Slc11a2

Summary

Gene Symbol: Slc11a2
Description: solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
Alias: DCT1, DMT1, Nramp2, van, natural resistance-associated macrophage protein 2, DMT-1, NRAMP 2, divalent cation transporter 1, divalent metal transporter 1, microcytic anemia, viable anaemia, solute carrier family 11 member 2
Species: mouse
Products:     Slc11a2

Top Publications

  1. Touret N, Furuya W, Forbes J, Gros P, Grinstein S. Dynamic traffic through the recycling compartment couples the metal transporter Nramp2 (DMT1) with the transferrin receptor. J Biol Chem. 2003;278:25548-57 pubmed
    Nramp2 (natural resistance-associated macrophage protein 2, also called DMT1 and Slc11a2) is a proton-dependent cation transporter, which plays a central role in iron homeostasis...
  2. Canonne Hergaux F, Zhang A, Ponka P, Gros P. Characterization of the iron transporter DMT1 (NRAMP2/DCT1) in red blood cells of normal and anemic mk/mk mice. Blood. 2001;98:3823-30 pubmed
    b>Divalent metal transporter 1 (DMT1) is the major transferrin-independent iron uptake system at the apical pole of intestinal cells, but it may also transport iron across the membrane of acidified endosomes in peripheral tissues...
  3. Fleming M, Romano M, Su M, Garrick L, Garrick M, Andrews N. Nramp2 is mutated in the anemic Belgrade (b) rat: evidence of a role for Nramp2 in endosomal iron transport. Proc Natl Acad Sci U S A. 1998;95:1148-53 pubmed
    ..Recently, mk has been attributed to a missense mutation in the gene encoding the putative iron transporter protein Nramp2. To investigate the possibility that Nramp2 was also mutated in the b rat, we established linkage of the phenotype ..
  4. Hubert N, Hentze M. Previously uncharacterized isoforms of divalent metal transporter (DMT)-1: implications for regulation and cellular function. Proc Natl Acad Sci U S A. 2002;99:12345-50 pubmed
    b>Divalent metal transporter 1 (DMT1) mediates apical iron uptake into duodenal enterocytes and also transfers iron from the endosome into the cytosol after cellular uptake via the transferrin receptor...
  5. Foot N, Leong Y, Dorstyn L, Dalton H, Ho K, Zhao L, et al. Ndfip1-deficient mice have impaired DMT1 regulation and iron homeostasis. Blood. 2011;117:638-46 pubmed publisher
    The divalent metal ion transporter DMT1 is critical for nonheme iron import. We have previously shown that DMT1 is regulated in vitro by ubiquitination that is facilitated by the adaptor proteins Ndfip1 and Ndfip2...
  6. Canonne Hergaux F, Fleming M, Levy J, Gauthier S, Ralph T, Picard V, et al. The Nramp2/DMT1 iron transporter is induced in the duodenum of microcytic anemia mk mice but is not properly targeted to the intestinal brush border. Blood. 2000;96:3964-70 pubmed
    ..carry a glycine to arginine substitution at position 185 in the iron transporter known as Nramp2/DMT1 (divalent metal transporter 1)...
  7. Lam Yuk Tseung S, Picard V, Gros P. Identification of a tyrosine-based motif (YGSI) in the amino terminus of Nramp1 (Slc11a1) that is important for lysosomal targeting. J Biol Chem. 2006;281:31677-88 pubmed
    ..Nramp2 (DMT1, Slc11a2) is expressed both at the duodenal brush border where it mediates uptake of dietary iron and ubiquitously at the ..
  8. Vidal S, Belouchi A, Cellier M, Beatty B, Gros P. Cloning and characterization of a second human NRAMP gene on chromosome 12q13. Mamm Genome. 1995;6:224-30 pubmed
    ..the isolation and characterization of a cDNA clone corresponding to the second member of the human NRAMP family, NRAMP2. Predicted amino acid sequence analysis of the NRAMP2 polypeptide identifies a polytopic membrane protein highly ..
  9. Fleming M, Trenor C, Su M, Foernzler D, Beier D, Dietrich W, et al. Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene. Nat Genet. 1997;16:383-6 pubmed
    ..of a strong candidate gene for mk, and suggest that the phenotype is a consequence of a missense mutation in Nramp2 (ref. 5), a previously identified gene of unknown function...

More Information

Publications77

  1. Lam Yuk Tseung S, Govoni G, Forbes J, Gros P. Iron transport by Nramp2/DMT1: pH regulation of transport by 2 histidines in transmembrane domain 6. Blood. 2003;101:3699-707 pubmed
    ..1 (Nramp1) impair phagocyte function and cause susceptibility to infections while mutations at Nramp2 (divalent metal transporter 1 [DMT1]) affect iron homeostasis and cause severe microcytic anemia...
  2. Lam Yuk Tseung S, Touret N, Grinstein S, Gros P. Carboxyl-terminus determinants of the iron transporter DMT1/SLC11A2 isoform II (-IRE/1B) mediate internalization from the plasma membrane into recycling endosomes. Biochemistry. 2005;44:12149-59 pubmed
    Mutations in DMT1 (Nramp2 and Slc11a2) impair iron metabolism and cause microcytic anemia...
  3. Picard V, Govoni G, Jabado N, Gros P. Nramp 2 (DCT1/DMT1) expressed at the plasma membrane transports iron and other divalent cations into a calcein-accessible cytoplasmic pool. J Biol Chem. 2000;275:35738-45 pubmed
    b>Nramp2, also known as DMT1 and DCT1, is a 12-transmembrane (TM) domain protein responsible for dietary iron uptake in the duodenum and iron acquisition from transferrin in peripheral tissues...
  4. Salazar J, Mena N, Hunot S, Prigent A, Alvarez Fischer D, Arredondo M, et al. Divalent metal transporter 1 (DMT1) contributes to neurodegeneration in animal models of Parkinson's disease. Proc Natl Acad Sci U S A. 2008;105:18578-83 pubmed publisher
    ..Here, we describe an increase in the expression of an isoform of the divalent metal transporter 1 (DMT1/Nramp2/Slc11a2) in the SN of PD patients...
  5. Foot N, Dalton H, Shearwin Whyatt L, Dorstyn L, Tan S, Yang B, et al. Regulation of the divalent metal ion transporter DMT1 and iron homeostasis by a ubiquitin-dependent mechanism involving Ndfips and WWP2. Blood. 2008;112:4268-75 pubmed publisher
    ..Here we report that the divalent metal ion transporter DMT1, the primary nonheme iron transporter in mammals, is regulated by ubiquitination mediated by the Nedd4 family ..
  6. Lam Yuk Tseung S, Gros P. Distinct targeting and recycling properties of two isoforms of the iron transporter DMT1 (NRAMP2, Slc11A2). Biochemistry. 2006;45:2294-301 pubmed
    The metal transporter DMT1 (Slc11a2) plays a vital role in iron metabolism...
  7. Zheng W, Xin N, Chi Z, Zhao B, Zhang J, Li J, et al. Divalent metal transporter 1 is involved in amyloid precursor protein processing and Abeta generation. FASEB J. 2009;23:4207-17 pubmed publisher
    ..In the present study, we found that two isoforms of the divalent metal transporter 1 (DMT1), DMT1-IRE, and DMT1-nonIRE, were colocalized with Abeta in the plaques of postmortem AD brain...
  8. LaVaute T, Smith S, Cooperman S, Iwai K, Land W, Meyron Holtz E, et al. Targeted deletion of the gene encoding iron regulatory protein-2 causes misregulation of iron metabolism and neurodegenerative disease in mice. Nat Genet. 2001;27:209-14 pubmed
    ..Thus, misregulation of iron metabolism leads to neurodegenerative disease in Ireb2(-/-) mice and may contribute to the pathogenesis of comparable human neurodegenerative diseases. ..
  9. Russell E, McFarland E, Kent E. Low viability, skin lesions, and reduced fertility associated with microcytic anemia in the mouse. Transplant Proc. 1970;2:144-51 pubmed
  10. Sassa S, Bernstein S. Studies of erythrocyte protoporphyrin in anemic mutant mice: use of a modified hematofluorometer for the detection of heterozygotes for hemolytic disease. Exp Hematol. 1978;6:479-87 pubmed
  11. Lam Yuk Tseung S, Mathieu M, Gros P. Functional characterization of the E399D DMT1/NRAMP2/SLC11A2 protein produced by an exon 12 mutation in a patient with microcytic anemia and iron overload. Blood Cells Mol Dis. 2005;35:212-6 pubmed
    DMT1 (Nramp2, Slc11a2) mediates iron uptake at the intestinal brush border and across the membrane of acidified endosomes...
  12. Tripathi A, Haldar S, Qian J, Beserra A, Suda S, Singh A, et al. Prion protein functions as a ferrireductase partner for ZIP14 and DMT1. Free Radic Biol Med. 2015;84:322-330 pubmed publisher
    ..expressed glycoprotein most abundant on neuronal cells, functions as a FR partner for divalent-metal transporter-1 (DMT1) and ZIP14...
  13. Yeh K, Yeh M, Polk P, Glass J. Hypoxia-inducible factor-2? and iron absorptive gene expression in Belgrade rat intestine. Am J Physiol Gastrointest Liver Physiol. 2011;301:G82-90 pubmed publisher
    The divalent metal transporter (DMT1, Slc11a2) is an important molecule for intestinal iron absorption. In the Belgrade (b/b) rat, the DMT1 G185R mutation markedly decreases intestinal iron absorption...
  14. CARLSON E, Tkac I, Magid R, O Connor M, Andrews N, Schallert T, et al. Iron is essential for neuron development and memory function in mouse hippocampus. J Nutr. 2009;139:672-9 pubmed publisher
    ..g. hypoxia due to anemia). We delineated the role of murine Slc11a2 [divalent metal ion transporter-1 (DMT-1)] in hippocampal neuronal iron uptake during development and memory ..
  15. Paradkar P, Roth J. Expression of the 1B isoforms of divalent metal transporter (DMT1) is regulated by interaction of NF-Y with a CCAAT-box element near the transcription start site. J Cell Physiol. 2007;211:183-8 pubmed
    The 1B isoforms of the divalent metal transporter (DMT1) have recently been shown to be regulated transcriptionally via NF-kappaB but whether other regulatory elements are present on this promoter, however, have not been determined...
  16. Yang F, Stonehuerner J, Richards J, Nguyen N, Callaghan K, Haile D, et al. Deficiency in the divalent metal transporter 1 increases bleomycin-induced lung injury. Biometals. 2010;23:657-67 pubmed publisher
    ..In lung cells, divalent metal transporter 1 (DMT1) can participate in metal transport resulting in control of an oxidative stress and tissue damage...
  17. Shirase T, Mori K, Okazaki Y, Itoh K, Yamamoto M, Tabuchi M, et al. Suppression of SLC11A2 expression is essential to maintain duodenal integrity during dietary iron overload. Am J Pathol. 2010;177:677-85 pubmed publisher
    ..To study the significance of the former process, we generated SLC11A2 transgenic mice (TGs) under the control of the chicken beta-actin promoter...
  18. Bannerman R. Genetic defects of iron transport. Fed Proc. 1976;35:2281-5 pubmed
  19. Canonne Hergaux F, Gros P. Expression of the iron transporter DMT1 in kidney from normal and anemic mk mice. Kidney Int. 2002;62:147-56 pubmed
    DMT1 (Nramp2/DCT1) is the major apical iron transporter in absorptive cells of the duodenum, but also transports transferrin-iron across the membrane of acidified endosomes in peripheral tissues...
  20. Wang C, Knutson M. Hepatocyte divalent metal-ion transporter-1 is dispensable for hepatic iron accumulation and non-transferrin-bound iron uptake in mice. Hepatology. 2013;58:788-98 pubmed publisher
    Divalent metal-ion transporter-1 (DMT1) is required for iron uptake by the intestine and developing erythroid cells...
  21. Beier D, Morton C, Leder A, Wallace R, Leder P. Perinatal lethality (ple): a mutation caused by integration of a transgene into distal mouse chromosome 15. Genomics. 1989;4:498-504 pubmed
    ..It appears likely that a recessive insertional mutation has occurred as a result of transgene integration into a locus required for postnatal viability. We call this mutation transgenic perinatal lethality (Tg.ple). ..
  22. Veuthey T, D Anna M, Roque M. Role of the kidney in iron homeostasis: renal expression of Prohepcidin, Ferroportin, and DMT1 in anemic mice. Am J Physiol Renal Physiol. 2008;295:F1213-21 pubmed publisher
    ..metabolism under hemolytic anemia studying renal expression of Prohepcidin, Ferroportin (MTP1), and divalent metal transporter 1 (DMT1). The relationship between these proteins and iron pigments was also investigated...
  23. Fleming R, Migas M, Zhou X, Jiang J, Britton R, Brunt E, et al. Mechanism of increased iron absorption in murine model of hereditary hemochromatosis: increased duodenal expression of the iron transporter DMT1. Proc Natl Acad Sci U S A. 1999;96:3143-8 pubmed
    ..we tested the hypothesis that HFE-/- mice have increased duodenal expression of the divalent metal transporter (DMT1)...
  24. Peters L, Andrews N, Eicher E, Davidson M, Orkin S, Lux S. Mouse microcytic anaemia caused by a defect in the gene encoding the globin enhancer-binding protein NF-E2. Nature. 1993;362:768-70 pubmed
    ..We propose that the mk mutation results in an impaired form of NF-E2 which fails to regulate both globin production and iron metabolism properly. ..
  25. Gunshin H, Fujiwara Y, Custodio A, Direnzo C, Robine S, Andrews N. Slc11a2 is required for intestinal iron absorption and erythropoiesis but dispensable in placenta and liver. J Clin Invest. 2005;115:1258-66 pubmed
    Solute carrier family 11, member 2 (SLC11A2) is the only transmembrane iron transporter known to be involved in cellular iron uptake...
  26. Ohgami R, Campagna D, Antiochos B, Wood E, Sharp J, Barker J, et al. nm1054: a spontaneous, recessive, hypochromic, microcytic anemia mutation in the mouse. Blood. 2005;106:3625-31 pubmed
    ..Linkage studies demonstrate that nm1054 maps to a genetic locus not previously implicated in microcytic anemia or iron phenotypes. ..
  27. Barton C, Biggs T, Baker S, Bowen H, Atkinson P. Nramp1: a link between intracellular iron transport and innate resistance to intracellular pathogens. J Leukoc Biol. 1999;66:757-62 pubmed
    ..Nramp1 exhibits sequence identity to Nramp2, which regulates intestinal and reticulocyte iron uptake...
  28. Zhang A, Canonne Hergaux F, Gruenheid S, Gros P, Ponka P. Use of Nramp2-transfected Chinese hamster ovary cells and reticulocytes from mk/mk mice to study iron transport mechanisms. Exp Hematol. 2008;36:1227-35 pubmed publisher
    We investigated mechanisms involved in iron (Fe) transport by DMT1 (endosomal Fe(II) exporter, encoded by the Nramp2 gene) using wild-type Chinese hamster ovary (CHO) cells and Nramp2-transfected CHO cells, as well as reticulocytes from ..
  29. Jia W, Xu H, Du X, Jiang H, Xie J. Ndfip1 attenuated 6-OHDA-induced iron accumulation via regulating the degradation of DMT1. Neurobiol Aging. 2015;36:1183-93 pubmed publisher
    Elevated iron levels and increased expression of divalent metal transporter 1 (DMT1) in the substantia nigra of Parkinson's disease (PD) have been reported...
  30. Ghio A, Wang X, Silbajoris R, Garrick M, Piantadosi C, Yang F. DMT1 expression is increased in the lungs of hypotransferrinemic mice. Am J Physiol Lung Cell Mol Physiol. 2003;284:L938-44 pubmed
    ..One potential candidate for such transferrin-independent uptake of iron is divalent metal transporter-1 (DMT1), an established iron transporter...
  31. Czachorowski M, Lam Yuk Tseung S, Cellier M, Gros P. Transmembrane topology of the mammalian Slc11a2 iron transporter. Biochemistry. 2009;48:8422-34 pubmed publisher
    The mammalian Slc11a1 and Slc11a2 proteins define a large family of secondary metal transporters...
  32. Mackenzie K, Foot N, Anand S, Dalton H, Chaudhary N, Collins B, et al. Regulation of the divalent metal ion transporter via membrane budding. Cell Discov. 2016;2:16011 pubmed publisher
    ..Here we present evidence that the divalent metal ion transporter (DMT1) is unexpectedly regulated through release in EVs...
  33. Anderson E, Taylor M, Xue X, Ramakrishnan S, Martin A, Xie L, et al. Intestinal HIF2α promotes tissue-iron accumulation in disorders of iron overload with anemia. Proc Natl Acad Sci U S A. 2013;110:E4922-30 pubmed publisher
    ..using genetic mouse models, that intestinal hypoxia-inducible factor-2α (HIF2α) and divalent metal transporter-1 (DMT1) are activated early in the pathogenesis of β-thalassemia and are essential for excess iron accumulation in mouse ..
  34. Meynard D, Kautz L, Darnaud V, Canonne Hergaux F, Coppin H, Roth M. Lack of the bone morphogenetic protein BMP6 induces massive iron overload. Nat Genet. 2009;41:478-81 pubmed publisher
  35. Xu H, Jin J, DeFelice L, Andrews N, Clapham D. A spontaneous, recurrent mutation in divalent metal transporter-1 exposes a calcium entry pathway. PLoS Biol. 2004;2:E50 pubmed
    Divalent metal transporter-1 (DMT1/DCT1/Nramp2) is the major Fe(2+) transporter mediating cellular iron uptake in mammals...
  36. Suzuki T, Momoi K, Hosoyamada M, Kimura M, Shibasaki T. Normal cadmium uptake in microcytic anemia mk/mk mice suggests that DMT1 is not the only cadmium transporter in vivo. Toxicol Appl Pharmacol. 2008;227:462-7 pubmed
    b>Divalent metal transporter 1 (DMT1) is a mammalian iron (Fe) transporter and also transports Cadmium (Cd) in vitro...
  37. Fujishiro H, Yano Y, Takada Y, Tanihara M, Himeno S. Roles of ZIP8, ZIP14, and DMT1 in transport of cadmium and manganese in mouse kidney proximal tubule cells. Metallomics. 2012;4:700-8 pubmed publisher
    ..Zinc transporters such as Zrt, Irt-related protein 8 (ZIP8) and ZIP14, and divalent metal transporter 1 (DMT1) have been reported to have affinities for Cd(2+) and Mn(2+)...
  38. Beisel K, Rocha Sanchez S, Ziegenbein S, Morris K, Kai C, Kawai J, et al. Diversity of Ca2+-activated K+ channel transcripts in inner ear hair cells. Gene. 2007;386:11-23 pubmed
    ..These results suggest that a diversity of splice variants exist in rodent cochlear hair cells and this diversity is similar to that observed for non-mammalian vertebrate hair cells, such as chicken and turtle. ..
  39. Zidova Z, Kapralova K, Koralkova P, Mojzikova R, Doležal D, Divoky V, et al. DMT1-mutant erythrocytes have shortened life span, accelerated glycolysis and increased oxidative stress. Cell Physiol Biochem. 2014;34:2221-31 pubmed publisher
    Deficiency of the divalent metal transporter 1 (DMT1) leads to hypochromic microcytic anemia. We have previously shown that DMT1 deficiency impairs erythroid differentiation and induces apoptosis of erythroid cells...
  40. Edwards J, Hoke J. Red cell iron uptake in hereditary microcytic anemia. Blood. 1975;46:381-8 pubmed
    ..These results support the hypothesis of a generalized impairment of cellular iron uptake in hereditary microcytic anemia and suggest that there might be a defect in red cell receptor sites for transferrin in this condition. ..
  41. Ingrassia R, Lanzillotta A, Sarnico I, Benarese M, Blasi F, Borgese L, et al. 1B/(-)IRE DMT1 expression during brain ischemia contributes to cell death mediated by NF-?B/RelA acetylation at Lys310. PLoS ONE. 2012;7:e38019 pubmed publisher
    ..hypothesized that the increase of iron through a NF-?B-regulated 1B isoform of the divalent metal transporter-1 (1B/DMT1) might contribute to post-ischemic neuronal damage...
  42. Techau M, Valdez Taubas J, Popoff J, Francis R, Seaman M, Blackwell J. Evolution of differences in transport function in Slc11a family members. J Biol Chem. 2007;282:35646-56 pubmed
    ..Slc11a1 (formerly Nramp1) is a proton/divalent cation transporter that regulates cation homeostasis in macrophages. Slc11a2 mediates divalent cation uptake via the gut and delivery into cells...
  43. Xue X, Ramakrishnan S, Weisz K, Triner D, Xie L, Attili D, et al. Iron Uptake via DMT1 Integrates Cell Cycle with JAK-STAT3 Signaling to Promote Colorectal Tumorigenesis. Cell Metab. 2016;24:447-461 pubmed publisher
    ..Gene expression and functional studies demonstrated that the cellular iron importer, divalent metal transporter 1 (DMT1), is highly expressed in CRC through hypoxia-inducible factor 2?-dependent transcription...
  44. Jabado N, Canonne Hergaux F, Gruenheid S, Picard V, Gros P. Iron transporter Nramp2/DMT-1 is associated with the membrane of phagosomes in macrophages and Sertoli cells. Blood. 2002;100:2617-22 pubmed
    b>Nramp2 (DMT1) is a pH-dependent divalent cation transporter that acts as the transferrin-independent iron uptake system at the intestinal brush border and also transports iron released from transferrin across the membrane of acidified ..
  45. Ney P, Farina S, Bodine D, Andrews N, Orkin S, Neinhuis A. Microcytic anemia in mk/mk mice is not corrected by retroviral-mediated gene transfer of wild-type p45 NF-E2. Exp Hematol. 1995;23:74-80 pubmed
    ..These results indicate that the mk mutation cannot be corrected by enforced expression of wild-type p45 NF-E2 and suggest that the 173V-->A mutation of the p45 NF-E2 gene is not the cause of anemia in mk/mk mice. ..
  46. Hansen J, Tonnesen M, Madsen A, Hagedorn P, Friberg J, Grunnet L, et al. Divalent metal transporter 1 regulates iron-mediated ROS and pancreatic ? cell fate in response to cytokines. Cell Metab. 2012;16:449-61 pubmed publisher
    ..combination of in vitro and in vivo studies, we show that the proinflammatory cytokine IL-1? induces divalent metal transporter 1 (DMT1) expression correlating with increased ? cell iron content and ROS production...
  47. Iacovelli J, Mlodnicka A, Veldman P, Ying G, Dunaief J, Schumacher A. Brain and retinal ferroportin 1 dysregulation in polycythaemia mice. Brain Res. 2009;1289:85-95 pubmed publisher
    ..This phenotype demonstrates the importance of iron homeostasis in retinal health. ..
  48. Harrison D. Marrow transplantation and iron therapy in mouse hereditary microcytic anemia. Blood. 1972;40:893-901 pubmed
  49. Landaw S, Russell E, Bernstein S. Splenic destruction of newly-formed red blood cells and shortened erythrocyte survival in mice with congenital microcytosis. Scand J Haematol. 1970;7:516-24 pubmed
  50. Levy J, Montross L, Andrews N. Genes that modify the hemochromatosis phenotype in mice. J Clin Invest. 2000;105:1209-16 pubmed
    ..Hfe knockout mice carrying mutations in the iron transporter DMT1 fail to load iron, indicating that hemochromatosis involves iron flux through DMT1...
  51. Handa S, Ferguson J, Wallace M, Bulfield G. Characterization and mapping of a viable anaemic mutant in the mouse: a new allele, mkvan, at the microcytic anaemia locus. Genet Res. 1988;51:41-5 pubmed
  52. Hsieh C, Jones P. Meddling with methylation. Nat Cell Biol. 2003;5:502-4 pubmed
  53. CARLSON E, Magid R, Petryk A, Georgieff M. Iron deficiency alters expression of genes implicated in Alzheimer disease pathogenesis. Brain Res. 2008;1237:75-83 pubmed publisher
    ..Our results suggest a role for neonatal iron deficiency in dysregulation of genes that may set the stage for long-term neurodegenerative disease and that this may occur through a histone modification mechanism. ..
  54. Arsenault P, Song D, Chung Y, Khurana T, Lee F. The Zinc Finger of Prolyl Hydroxylase Domain Protein 2 Is Essential for Efficient Hydroxylation of Hypoxia-Inducible Factor α. Mol Cell Biol. 2016;36:2328-43 pubmed publisher
    ..Thus, these findings have important implications for understanding both the molecular mechanism of the hypoxic response and human adaptation to high altitude. ..
  55. Takeuchi K, Bjarnason I, Laftah A, Latunde Dada G, Simpson R, McKie A. Expression of iron absorption genes in mouse large intestine. Scand J Gastroenterol. 2005;40:169-77 pubmed
    ..reductase) was expressed at very low levels in the large intestine, compared to the duodenum, while Ireg1 and DMT1 were expressed at significant levels in the large intestine and were increased in iron-deficient caecum, proximal ..
  56. Shawki A, Anthony S, Nose Y, Engevik M, Niespodzany E, Barrientos T, et al. Intestinal DMT1 is critical for iron absorption in the mouse but is not required for the absorption of copper or manganese. Am J Physiol Gastrointest Liver Physiol. 2015;309:G635-47 pubmed publisher
    Divalent metal-ion transporter-1 (DMT1) is a widely expressed iron-preferring membrane-transport protein that serves a critical role in erythroid iron utilization...
  57. Foot N, Gembus K, MacKenzie K, Kumar S. Ndfip2 is a potential regulator of the iron transporter DMT1 in the liver. Sci Rep. 2016;6:24045 pubmed publisher
    The regulation of divalent metal ion transporter DMT1, the primary non-heme iron importer in mammals, is critical for maintaining iron homeostasis...
  58. Moffett P, Dayo M, Reece M, McCormick M, Pelletier J. Characterization of msim, a murine homologue of the Drosophila sim transcription factor. Genomics. 1996;35:144-55 pubmed
    ..The characteristics of the msim gene are consistent with its putative function as a transcriptional regulator. ..
  59. Russell E, Nash D, Bernstein S, Kent E, McFarland E, Matthews S, et al. Characterization and genetic studies of microcytic anemia in house mouse. Blood. 1970;35:838-50 pubmed
  60. Ludwiczek S, Theurl I, Muckenthaler M, Jakab M, Mair S, Theurl M, et al. Ca2+ channel blockers reverse iron overload by a new mechanism via divalent metal transporter-1. Nat Med. 2007;13:448-54 pubmed
    ..Modulation of DMT-1 function by L-type calcium channel blockers emerges as a new pharmacological therapy for the treatment of iron overload disorders. ..
  61. Ohgami R, Campagna D, Greer E, Antiochos B, McDonald A, Chen J, et al. Identification of a ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells. Nat Genet. 2005;37:1264-9 pubmed
    ..Taken together, these findings indicate that Steap3 is an endosomal ferrireductase required for efficient Tf-dependent iron uptake in erythroid cells. ..
  62. Canonne Hergaux F, Levy J, Fleming M, Montross L, Andrews N, Gros P. Expression of the DMT1 (NRAMP2/DCT1) iron transporter in mice with genetic iron overload disorders. Blood. 2001;97:1138-40 pubmed
    Iron overload is highly prevalent, but its molecular pathogenesis is poorly understood. Recently, DMT1 was shown to be a major apical iron transporter in absorptive cells of the duodenum...
  63. Latunde Dada G, Vulpe C, Anderson G, Simpson R, McKie A. Tissue-specific changes in iron metabolism genes in mice following phenylhydrazine-induced haemolysis. Biochim Biophys Acta. 2004;1690:169-76 pubmed
    ..However, recent studies have shown increased expression of the ferrous transporter DMT1 in the duodenum and other tissues of mice administered PHZ...
  64. Knutson M, Menzies S, Connor J, Wessling Resnick M. Developmental, regional, and cellular expression of SFT/UbcH5A and DMT1 mRNA in brain. J Neurosci Res. 2004;76:633-41 pubmed
    ..for iron transport into and within the brain, we have analyzed expression patterns of two factors: divalent metal transporter 1 (DMT1) and stimulator of Fe transport (SFT)...
  65. Jeong S, David S. Glycosylphosphatidylinositol-anchored ceruloplasmin is required for iron efflux from cells in the central nervous system. J Biol Chem. 2003;278:27144-8 pubmed
    ..We also provide evidence that the divalent metal influx transporter DMT1 is expressed by astrocytes and is likely to mediate iron influx into these glial cells...
  66. Lopez V, Suzuki Y, Lonnerdal B. Ontogenic changes in lactoferrin receptor and DMT1 in mouse small intestine: implications for iron absorption during early life. Biochem Cell Biol. 2006;84:337-44 pubmed
    ..However, it is known that iron homeostasis is regulated by divalent metal transporter 1 (DMT1; Nramp2/DCT1) in the adult small intestine...
  67. Tchernitchko D, Bourgeois M, Martin M, Beaumont C. Expression of the two mRNA isoforms of the iron transporter Nramp2/DMTI in mice and function of the iron responsive element. Biochem J. 2002;363:449-55 pubmed
    b>Nramp2/DMT1 is a transmembrane proton-coupled Fe(2+) transporter. Two different mRNAs are generated by alternative splicing; isoform I contains an iron responsive element (IRE), whereas isoform II does not...
  68. Zhou S, Du X, Xie J, Wang J. Interleukin-6 regulates iron-related proteins through c-Jun N-terminal kinase activation in BV2 microglial cell lines. PLoS ONE. 2017;12:e0180464 pubmed publisher
    ..Iron regulatory protein 1 (IRP1) and divalent metal transporter 1 (DMT1) were up-regulated and iron exporter ferroportin 1 (FPN1) was down-regulated in BV2 cells after ..