Gene Symbol: Slc25a14
Description: solute carrier family 25 (mitochondrial carrier, brain), member 14
Alias: BMCP1, UCP5, UCP5L, UCP5S, brain mitochondrial carrier protein 1, mitochondrial uncoupling protein 5
Species: mouse
Products:     Slc25a14

Top Publications

  1. Lengacher S, Magistretti P, Pellerin L. Quantitative rt-PCR analysis of uncoupling protein isoforms in mouse brain cortex: methodological optimization and comparison of expression with brown adipose tissue and skeletal muscle. J Cereb Blood Flow Metab. 2004;24:780-8 pubmed
    ..Results indicate that brain cortex contains significant amounts of all UCP mRNAs, with UCP5 and UCP4 being the most abundant, as opposed to brown adipose tissue and skeletal muscle, which predominantly ..
  2. Kitahara T, Li Korotky H, Balaban C. Regulation of mitochondrial uncoupling proteins in mouse inner ear ganglion cells in response to systemic kanamycin challenge. Neuroscience. 2005;135:639-53 pubmed
    ..mRNA for uncoupling protein 1, uncoupling protein 2, uncoupling protein 3, Slc25a27 (uncoupling protein 4) and Slc25a14 (uncoupling protein 5/BMCP1) was expressed in the spiral and vestibular ganglia...
  3. Echtay K. Mitochondrial uncoupling proteins--what is their physiological role?. Free Radic Biol Med. 2007;43:1351-71 pubmed
    ..Beside, available scientific data on UCP4 and UCP5/BMCP1 will be reviewed. However, their physiological function has not yet been established.
  4. Cioffi F, Senese R, de Lange P, Goglia F, Lanni A, Lombardi A. Uncoupling proteins: a complex journey to function discovery. Biofactors. 2009;35:417-28 pubmed publisher
    ..From the above, it is evident that more research will be needed to establish universally accepted functions for UCPs. ..
  5. Sanchis D, Fleury C, Chomiki N, Goubern M, Huang Q, Neverova M, et al. BMCP1, a novel mitochondrial carrier with high expression in the central nervous system of humans and rodents, and respiration uncoupling activity in recombinant yeast. J Biol Chem. 1998;273:34611-5 pubmed
    ..homologue of the mitochondrial carriers predominantly expressed in the central nervous system and referred to as BMCP1 (brain mitochondrial carrier protein-1)...
  6. Stuart J, Brindle K, Harper J, Brand M. Mitochondrial proton leak and the uncoupling proteins. J Bioenerg Biomembr. 1999;31:517-25 pubmed
    ..The newly discovered UCP1 homologs, UCP2, UCP3, and brain mitochondrial carrier protein 1 (BMCP1) may participate in the augmentative component of proton leak...
  7. Mizuno T, Miura Suzuki T, Yamashita H, Mori N. Distinct regulation of brain mitochondrial carrier protein-1 and uncoupling protein-2 genes in the rat brain during cold exposure and aging. Biochem Biophys Res Commun. 2000;278:691-7 pubmed
    ..Brain mitochondrial carrier protein-1 (BMCP1) is a new member of the UCP family, but little is known about the gene regulation and the role of BMCP1 in the ..
  8. Erlanson Albertsson C. The role of uncoupling proteins in the regulation of metabolism. Acta Physiol Scand. 2003;178:405-12 pubmed a newly discovered family of proteins, consisting of at least five proteins, namely UCP1, UCP2, UCP3, UCP4 and UCP5. Although a role for UCP1 in thermogenesis is unequivocal, the physiological function of the newer uncoupling ..
  9. Smorodchenko A, Rupprecht A, Sarilova I, Ninnemann O, Bräuer A, Franke K, et al. Comparative analysis of uncoupling protein 4 distribution in various tissues under physiological conditions and during development. Biochim Biophys Acta. 2009;1788:2309-19 pubmed publisher
    UCP4 is a member of the mitochondrial uncoupling protein subfamily and one of the three UCPs (UCP2, UCP4, UCP5), associated with the nervous system...

More Information


  1. Ji F, Shen T, Zou W, Jiao J. UCP2 Regulates Embryonic Neurogenesis via ROS-Mediated Yap Alternation in the Developing Neocortex. Stem Cells. 2017;35:1479-1492 pubmed publisher
    ..Collectively, our results demonstrate that UCP2 regulates embryonic neurogenesis through ROS-mediated Yap alternation, thus shedding new sight on mitochondrial metabolism involved in embryonic neurogenesis. Stem Cells 2017;35:1479-1492. ..
  2. Adams S. Uncoupling protein homologs: emerging views of physiological function. J Nutr. 2000;130:711-4 pubmed
    ..of widely expressed putative UCP1 homologs [UCP2, UCP3, UCP4, UCP5/brain mitochondrial carrier protein-1 (BMCP1)] raised the possibility that innate proton leak and metabolic rate are regulated by UCP1-like proteins...
  3. Yu X, Mao W, Zhong A, Schow P, Brush J, Sherwood S, et al. Characterization of novel UCP5/BMCP1 isoforms and differential regulation of UCP4 and UCP5 expression through dietary or temperature manipulation. FASEB J. 2000;14:1611-8 pubmed
    ..Here we characterized another newly described member of the uncoupling protein family, termed UCP5 (also called BMCP1)...