Genomes and Genes
Gene Symbol: Slc22a12
Description: solute carrier family 22 (organic anion/cation transporter), member 12
Alias: AI987855, OAT4L, Rst, Slc22al2, URAT1, solute carrier family 22 member 12, renal-specific transporter, solute carrier family 22 (organic cation transporter)-like 2, urate anion exchanger 1
- Cheng X, Klaassen C. Tissue distribution, ontogeny, and hormonal regulation of xenobiotic transporters in mouse kidneys. Drug Metab Dispos. 2009;37:2178-85 pubmed publisher..Gender-divergent expression of male-predominant (Urat1 and Oatp4c1) and female-predominant (Oat5) transporters in mouse kidneys is primarily due to stimulatory effects ..
- Hosoyamada M, Takiue Y, Morisaki H, Cheng J, Ikawa M, Okabe M, et al. Establishment and analysis of SLC22A12 (URAT1) knockout mouse. Nucleosides Nucleotides Nucleic Acids. 2010;29:314-20 pubmed publisher..acute renal failure, one of the complications of hereditary renal hypouricemia, we have targeted the mouse Slc22a12 gene by the exchange of exons 1-4 with pMC1neo-polyA. The knockout mice revealed no gross anomalies...
- Hosoyamada M, Tsurumi Y, Hirano H, Tomioka N, Sekine Y, Morisaki T, et al. Urat1-Uox double knockout mice are experimental animal models of renal hypouricemia and exercise-induced acute kidney injury. Nucleosides Nucleotides Nucleic Acids. 2016;35:543-549 pubmed..RHUC type 1 is caused by mutations of the urate transporter URAT1 gene (SLC22A12). However, the plasma urate levels of URAT1 knockout mice are no different from those of wild-type mice...
- Tomioka N, Tamura Y, Takada T, Shibata S, Suzuki H, Uchida S, et al. Immunohistochemical and in situ hybridization study of urate transporters GLUT9/URATv1, ABCG2, and URAT1 in the murine brain. Fluids Barriers CNS. 2016;13:22 pubmed..In our previous study, we described that the mouse urate transporter URAT1 is localized to the cilia and apical surface of ventricular ependymal cells...