang J, Zhang W, Yamashita T, Gao J, Zhu M, Zuo J. Outer hair cell-specific prestin-CreERT2 knockin mouse lines. Genesis. 2012;50:124-31 pubmed publisher
    ..Moreover, prestin-CreERT2+/-(heterozygotes) and +/+(homozygotes) as well as prestin-CreERT2-NN+/-mice displayed normal hearing. These two prestin-CreERT2 mouse lines are therefore useful tools to analyze gene function in OHCs in vivo. ..
  14. Loers G, Makhina T, Bork U, Dorner A, Schachner M, Kleene R. The interaction between cell adhesion molecule L1, matrix metalloproteinase 14, and adenine nucleotide translocator at the plasma membrane regulates L1-mediated neurite outgrowth of murine cerebellar neurons. J Neurosci. 2012;32:3917-30 pubmed publisher
    We have identified the adenine nucleotide translocator (ANT) isoforms ANT1 and ANT2 that are present in the plasma membrane of mouse cerebellar neurons as novel binding partners of the cell adhesion molecule L1...
  15. Shi H, Teng C. Characterization of a mitogen-response unit in the mouse lactoferrin gene promoter. J Biol Chem. 1994;269:12973-80 pubmed
    ..The mobility shift assay suggested that AP1 and CREB or related proteins participated in complex formation with the mLF-CRE, whereas different proteins bound to the EGF/TGF-alpha-response element. ..