Slc1a2

Summary

Gene Symbol: Slc1a2
Description: solute carrier family 1 (glial high affinity glutamate transporter), member 2
Alias: 1700091C19Rik, 2900019G14Rik, AI159670, Eaat2, GLT-1, GLT1, MGLT1, excitatory amino acid transporter 2, EAAT2 variant mEAAT2/5UT2, EAAT2 variant mEAAT2/5UT5, glutamate transporter 1c, sodium-dependent glutamate/aspartate transporter 2, solute carrier family 1, member 2
Species: mouse
Products:     Slc1a2

Top Publications

  1. Mitani A, Tanaka K. Functional changes of glial glutamate transporter GLT-1 during ischemia: an in vivo study in the hippocampal CA1 of normal mice and mutant mice lacking GLT-1. J Neurosci. 2003;23:7176-82 pubmed
    ..The function of GLT-1 may change from neuroprotective to neurodegenerative during ischemia. ..
  2. Rinholm J, Slettaløkken G, Marcaggi P, Skare Ø, Storm Mathisen J, Bergersen L. Subcellular localization of the glutamate transporters GLAST and GLT at the neuromuscular junction in rodents. Neuroscience. 2007;145:579-91 pubmed
    ..This indicates a signaling role for glutamate at the normal NMJ and provides a basis for the ability of denervated muscle to be reinnervated by glutamatergic axons from the CNS. ..
  3. Carmen J, Rothstein J, Kerr D. Tumor necrosis factor-alpha modulates glutamate transport in the CNS and is a critical determinant of outcome from viral encephalomyelitis. Brain Res. 2009;1263:143-54 pubmed publisher
    ..These findings have implications for disease intervention and therapeutic development for the prevention of CNS damage associated with inflammatory responses. ..
  4. Wu J, Lee M, Kim T, Johng S, Rohrback S, Kang N, et al. Regulation of ethanol-sensitive EAAT2 expression through adenosine A1 receptor in astrocytes. Biochem Biophys Res Commun. 2011;406:47-52 pubmed publisher
    ..In this study, we examined whether adenosine A1 receptor regulates EAAT2 expression in astrocytes using pharmacological agents and siRNAs...
  5. Hamann M, Rossi D, Marie H, Attwell D. Knocking out the glial glutamate transporter GLT-1 reduces glutamate uptake but does not affect hippocampal glutamate dynamics in early simulated ischaemia. Eur J Neurosci. 2002;15:308-14 pubmed
    ..These data are consistent with glutamate release being by reversal of neuronal transporters, and with uptake into glia being compromised by the ischaemia-evoked fall in the level of ATP needed to convert glutamate into glutamine. ..
  6. Matsugami T, Tanemura K, Mieda M, Nakatomi R, Yamada K, Kondo T, et al. From the Cover: Indispensability of the glutamate transporters GLAST and GLT1 to brain development. Proc Natl Acad Sci U S A. 2006;103:12161-6 pubmed
    ..brain development of extracellular glutamate buildup due to the depletion of the glutamate transporters GLAST and GLT1. GLAST/GLT1 double knockout mice show multiple brain defects, including cortical, hippocampal, and olfactory bulb ..
  7. Sheean R, Lau C, Shin Y, O Shea R, Beart P. Links between L-glutamate transporters, Na+/K+-ATPase and cytoskeleton in astrocytes: evidence following inhibition with rottlerin. Neuroscience. 2013;254:335-46 pubmed publisher
    ..and pathology, including via their glutamate transporters, excitatory amino acid transporter (EAAT)1 and EAAT2, maintaining low extracellular glutamate concentrations and protecting against excitotoxic neuronal injury...
  8. Tanaka K, Watase K, Manabe T, Yamada K, Watanabe M, Takahashi K, et al. Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT-1. Science. 1997;276:1699-702 pubmed
    ..These effects can be attributed to elevated levels of residual glutamate in the brains of these mice...
  9. Morel L, Regan M, Higashimori H, Ng S, Esau C, Vidensky S, et al. Neuronal exosomal miRNA-dependent translational regulation of astroglial glutamate transporter GLT1. J Biol Chem. 2013;288:7105-16 pubmed publisher
    Perisynaptic astrocytes express important glutamate transporters, especially excitatory amino acid transporter 2 (EAAT2, rodent analog GLT1) to regulate extracellular glutamate levels and modulate synaptic activation...

More Information

Publications89

  1. Yamada K, Watanabe M, Shibata T, Nagashima M, Tanaka K, Inoue Y. Glutamate transporter GLT-1 is transiently localized on growing axons of the mouse spinal cord before establishing astrocytic expression. J Neurosci. 1998;18:5706-13 pubmed
  2. Mashimo M, Okubo Y, Yamazawa T, Yamasaki M, Watanabe M, Murayama T, et al. Inositol 1,4,5-trisphosphate signaling maintains the activity of glutamate uptake in Bergmann glia. Eur J Neurosci. 2010;32:1668-77 pubmed publisher
    ..These results suggest that the IP(3) signaling cascade is involved in regulating GLAST levels in BGs to maintain glutamate clearance in the mature cerebellum. ..
  3. Behrens P, Franz P, Woodman B, Lindenberg K, Landwehrmeyer G. Impaired glutamate transport and glutamate-glutamine cycling: downstream effects of the Huntington mutation. Brain. 2002;125:1908-22 pubmed
  4. Mennini T, Bastone A, Crespi D, Comoletti D, Manzoni C. Spinal cord GLT-1 glutamate transporter and blood glutamic acid alterations in motor neuron degeneration (Mnd) mice. J Neurol Sci. 1998;157:31-6 pubmed
  5. Dabir D, Robinson M, Swanson E, Zhang B, Trojanowski J, Lee V, et al. Impaired glutamate transport in a mouse model of tau pathology in astrocytes. J Neurosci. 2006;26:644-54 pubmed
    ..Thus, these Tg mice recapitulate features of astrocytic pathology observed in tauopathies and implicate a role for altered astrocyte function in the pathogenesis of these disorders. ..
  6. Bellesi M, Melone M, Gubbini A, Battistacci S, Conti F. GLT-1 upregulation impairs prepulse inhibition of the startle reflex in adult rats. Glia. 2009;57:703-13 pubmed publisher
    We tested the hypothesis that glutamate transporter GLT-1 (also known as EAAT2) plays a role in the regulation of prepulse inhibition (PPI) of the acoustic startle reflex, a simple form of information processing which is reduced in ..
  7. Schmitt A, Asan E, Lesch K, Kugler P. A splice variant of glutamate transporter GLT1/EAAT2 expressed in neurons: cloning and localization in rat nervous system. Neuroscience. 2002;109:45-61 pubmed
    Rapid uptake of synaptically released glutamate via the high affinity glutamate transporter 1 (GLT1; EAAT2) is important for limiting transmitter signalling and prevents a harmful receptor overstimulation...
  8. Munch C, Ebstein M, Seefried U, Zhu B, Stamm S, Landwehrmeyer G, et al. Alternative splicing of the 5'-sequences of the mouse EAAT2 glutamate transporter and expression in a transgenic model for amyotrophic lateral sclerosis. J Neurochem. 2002;82:594-603 pubmed
    Glutamate-mediated neurotoxicity and a reduced expression of the excitatory amino acid transporter 2 (EAAT2) have been described in the pathogenesis of several acute and chronic neurological conditions...
  9. Butchbach M, Tian G, Guo H, Lin C. Association of excitatory amino acid transporters, especially EAAT2, with cholesterol-rich lipid raft microdomains: importance for excitatory amino acid transporter localization and function. J Biol Chem. 2004;279:34388-96 pubmed
    ..Glial glutamate transporter EAAT2-mediated uptake was more sensitive to this effect...
  10. Arranz A, Hussein A, Alix J, Pérez Cerdá F, Allcock N, Matute C, et al. Functional glutamate transport in rodent optic nerve axons and glia. Glia. 2008;56:1353-67 pubmed publisher
    ..The findings support the possibility of functional synaptic-type glutamate release from central axons, an event that will require axonal glutamate reuptake. ..
  11. Zhou J, Sutherland M. Glutamate transporter cluster formation in astrocytic processes regulates glutamate uptake activity. J Neurosci. 2004;24:6301-6 pubmed
    ..Together, these data indicate that GLT-1 trafficking and cluster formation in glial cell processes are dynamic events that play important roles in regulating glutamate uptake in astrocytes and glioma cells. ..
  12. Lepore A, O DONNELL J, Kim A, Yang E, Tuteja A, Haidet Phillips A, et al. Reduction in expression of the astrocyte glutamate transporter, GLT1, worsens functional and histological outcomes following traumatic spinal cord injury. Glia. 2011;59:1996-2005 pubmed publisher
    The astrocyte glutamate transporter, GLT1, is responsible for the vast majority of glutamate uptake in the adult central nervous system (CNS), thereby regulating extracellular glutamate homeostasis and preventing excitotoxicity...
  13. Di Cairano E, Davalli A, Perego L, Sala S, Sacchi V, La Rosa S, et al. The glial glutamate transporter 1 (GLT1) is expressed by pancreatic beta-cells and prevents glutamate-induced beta-cell death. J Biol Chem. 2011;286:14007-18 pubmed publisher
    ..that the key regulator of extracellular islet glutamate concentration is the glial glutamate transporter 1 (GLT1)...
  14. Ait Lounis A, Bonal C, Seguín Estévez Q, Schmid C, Bucher P, Herrera P, et al. The transcription factor Rfx3 regulates beta-cell differentiation, function, and glucokinase expression. Diabetes. 2010;59:1674-85 pubmed publisher
    ..Our results show that Rfx3 is required for the differentiation and function of mature beta-cells and regulates the beta-cell promoter of the glucokinase gene. ..
  15. Melendez R, Roman C, Capó Vélez C, Lasalde Dominicci J. Decreased glial and synaptic glutamate uptake in the striatum of HIV-1 gp120 transgenic mice. J Neurovirol. 2016;22:358-65 pubmed publisher
    ..Understanding the role of striatal glutamate uptake systems in HIV-1 gp120 may advance the development of new therapeutic strategies to prevent neuronal damage and improve cognitive function in HIV patients. ..
  16. Ratelade J, Bennett J, Verkman A. Evidence against cellular internalization in vivo of NMO-IgG, aquaporin-4, and excitatory amino acid transporter 2 in neuromyelitis optica. J Biol Chem. 2011;286:45156-64 pubmed publisher
    ..of NMO autoantibody (NMO-IgG) pathogenesis is internalization of AQP4 and the associated glutamate transporter EAAT2, leading to glutamate excitotoxicity...
  17. Sicot G, Servais L, Dinca D, Leroy A, Prigogine C, Medja F, et al. Downregulation of the Glial GLT1 Glutamate Transporter and Purkinje Cell Dysfunction in a Mouse Model of Myotonic Dystrophy. Cell Rep. 2017;19:2718-2729 pubmed publisher
    ..A global proteomics approach revealed downregulation of the GLT1 glutamate transporter in DM1 mice and human patients, which we found to be the result of MBNL1 inactivation...
  18. Sutherland M, Delaney T, Noebels J. Glutamate transporter mRNA expression in proliferative zones of the developing and adult murine CNS. J Neurosci. 1996;16:2191-207 pubmed
  19. Voutsinos Porche B, Bonvento G, Tanaka K, Steiner P, Welker E, Chatton J, et al. Glial glutamate transporters mediate a functional metabolic crosstalk between neurons and astrocytes in the mouse developing cortex. Neuron. 2003;37:275-86 pubmed
    ..These data suggest that a metabolic crosstalk takes place between neurons and astrocytes in the developing cortex, which would be regulated by synaptic activity and mediated by glial glutamate transporters. ..
  20. Sarthy V, Marc R, Pignataro L, Tanaka K. Contribution of a glial glutamate transporter to GABA synthesis in the retina. Neuroreport. 2004;15:1895-8 pubmed
    ..An increase in GABAergic activity can be expected to affect trigger features such as directional selective response of neurons in the GLAST-/- mouse retina. ..
  21. Mancic B, Stevanovic I, Ilic T, Djuric A, Stojanovic I, Milanovic S, et al. Transcranial theta-burst stimulation alters GLT-1 and vGluT1 expression in rat cerebellar cortex. Neurochem Int. 2016;100:120-127 pubmed publisher
    ..Present study gives insight in molecular and biochemical mechanisms by which iTBS and cTBS exerts its effects on rats cerebellar cortex. ..
  22. Cui W, Mizukami H, Yanagisawa M, Aida T, Nomura M, Isomura Y, et al. Glial dysfunction in the mouse habenula causes depressive-like behaviors and sleep disturbance. J Neurosci. 2014;34:16273-85 pubmed publisher
    ..These results provide evidence that disrupting glutamate clearance in habenular astrocytes increases neuronal excitability and depressive-like phenotypes in behaviors and sleep. ..
  23. Shiwaku H, Yoshimura N, Tamura T, Sone M, Ogishima S, Watase K, et al. Suppression of the novel ER protein Maxer by mutant ataxin-1 in Bergman glia contributes to non-cell-autonomous toxicity. EMBO J. 2010;29:2446-60 pubmed publisher
    ..Collectively, these results suggest that the reduction of Maxer mediates functional deficiency of Bergmann glia, and might contribute to the non-cell-autonomous pathology of SCA1. ..
  24. Underhill S, Wheeler D, Amara S. Differential regulation of two isoforms of the glial glutamate transporter EAAT2 by DLG1 and CaMKII. J Neurosci. 2015;35:5260-70 pubmed publisher
    The gene for EAAT2, the major astrocytic glutamate transporter, generates two carrier isoforms (EAAT2a and EAAT2b) that vary at their C termini as a consequence of alternative RNA splicing...
  25. Aida T, Ito Y, Takahashi Y, Tanaka K. Overstimulation of NMDA receptors impairs early brain development in vivo. PLoS ONE. 2012;7:e36853 pubmed publisher
    ..Glutamate transporter GLAST/GLT1 double-knockout (DKO) mice carrying the NMDA receptor 1 subunit (NR1)-null mutation were generated...
  26. Brunne B, FRANCO S, Bouché E, Herz J, Howell B, Pahle J, et al. Role of the postnatal radial glial scaffold for the development of the dentate gyrus as revealed by Reelin signaling mutant mice. Glia. 2013;61:1347-63 pubmed publisher
  27. Zeng L, Bero A, Zhang B, Holtzman D, Wong M. Modulation of astrocyte glutamate transporters decreases seizures in a mouse model of Tuberous Sclerosis Complex. Neurobiol Dis. 2010;37:764-71 pubmed publisher
    ..These results indicate that astrocyte glutamate transporters contribute to epileptogenesis in Tsc1(GFAP)CKO mice and suggest novel therapeutic strategies for epilepsy in TSC directed at astrocytes. ..
  28. Brunne B, Zhao S, Derouiche A, Herz J, May P, Frotscher M, et al. Origin, maturation, and astroglial transformation of secondary radial glial cells in the developing dentate gyrus. Glia. 2010;58:1553-69 pubmed publisher
    ..Time-lapse imaging of acute hippocampal slices from hGFAP-eGFP transgenic mice provides direct evidence for such a migration mode of differentiating astroglial cells in the developing dentate gyrus. ..
  29. Petr G, Schultheis L, Hussey K, Sun Y, Dubinsky J, Aoki C, et al. Decreased expression of GLT-1 in the R6/2 model of Huntington's disease does not worsen disease progression. Eur J Neurosci. 2013;38:2477-90 pubmed publisher
    ..These results suggest that changes in GLT-1 expression or function per se are unlikely to potentiate or ameliorate the progression of HD...
  30. Guo H, Lai L, Butchbach M, Stockinger M, Shan X, Bishop G, et al. Increased expression of the glial glutamate transporter EAAT2 modulates excitotoxicity and delays the onset but not the outcome of ALS in mice. Hum Mol Genet. 2003;12:2519-32 pubmed
    The glial glutamate transporter EAAT2 is primarily responsible for clearance of glutamate from the synaptic cleft and loss of EAAT2 has been previously reported in amyotrophic lateral sclerosis (ALS) and Alzheimer's disease...
  31. Munch C, Zhu B, Leven A, Stamm S, Einkörn H, Schwalenstocker B, et al. Differential regulation of 5' splice variants of the glutamate transporter EAAT2 in an in vivo model of chemical hypoxia induced by 3-nitropropionic acid. J Neurosci Res. 2003;71:819-25 pubmed
    ..In several models of ischemia-hypoxia, a reduced immunoreactivity and altered RNA expression of excitatory amino acid transporter 2 (EAAT2), the major excitatory amino acid transporter, have been reported...
  32. Li K, Hala T, Seetharam S, Poulsen D, Wright M, Lepore A. GLT1 overexpression in SOD1(G93A) mouse cervical spinal cord does not preserve diaphragm function or extend disease. Neurobiol Dis. 2015;78:12-23 pubmed publisher
    ..example, decreased levels and aberrant functioning of the major central nervous system (CNS) glutamate transporter, GLT1, occur in spinal cord and motor cortex astrocytes of both humans with ALS and in SOD1(G93A) rodents, a widely ..
  33. Voutsinos Porche B, Knott G, Tanaka K, Quairiaux C, Welker E, Bonvento G. Glial glutamate transporters and maturation of the mouse somatosensory cortex. Cereb Cortex. 2003;13:1110-21 pubmed
    ..Our data suggest that astrocyte-neuron interactions via the glial glutamate transporters are involved in the functional maturation of the whisker representation in the somatosensory cortex. ..
  34. Schneider N, Cordeiro S, Machtens J, Braams S, Rauen T, Fahlke C. Functional properties of the retinal glutamate transporters GLT-1c and EAAT5. J Biol Chem. 2014;289:1815-24 pubmed publisher
    ..quot; Here we cloned and functionally characterized two retinal EAATs from mouse, the GLT-1/EAAT2 splice variant GLT-1c, and EAAT5...
  35. Lee M, Martinez Lozada Z, Krizman E, Robinson M. Brain endothelial cells induce astrocytic expression of the glutamate transporter GLT-1 by a Notch-dependent mechanism. J Neurochem. 2017;143:489-506 pubmed publisher
    Neuron-secreted factors induce astrocytic expression of the glutamate transporter, GLT-1 (excitatory amino acid transporter 2)...
  36. Kirschner M, Copeland N, Gilbert D, Jenkins N, Amara S. Mouse excitatory amino acid transporter EAAT2: isolation, characterization, and proximity to neuroexcitability loci on mouse chromosome 2. Genomics. 1994;24:218-24 pubmed
    ..We have isolated the mouse cDNA for EAAT2, a neurotransmitter transporter that shares extensive amino acid sequence homology with one of several previously ..
  37. Hu J, Yang N, Ma Y, Jiang J, Zhang J, Fei J, et al. Identification of glutamate receptors and transporters in mouse and human sperm. J Androl. 2004;25:140-6 pubmed
    ..used to investigate the existence and location of glutamate, glutamate receptor (NR2B), and glutamate transporter (GLT1) in mouse and human sperm...
  38. Tian G, Lai L, Guo H, Lin Y, Butchbach M, Chang Y, et al. Translational control of glial glutamate transporter EAAT2 expression. J Biol Chem. 2007;282:1727-37 pubmed
    ..The glial glutamate transporter EAAT2 is the main mediator of glutamate clearance...
  39. Yamada K, Wada S, Watanabe M, Tanaka K, Wada K, Inoue Y. Changes in expression and distribution of the glutamate transporter EAAT4 in developing mouse Purkinje cells. Neurosci Res. 1997;27:191-8 pubmed
  40. Furness D, Dehnes Y, Akhtar A, Rossi D, Hamann M, Grutle N, et al. A quantitative assessment of glutamate uptake into hippocampal synaptic terminals and astrocytes: new insights into a neuronal role for excitatory amino acid transporter 2 (EAAT2). Neuroscience. 2008;157:80-94 pubmed publisher
    The relative distribution of the excitatory amino acid transporter 2 (EAAT2) between synaptic terminals and astroglia, and the importance of EAAT2 for the uptake into terminals is still unresolved...
  41. Sarthy V, Pignataro L, Pannicke T, Weick M, Reichenbach A, Harada T, et al. Glutamate transport by retinal Muller cells in glutamate/aspartate transporter-knockout mice. Glia. 2005;49:184-96 pubmed
    ..The present study shows that while several known glutamate transporters are expressed by mammalian Muller cells, new Na+-dependent, high-affinity glutamate transporters remain to be identified. ..
  42. Sutherland M, Delaney T, Noebels J. Molecular characterization of a high-affinity mouse glutamate transporter. Gene. 1995;162:271-4 pubmed
    ..The deduced amino-acid sequence of mEAAT2 shares 96 and 93% identity with the rat and human EAAT2 homologues, respectively.
  43. Guo Y, Duan W, Li Z, Huang J, Yin Y, Zhang K, et al. Decreased GLT-1 and increased SOD1 and HO-1 expression in astrocytes contribute to lumbar spinal cord vulnerability of SOD1-G93A transgenic mice. FEBS Lett. 2010;584:1615-22 pubmed publisher
    ..Our data link spinal cord vulnerability to relatively decreased expression of GLT-1, and high expression of the transgene and HO-1 in astrocytes in SOD1-G93A transgenic mice. ..
  44. Foran E, Rosenblum L, Bogush A, Pasinelli P, Trotti D. Sumoylation of the astroglial glutamate transporter EAAT2 governs its intracellular compartmentalization. Glia. 2014;62:1241-53 pubmed publisher
    b>EAAT2 is a predominantly astroglial glutamate transporter responsible for the majority of synaptic glutamate clearance in the mammalian central nervous system (CNS)...
  45. Ketheeswaranathan P, Turner N, Spary E, Batten T, McColl B, Saha S. Changes in glutamate transporter expression in mouse forebrain areas following focal ischemia. Brain Res. 2011;1418:93-103 pubmed publisher
    ..Down regulation of GLT-1 in these brain areas may impair normal clearance of synaptically-released glutamate and contribute to neural damage following focal ischemic insult. ..
  46. Karatas Wulf U, Koepsell H, Bergert M, Sönnekes S, Kugler P. Protein kinase C-dependent trafficking of glutamate transporters excitatory amino acid carrier 1 and glutamate transporter 1b in cultured cerebellar granule cells. Neuroscience. 2009;161:794-805 pubmed publisher
    ..The findings suggest that PKC is similarly involved in regulation of surface trafficking of GLT1b and EAAC1 and that PKC stimulated increase in surface location of GLT1b and EAAC1 in glutamatergic CGCs. ..
  47. Zhou Y, Waanders L, Holmseth S, Guo C, Berger U, Li Y, et al. Proteome analysis and conditional deletion of the EAAT2 glutamate transporter provide evidence against a role of EAAT2 in pancreatic insulin secretion in mice. J Biol Chem. 2014;289:1329-44 pubmed publisher
    ..The glutamate (excitatory amino acid) transporter 2 (EAAT2; Slc1a2) has been hypothesized to (a) provide islet cells with glutamate, (b) protect islet cells against high ..
  48. Meabon J, Lee A, Meeker K, Bekris L, Fujimura R, Yu C, et al. Differential expression of the glutamate transporter GLT-1 in pancreas. J Histochem Cytochem. 2012;60:139-51 pubmed publisher
    ..Finally, glutamine synthetase was coexpressed with GLT-1 in islets, which suggests that, as with liver and brain, one possible role of GLT-1 in the pancreas is to support glutamine synthesis. ..
  49. Marcaggi P, Billups D, Attwell D. The role of glial glutamate transporters in maintaining the independent operation of juvenile mouse cerebellar parallel fibre synapses. J Physiol. 2003;552:89-107 pubmed
    ..These results show that glial cell glutamate transporters allow neighbouring synapses to operate more independently, and control the postsynaptic response to high frequency bursts of action potentials. ..
  50. Katagiri H, Tanaka K, Manabe T. Requirement of appropriate glutamate concentrations in the synaptic cleft for hippocampal LTP induction. Eur J Neurosci. 2001;14:547-53 pubmed
    ..These findings suggest that GLT-1 plays critical roles in LTP induction, as well as in short-term potentiation, through regulation of extracellular levels of glutamate, which enables appropriate NMDA receptor activation...
  51. Gupta R, Prasad S. Age-Dependent Alterations in the Interactions of NF-κB and N-myc with GLT-1/EAAT2 Promoter in the Pericontusional Cortex of Mice Subjected to Traumatic Brain Injury. Mol Neurobiol. 2016;53:3377-3388 pubmed publisher
    ..We have previously reported that expression of the astrocytic glutamate transporter GLT-1/EAAT2 is downregulated in the pericontusional cortex of adult and old mice in post-TBI time-dependent manner, and the ..
  52. Takasaki C, Okada R, Mitani A, Fukaya M, Yamasaki M, Fujihara Y, et al. Glutamate transporters regulate lesion-induced plasticity in the developing somatosensory cortex. J Neurosci. 2008;28:4995-5006 pubmed publisher
    ..In the present study, we examined glutamate transporter 1 (GLT1) expression in the neonatal somatosensory cortex of C57BL/6 mice, and pursued its role in somatosensory development ..
  53. Bacigaluppi M, Russo G, Peruzzotti Jametti L, Rossi S, Sandrone S, Butti E, et al. Neural Stem Cell Transplantation Induces Stroke Recovery by Upregulating Glutamate Transporter GLT-1 in Astrocytes. J Neurosci. 2016;36:10529-10544 pubmed
    ..Cell-based approaches able to influence plasticity seem particularly suited to favor poststroke recovery. ..
  54. Harada T, Harada C, Watanabe M, Inoue Y, Sakagawa T, Nakayama N, et al. Functions of the two glutamate transporters GLAST and GLT-1 in the retina. Proc Natl Acad Sci U S A. 1998;95:4663-6 pubmed
    ..These results demonstrate that GLAST is required for normal signal transmission between photoreceptors and bipolar cells and that both GLAST and GLT-1 play a neuroprotective role during ischemia in the retina...
  55. Falnikar A, Hala T, Poulsen D, Lepore A. GLT1 overexpression reverses established neuropathic pain-related behavior and attenuates chronic dorsal horn neuron activation following cervical spinal cord injury. Glia. 2016;64:396-406 pubmed publisher
    ..Astrocytes express the major CNS glutamate transporter, GLT1, which is responsible for the vast majority of functional glutamate uptake, particularly in the spinal cord...
  56. Boston Howes W, Gibb S, Williams E, Pasinelli P, Brown R, Trotti D. Caspase-3 cleaves and inactivates the glutamate transporter EAAT2. J Biol Chem. 2006;281:14076-84 pubmed
    b>EAAT2 is a high affinity, Na+-dependent glutamate transporter with predominant astroglial localization...
  57. Yang Y, Gozen O, Vidensky S, Robinson M, Rothstein J. Epigenetic regulation of neuron-dependent induction of astroglial synaptic protein GLT1. Glia. 2010;58:277-86 pubmed publisher
    Astroglial glutamate transporter EAAT2/GLT1 prevents glutamate-induced excitotoxicity in the central nervous system. Expression of EAAT2/GLT1 is dynamically regulated by neurons...
  58. Chen Y, Swanson R. The glutamate transporters EAAT2 and EAAT3 mediate cysteine uptake in cortical neuron cultures. J Neurochem. 2003;84:1332-9 pubmed
    ..The cultured neurons expressed both EAAT2 and EAAT3. Cysteine uptake was predominantly (> 85%) Na+-dependent, with an apparent Km of 37 microm...
  59. Morrison B, Tsingalia A, Vidensky S, Lee Y, Jin L, Farah M, et al. Deficiency in monocarboxylate transporter 1 (MCT1) in mice delays regeneration of peripheral nerves following sciatic nerve crush. Exp Neurol. 2015;263:325-38 pubmed publisher
    ..These data for the first time demonstrate that MCT1 is critical for regeneration of both sensory and motor axons in mice following sciatic nerve crush. ..
  60. Shibata T, Watanabe M, Tanaka K, Wada K, Inoue Y. Dynamic changes in expression of glutamate transporter mRNAs in developing brain. Neuroreport. 1996;7:705-9 pubmed
    ..These dynamic developmental regulations suggest that the glutamate transporter not only regulates the excitatory synaptic transmission at mature stages, but might also be intimately involved in the brain development...
  61. Liao G, Zhou M, Cheung S, Galeano J, Nguyen N, Baudry M, et al. Reduced early hypoxic/ischemic brain damage is associated with increased GLT-1 levels in mice expressing mutant (P301L) human tau. Brain Res. 2009;1247:159-70 pubmed publisher
    ..These results support the idea that enhanced levels of GLT-1 in transgenic mice are responsible for reducing H/I-induced brain damage by decreasing extracellular glutamate accumulation and subsequent calpain and caspase activation. ..
  62. Araya R, Kudo M, Kawano M, Ishii K, Hashikawa T, Iwasato T, et al. BMP signaling through BMPRIA in astrocytes is essential for proper cerebral angiogenesis and formation of the blood-brain-barrier. Mol Cell Neurosci. 2008;38:417-30 pubmed publisher
    ..These results suggest that BMPRIA signaling in astrocytes regulates the expression of VEGF for proper cerebrovascular angiogenesis and has a role on in the formation of the blood-brain-barrier. ..
  63. Gibb S, Boston Howes W, Lavina Z, Gustincich S, Brown R, Pasinelli P, et al. A caspase-3-cleaved fragment of the glial glutamate transporter EAAT2 is sumoylated and targeted to promyelocytic leukemia nuclear bodies in mutant SOD1-linked amyotrophic lateral sclerosis. J Biol Chem. 2007;282:32480-90 pubmed
    EAAT2 (excitatory amino acid transporter 2) is a high affinity, Na+-dependent glutamate transporter of glial origin that is essential for the clearance of synaptically released glutamate and prevention of excitotoxicity...
  64. Yang M, Roman K, Chen D, Wang Z, Lin Y, Stephens R. GLT-1 overexpression attenuates bladder nociception and local/cross-organ sensitization of bladder nociception. Am J Physiol Renal Physiol. 2011;300:F1353-9 pubmed publisher
    ..The study suggests that GLT-1 overexpression attenuates the visceromotor response to bladder distension and both local irritant-induced and cross-organ-sensitized visceromotor response to bladder distension. ..
  65. Takatsuru Y, Takayasu Y, Iino M, Nikkuni O, Ueda Y, Tanaka K, et al. Roles of glial glutamate transporters in shaping EPSCs at the climbing fiber-Purkinje cell synapses. Neurosci Res. 2006;54:140-8 pubmed
    ..These results indicate that glial glutamate transporters can apparently retain the fast decay kinetics of CF-EPSCs if a small proportion ( approximately 20%) of functional transporters is preserved. ..
  66. David C, Frias E, Szu J, Vieira P, Hubbard J, Lovelace J, et al. GLT-1-Dependent Disruption of CNS Glutamate Homeostasis and Neuronal Function by the Protozoan Parasite Toxoplasma gondii. PLoS Pathog. 2016;12:e1005643 pubmed publisher
    ..Altogether, these data demonstrate that following an infection with T. gondii, the delicate regulation of glutamate by astrocytes is disrupted and accounts for a range of deficits observed in chronic infection. ..
  67. Harada T, Harada C, Nakamura K, Quah H, Okumura A, Namekata K, et al. The potential role of glutamate transporters in the pathogenesis of normal tension glaucoma. J Clin Invest. 2007;117:1763-70 pubmed
    ..We believe these mice are the first animal models of NTG that offer a powerful system for investigating mechanisms of neurodegeneration in NTG and developing therapies directed at IOP-independent mechanisms of RGC loss. ..
  68. Gilley J, Kernie S. Excitatory amino acid transporter 2 and excitatory amino acid transporter 1 negatively regulate calcium-dependent proliferation of hippocampal neural progenitor cells and are persistently upregulated after injury. Eur J Neurosci. 2011;34:1712-23 pubmed publisher
    ..are labeled with enhanced green fluorescent protein, we previously characterized the expression of excitatory amino acid transporter 2 (GltI) and excitatory amino acid transporter 1 (Glast) on early neural progenitors in vivo...
  69. Scimemi A, Meabon J, Woltjer R, Sullivan J, Diamond J, Cook D. Amyloid-β1-42 slows clearance of synaptically released glutamate by mislocalizing astrocytic GLT-1. J Neurosci. 2013;33:5312-8 pubmed publisher
  70. Maeno Hikichi Y, Tanaka K, Shibata T, Watanabe M, Inoue Y, Mukainaka Y, et al. Structure and functional expression of the cloned mouse neuronal high-affinity glutamate transporter. Brain Res Mol Brain Res. 1997;48:176-80 pubmed
    ..In situ hybridization in mouse brain sections showed that the mRNA is expressed densely and selectively in cell bodies of Purkinje cells...
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    ..This may be implicated in the TBI induced early and severe neuronal depolarization and excito-neurotoxicity in old age. ..
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