Gene Symbol: Slc25a28
Description: solute carrier family 25, member 28
Alias: Mfrn2, Mrs3/4, mitoferrin-2, mitochondrial RNA-splicing protein 3/4 homolog, mitochondrial iron transporter 2
Li F, Nikali K, Gregan J, Leibiger I, Leibiger B, Schweyen R, et al
. Characterization of a novel human putative mitochondrial transporter homologous to the yeast mitochondrial RNA splicing proteins 3 and 4. FEBS Lett. 2001;494:79-84 pubmed
..Ubiquitous expression in human tissues and a well-conserved structure and function suggest an important role for hMRS3/4 in human cells. ..
Li F, Leibiger B, Leibiger I, Larsson C. Characterization of a putative murine mitochondrial transporter homology of hMRS3/4. Mamm Genome. 2002;13:20-3 pubmed
Shaw G, Cope J, Li L, Corson K, Hersey C, Ackermann G, et al
. Mitoferrin is essential for erythroid iron assimilation. Nature. 2006;440:96-100 pubmed
..Our data show that mfrn functions as the principal mitochondrial iron importer essential for haem biosynthesis in vertebrate erythroblasts...
Paradkar P, Zumbrennen K, Paw B, Ward D, Kaplan J. Regulation of mitochondrial iron import through differential turnover of mitoferrin 1 and mitoferrin 2. Mol Cell Biol. 2009;29:1007-16 pubmed publisher
Mitoferrin 1 and mitoferrin 2 are homologous members of the mitochondrial solute carrier family. Mitoferrin 1 is required for mitochondrial iron delivery in developing erythrocytes...
Amigo J, Yu M, Troadec M, Gwynn B, Cooney J, Lambert A, et al
. Identification of distal cis-regulatory elements at mouse mitoferrin loci using zebrafish transgenesis. Mol Cell Biol. 2011;31:1344-56 pubmed publisher
Mitoferrin 1 (Mfrn1; Slc25a37) and mitoferrin 2 (Mfrn2; Slc25a28) function as essential mitochondrial iron importers for heme and Fe/S cluster biogenesis...
Chen W, Paradkar P, Li L, Pierce E, Langer N, Takahashi Makise N, et al
. Abcb10 physically interacts with mitoferrin-1 (Slc25a37) to enhance its stability and function in the erythroid mitochondria. Proc Natl Acad Sci U S A. 2009;106:16263-8 pubmed publisher
Troadec M, Warner D, Wallace J, Thomas K, Spangrude G, Phillips J, et al
. Targeted deletion of the mouse Mitoferrin1 gene: from anemia to protoporphyria. Blood. 2011;117:5494-502 pubmed publisher
..Our results show that the activity of mitoferrin1 is required to manage an increase in heme synthesis. The data also show that alterations in heme synthesis within hepatocytes can lead to protoporphyria and hepatotoxicity. ..