Slc16a7

Summary

Gene Symbol: Slc16a7
Description: solute carrier family 16 (monocarboxylic acid transporters), member 7
Alias: 4921534N07Rik, 9030411M13Rik, D630004K10Rik, Mct2, monocarboxylate transporter 2, solute carrier family 16 member 7
Species: mouse
Products:     Slc16a7

Top Publications

  1. Pierre K, Parent A, Jayet P, Halestrap A, Scherrer U, Pellerin L. Enhanced expression of three monocarboxylate transporter isoforms in the brain of obese mice. J Physiol. 2007;583:469-86 pubmed
    Monocarboxylate transporters (MCTs) are membrane carriers for lactate and ketone bodies. Three isoforms, MCT1, MCT2 and MCT4, have been described in the central nervous system but little information is available about the regulation of ..
  2. Pierre K, Magistretti P, Pellerin L. MCT2 is a major neuronal monocarboxylate transporter in the adult mouse brain. J Cereb Blood Flow Metab. 2002;22:586-95 pubmed
    ..Northern blot and in situ hybridization studies suggested that neurons express the monocarboxylate transporter MCT2, subsequent immunohistochemical analyzes either failed to confirm the presence of this transporter or revealed only ..
  3. Chen C, Maekawa M, Yamatoya K, Nozaki M, Ito C, Iwanaga T, et al. Interaction between basigin and monocarboxylate transporter 2 in the mouse testes and spermatozoa. Asian J Androl. 2016;18:600-6 pubmed publisher
    ..is known to be a chaperone for the monocarboxylate transporter 1 (MCT1), the localization of basigin, MCT1 and MCT2 was examined during postnatal testicular development...
  4. Pierre K, Debernardi R, Magistretti P, Pellerin L. Noradrenaline enhances monocarboxylate transporter 2 expression in cultured mouse cortical neurons via a translational regulation. J Neurochem. 2003;86:1468-76 pubmed
    Regulation of the expression of MCT1 and MCT2, two isoforms of the monocarboxylate transporter (MCT) family, was investigated in primary cultures of mouse cortical neurons...
  5. Chenal J, Pellerin L. Noradrenaline enhances the expression of the neuronal monocarboxylate transporter MCT2 by translational activation via stimulation of PI3K/Akt and the mTOR/S6K pathway. J Neurochem. 2007;102:389-97 pubmed
    b>Monocarboxylate transporter 2 (MCT2) expression is up-regulated by noradrenaline (NA) in cultured cortical neurons via a putative but undetermined translational mechanism...
  6. Mannowetz N, Wandernoth P, Wennemuth G. Basigin interacts with both MCT1 and MCT2 in murine spermatozoa. J Cell Physiol. 2012;227:2154-62 pubmed publisher
    ..In the case of several cell types it is known that MCT1 is associated with basigin and MCT2 with embigin...
  7. Zhang S, Searcy T, WU Y, Gozal D, Wang Y. Alternative promoter usage and alternative splicing contribute to mRNA heterogeneity of mouse monocarboxylate transporter 2. Physiol Genomics. 2007;32:95-104 pubmed
    Expression patterns of monocarboxylate transporter 2 (MCT2) display mRNA diversity in a tissue-specific fashion...
  8. Jansen S, Cashman K, Thompson J, Pantaleon M, Kaye P. Glucose deprivation, oxidative stress and peroxisome proliferator-activated receptor-alpha (PPARA) cause peroxisome proliferation in preimplantation mouse embryos. Reproduction. 2009;138:493-505 pubmed publisher
    ..to their death, these glucose-deprived morulae exhibit upregulation of the H+-monocarboxylate co-transporter SLC16A7 and catalase, which partly co-localize in peroxisomes...
  9. Koehler Stec E, Simpson I, Vannucci S, Landschulz K, Landschulz W. Monocarboxylate transporter expression in mouse brain. Am J Physiol. 1998;275:E516-24 pubmed
    ..We have recently cloned two MCT isoforms (MCT1 and MCT2) from a mouse kidney cDNA library...

More Information

Publications23

  1. Rosafio K, Castillo X, Hirt L, Pellerin L. Cell-specific modulation of monocarboxylate transporter expression contributes to the metabolic reprograming taking place following cerebral ischemia. Neuroscience. 2016;317:108-20 pubmed publisher
    ..73 ± 0.2 and contralateral 2.01 ± 0.4; MCT2 ipsilateral 2.1 ± 0.1; MCT4 ipsilateral 1.65 ± 0...
  2. Cortés Campos C, Elizondo R, Carril C, Martinez F, Boric K, Nualart F, et al. MCT2 expression and lactate influx in anorexigenic and orexigenic neurons of the arcuate nucleus. PLoS ONE. 2013;8:e62532 pubmed publisher
    ..Furthermore, the expression and function of MCT2 was demonstrated in the hypothalamic neuronal cell line, GT1-7, using kinetic and inhibition assays...
  3. Robinet C, Pellerin L. Brain-derived neurotrophic factor enhances the hippocampal expression of key postsynaptic proteins in vivo including the monocarboxylate transporter MCT2. Neuroscience. 2011;192:155-63 pubmed publisher
    ..Recent results suggest that the neuronal monocarboxylate transporter MCT2 is a postsynaptic protein critically involved in synaptic plasticity and long-term memory...
  4. Hippenmeyer S, Huber R, Ladle D, Murphy K, Arber S. ETS transcription factor Erm controls subsynaptic gene expression in skeletal muscles. Neuron. 2007;55:726-40 pubmed
    ..Together, our findings define Erm as an upstream regulator of a transcriptional program selective to subsynaptic nuclei at the NMJ and underscore the importance of transcriptional control of local synaptic protein accumulation. ..
  5. Hérubel F, El Mouatassim S, Guérin P, Frydman R, Menezo Y. Genetic expression of monocarboxylate transporters during human and murine oocyte maturation and early embryonic development. Zygote. 2002;10:175-81 pubmed
    ..Transcripts encoding for MCT1 and MCT2 were present, under a polyadenylated form, in the majority of the human and mouse oocytes and early embryos...
  6. Pellerin L, Pellegri G, Martin J, Magistretti P. Expression of monocarboxylate transporter mRNAs in mouse brain: support for a distinct role of lactate as an energy substrate for the neonatal vs. adult brain. Proc Natl Acad Sci U S A. 1998;95:3990-5 pubmed
    ..Recently, two monocarboxylate transporters, MCT1 and MCT2, have been cloned...
  7. Pierre K, Chatton J, Parent A, Repond C, Gardoni F, Di Luca M, et al. Linking supply to demand: the neuronal monocarboxylate transporter MCT2 and the alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-propionic acid receptor GluR2/3 subunit are associated in a common trafficking process. Eur J Neurosci. 2009;29:1951-63 pubmed publisher
    b>MCT2 is the major neuronal monocarboxylate transporter (MCT) that allows the supply of alternative energy substrates such as lactate to neurons...
  8. Yanase H, Takebe K, Nio Kobayashi J, Takahashi Iwanaga H, Iwanaga T. Cellular expression of a sodium-dependent monocarboxylate transporter (Slc5a8) and the MCT family in the mouse kidney. Histochem Cell Biol. 2008;130:957-66 pubmed publisher
    ..Among these, signals for SMCT, MCT2 and MCT8 were predominant; transcripts of SMCT were restricted to the cortex and the outer stripe of outer medulla, ..
  9. Robinet C, Pellerin L. Brain-derived neurotrophic factor enhances the expression of the monocarboxylate transporter 2 through translational activation in mouse cultured cortical neurons. J Cereb Blood Flow Metab. 2010;30:286-98 pubmed publisher
    b>MCT2 is the predominant neuronal monocarboxylate transporter allowing lactate use as an alternative energy substrate. It is suggested that MCT2 is upregulated to meet enhanced energy demands after modifications in synaptic transmission...
  10. Becker H, Mohebbi N, Perna A, Ganapathy V, Capasso G, Wagner C. Localization of members of MCT monocarboxylate transporter family Slc16 in the kidney and regulation during metabolic acidosis. Am J Physiol Renal Physiol. 2010;299:F141-54 pubmed publisher
    ..Here, we investigated selected members of the MCT family in the mouse kidney. MCT1, MCT2, MCT7, and MCT8 localized to basolateral membranes of the epithelial cells lining the nephron...
  11. Jansen S, Pantaleon M, Kaye P. Characterization and regulation of monocarboxylate cotransporters Slc16a7 and Slc16a3 in preimplantation mouse embryos. Biol Reprod. 2008;79:84-92 pubmed publisher
    ..The expression and localization of SLC16A7 and SLC16A3 have therefore been examined to clarify their respective roles in embryos derived from the ..
  12. Debernardi R, Pierre K, Lengacher S, Magistretti P, Pellerin L. Cell-specific expression pattern of monocarboxylate transporters in astrocytes and neurons observed in different mouse brain cortical cell cultures. J Neurosci Res. 2003;73:141-55 pubmed
    ..Expression of MCT1 and MCT2, two isoforms of the monocarboxylate transporter (MCT) family, was studied in enriched cultures of mouse cortical ..
  13. Moreau J, Artap S, Shi H, Chapman G, Leone G, Sparrow D, et al. Cited2 is required in trophoblasts for correct placental capillary patterning. Dev Biol. 2014;392:62-79 pubmed publisher
  14. Domènech Estévez E, Baloui H, Repond C, Rosafio K, Médard J, Tricaud N, et al. Distribution of monocarboxylate transporters in the peripheral nervous system suggests putative roles in lactate shuttling and myelination. J Neurosci. 2015;35:4151-6 pubmed publisher
    ..Here we show that mouse MCT1, MCT2, and MCT4 are expressed in the PNS...