Genomes and Genes
Gene Symbol: Slc1a5
Description: solute carrier family 1 (neutral amino acid transporter), member 5
Alias: AAAT, ASCT2, ATBO, M7V1, M7VS1, R16, RDRC, Slc1a7, neutral amino acid transporter B(0), ASC-like Na(+)-dependent neutral amino acid transporter ASCT2, ATB(0), insulin-activated amino acid transporter, sodium-dependent neutral amino acid transporter type 2, solute carrier family 1 member 5, solute carrier family 1, member 7
- Sidoryk Wegrzynowicz M, Lee E, Mingwei N, Aschner M. Disruption of astrocytic glutamine turnover by manganese is mediated by the protein kinase C pathway. Glia. 2011;59:1732-43 pubmed publisher..Exposure to ?-phorbol 12-myristate 13-acetate significantly decreased SNAT3 (system N) and ASCT2 (system ASC) protein levels...
- Seyer P, Vandermoere F, Cassier E, Bockaert J, Marin P. Physical and functional interactions between the serotonin transporter and the neutral amino acid transporter ASCT2. Biochem J. 2016;473:1953-65 pubmed publisher..Using a proteomics strategy, we show that SERT associates with ASCT2 (alanine-serine-cysteine-threonine 2), a member of the solute carrier 1 family co-expressed with SERT in ..
- Gliddon C, Shao Z, LeMaistre J, Anderson C. Cellular distribution of the neutral amino acid transporter subtype ASCT2 in mouse brain. J Neurochem. 2009;108:372-83 pubmed publisherb>ASCT2 is an ASC (alanine-, serine-, cysteine-preferring) neutral amino acid exchanger that may regulate CNS function by transporting amino acid substrates including L-serine, L-cysteine, L-glutamine, L-glutamate and D-serine...
- Nakaya M, Xiao Y, Zhou X, Chang J, Chang M, Cheng X, et al. Inflammatory T cell responses rely on amino acid transporter ASCT2 facilitation of glutamine uptake and mTORC1 kinase activation. Immunity. 2014;40:692-705 pubmed publisher..that naive T cell activation is coupled with rapid glutamine uptake, which depended on the amino acid transporter ASCT2. ASCT2 deficiency impaired the induction of T helper 1 (Th1) and Th17 cells and attenuated inflammatory T cell ..