Gene Symbol: Slc16a1
Description: solute carrier family 16 (monocarboxylic acid transporters), member 1
Alias: AL022710, Mct1, monocarboxylate transporter 1, solute carrier family 16 member 1
Species: mouse
Products:     Slc16a1

Top Publications

  1. Carpenter L, Poole R, Halestrap A. Cloning and sequencing of the monocarboxylate transporter from mouse Ehrlich Lettré tumour cell confirms its identity as MCT1 and demonstrates that glycosylation is not required for MCT1 function. Biochim Biophys Acta. 1996;1279:157-63 pubmed
    ..the lactate transporter from Ehrlich Lettré tumour cells by using the polymerase chain reaction (PCR) to amplify MCT1-related sequence from cDNA...
  2. Pellerin L, Pellegri G, Martin J, Magistretti P. Expression of monocarboxylate transporter mRNAs in mouse brain: support for a distinct role of lactate as an energy substrate for the neonatal vs. adult brain. Proc Natl Acad Sci U S A. 1998;95:3990-5 pubmed
    ..Recently, two monocarboxylate transporters, MCT1 and MCT2, have been cloned...
  3. Koehler Stec E, Simpson I, Vannucci S, Landschulz K, Landschulz W. Monocarboxylate transporter expression in mouse brain. Am J Physiol. 1998;275:E516-24 pubmed
    ..We have recently cloned two MCT isoforms (MCT1 and MCT2) from a mouse kidney cDNA library...
  4. Nagai A, Takebe K, Nio Kobayashi J, Takahashi Iwanaga H, Iwanaga T. Cellular expression of the monocarboxylate transporter (MCT) family in the placenta of mice. Placenta. 2010;31:126-33 pubmed publisher
    ..An in situ hybridization survey of all MCT subtypes detected intense mRNA expressions of MCT1, MCT4, and MCT9 as well as GLUT1 in the placenta from gestational day 11.5...
  5. Maekawa F, Minehira K, Kadomatsu K, Pellerin L. Basal and stimulated lactate fluxes in primary cultures of astrocytes are differentially controlled by distinct proteins. J Neurochem. 2008;107:789-98 pubmed publisher
    ..Basal lactate uptake and release were significantly reduced by MCT1 knockdown, even more so than with basigin knockdown, whereas glutamate-driven or sodium azide-induced enhancement ..
  6. Otonkoski T, Jiao H, Kaminen Ahola N, Tapia Paez I, Ullah M, Parton L, et al. Physical exercise-induced hypoglycemia caused by failed silencing of monocarboxylate transporter 1 in pancreatic beta cells. Am J Hum Genet. 2007;81:467-74 pubmed
    ..Mutational analysis of the promoter of the SLC16A1 gene, which encodes monocarboxylate transporter 1 (MCT1), located under the linkage peak, revealed changes in all 13 identified patients with EIHI...
  7. Mannowetz N, Wandernoth P, Wennemuth G. Basigin interacts with both MCT1 and MCT2 in murine spermatozoa. J Cell Physiol. 2012;227:2154-62 pubmed publisher
    ..In the case of several cell types it is known that MCT1 is associated with basigin and MCT2 with embigin...
  8. Chatel B, Bendahan D, Hourde C, Pellerin L, Lengacher S, Magistretti P, et al. Role of MCT1 and CAII in skeletal muscle pH homeostasis, energetics, and function: in vivo insights from MCT1 haploinsufficient mice. FASEB J. 2017;31:2562-2575 pubmed publisher
    ..of a partial suppression of monocarboxylate transporter (MCT)-1 on skeletal muscle pH, energetics, and function (MCT1+/- mice)...
  9. Bonnin A, Goeden N, Chen K, Wilson M, King J, Shih J, et al. A transient placental source of serotonin for the fetal forebrain. Nature. 2011;472:347-50 pubmed publisher

More Information


  1. Kitaoka Y, Machida M, Takemasa T, Hatta H. Expression of monocarboxylate transporter (MCT) 1 and MCT4 in overloaded mice plantaris muscle. J Physiol Sci. 2011;61:467-72 pubmed publisher
    ..The aim of this study was to investigate the effect of functional overload on MCT1 and MCT4 protein expression...
  2. Pierre K, Parent A, Jayet P, Halestrap A, Scherrer U, Pellerin L. Enhanced expression of three monocarboxylate transporter isoforms in the brain of obese mice. J Physiol. 2007;583:469-86 pubmed
    Monocarboxylate transporters (MCTs) are membrane carriers for lactate and ketone bodies. Three isoforms, MCT1, MCT2 and MCT4, have been described in the central nervous system but little information is available about the regulation of ..
  3. Finch N, Linser P, Ochrietor J. Hydrophobic interactions stabilize the basigin-MCT1 complex. Protein J. 2009;28:362-8 pubmed publisher
    Previous reports demonstrated that monocarboxylate transporter-1 (MCT1) interacts with Basigin...
  4. Pullen T, Sylow L, Sun G, Halestrap A, Richter E, Rutter G. Overexpression of monocarboxylate transporter-1 (SLC16A1) in mouse pancreatic β-cells leads to relative hyperinsulinism during exercise. Diabetes. 2012;61:1719-25 pubmed publisher
    ..Activating mutations in the monocarboxylate transporter-1 (MCT1, SLC16A1) promoter have been linked to EIHI...
  5. Nualart F, Castro T, Low M, Henriquez J, Oyarce K, Cisternas P, et al. Dynamic expression of the sodium-vitamin C co-transporters, SVCT1 and SVCT2, during perinatal kidney development. Histochem Cell Biol. 2013;139:233-47 pubmed publisher
    ..These studies suggest that the uptake of vitamin C mediated by different SVCTs plays differential roles during the ontogeny of kidney tubular epithelial cells. ..
  6. Jansen S, Esmaeilpour T, Pantaleon M, Kaye P. Glucose affects monocarboxylate cotransporter (MCT) 1 expression during mouse preimplantation development. Reproduction. 2006;131:469-79 pubmed
    ..transport characteristics for DL-lactate were examined, as were mRNA expression and protein localisation for MCT1 and MCT3, using confocal laser scanning immunofluorescence in freshly collected and cultured embryos...
  7. Tai Nagara I, Yoshikawa Y, Numata N, Ando T, Okabe K, Sugiura Y, et al. Placental labyrinth formation in mice requires endothelial FLRT2/UNC5B signaling. Development. 2017;144:2392-2401 pubmed publisher
    ..Our results suggest that the proper organization of the placental labyrinth depends on coordinated inter-endothelial repulsion, which prevents uncontrolled layering of the endothelium. ..
  8. Lee Y, Morrison B, Li Y, Lengacher S, Farah M, Hoffman P, et al. Oligodendroglia metabolically support axons and contribute to neurodegeneration. Nature. 2012;487:443-8 pubmed publisher
    ..Here we show that the most abundant lactate transporter in the central nervous system, monocarboxylate transporter 1 (MCT1, also known as SLC16A1), is highly enriched within oligodendroglia and that disruption of this ..
  9. Becker H, Mohebbi N, Perna A, Ganapathy V, Capasso G, Wagner C. Localization of members of MCT monocarboxylate transporter family Slc16 in the kidney and regulation during metabolic acidosis. Am J Physiol Renal Physiol. 2010;299:F141-54 pubmed publisher
    ..Here, we investigated selected members of the MCT family in the mouse kidney. MCT1, MCT2, MCT7, and MCT8 localized to basolateral membranes of the epithelial cells lining the nephron...
  10. Puchades M, Sogn C, Maehlen J, Bergersen L, Gundersen V. Unaltered lactate and glucose transporter levels in the MPTP mouse model of Parkinson's disease. J Parkinsons Dis. 2013;3:371-85 pubmed publisher
    ..electron microscopic techniques to study whether there are altered levels of the transporters for monocarboxylates (MCT1 and MCT2) and glucose (GLUT1) in the MPTP mouse model of PD...
  11. Domènech Estévez E, Baloui H, Repond C, Rosafio K, Médard J, Tricaud N, et al. Distribution of monocarboxylate transporters in the peripheral nervous system suggests putative roles in lactate shuttling and myelination. J Neurosci. 2015;35:4151-6 pubmed publisher
    ..Here we show that mouse MCT1, MCT2, and MCT4 are expressed in the PNS...
  12. Garcia C, Li X, Luna J, Francke U. cDNA cloning of the human monocarboxylate transporter 1 and chromosomal localization of the SLC16A1 locus to 1p13.2-p12. Genomics. 1994;23:500-3 pubmed
    ..The gene for human MCT1 (gene symbol, SLC16A1) was localized to human chromosome bands 1p13...
  13. Hérubel F, El Mouatassim S, Guérin P, Frydman R, Menezo Y. Genetic expression of monocarboxylate transporters during human and murine oocyte maturation and early embryonic development. Zygote. 2002;10:175-81 pubmed
    ..Human and mouse genetic expression of MCT members 1, 2, 3, 4 and basigin, a chaperone protein of MCT1 and MCT4, was qualitatively analysed using the reverse transcription nested polymerase chain reaction (RT-nested ..
  14. Yanase H, Takebe K, Nio Kobayashi J, Takahashi Iwanaga H, Iwanaga T. Cellular expression of a sodium-dependent monocarboxylate transporter (Slc5a8) and the MCT family in the mouse kidney. Histochem Cell Biol. 2008;130:957-66 pubmed publisher
    ..b>MCT1 and MCT2 immunoreactivities were respectively found baso-laterally in S1 and thick ascending limbs of Henle's loop...
  15. Howard J, Finch N, Ochrietor J. Characterization of monocarboxylate transporter 1 (MCT1) binding affinity for Basigin gene products and L1cam. Cell Mol Neurobiol. 2010;30:671-4 pubmed publisher
    ..affinities of Basigin gene products and neural cell adhesion molecule L1cam for monocarboxylate transporter-1 (MCT1)...
  16. Payen V, Hsu M, Rädecke K, Wyart E, Vazeille T, Bouzin C, et al. Monocarboxylate Transporter MCT1 Promotes Tumor Metastasis Independently of Its Activity as a Lactate Transporter. Cancer Res. 2017;77:5591-5601 pubmed publisher
    ..Monocarboxylate transporter MCT1 is a passive transporter of lactic acid that has attracted interest as a target for small-molecule drugs to prevent ..
  17. Aveseh M, Nikooie R, Aminaie M. Exercise-induced changes in tumour LDH-B and MCT1 expression are modulated by oestrogen-related receptor alpha in breast cancer-bearing BALB/c mice. J Physiol. 2015;593:2635-48 pubmed publisher
    ..This study showed that endurance training decreases expression of the MCT1 basigin (CD147) and LDH-A , and also increases LDH-B expression in solid tumours and attenuates tumour lactate ..
  18. Morrison B, Tsingalia A, Vidensky S, Lee Y, Jin L, Farah M, et al. Deficiency in monocarboxylate transporter 1 (MCT1) in mice delays regeneration of peripheral nerves following sciatic nerve crush. Exp Neurol. 2015;263:325-38 pubmed publisher
    ..In the central nervous system, monocarboxylate transporter 1 (MCT1), expressed in oligodendroglia, is critical for supplying lactate or other energy metabolites to ..
  19. Nakai M, Chen L, Nowak R. Tissue distribution of basigin and monocarboxylate transporter 1 in the adult male mouse: a study using the wild-type and basigin gene knockout mice. Anat Rec A Discov Mol Cell Evol Biol. 2006;288:527-35 pubmed was conducted to determine whether or not Bsg was required for the proper localization of MCT isoform 1 (MCT1) in a wide range of tissues in adult male mice...
  20. Lengacher S, Nehiri Sitayeb T, Steiner N, Carneiro L, Favrod C, Preitner F, et al. Resistance to diet-induced obesity and associated metabolic perturbations in haploinsufficient monocarboxylate transporter 1 mice. PLoS ONE. 2013;8:e82505 pubmed publisher
    The monocarboxylate transporter 1 (MCT1 or SLC16A1) is a carrier of short-chain fatty acids, ketone bodies, and lactate in several tissues...
  21. Yoshida Y, Hatta H, Kato M, Enoki T, Kato H, Bonen A. Relationship between skeletal muscle MCT1 and accumulated exercise during voluntary wheel running. J Appl Physiol (1985). 2004;97:527-34 pubmed
    ..Differences in muscle MCT1 and MCT4 among animals, before the initiation of running, were not related to the quantity of exercise performed on ..
  22. Wu H, Choi S, Levitt P. Differential patterning of genes involved in serotonin metabolism and transport in extra-embryonic tissues of the mouse. Placenta. 2016;42:74-83 pubmed publisher
  23. Clamp M, Ochrietor J, Moroz T, Linser P. Developmental analyses of 5A11/Basigin, 5A11/Basigin-2 and their putative binding partner MCT1 in the mouse eye. Exp Eye Res. 2004;78:777-89 pubmed
    ..between 5A11/Basigin, a member of the immunoglobulin gene superfamily, and monocarboxylate transporter-1 (MCT1), a lactose transporter...
  24. Pablo K, Ochrietor J. Deletion of the Basigin gene results in reduced mitochondria in the neural retina. Biochem Biophys Res Commun. 2013;438:546-50 pubmed publisher
    ..results suggest that a reduction in mitochondria is a result, rather than the cause, of the metabolic deficiency observed in Basigin-null mice, and likely occurs because of reduced metabolic activity in the absence of MCT1 expression.
  25. Takebe K, Nio Kobayashi J, Takahashi Iwanaga H, Yajima T, Iwanaga T. Cellular expression of a monocarboxylate transporter (MCT1) in the mammary gland and sebaceous gland of mice. Histochem Cell Biol. 2009;131:401-9 pubmed publisher
    ..An in situ hybridization survey of major MCT subtypes detected an intense expression of MCT1 mRNA in the mammary gland, Harderian gland, and sebaceous gland...
  26. Pullen T, Da Silva Xavier G, Kelsey G, Rutter G. miR-29a and miR-29b contribute to pancreatic beta-cell-specific silencing of monocarboxylate transporter 1 (Mct1). Mol Cell Biol. 2011;31:3182-94 pubmed publisher
    ..Unusually low levels of expression of genes encoding the plasma membrane monocarboxylate transporter, MCT1 (SLC16A1), as well as lactate dehydrogenase A (LDHA) ensure that glucose-derived pyruvate is efficiently metabolized by ..
  27. Martinov V, Rizvi S, Weiseth S, Sagave J, Bergersen L, Valen G. Increased expression of monocarboxylate transporter 1 after acute ischemia of isolated, perfused mouse hearts. Life Sci. 2009;85:379-85 pubmed publisher
    Lactate is transported by stereo-specific, pH-dependent monocarboxylate transporters (MCTs), of which MCT1 is expressed in abundance in rodent and human hearts...
  28. Yoshimura K, Miyamoto Y, Yasuhara R, Maruyama T, Akiyama T, Yamada A, et al. Monocarboxylate transporter-1 is required for cell death in mouse chondrocytic ATDC5 cells exposed to interleukin-1beta via late phase activation of nuclear factor kappaB and expression of phagocyte-type NADPH oxidase. J Biol Chem. 2011;286:14744-52 pubmed publisher
    ..These results suggest that MCT-1 contributes to NOX-2 expression via late phase activation of NF-?B in a ROS-dependent manner in ATDC5 cells exposed to IL-1?. ..
  29. Moreau J, Artap S, Shi H, Chapman G, Leone G, Sparrow D, et al. Cited2 is required in trophoblasts for correct placental capillary patterning. Dev Biol. 2014;392:62-79 pubmed publisher
  30. Hoshino D, Hanawa T, Takahashi Y, Masuda H, Kato M, Hatta H. Chronic post-exercise lactate administration with endurance training increases glycogen concentration and monocarboxylate transporter 1 protein in mouse white muscle. J Nutr Sci Vitaminol (Tokyo). 2014;60:413-9 pubmed publisher
    ..with training can increase muscle glycogen storage and whether such changes are associated with monocarboxylate transporter 1 (MCT1) protein expression in mice...
  31. Takebe K, Nio Kobayashi J, Takahashi Iwanaga H, Iwanaga T. Histochemical demonstration of a monocarboxylate transporter in the mouse perineurium with special reference to GLUT1. Biomed Res. 2008;29:297-306 pubmed
    ..such as ketone bodies and lactate, being accompanied by an elevated expression of a monocarboxylate transporter (MCT1) in the blood-brain barrier...
  32. Debernardi R, Pierre K, Lengacher S, Magistretti P, Pellerin L. Cell-specific expression pattern of monocarboxylate transporters in astrocytes and neurons observed in different mouse brain cortical cell cultures. J Neurosci Res. 2003;73:141-55 pubmed
    ..Such a process implies the presence of specific monocarboxylate transporters on both cell types. Expression of MCT1 and MCT2, two isoforms of the monocarboxylate transporter (MCT) family, was studied in enriched cultures of mouse ..
  33. König B, Koch A, Giggel K, Dordschbal B, Eder K, Stangl G. Monocarboxylate transporter (MCT)-1 is up-regulated by PPARalpha. Biochim Biophys Acta. 2008;1780:899-904 pubmed publisher
    ..that activation of PPARalpha in rats by clofibrate treatment or fasting increased hepatic mRNA concentration of MCT1. In Fao rat hepatoma cells, incubation with the PPARalpha agonist WY 14,643 increased mRNA concentration of MCT1 ..