Skap2

Summary

Gene Symbol: Skap2
Description: src family associated phosphoprotein 2
Alias: 2610021A10Rik, AA960083, BB137539, RA70, SKAP-HOM, Saps, Scap2, mSKAP55R, src kinase-associated phosphoprotein 2, SKAP55 homolog, SKAP55 homologue, Src-associated adaptor protein, pyk2/RAFTK-associated protein, src kinase-associated phosphoprotein 55-related protein, src-associated adapter protein with PH and SH3 domains
Species: mouse
Products:     Skap2

Top Publications

  1. Marie Cardine A, Verhagen A, Eckerskorn C, Schraven B. SKAP-HOM, a novel adaptor protein homologous to the FYN-associated protein SKAP55. FEBS Lett. 1998;435:55-60 pubmed
    ..This protein was termed SKAP-HOM (SKAP55 homologue). Despite their striking homology, SKAP55 and SKAP-HOM have distinct characteristics...
  2. Reinhold A, Reimann S, Reinhold D, Schraven B, Togni M. Expression of SKAP-HOM in DCs is required for an optimal immune response in vivo. J Leukoc Biol. 2009;86:61-71 pubmed publisher
    ..Thus, these findings suggest that SKAP-HOM expression in DCs is required for the induction of an optimal immune response. ..
  3. Boras M, Volmering S, Bokemeyer A, Rossaint J, Block H, Bardel B, et al. Skap2 is required for ?2 integrin-mediated neutrophil recruitment and functions. J Exp Med. 2017;214:851-874 pubmed publisher
    ..The Src kinase-associated phosphoprotein 2 (Skap2) is involved in integrin functions in different leukocyte subtypes...
  4. Alenghat F, Baca Q, Rubin N, Pao L, Matozaki T, Lowell C, et al. Macrophages require Skap2 and Sirp? for integrin-stimulated cytoskeletal rearrangement. J Cell Sci. 2012;125:5535-45 pubmed publisher
    ..We have discovered that the hematopoietic adaptor protein Skap2 is necessary for macrophage migration, chemotaxis, global actin reorganization and local actin reorganization upon ..
  5. Swanson K, Tang Y, Ceccarelli D, Poy F, Sliwa J, Neel B, et al. The Skap-hom dimerization and PH domains comprise a 3'-phosphoinositide-gated molecular switch. Mol Cell. 2008;32:564-75 pubmed publisher
    ..Thus, the dimerization and PH domain form a PI[3,4,5]P(3)-responsive molecular switch that controls Skap-hom function. ..
  6. Kirchgessner H, Dietrich J, Scherer J, Isomaki P, Korinek V, Hilgert I, et al. The transmembrane adaptor protein TRIM regulates T cell receptor (TCR) expression and TCR-mediated signaling via an association with the TCR zeta chain. J Exp Med. 2001;193:1269-84 pubmed
  7. Curtis D, Jane S, Hilton D, Dougherty L, Bodine D, Begley C. Adaptor protein SKAP55R is associated with myeloid differentiation and growth arrest. Exp Hematol. 2000;28:1250-9 pubmed
    ..In this report, we describe the cloning and functional characterization of murine SKAP55R (mSKAP55R), an SRC family kinase substrate. Expression of mSKAP55R was examined by Northern blot...
  8. Fiedler A, Grecksch G, Reinhold A, Schraven B, Becker A. Hippocampus-dependent learning in SKAP-HOM deficient mice. Behav Brain Res. 2014;270:125-30 pubmed publisher
    ..It was hypothesized that SKAP-HOM deficiency does not affect hippocampus-dependent learning in general, but that its effects on cognitive tasks seem to be dependent on the nature of the cognitive task, i.e. spatial vs. non-spatial. ..
  9. Kliche S, Breitling D, Togni M, Pusch R, Heuer K, Wang X, et al. The ADAP/SKAP55 signaling module regulates T-cell receptor-mediated integrin activation through plasma membrane targeting of Rap1. Mol Cell Biol. 2006;26:7130-44 pubmed
    ..However, it appears as if the ADAP/SKAP55 module can exert its signaling function outside of the classical raft fraction of the cell membrane. ..

More Information

Publications24

  1. Mitchell J, Burbach B, Srivastava R, Fife B, Shimizu Y. Multistage T cell-dendritic cell interactions control optimal CD4 T cell activation through the ADAP-SKAP55-signaling module. J Immunol. 2013;191:2372-83 pubmed publisher
    ..Thus, integrin activation by the ADAP-SKAP55-signaling module controls the stability and duration of T cell-dendritic cell contacts during the progressive phases necessary for optimal T cell activation. ..
  2. Ayoub E, Hall A, Scott A, Chagnon M, Miquel G, Halle M, et al. Regulation of the Src kinase-associated phosphoprotein 55 homologue by the protein tyrosine phosphatase PTP-PEST in the control of cell motility. J Biol Chem. 2013;288:25739-48 pubmed publisher
    ..These findings suggest a novel role of SKAP-Hom and its phosphorylation in the regulation of cellular motility. Moreover, these results open new avenues by which PTP-PEST regulates cellular migration, a hallmark of metastasis. ..
  3. Kasirer Friede A, Ruggeri Z, Shattil S. Role for ADAP in shear flow-induced platelet mechanotransduction. Blood. 2010;115:2274-82 pubmed publisher
    ..These results establish that ADAP is an essential component of alphaIIbbeta3-mediated platelet mechanotransduction that promotes F-actin assembly and enables platelet spreading and thrombus stabilization under fluid shear stress. ..
  4. Zhou L, Zhang Z, Zheng Y, Zhu Y, Wei Z, Xu H, et al. SKAP2, a novel target of HSF4b, associates with NCK2/F-actin at membrane ruffles and regulates actin reorganization in lens cell. J Cell Mol Med. 2011;15:783-95 pubmed publisher
    ..However, the mechanism remains obscure. Here, we identified Src kinase-associated phosphoprotein 2 (SKAP2) as a downstream target of HSF4b and it was highly expressed at the anterior tip of lens elongating fibre cells in ..
  5. Yu X, Chen M, Zhang S, Yu Z, Sun J, Wang L, et al. Substrate specificity of lymphoid-specific tyrosine phosphatase (Lyp) and identification of Src kinase-associated protein of 55 kDa homolog (SKAP-HOM) as a Lyp substrate. J Biol Chem. 2011;286:30526-34 pubmed publisher
  6. Timms J, Swanson K, Marie Cardine A, Raab M, Rudd C, Schraven B, et al. SHPS-1 is a scaffold for assembling distinct adhesion-regulated multi-protein complexes in macrophages. Curr Biol. 1999;9:927-30 pubmed
    ..Other inhibitory immunoreceptors might have similar scaffold-like functions. ..
  7. Tanaka M, Shimamura S, Kuriyama S, Maeda D, Goto A, Aiba N. SKAP2 Promotes Podosome Formation to Facilitate Tumor-Associated Macrophage Infiltration and Metastatic Progression. Cancer Res. 2016;76:358-69 pubmed publisher
    ..Src kinase-associated phosphoprotein 2 (SKAP2), a substrate of Src family kinases, is highly expressed in macrophages from various tumors, but its contribution ..
  8. Tanabe Y, Shiota A, Kouroku Murakami Y, Fujita Jimbo E, Urase K, Takahashi K, et al. Spatial and temporal expression of RA70/Scap2 in the developing neural tube. Neurosci Lett. 2014;576:1-5 pubmed publisher
    Src kinase-associated phosphoprotein 2 (Ra70/scap2), which was originally isolated as a retinoic acid (RA)-induced gene, associates with molecules that modulate integrin-survival signals...
  9. Togni M, Swanson K, Reimann S, Kliche S, Pearce A, Simeoni L, et al. Regulation of in vitro and in vivo immune functions by the cytosolic adaptor protein SKAP-HOM. Mol Cell Biol. 2005;25:8052-63 pubmed
    ..In summary, our data suggest that SKAP-HOM is required for proper activation of the immune system, likely by regulating the cross-talk between immunoreceptors and integrins. ..
  10. Kliche S, Worbs T, Wang X, Degen J, Patzak I, Meineke B, et al. CCR7-mediated LFA-1 functions in T cells are regulated by 2 independent ADAP/SKAP55 modules. Blood. 2012;119:777-85 pubmed publisher
    ..Hence, 2 independent ADAP/SKAP55 modules are essential components of the signaling machinery that regulates affinity and avidity of LFA-1 in response to CCR7. ..
  11. Menasche G, Kliche S, Chen E, Stradal T, Schraven B, Koretzky G. RIAM links the ADAP/SKAP-55 signaling module to Rap1, facilitating T-cell-receptor-mediated integrin activation. Mol Cell Biol. 2007;27:4070-81 pubmed
    ..These results describe for the first time a link between ADAP/SKAP-55 and the Rap1/RIAM complex and provide a potential new mechanism for TCR-mediated integrin activation. ..
  12. Lickert H, Cox B, Wehrle C, Taketo M, Kemler R, Rossant J. Dissecting Wnt/beta-catenin signaling during gastrulation using RNA interference in mouse embryos. Development. 2005;132:2599-609 pubmed
    ..This functional genomic approach allows the rapid identification of functionally important components of embryonic development from large datasets of putative targets. ..
  13. Black D, Marie Cardine A, Schraven B, Bliska J. The Yersinia tyrosine phosphatase YopH targets a novel adhesion-regulated signalling complex in macrophages. Cell Microbiol. 2000;2:401-14 pubmed
    ..We suggest that dephosphorylation of SKAP-HOM and Fyb by YopH allows yersiniae to interfere with a novel adhesion-regulated signal transduction pathway in macrophages. ..
  14. Bourette R, Thérier J, Mouchiroud G. Macrophage colony-stimulating factor receptor induces tyrosine phosphorylation of SKAP55R adaptor and its association with actin. Cell Signal. 2005;17:941-9 pubmed
    ..Moreover, specific association between SKAP55R and actin support the idea that SKAP55R is implicated in the regulation of actin dynamics under the control of M-CSF. ..
  15. Takahashi T, Yamashita H, Nagano Y, Nakamura T, Ohmori H, Avraham H, et al. Identification and characterization of a novel Pyk2/related adhesion focal tyrosine kinase-associated protein that inhibits alpha-synuclein phosphorylation. J Biol Chem. 2003;278:42225-33 pubmed
    ..In conclusion, PRAP functions as a downstream target for Pyk2/RAFTK and plays a role in alpha-synuclein phosphorylation. ..