Skap1

Summary

Gene Symbol: Skap1
Description: src family associated phosphoprotein 1
Alias: 1700091G21Rik, Scap1, Skap-55, ortholog of human src family associated phosphoprotein 1 SCAP1, src family-associated phosphoprotein 1, src kinase-associated phosphoprotein 1
Species: mouse

Top Publications

  1. pmc RIAM links the ADAP/SKAP-55 signaling module to Rap1, facilitating T-cell-receptor-mediated integrin activation
    Gael Menasche
    Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, 415 BRBII III, 421 Curie Blvd, Philadelphia, PA 19104 6160, USA
    Mol Cell Biol 27:4070-81. 2007
  2. pmc An essential role for SKAP-55 in LFA-1 clustering on T cells that cannot be substituted by SKAP-55R
    Eun Kyeong Jo
    Molecular Immunology Section, Department of Immunology, Faculty of Medicine, Imperial College London, Hammersmith Hospital, London W12 ONN, England, UK
    J Exp Med 201:1733-9. 2005
  3. pmc Functional defects of SKAP-55-deficient T cells identify a regulatory role for the adaptor in LFA-1 adhesion
    Hongyan Wang
    Department of Pathology, Cambridge University, Tennis Court Road, Cambridge, UK
    Mol Cell Biol 27:6863-75. 2007
  4. pmc Adaptor SKAP-55 binds p21 activating exchange factor RasGRP1 and negatively regulates the p21-ERK pathway in T-cells
    Helga Schneider
    Cell Signalling Section, Department of Pathology, University of Cambridge, Cambridge, United Kingdom
    PLoS ONE 3:e1718. 2008
  5. pmc SKAP1 is dispensable for chemokine-induced migration of primary T-cells
    Hongyan Wang
    Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK
    Immunol Lett 128:148-53. 2010
  6. pmc T cell receptor "inside-out" pathway via signaling module SKAP1-RapL regulates T cell motility and interactions in lymph nodes
    Monika Raab
    Cell Signaling Section, Department of Pathology, Tennis Court Road, University of Cambridge, Cambridge UK, CB2 1Q
    Immunity 32:541-56. 2010
  7. pmc HPK1 associates with SKAP-HOM to negatively regulate Rap1-mediated B-lymphocyte adhesion
    Sebastian Königsberger
    Department of Molecular Biology, University of Salzburg, Salzburg, Austria
    PLoS ONE 5:. 2010
  8. pmc The pleckstrin homology domain in the SKAP55 adapter protein defines the ability of the adapter protein ADAP to regulate integrin function and NF-kappaB activation
    Brandon J Burbach
    Department of Laboratory Medicine and Pathology, Center for Immunology, Masonic Cancer Center, University of Minnesota Medical School, Minneapolis, MN 55414, USA
    J Immunol 186:6227-37. 2011

Scientific Experts

  • Brandon J Burbach
  • Hongyan Wang
  • Christopher E Rudd
  • Monika Raab
  • Yuning Lu
  • Sebastian Königsberger
  • Xin Smith
  • Klaus Strebhardt
  • Zhonglin Wu
  • Helga Schneider
  • Matt Lovatt
  • Gael Menasche
  • Eun Kyeong Jo
  • Irene Patzak
  • John E Ladbury
  • Doris Peckl-Schmid
  • Nadja Zaborsky
  • Gernot Achatz
  • Friedemann Kiefer
  • Braudel Maqueira-Iglesias
  • Elke Valk
  • Emily J H Chen
  • Theresia E B Stradal
  • Gary Koretzky
  • Hebin Liu
  • Bin Wei
  • Stefanie Kliche
  • Burkhart Schraven

Detail Information

Publications8

  1. pmc RIAM links the ADAP/SKAP-55 signaling module to Rap1, facilitating T-cell-receptor-mediated integrin activation
    Gael Menasche
    Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, 415 BRBII III, 421 Curie Blvd, Philadelphia, PA 19104 6160, USA
    Mol Cell Biol 27:4070-81. 2007
    ..These results describe for the first time a link between ADAP/SKAP-55 and the Rap1/RIAM complex and provide a potential new mechanism for TCR-mediated integrin activation...
  2. pmc An essential role for SKAP-55 in LFA-1 clustering on T cells that cannot be substituted by SKAP-55R
    Eun Kyeong Jo
    Molecular Immunology Section, Department of Immunology, Faculty of Medicine, Imperial College London, Hammersmith Hospital, London W12 ONN, England, UK
    J Exp Med 201:1733-9. 2005
    ..Our findings therefore indicate that SKAP-55, unlike SKAP-55R, is specifically tailored as an essential component of the inside-out signaling events that couple the TCR to LFA-1 clustering and T cell-APC conjugation...
  3. pmc Functional defects of SKAP-55-deficient T cells identify a regulatory role for the adaptor in LFA-1 adhesion
    Hongyan Wang
    Department of Pathology, Cambridge University, Tennis Court Road, Cambridge, UK
    Mol Cell Biol 27:6863-75. 2007
    ..Our findings identify a clear effector role for SKAP-55 in LFA-1 adhesion in peripheral T cells and demonstrate that dependency on SKAP-55 and ADAP differs among T cells and differs with the strength of the TCR signal...
  4. pmc Adaptor SKAP-55 binds p21 activating exchange factor RasGRP1 and negatively regulates the p21-ERK pathway in T-cells
    Helga Schneider
    Cell Signalling Section, Department of Pathology, University of Cambridge, Cambridge, United Kingdom
    PLoS ONE 3:e1718. 2008
    ..Our findings indicate that SKAP-55 has a dual role in regulating p21(ras)-ERK pathway via RasGRP1, as a possible mechanism to restrict activation during T-cell adhesion...
  5. pmc SKAP1 is dispensable for chemokine-induced migration of primary T-cells
    Hongyan Wang
    Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK
    Immunol Lett 128:148-53. 2010
    Immune adaptors SLP-76, ADAP and SKAP1 (SKAP-55) play central roles in anti-CD3 induced 'inside-out' signalling for LFA-1 activation and ICAM-1 adhesion...
  6. pmc T cell receptor "inside-out" pathway via signaling module SKAP1-RapL regulates T cell motility and interactions in lymph nodes
    Monika Raab
    Cell Signaling Section, Department of Pathology, Tennis Court Road, University of Cambridge, Cambridge UK, CB2 1Q
    Immunity 32:541-56. 2010
    ..Here, we define the "inside-out" pathway mediated by N-terminal SKAP1 (SKAP-55) domain binding to the C-terminal SARAH domain of RapL...
  7. pmc HPK1 associates with SKAP-HOM to negatively regulate Rap1-mediated B-lymphocyte adhesion
    Sebastian Königsberger
    Department of Molecular Biology, University of Salzburg, Salzburg, Austria
    PLoS ONE 5:. 2010
    ..Being inducibly recruited to membrane-proximal signalling scaffolds to regulate NFAT, AP-1 and NFkappaB-mediated gene transcription in T-cells, the function of HPK1 in B-cells to date remains rather ill-defined...
  8. pmc The pleckstrin homology domain in the SKAP55 adapter protein defines the ability of the adapter protein ADAP to regulate integrin function and NF-kappaB activation
    Brandon J Burbach
    Department of Laboratory Medicine and Pathology, Center for Immunology, Masonic Cancer Center, University of Minnesota Medical School, Minneapolis, MN 55414, USA
    J Immunol 186:6227-37. 2011
    ....