Gene Symbol: Slc13a1
Description: solute carrier family 13 (sodium/sulfate symporters), member 1
Alias: AI314066, AI987826, NaSi-1, Nas1, solute carrier family 13 member 1, Na(+)/sulfate cotransporter, renal sodium/sulfate cotransporter, solute carrier family 13 (sodium/sulphate symporters), member 1
Species: mouse
Products:     Slc13a1

Top Publications

  1. Lee A, Beck L, Markovich D. The human renal sodium sulfate cotransporter (SLC13A1; hNaSi-1) cDNA and gene: organization, chromosomal localization, and functional characterization. Genomics. 2000;70:354-63 pubmed
    ..of the human Na+-sulfate cotransporter (hNaSi-1) cDNA (Human Genome Nomenclature Committee-approved symbol SLC13A1) and gene (NAS1). hNaSi-1 encodes a protein of 595 amino acids with 13 putative transmembrane domains...
  2. Dawson P, Gardiner B, Lee S, Grimmond S, Markovich D. Kidney transcriptome reveals altered steroid homeostasis in NaS1 sulfate transporter null mice. J Steroid Biochem Mol Biol. 2008;112:55-62 pubmed publisher
    Sulfate is essential for human growth and development, and circulating sulfate levels are maintained by the NaS1 sulfate transporter which is expressed in the kidney...
  3. Beck L, Markovich D. The mouse Na(+)-sulfate cotransporter gene Nas1. Cloning, tissue distribution, gene structure, chromosomal assignment, and transcriptional regulation by vitamin D. J Biol Chem. 2000;275:11880-90 pubmed
    ..that mediate the regulation of NaSi-1, we have isolated and characterized the mouse NaSi-1 cDNA (mNaSi-1), gene (Nas1), and promoter region and determined Nas1 chromosomal localization...
  4. Dawson P, Markovich D. Transcriptional regulation of the sodium-sulfate cotransporter NaS(i)-1 gene. Cell Biochem Biophys. 2002;36:175-82 pubmed
    ..In this study, we describe the transcriptional regulation of NaS(i)-1, with a focus on the mouse NaS(i)-1 gene (Nas1) that was recently cloned in our laboratory...
  5. Dawson P, Steane S, Markovich D. Impaired memory and olfactory performance in NaSi-1 sulphate transporter deficient mice. Behav Brain Res. 2005;159:15-20 pubmed
    In the present study, NaSi-1 sulphate transporter knock-out (Nas1-/-) mice, an animal model of hyposulphataemia, were examined for spatial memory and learning in a Morris water maze, and for olfactory function in a cookie test...
  6. Dawson P, Gardiner B, Grimmond S, Markovich D. Transcriptional profile reveals altered hepatic lipid and cholesterol metabolism in hyposulfatemic NaS1 null mice. Physiol Genomics. 2006;26:116-24 pubmed human growth and development, and its circulating levels are maintained by the renal Na+-SO42- cotransporter, NaS1. We previously generated a NaS1 knockout (Nas1-/-) mouse, an animal model for hyposulfatemia, that exhibits reduced ..
  7. Dawson P, Sim P, Simmons D, Markovich D. Fetal loss and hyposulfataemia in pregnant NaS1 transporter null mice. J Reprod Dev. 2011;57:444-9 pubmed
    Sulfate is important for growth and development, and is supplied from mother to fetus throughout pregnancy. We used NaS1 sulfate transporter null (Nas1(-/-)) mice to investigate the role of NaS1 in maintaining sulfate homeostasis during ..
  8. Dawson P, Markovich D. Regulation of the mouse Nas1 promoter by vitamin D and thyroid hormone. Pflugers Arch. 2002;444:353-9 pubmed
    ..Recently, we cloned the mouse NaS(i)-1 gene ( Nas1) and in the present study identified a 1,25-(OH)(2)D(3)- and T(3)-responsive element located within the Nas1 ..
  9. Dawson P, Beck L, Markovich D. Hyposulfatemia, growth retardation, reduced fertility, and seizures in mice lacking a functional NaSi-1 gene. Proc Natl Acad Sci U S A. 2003;100:13704-9 pubmed
    ..and the physiological consequences in its absence, we have generated a mouse lacking a functional NaSi-1 gene, Nas1. Serum sulfate concentration was reduced by >75% in Nas1-/- mice when compared with Nas1+/+ mice...

More Information


  1. Dawson P, Steane S, Markovich D. Behavioural abnormalities of the hyposulphataemic Nas1 knock-out mouse. Behav Brain Res. 2004;154:457-63 pubmed
    We recently generated a sodium sulphate cotransporter knock-out mouse (Nas1-/-) which has increased urinary sulphate excretion and hyposulphataemia...
  2. Lee S, Kesby J, Muslim M, Steane S, Eyles D, Dawson P, et al. Hyperserotonaemia and reduced brain serotonin levels in NaS1 sulphate transporter null mice. Neuroreport. 2007;18:1981-5 pubmed
    Sulphate (SO4) is conjugated to numerous endogenous compounds, including serotonin (5-HT). The NaS1 sulphate transporter is primarily expressed in the kidney, where it maintains blood SO4 concentrations...
  3. Dawson P, Choyce A, Chuang C, Whitelock J, Markovich D, Leggatt G. Enhanced tumor growth in the NaS1 sulfate transporter null mouse. Cancer Sci. 2010;101:369-73 pubmed publisher
    ..In this study, we investigated tumor growth in a mouse model of hyposulfatemia (Nas1(-/-)) and compared it to wild-type (Nas1(+/+)) mice...
  4. Markovich D, Ku M, Muslim D. Increased lifespan in hyposulfatemic NaS1 null mice. Exp Gerontol. 2011;46:833-5 pubmed publisher
    Sulfate (SO(4)(2-)) plays an important role in mammalian growth and development. In this study, hyposulfatemic NaS1 null (Nas1-/-) mice were used to investigate the consequences of perturbed SO(4)(2-) homeostasis on longevity...
  5. Dawson P, Rakoczy J, Simmons D. Placental, renal, and ileal sulfate transporter gene expression in mouse gestation. Biol Reprod. 2012;87:43 pubmed publisher
    ..In the kidney, Slc13a1 and Slc26a1 were the most abundant sulfate transporter mRNAs, which increased by ?2-fold at E4.5 or E6...