Gene Symbol: Slc25a27
Description: solute carrier family 25, member 27
Alias: 3632410G24Rik, 9430092A03Rik, D530043E16Rik, Ucp4, mitochondrial uncoupling protein 4
Liu D, Chan S, de Souza Pinto N, Slevin J, Wersto R, Zhan M, et al
. Mitochondrial UCP4 mediates an adaptive shift in energy metabolism and increases the resistance of neurons to metabolic and oxidative stress. Neuromolecular Med. 2006;8:389-414 pubmed
..The authors cloned UCP4 cDNA from mouse and rat brain, and demonstrate that UCP4 mRNA is expressed abundantly in brain and at particularly ..
Smorodchenko A, Rupprecht A, Sarilova I, Ninnemann O, Bräuer A, Franke K, et al
. Comparative analysis of uncoupling protein 4 distribution in various tissues under physiological conditions and during development. Biochim Biophys Acta. 2009;1788:2309-19 pubmed publisher
b>UCP4 is a member of the mitochondrial uncoupling protein subfamily and one of the three UCPs (UCP2, UCP4, UCP5), associated with the nervous system...
Gao C, Zhu J, Zhao Y, Chen X, Ji C, Zhang C, et al
. Mitochondrial dysfunction is induced by the overexpression of UCP4 in 3T3-L1 adipocytes. Int J Mol Med. 2010;25:71-80 pubmed
..We have previously shown that uncoupling protein 4 (UCP4) is differentially expressed in omental adipose tissue in diet-induced obese and normal rats...
Rupprecht A, Sittner D, Smorodchenko A, Hilse K, Goyn J, Moldzio R, et al
. Uncoupling protein 2 and 4 expression pattern during stem cell differentiation provides new insight into their putative function. PLoS ONE. 2014;9:e88474 pubmed publisher
..In contrast, UCP4 is simultaneously up-regulated together with typical neuronal marker proteins TUJ-1 and NeuN during mESC ..
Klotzsch E, Smorodchenko A, LÃ¶fler L, Moldzio R, Parkinson E, SchÃ¼tz G, et al
. Superresolution microscopy reveals spatial separation of UCP4 and F0F1-ATP synthase in neuronal mitochondria. Proc Natl Acad Sci U S A. 2015;112:130-5 pubmed publisher
..several mitochondrial proteins in primary mouse neurons and test the hypothesis that uncoupling protein 4 (UCP4) and F0F1-ATP synthase are spatially separated to eliminate competition for the proton motive force...
Ji F, Shen T, Zou W, Jiao J. UCP2 Regulates Embryonic Neurogenesis via ROS-Mediated Yap Alternation in the Developing Neocortex. Stem Cells. 2017;35:1479-1492 pubmed publisher
..Collectively, our results demonstrate that UCP2 regulates embryonic neurogenesis through ROS-mediated Yap alternation, thus shedding new sight on mitochondrial metabolism involved in embryonic neurogenesis. Stem Cells 2017;35:1479-1492. ..
Parker J, Vázquez Manrique R, Tourette C, Farina F, Offner N, Mukhopadhyay A, et al
. Integration of ?-catenin, sirtuin, and FOXO signaling protects from mutant huntingtin toxicity. J Neurosci. 2012;32:12630-40 pubmed publisher
..Taken together, these results suggest that integration of ?-catenin, sirtuin and FOXO signaling protects from the early phases of mutant huntingtin toxicity. ..
Perreten Lambert H, Zenger M, Azarias G, Chatton J, Magistretti P, Lengacher S. Control of mitochondrial pH by uncoupling protein 4 in astrocytes promotes neuronal survival. J Biol Chem. 2014;289:31014-28 pubmed publisher
..The main UCP isoforms expressed in the brain are UCP2, UCP4, and UCP5...