Gene Symbol: Slc1a5
Description: solute carrier family 1 (neutral amino acid transporter), member 5
Alias: AAAT, ASCT2, ATBO, M7V1, M7VS1, R16, RDRC, Slc1a7, neutral amino acid transporter B(0), ASC-like Na(+)-dependent neutral amino acid transporter ASCT2, ATB(0), insulin-activated amino acid transporter, sodium-dependent neutral amino acid transporter type 2, solute carrier family 1 member 5, solute carrier family 1, member 7
Species: mouse
Products:     Slc1a5

Top Publications

  1. Liao K, Lane M. Expression of a novel insulin-activated amino acid transporter gene during differentiation of 3T3-L1 preadipocytes into adipocytes. Biochem Biophys Res Commun. 1995;208:1008-15 pubmed
    A cDNA encoding a novel insulin-activated adipocyte amino acid transporter (designated AAAT) was cloned from a mouse 3T3-L1 adipocyte library...
  2. Utsunomiya Tate N, Endou H, Kanai Y. Cloning and functional characterization of a system ASC-like Na+-dependent neutral amino acid transporter. J Biol Chem. 1996;271:14883-90 pubmed
    ..The encoded protein, designated ASCT2, showed amino acid sequence similarity to the mammalian glutamate transporters (40-44% identity), Na+-dependent ..
  3. Marin M, Tailor C, Nouri A, Kabat D. Sodium-dependent neutral amino acid transporter type 1 is an auxiliary receptor for baboon endogenous retrovirus. J Virol. 2000;74:8085-93 pubmed
    ..To investigate this host range difference, we cloned and analyzed NIH Swiss mouse ASCT2 (mASCT2)...
  4. Lavillette D, Marin M, Ruggieri A, Mallet F, Cosset F, Kabat D. The envelope glycoprotein of human endogenous retrovirus type W uses a divergent family of amino acid transporters/cell surface receptors. J Virol. 2002;76:6442-52 pubmed
    ..formation by interacting with the human sodium-dependent neutral amino acid transporter type 2 (hASCT2; gene name, SLC1A5) (J.-L. Blond, D. Lavillette, V. Cheynet, O. Bouton, G. Oriol, S. Chapel-Fernandez, B. Mandrand, F. Mallet, and F...
  5. Komatsu Y, Yukutake Y, Yoshida M. Four different clones of mouse anti-acetyllysine monoclonal antibodies having different recognition properties share a common immunoglobulin framework structure. J Immunol Methods. 2003;272:161-75 pubmed
  6. Marin M, Lavillette D, Kelly S, Kabat D. N-linked glycosylation and sequence changes in a critical negative control region of the ASCT1 and ASCT2 neutral amino acid transporters determine their retroviral receptor functions. J Virol. 2003;77:2936-45 pubmed
    ..D primate retroviruses uses the human Na(+)-dependent neutral amino acid transporter type 2 (hASCT2; gene name, SLC1A5) as a common cell surface receptor...
  7. Fuchs B, Perez J, Suetterlin J, Chaudhry S, Bode B. Inducible antisense RNA targeting amino acid transporter ATB0/ASCT2 elicits apoptosis in human hepatoma cells. Am J Physiol Gastrointest Liver Physiol. 2004;286:G467-78 pubmed
    Amino acid transporter B(0)/ASC transporter 2 (ATB(0)/ASCT2) is responsible for most glutamine uptake in human hepatoma cells...
  8. Tetsuka K, Takanaga H, Ohtsuki S, Hosoya K, Terasaki T. The l-isomer-selective transport of aspartic acid is mediated by ASCT2 at the blood-brain barrier. J Neurochem. 2003;87:891-901 pubmed system ASC substrates such as l-alanine and l-serine, suggesting that system ASC transporters, ASCT1 and ASCT2, are involved in the l-isomer selective transport...
  9. Shao Z, Kamboj A, Anderson C. Functional and immunocytochemical characterization of D-serine transporters in cortical neuron and astrocyte cultures. J Neurosci Res. 2009;87:2520-30 pubmed publisher
    ..D-serine can be transported with low affinity through the Na(+)-dependent amino acid transporter termed ASCT2, whereas high-affinity D-serine uptake has been reported through the Na(+)-independent transporter termed asc-1...

More Information


  1. Sidoryk Wegrzynowicz M, Lee E, Mingwei N, Aschner M. Disruption of astrocytic glutamine turnover by manganese is mediated by the protein kinase C pathway. Glia. 2011;59:1732-43 pubmed publisher
    ..Exposure to ?-phorbol 12-myristate 13-acetate significantly decreased SNAT3 (system N) and ASCT2 (system ASC) protein levels...
  2. Seyer P, Vandermoere F, Cassier E, Bockaert J, Marin P. Physical and functional interactions between the serotonin transporter and the neutral amino acid transporter ASCT2. Biochem J. 2016;473:1953-65 pubmed publisher
    ..Using a proteomics strategy, we show that SERT associates with ASCT2 (alanine-serine-cysteine-threonine 2), a member of the solute carrier 1 family co-expressed with SERT in ..
  3. Gliddon C, Shao Z, LeMaistre J, Anderson C. Cellular distribution of the neutral amino acid transporter subtype ASCT2 in mouse brain. J Neurochem. 2009;108:372-83 pubmed publisher
    b>ASCT2 is an ASC (alanine-, serine-, cysteine-preferring) neutral amino acid exchanger that may regulate CNS function by transporting amino acid substrates including L-serine, L-cysteine, L-glutamine, L-glutamate and D-serine...
  4. Nakaya M, Xiao Y, Zhou X, Chang J, Chang M, Cheng X, et al. Inflammatory T cell responses rely on amino acid transporter ASCT2 facilitation of glutamine uptake and mTORC1 kinase activation. Immunity. 2014;40:692-705 pubmed publisher
    ..that naive T cell activation is coupled with rapid glutamine uptake, which depended on the amino acid transporter ASCT2. ASCT2 deficiency impaired the induction of T helper 1 (Th1) and Th17 cells and attenuated inflammatory T cell ..