Sirt6

Summary

Gene Symbol: Sirt6
Description: sirtuin 6
Alias: 2810449N18Rik, AI043036, Sir2l6, NAD-dependent protein deacetylase sirtuin-6, NAD-dependent deacetylase sirtuin-6, SIR2-like protein 6, regulatory protein SIR2 homolog 6
Species: mouse
Products:     Sirt6

Top Publications

  1. Xiao C, Kim H, Lahusen T, Wang R, Xu X, Gavrilova O, et al. SIRT6 deficiency results in severe hypoglycemia by enhancing both basal and insulin-stimulated glucose uptake in mice. J Biol Chem. 2010;285:36776-84 pubmed publisher
    Glucose homeostasis in mammals is mainly regulated by insulin signaling. It was previously shown that SIRT6 mutant mice die before 4 weeks of age, displaying profound abnormalities, including low insulin, hypoglycemia, and premature ..
  2. Kaidi A, Weinert B, Choudhary C, Jackson S. Human SIRT6 promotes DNA end resection through CtIP deacetylation. Science. 2010;329:1348-53 pubmed publisher
    b>SIRT6 belongs to the sirtuin family of protein lysine deacetylases, which regulate aging and genome stability...
  3. Kim H, Xiao C, Wang R, Lahusen T, Xu X, Vassilopoulos A, et al. Hepatic-specific disruption of SIRT6 in mice results in fatty liver formation due to enhanced glycolysis and triglyceride synthesis. Cell Metab. 2010;12:224-36 pubmed publisher
    ..Here, we show that SIRT1 forms a complex with FOXO3a and NRF1 on the SIRT6 promoter and positively regulates expression of SIRT6, which, in turn, negatively regulates glycolysis, ..
  4. Sebastian C, Zwaans B, Silberman D, Gymrek M, Goren A, Zhong L, et al. The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism. Cell. 2012;151:1185-99 pubmed publisher
    ..Here, we identify SIRT6 as a tumor suppressor that regulates aerobic glycolysis in cancer cells...
  5. Bauer I, Grozio A, Lasiglié D, Basile G, Sturla L, Magnone M, et al. The NAD+-dependent histone deacetylase SIRT6 promotes cytokine production and migration in pancreatic cancer cells by regulating Ca2+ responses. J Biol Chem. 2012;287:40924-37 pubmed publisher
    ..Studies show that the sirtuin SIRT6 promotes inflammation by enhancing TNF expression...
  6. Toiber D, Erdel F, Bouazoune K, Silberman D, Zhong L, Mulligan P, et al. SIRT6 recruits SNF2H to DNA break sites, preventing genomic instability through chromatin remodeling. Mol Cell. 2013;51:454-68 pubmed publisher
    ..Here, we find that the deacetylase sirtuin 6 (SIRT6) is one of the earliest factors recruited to double-strand breaks (DSBs)...
  7. Liszt G, Ford E, Kurtev M, Guarente L. Mouse Sir2 homolog SIRT6 is a nuclear ADP-ribosyltransferase. J Biol Chem. 2005;280:21313-20 pubmed
    ..Here, we report that the distant mammalian Sir2 homolog SIRT6 is a broadly expressed, predominantly nuclear protein...
  8. Kanfi Y, Peshti V, Gil R, Naiman S, Nahum L, Levin E, et al. SIRT6 protects against pathological damage caused by diet-induced obesity. Aging Cell. 2010;9:162-73 pubmed publisher
    The NAD+-dependent SIRT6 deacetylase is a therapeutic candidate against the emerging metabolic syndrome epidemic...
  9. Mostoslavsky R, Chua K, Lombard D, Pang W, Fischer M, Gellon L, et al. Genomic instability and aging-like phenotype in the absence of mammalian SIRT6. Cell. 2006;124:315-29 pubmed
    ..Here, we demonstrate that SIRT6 is a nuclear, chromatin-associated protein that promotes resistance to DNA damage and suppresses genomic ..

More Information

Publications75

  1. Lee H, Ka S, Lee S, Lee S, Park J, Park B. Overexpression of sirtuin 6 suppresses inflammatory responses and bone destruction in mice with collagen-induced arthritis. Arthritis Rheum. 2013;65:1776-85 pubmed publisher
    ..An adenovirus containing SIRT-6 complementary DNA (Ad-SIRT6) was used to deliver SIRT-6 to human RA fibroblast-like synoviocytes in vitro as well as to mice with collagen-..
  2. Mao Z, Hine C, Tian X, Van Meter M, Au M, Vaidya A, et al. SIRT6 promotes DNA repair under stress by activating PARP1. Science. 2011;332:1443-6 pubmed publisher
    Sirtuin 6 (SIRT6) is a mammalian homolog of the yeast Sir2 deacetylase. Mice deficient for SIRT6 exhibit genome instability...
  3. Schwer B, Schumacher B, Lombard D, Xiao C, Kurtev M, Gao J, et al. Neural sirtuin 6 (Sirt6) ablation attenuates somatic growth and causes obesity. Proc Natl Acad Sci U S A. 2010;107:21790-4 pubmed publisher
    ..We report that neural-specific deletion of sirtuin 6 (Sirt6) in mice leads to postnatal growth retardation due to somatotropic attenuation through low growth hormone (GH) and ..
  4. Kawahara T, Michishita E, Adler A, Damian M, Berber E, Lin M, et al. SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span. Cell. 2009;136:62-74 pubmed publisher
    ..Deficiency of mammalian SIRT6 leads to shortened life span and an aging-like phenotype in mice, but the underlying molecular mechanisms are ..
  5. Zhong L, D Urso A, Toiber D, Sebastian C, Henry R, Vadysirisack D, et al. The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha. Cell. 2010;140:280-93 pubmed publisher
    b>SIRT6 is a member of a highly conserved family of NAD(+)-dependent deacetylases with various roles in metabolism, stress resistance, and life span...
  6. Kanfi Y, Naiman S, Amir G, Peshti V, Zinman G, Nahum L, et al. The sirtuin SIRT6 regulates lifespan in male mice. Nature. 2012;483:218-21 pubmed publisher
    ..Here we show that male, but not female, transgenic mice overexpressing Sirt6 (ref. 4) have a significantly longer lifespan than wild-type mice...
  7. Xiao C, Wang R, Lahusen T, Park O, Bertola A, Maruyama T, et al. Progression of chronic liver inflammation and fibrosis driven by activation of c-JUN signaling in Sirt6 mutant mice. J Biol Chem. 2012;287:41903-13 pubmed publisher
    ..b>Sirt6 is critical for metabolism and lifespan; however, its role in inflammation is unknown...
  8. Sundaresan N, Vasudevan P, Zhong L, Kim G, Samant S, Parekh V, et al. The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun. Nat Med. 2012;18:1643-50 pubmed publisher
    ..Here we show that sirtuin 6 (SIRT6), a nuclear histone deacetylase, functions at the level of chromatin to directly attenuate IGF-Akt signaling...
  9. Jiang H, Khan S, Wang Y, Charron G, He B, Sebastian C, et al. SIRT6 regulates TNF-? secretion through hydrolysis of long-chain fatty acyl lysine. Nature. 2013;496:110-3 pubmed publisher
    ..Here we show that human SIRT6 efficiently removes long-chain fatty acyl groups, such as myristoyl, from lysine residues...
  10. Jung E, Choi H, Song H, Hwang Y, Kim A, Ryu H, et al. p53-dependent SIRT6 expression protects Aβ42-induced DNA damage. Sci Rep. 2016;6:25628 pubmed publisher
    ..b>SIRT6 is a member of the mammalian sirtuin family of anti-aging genes...
  11. Zhang X, Spiegelman N, Nelson O, Jing H, Lin H. SIRT6 regulates Ras-related protein R-Ras2 by lysine defatty-acylation. elife. 2017;6: pubmed publisher
    ..b>SIRT6, a sirtuin with established tumor suppressor function, regulates the lysine fatty acylation of R-Ras2...
  12. Min L, Ji Y, Bakiri L, Qiu Z, Cen J, Chen X, et al. Liver cancer initiation is controlled by AP-1 through SIRT6-dependent inhibition of survivin. Nat Cell Biol. 2012;14:1203-11 pubmed publisher
    ..Mechanistically, c-Fos induces SIRT6 transcription, which represses survivin by reducing histone H3K9 acetylation and NF-?B activation...
  13. Wang H, Diao D, Shi Z, Zhu X, Gao Y, Gao S, et al. SIRT6 Controls Hematopoietic Stem Cell Homeostasis through Epigenetic Regulation of Wnt Signaling. Cell Stem Cell. 2016;18:495-507 pubmed publisher
    ..Here, we report that the histone deacetylase SIRT6 regulates HSC homeostasis through the transcriptional repression of Wnt target genes...
  14. Feng Y, Liang J, Zhai Y, Sun J, Wang J, She X, et al. Autophagy activated by SIRT6 regulates Aβ induced inflammatory response in RPEs. Biochem Biophys Res Commun. 2018;496:1148-1154 pubmed publisher
    ..In this study, we found that expression of Sirtuin 6 (SIRT6) and autophagic markers are upregulated in RPEs of aged mice where subretinal deposition of amyloid-β is ..
  15. Cardinale A, De Stefano M, Mollinari C, Racaniello M, Garaci E, Merlo D. Biochemical characterization of sirtuin 6 in the brain and its involvement in oxidative stress response. Neurochem Res. 2015;40:59-69 pubmed publisher
    Sirtuin 6 (SIRT6) is a member of nicotinamide adenine dinucleotide-dependent deacetylase protein family and has been implicated in the control of glucose and lipid metabolism, cancer, genomic stability and DNA repair...
  16. Chen Y, Sun T, Wu J, Kalionis B, Zhang C, Yuan D, et al. Icariin intervenes in cardiac inflammaging through upregulation of SIRT6 enzyme activity and inhibition of the NF-kappa B pathway. Biomed Res Int. 2015;2015:895976 pubmed publisher
    The aim of the study was to investigate the effect of icariin (ICA) on cardiac aging through its effects on the SIRT6 enzyme and on the NF-κB pathway...
  17. Peshti V, Obolensky A, Nahum L, Kanfi Y, Rathaus M, Avraham M, et al. Characterization of physiological defects in adult SIRT6-/- mice. PLoS ONE. 2017;12:e0176371 pubmed publisher
    The NAD+-dependent SIRT6 deacetylase was shown to be a major regulator of lifespan and healthspan. Mice deficient for SIRT6 develop a premature aging phenotype and metabolic defects, and die before four weeks of age...
  18. Wu Y, Chen L, Wang Y, Li W, Lin Y, Yu D, et al. Overexpression of Sirtuin 6 suppresses cellular senescence and NF-κB mediated inflammatory responses in osteoarthritis development. Sci Rep. 2015;5:17602 pubmed publisher
    The aim of our study was to evaluate if Sirt6, a NAD + dependent histone deacetylase, plays a protective role in cartilage degeneration by suppressing cellular senescence and inflammatory responses...
  19. Ming M, Han W, Zhao B, Sundaresan N, Deng C, Gupta M, et al. SIRT6 promotes COX-2 expression and acts as an oncogene in skin cancer. Cancer Res. 2014;74:5925-33 pubmed publisher
    b>SIRT6 is a SIR2 family member that regulates multiple molecular pathways involved in metabolism, genomic stability, and aging. It has been proposed previously that SIRT6 is a tumor suppressor in cancer...
  20. Tao R, Xiong X, Depinho R, Deng C, Dong X. FoxO3 transcription factor and Sirt6 deacetylase regulate low density lipoprotein (LDL)-cholesterol homeostasis via control of the proprotein convertase subtilisin/kexin type 9 (Pcsk9) gene expression. J Biol Chem. 2013;288:29252-9 pubmed publisher
    ..In this work we have discovered that Sirt6, an NAD(+)-dependent histone deacetylase, plays a critical role in the regulation of the Pcsk9 gene expression in ..
  21. Kaluski S, Portillo M, Besnard A, Stein D, Einav M, Zhong L, et al. Neuroprotective Functions for the Histone Deacetylase SIRT6. Cell Rep. 2017;18:3052-3062 pubmed publisher
    The histone deacetylase SIRT6 promotes DNA repair, but its activity declines with age with a concomitant accumulation of DNA damage. Furthermore, SIRT6 knockout mice exhibit an accelerated aging phenotype and die prematurely...
  22. Zhang L, Du J, Justus S, Hsu C, Bonet Ponce L, Wu W, et al. Reprogramming metabolism by targeting sirtuin 6 attenuates retinal degeneration. J Clin Invest. 2016;126:4659-4673 pubmed publisher
    ..Inhibition of sirtuin 6 (SIRT6), a histone deacetylase repressor of glycolytic flux, reprogrammed rods into perpetual glycolysis, thereby driving ..
  23. Yao L, Cui X, Chen Q, Yang X, Fang F, Zhang J, et al. Cold-Inducible SIRT6 Regulates Thermogenesis of Brown and Beige Fat. Cell Rep. 2017;20:641-654 pubmed publisher
    Promoting development and function of brown and beige fat may reduce obesity. Here, we show that fat SIRT6 expression is markedly induced by cold exposure and a ?-adrenergic agonist...
  24. Cui X, Yao L, Yang X, Gao Y, Fang F, Zhang J, et al. SIRT6 regulates metabolic homeostasis in skeletal muscle through activation of AMPK. Am J Physiol Endocrinol Metab. 2017;313:E493-E505 pubmed publisher
    ..b>SIRT6, a histone deacetylase, has been shown to regulate metabolism in liver and brain; however, its specific role in ..
  25. Tang Y, Zhou Y, Wang Y, Wang J, Ding J. SIRT6/NF-κB signaling axis in ginsenoside Rg1-delayed hematopoietic stem/progenitor cell senescence. Int J Clin Exp Pathol. 2015;8:5591-6 pubmed
    To investigate the role of SIRT6/NF-κB signaling axis in ginsenoside Rg1-delayed hematopoietic stem/progenitor cell senescence and to provide theoretical and experimental evidence for delaying HSC/HPC senescence pathway...
  26. Huang W, Liu H, Zhu S, Woodson M, Liu R, Tilton R, et al. Sirt6 deficiency results in progression of glomerular injury in the kidney. Aging (Albany NY). 2017;9:1069-1083 pubmed publisher
    ..deacetylase, has been shown to protect against multiple age-associated phenotypes; however it is unknown whether Sirt6 has a direct pathophysiologic role in the kidney...
  27. Kuang J, Zhang Y, Liu Q, Shen J, Pu S, Cheng S, et al. Fat-Specific Sirt6 Ablation Sensitizes Mice to High-Fat Diet-Induced Obesity and Insulin Resistance by Inhibiting Lipolysis. Diabetes. 2017;66:1159-1171 pubmed publisher
    b>Sirt6 is an NAD+-dependent deacetylase that is involved in the control of energy metabolism. However, the tissue-specific function of Sirt6 in the adipose tissue remains unknown...
  28. Dominy J, Lee Y, Jedrychowski M, Chim H, Jurczak M, Camporez J, et al. The deacetylase Sirt6 activates the acetyltransferase GCN5 and suppresses hepatic gluconeogenesis. Mol Cell. 2012;48:900-13 pubmed publisher
    ..Herein, we report that Sirt6 strongly controls PGC-1? acetylation. Surprisingly, Sirt6 induces PGC-1? acetylation and suppresses HGP...
  29. Xiong X, Sun X, Wang Q, Qian X, Zhang Y, Pan X, et al. SIRT6 protects against palmitate-induced pancreatic ?-cell dysfunction and apoptosis. J Endocrinol. 2016;231:159-165 pubmed
    ..In pancreatic ?-cells, sirtuin 6 (SIRT6) has been shown to regulate insulin secretion in response to glucose stimulation...
  30. Hu Y, Li R, Yang H, Luo H, Chen Z. Sirtuin 6 is essential for sodium sulfide-mediated cytoprotective effect in ischemia/reperfusion-stimulated brain endothelial cells. J Stroke Cerebrovasc Dis. 2015;24:601-9 pubmed publisher
    ..glucose deprivation and reperfusion (OGD/R)-stimulated brain endothelial cells and its association with sirtuin 6 (SIRT6). Cultured bEnd.3 brain endothelial cells were exposed to OGD/R...
  31. Park S, Huh J, Shin J, Park D, Ko R, Jin G, et al. Sirt6 cooperates with Blimp1 to positively regulate osteoclast differentiation. Sci Rep. 2016;6:26186 pubmed publisher
    Global deletion of the gene encoding a nuclear histone deacetylase sirtuin 6 (Sirt6) in mice leads to osteopenia with a low bone turnover due to impaired bone formation...
  32. Du J, Jiang H, Lin H. Investigating the ADP-ribosyltransferase activity of sirtuins with NAD analogues and 32P-NAD. Biochemistry. 2009;48:2878-90 pubmed publisher
    ..activity of several different sirtuins, including yeast Sir2, human SirT1, mouse SirT4, and mouse SirT6. The results showed that an alkyne-tagged NAD is the substrate for deacetylation reactions but cannot detect the ..
  33. Engler A, Niederer F, Klein K, Gay R, Kyburz D, Camici G, et al. SIRT6 regulates the cigarette smoke-induced signalling in rheumatoid arthritis synovial fibroblasts. J Mol Med (Berl). 2014;92:757-67 pubmed publisher
    ..Furthermore, the functional role of Sirtuin 6 (SIRT6) in the regulation of the signalling induced by cigarette smoke or by tumor necrosis factor alpha (TNF?) was ..
  34. Sugatani T, Agapova O, Malluche H, Hruska K. SIRT6 deficiency culminates in low-turnover osteopenia. Bone. 2015;81:168-177 pubmed publisher
    Deficiency of Sirtuin 6 (SIRT6), a chromatin-related deacetylase, in mice reveals severe premature aging phenotypes including osteopenia. However, the underlying molecular mechanisms of SIRT6 in bone metabolism are unknown...
  35. Xiong X, Wang G, Tao R, Wu P, Kono T, Li K, et al. Sirtuin 6 regulates glucose-stimulated insulin secretion in mouse pancreatic beta cells. Diabetologia. 2016;59:151-60 pubmed
    Sirtuin 6 (SIRT6) has been implicated in ageing, DNA repair and metabolism; however, its function in pancreatic beta cells is unclear. The aim of this study is to elucidate the role of SIRT6 in pancreatic beta cells...
  36. Kugel S, Sebastian C, Fitamant J, Ross K, Saha S, Jain E, et al. SIRT6 Suppresses Pancreatic Cancer through Control of Lin28b. Cell. 2016;165:1401-1415 pubmed publisher
    ..Here, we uncover an epigenetic program mediated by the NAD(+)-dependent histone deacetylase Sirtuin 6 (SIRT6) that is critical for suppression of pancreatic ductal adenocarcinoma (PDAC), one of the most lethal malignancies...
  37. Maksin Matveev A, Kanfi Y, Hochhauser E, Isak A, Cohen H, Shainberg A. Sirtuin 6 protects the heart from hypoxic damage. Exp Cell Res. 2015;330:81-90 pubmed publisher
    Sirtuin 6 (SIRT6) is a protein associated with prolonged life expectancy. We investigated whether life extension is associated with cardioprotection against hypoxia...
  38. Etchegaray J, Chavez L, Huang Y, Ross K, Choi J, Martinez Pastor B, et al. The histone deacetylase SIRT6 controls embryonic stem cell fate via TET-mediated production of 5-hydroxymethylcytosine. Nat Cell Biol. 2015;17:545-57 pubmed publisher
    ..Here we demonstrate the interplay between the histone deacetylase sirtuin 6 (SIRT6) and the ten-eleven translocation enzymes (TETs)...
  39. Zhang G, Liu Z, Qin S, Li K. Decreased expression of SIRT6 promotes tumor cell growth correlates closely with poor prognosis of ovarian cancer. Eur J Gynaecol Oncol. 2015;36:629-32 pubmed
    ..Sirtunins belong to a protein family and it is present in all organisms. SIRT6 is downregulated in tumor and acts as tumor suppressor...
  40. Ghiraldini F, Crispim A, Mello M. Effects of hyperglycemia and aging on nuclear sirtuins and DNA damage of mouse hepatocytes. Mol Biol Cell. 2013;24:2467-76 pubmed publisher
    ..Here we investigate the abundance and activity of the nuclear sirtuins Sirt1, Sirt6, and Sirt7 in mouse hepatocytes in association with specific histone acetylation, DNA damage, and the activation ..
  41. Zhang N, Li Z, Mu W, Li L, Liang Y, Lu M, et al. Calorie restriction-induced SIRT6 activation delays aging by suppressing NF-κB signaling. Cell Cycle. 2016;15:1009-18 pubmed publisher
    Calorie restriction (CR) extends lifespan from yeast to mammals. SIRT6 is a member of the sirtuin family of NAD(+)-dependent histone deacetylases, which is responsible for mediating the effects of CR...
  42. Van Meter M, Kashyap M, Rezazadeh S, Geneva A, Morello T, Seluanov A, et al. SIRT6 represses LINE1 retrotransposons by ribosylating KAP1 but this repression fails with stress and age. Nat Commun. 2014;5:5011 pubmed publisher
    ..Here we report that the longevity regulating protein, SIRT6, is a powerful repressor of L1 activity...
  43. Anderson J, Ramadori G, Ioris R, Galiè M, Berglund E, Coate K, et al. Enhanced insulin sensitivity in skeletal muscle and liver by physiological overexpression of SIRT6. Mol Metab. 2015;4:846-56 pubmed publisher
    ..b>Sirt6 loss- and gain-of-function studies have generated confounding data regarding the role of this sirtuin on energy ..
  44. Kawamura Y, Uchijima Y, Horike N, Tonami K, Nishiyama K, Amano T, et al. Sirt3 protects in vitro-fertilized mouse preimplantation embryos against oxidative stress-induced p53-mediated developmental arrest. J Clin Invest. 2010;120:2817-28 pubmed publisher
    ..These results indicate that Sirt3 plays a protective role in preimplantation embryos against stress conditions during in vitro fertilization and culture...
  45. Liao X, Feng B, Zhang D, Liu P, Zhou X, Li R, et al. The Sirt6 gene: Does it play a role in tooth development?. PLoS ONE. 2017;12:e0174255 pubmed publisher
    ..Sirtuin-6 (SIRT6), a key regulator of aging, can exert an impact on embryonic stem cell (ESC) differentiation...
  46. Santos Barriopedro I, Bosch Presegué L, Marazuela Duque A, de la Torre C, Colomer C, Vazquez B, et al. SIRT6-dependent cysteine monoubiquitination in the PRE-SET domain of Suv39h1 regulates the NF-?B pathway. Nat Commun. 2018;9:101 pubmed publisher
    Sirtuins are NAD+-dependent deacetylases that facilitate cellular stress response. They include SirT6, which protects genome stability and regulates metabolic homeostasis through gene silencing, and whose loss induces an ..
  47. Kanfi Y, Shalman R, Peshti V, Pilosof S, Gozlan Y, Pearson K, et al. Regulation of SIRT6 protein levels by nutrient availability. FEBS Lett. 2008;582:543-8 pubmed publisher
    ..We show here that levels of the mammalian sirtuin, SIRT6, increased upon nutrient deprivation in cultured cells, in mice after fasting, and in rats fed a calorie-..
  48. Liu Z, Wang J, Huang X, Li Z, Liu P. Deletion of sirtuin 6 accelerates endothelial dysfunction and atherosclerosis in apolipoprotein E-deficient mice. Transl Res. 2016;172:18-29.e2 pubmed publisher
    Sirtuin 6 (SIRT6) is a chromatin-associated deacetylase that plays a leading role in genomic stability and aging. However, the precise role of SIRT6 in atherosclerosis, an aging-associated cardiovascular disease, remains elusive...
  49. Wang X, Wang X, Tong M, Gan L, Chen H, Wu S, et al. SIRT6 protects cardiomyocytes against ischemia/reperfusion injury by augmenting FoxO3α-dependent antioxidant defense mechanisms. Basic Res Cardiol. 2016;111:13 pubmed publisher
    b>SIRT6, a member of the NAD(+)-dependent class III deacetylase sirtuin family, has been revealed to play important roles in promoting cellular resistance against oxidative stress...
  50. Ronnebaum S, Wu Y, McDonough H, Patterson C. The ubiquitin ligase CHIP prevents SirT6 degradation through noncanonical ubiquitination. Mol Cell Biol. 2013;33:4461-72 pubmed publisher
    ..a mechanism for CHIP's influence on longevity by demonstrating that CHIP stabilizes the sirtuin family member SirT6, a lysine deacetylase/ADP ribosylase involved in DNA repair, metabolism, and longevity...
  51. Favero G, Rezzani R, Rodella L. Sirtuin 6 nuclear localization at cortical brain level of young diabetic mice: an immunohistochemical study. Acta Histochem. 2014;116:272-7 pubmed publisher
    A study was conducted to assess the physiopathological significance of sirtuin 6 (SIRT6) at the brain cortical level...
  52. Palmer N, Fullston T, Mitchell M, Setchell B, Lane M. SIRT6 in mouse spermatogenesis is modulated by diet-induced obesity. Reprod Fertil Dev. 2011;23:929-39 pubmed publisher
    ..Mammalian SIRT6 protein is involved in caloric-dependant DNA damage repair in other tissue types, yet a possible role for SIRT6 in ..
  53. Tao R, Xiong X, Depinho R, Deng C, Dong X. Hepatic SREBP-2 and cholesterol biosynthesis are regulated by FoxO3 and Sirt6. J Lipid Res. 2013;54:2745-53 pubmed publisher
    ..Here we have identified sirtuin (Sirt)6 as a critical factor for Srebp2 gene regulation. Hepatic deficiency of Sirt6 in mice leads to elevated cholesterol levels...
  54. Chen W, Liu N, Zhang H, Zhang H, Qiao J, Jia W, et al. Sirt6 Promotes DNA End Joining in iPSCs Derived from Old Mice. Cell Rep. 2017;18:2880-2892 pubmed publisher
    ..We further find that Sirt6 is downregulated in iPSCs from old mice...
  55. Zhang P, Tu B, Wang H, Cao Z, Tang M, Zhang C, et al. Tumor suppressor p53 cooperates with SIRT6 to regulate gluconeogenesis by promoting FoxO1 nuclear exclusion. Proc Natl Acad Sci U S A. 2014;111:10684-9 pubmed publisher
    ..studies show that p53 directly activates expression of the NAD(+)-dependent histone deacetylase sirtuin 6 (SIRT6), whose interaction with FoxO1 leads to FoxO1 deacetylation and export to the cytoplasm...
  56. Silberman D, Ross K, Sande P, Kubota S, Ramaswamy S, Apte R, et al. SIRT6 is required for normal retinal function. PLoS ONE. 2014;9:e98831 pubmed publisher
    ..Sirtuin 6 (SIRT6), a NAD-dependent deacylase, plays a key role in regulating glucose metabolism...
  57. Xiong X, Zhang C, Zhang Y, Fan R, Qian X, Dong X. Fabp4-Cre-mediated Sirt6 deletion impairs adipose tissue function and metabolic homeostasis in mice. J Endocrinol. 2017;233:307-314 pubmed publisher
    b>SIRT6 is a member of sirtuin family of deacetylases involved in diverse processes including genome stability, metabolic homeostasis and anti-inflammation. However, its function in the adipose tissue is not well understood...
  58. Elhanati S, Kanfi Y, Varvak A, Roichman A, Carmel Gross I, Barth S, et al. Multiple regulatory layers of SREBP1/2 by SIRT6. Cell Rep. 2013;4:905-12 pubmed publisher
    The NAD(+)-dependent protein deacetylase SIRT6 regulates genome stability, cancer, and lifespan...
  59. Lall S. No SIRT6. Nat Struct Mol Biol. 2008;15:336 pubmed publisher
  60. Masri S, Rigor P, Cervantes M, Ceglia N, Sebastian C, Xiao C, et al. Partitioning circadian transcription by SIRT6 leads to segregated control of cellular metabolism. Cell. 2014;158:659-72 pubmed publisher
    ..Whereas SIRT1 exhibits diversity in deacetylation targets and subcellular localization, SIRT6 is the only constitutively chromatin-associated sirtuin and is prominently present at transcriptionally active ..
  61. Lee Y, Ka S, Cha H, Chae Y, Kim M, Park S, et al. Myeloid Sirtuin 6 Deficiency Causes Insulin Resistance in High-Fat Diet-Fed Mice by Eliciting Macrophage Polarization Toward an M1 Phenotype. Diabetes. 2017;66:2659-2668 pubmed publisher
    ..Sirtuin 6 (Sirt6) is known to exert an anti-inflammatory function, but its role in macrophages in the context of obesity has not ..
  62. Okun E, Marton D, Cohen D, Griffioen K, Kanfi Y, Illouz T, et al. Sirt6 alters adult hippocampal neurogenesis. PLoS ONE. 2017;12:e0179681 pubmed publisher
    ..b>SIRT6, a member of the sirtuin family, regulates the process of normal aging and increases the lifespan of male mice ..
  63. Han L, Ge J, Zhang L, Ma R, Hou X, Li B, et al. Sirt6 depletion causes spindle defects and chromosome misalignment during meiosis of mouse oocyte. Sci Rep. 2015;5:15366 pubmed publisher
    b>Sirt6, a member of the sirtuin family of NAD-dependent protein deacetylases, has been implicated in multiple biological processes. However, the roles of Sirt6 in meiosis have not been addressed...
  64. Xu S, Yin M, Koroleva M, Mastrangelo M, Zhang W, Bai P, et al. SIRT6 protects against endothelial dysfunction and atherosclerosis in mice. Aging (Albany NY). 2016;8:1064-82 pubmed publisher
    b>SIRT6 is an important member of sirtuin family that represses inflammation, aging and DNA damage, three of which are causing factors for endothelial dysfunction...
  65. Witt O, Deubzer H, Milde T, Oehme I. HDAC family: What are the cancer relevant targets?. Cancer Lett. 2009;277:8-21 pubmed publisher
    ..The aim of this review is to discuss individual HDAC family members as drug targets in cancer taking into consideration their function under physiological conditions and their oncogenic potential in malignant disease. ..
  66. Piao J, Tsuji K, Ochi H, Iwata M, Koga D, Okawa A, et al. Sirt6 regulates postnatal growth plate differentiation and proliferation via Ihh signaling. Sci Rep. 2013;3:3022 pubmed publisher
    Sirtuin 6 (Sirt6) is a mammalian homologue of NAD?-dependent histone deacetylase Sir2. Although Sirt6?/? mice exhibit growth retardation, the role of Sirt6 in cartilage metabolism is unclear...