Slc22a12

Summary

Gene Symbol: Slc22a12
Description: solute carrier family 22 (organic anion/cation transporter), member 12
Alias: AI987855, OAT4L, Rst, Slc22al2, URAT1, solute carrier family 22 member 12, renal-specific transporter, solute carrier family 22 (organic cation transporter)-like 2, urate anion exchanger 1
Species: mouse
Products:     Slc22a12

Top Publications

  1. Mori K, Ogawa Y, Ebihara K, Aoki T, Tamura N, Sugawara A, et al. Kidney-specific expression of a novel mouse organic cation transporter-like protein. FEBS Lett. 1997;417:371-4 pubmed
    ..method, we have cloned a novel 12-membrane-spanning transporter-like protein, termed renal-specific transporter (RST), from the mouse kidney...
  2. Monte J, Nagle M, Eraly S, Nigam S. Identification of a novel murine organic anion transporter family member, OAT6, expressed in olfactory mucosa. Biochem Biophys Res Commun. 2004;323:429-36 pubmed
    ..Furthermore, e-blot data suggest very different expression of individual OATs, OCTs and OCTNs in kidney, brain, liver, and eye. ..
  3. Cunningham R, Brazie M, Kanumuru S, E X, Biswas R, Wang F, et al. Sodium-hydrogen exchanger regulatory factor-1 interacts with mouse urate transporter 1 to regulate renal proximal tubule uric acid transport. J Am Soc Nephrol. 2007;18:1419-25 pubmed
    ..These findings indicate that NHERF-1 exerts a significant effect on the renal tubular reabsorption of uric acid in the mouse by modulating the BBM abundance of mURAT1 and possibly other BBM uric acid transporters. ..
  4. Gisler S, Pribanic S, Bacic D, Forrer P, Gantenbein A, Sabourin L, et al. PDZK1: I. a major scaffolder in brush borders of proximal tubular cells. Kidney Int. 2003;64:1733-45 pubmed
    ..NHE-3), organic cation transporter (OCTN1), chloride-formate exchanger (CFEX), and urate-anion exchanger (URAT1)...
  5. Hosoyamada M, Ichida K, Enomoto A, Hosoya T, Endou H. Function and localization of urate transporter 1 in mouse kidney. J Am Soc Nephrol. 2004;15:261-8 pubmed
    ..or intracellular membrane of proximal tubules was stained by an affinity-purified antibody that recognized mouse URAT1 (mURAT1) expressed on Xenopus oocyte...
  6. Imaoka T, Kusuhara H, Adachi Akahane S, Hasegawa M, Morita N, Endou H, et al. The renal-specific transporter mediates facilitative transport of organic anions at the brush border membrane of mouse renal tubules. J Am Soc Nephrol. 2004;15:2012-22 pubmed
    ..This study reports the expression, localization, and functional properties of mouse renal-specific transporter (RST)...
  7. Sekine T, Miyazaki H, Endou H. Molecular physiology of renal organic anion transporters. Am J Physiol Renal Physiol. 2006;290:F251-61 pubmed
    ..We will also discuss the physiological roles of each organic anion transporter in the light of the transepithelial transport of organic anions in the kidneys...
  8. Eraly S, Vallon V, Rieg T, Gangoiti J, Wikoff W, Siuzdak G, et al. Multiple organic anion transporters contribute to net renal excretion of uric acid. Physiol Genomics. 2008;33:180-92 pubmed publisher
    ..The latter process has been suggested to be principally mediated by urate transporter 1 (URAT1; slc22a12), but the role of various putative urate transporters has been much debated...
  9. Doshi M, Takiue Y, Saito H, Hosoyamada M. The increased protein level of URAT1 was observed in obesity/metabolic syndrome model mice. Nucleosides Nucleotides Nucleic Acids. 2011;30:1290-4 pubmed publisher
    ..1) 8-week-old male ob/ob mice demonstrated the increased protein levels of Slc22a12 (Urat1), Slc2a9 (Glut9), and Abcg2 (Abcg2) and a decreased protein level of Slc5a8 (Smct1)...

More Information

Publications13

  1. Cheng X, Klaassen C. Tissue distribution, ontogeny, and hormonal regulation of xenobiotic transporters in mouse kidneys. Drug Metab Dispos. 2009;37:2178-85 pubmed publisher
    ..Gender-divergent expression of male-predominant (Urat1 and Oatp4c1) and female-predominant (Oat5) transporters in mouse kidneys is primarily due to stimulatory effects ..
  2. Hosoyamada M, Takiue Y, Morisaki H, Cheng J, Ikawa M, Okabe M, et al. Establishment and analysis of SLC22A12 (URAT1) knockout mouse. Nucleosides Nucleotides Nucleic Acids. 2010;29:314-20 pubmed publisher
    ..acute renal failure, one of the complications of hereditary renal hypouricemia, we have targeted the mouse Slc22a12 gene by the exchange of exons 1-4 with pMC1neo-polyA. The knockout mice revealed no gross anomalies...
  3. Hosoyamada M, Tsurumi Y, Hirano H, Tomioka N, Sekine Y, Morisaki T, et al. Urat1-Uox double knockout mice are experimental animal models of renal hypouricemia and exercise-induced acute kidney injury. Nucleosides Nucleotides Nucleic Acids. 2016;35:543-549 pubmed
    ..RHUC type 1 is caused by mutations of the urate transporter URAT1 gene (SLC22A12). However, the plasma urate levels of URAT1 knockout mice are no different from those of wild-type mice...
  4. Tomioka N, Tamura Y, Takada T, Shibata S, Suzuki H, Uchida S, et al. Immunohistochemical and in situ hybridization study of urate transporters GLUT9/URATv1, ABCG2, and URAT1 in the murine brain. Fluids Barriers CNS. 2016;13:22 pubmed
    ..In our previous study, we described that the mouse urate transporter URAT1 is localized to the cilia and apical surface of ventricular ependymal cells...