Sirt3

Summary

Gene Symbol: Sirt3
Description: sirtuin 3
Alias: 2310003L23Rik, AI848213, Sir2l3, NAD-dependent deacetylase sirtuin-3, NAD-dependent protein deacetylase sirtuin-3, SIR2-like protein 3, SIRT3L mitochondrial, mSIR2L3, mitochondrial protein lysine deacetylase, regulatory protein SIR2 homolog 3, silent mating type information regulation 2, (S.cerevisiae, homolog)-like 3
Species: mouse

Top Publications

  1. pmc SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation
    Matthew D Hirschey
    Gladstone Institute of Virology and Immunology, San Francisco, California 94158, USA
    Nature 464:121-5. 2010
  2. pmc SIRT3 is a mitochondria-localized tumor suppressor required for maintenance of mitochondrial integrity and metabolism during stress
    Hyun Seok Kim
    Genetics of Development and Disease Branch, NIDDK, NIH, Bethesda, MD 20892, USA
    Cancer Cell 17:41-52. 2010
  3. pmc Sirt3-mediated deacetylation of evolutionarily conserved lysine 122 regulates MnSOD activity in response to stress
    Randa Tao
    Howard Hughes Medical Institute and Molecular Radiation Oncology, Radiation Oncology Branch, Center for Cancer Research, NCI, NIH, Bethesda, MD 20892, USA
    Mol Cell 40:893-904. 2010
  4. pmc A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis
    Bong Hyun Ahn
    Translational Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 105:14447-52. 2008
  5. pmc Sirt3 promotes the urea cycle and fatty acid oxidation during dietary restriction
    William C Hallows
    Department of Biomolecular Chemistry, University of Wisconsin, Madison, WI 53706, USA
    Mol Cell 41:139-49. 2011
  6. pmc SIRT3 deacetylates mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase 2 and regulates ketone body production
    Tadahiro Shimazu
    Gladstone Institute of Virology and Immunology, San Francisco, CA 94158, USA
    Cell Metab 12:654-61. 2010
  7. pmc Diet and exercise signals regulate SIRT3 and activate AMPK and PGC-1alpha in skeletal muscle
    Orsolya M Palacios
    USDA ARS Children s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
    Aging (Albany NY) 1:771-83. 2009
  8. pmc Neuronal Sirt3 protects against excitotoxic injury in mouse cortical neuron culture
    Sun Hee Kim
    Department of Neurology, Veterans Affairs Medical Center, San Francisco, California, United States of America
    PLoS ONE 6:e14731. 2011
  9. pmc Sirtuin-3 (Sirt3) regulates skeletal muscle metabolism and insulin signaling via altered mitochondrial oxidation and reactive oxygen species production
    Enxuan Jing
    Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 108:14608-13. 2011
  10. pmc SIRT5 Deacetylates carbamoyl phosphate synthetase 1 and regulates the urea cycle
    Takashi Nakagawa
    Department of Biology, Massachusetts Institute of Technology, Cambridge, 02139, USA
    Cell 137:560-70. 2009

Scientific Experts

  • Yu Hua Tseng
  • Ulrich Mahlknecht
  • Olaf Witt
  • Lei Jin
  • Xinning Wu
  • Matthew D Hirschey
  • Yongjie Yang
  • Eric Verdin
  • John M Denu
  • Qiang Tong
  • Wei Yu
  • Lydia W S Finley
  • C Ronald Kahn
  • Enxuan Jing
  • Hyun Seok Kim
  • William C Hallows
  • David B Lombard
  • Nagalingam R Sundaresan
  • Marcia C Haigis
  • Tadahiro Shimazu
  • David Gius
  • Bjoern Schwer
  • Frederick W Alt
  • Katharine Brown
  • Kristin E Dittenhafer-Reed
  • Xiaolei Qiu
  • Zhongping Lu
  • Michael N Sack
  • Shinichi Someya
  • Jianjun Bao
  • Chu Xia Deng
  • Huseyin Cimen
  • Orsolya M Palacios
  • Robert V Farese
  • Vinodkumar B Pillai
  • Senthilkumar B Rajamohan
  • Mahesh P Gupta
  • Tong Shi
  • Matthew J Rardin
  • Jinhan He
  • Jun Mori
  • Alessia Peserico
  • Alexander S Hebert
  • Pablo J Fernandez-Marcos
  • Eri Maria Sol
  • Heather J M Weir
  • J Alex Parker
  • Gregory R Wagner
  • ERIC M VERDIN
  • Tomas A Prolla
  • Danica Chen
  • Sun Hee Kim
  • Tetsuro Koyama
  • Agnieszka A Kendrick
  • Kristofer S Fritz
  • Albert Giralt
  • Eric Goetzman
  • Robert D Stevens
  • Carrie A Grueter
  • Christopher B Newgard
  • Yong Chen
  • Xingxing Kong
  • Emine C Koc
  • Ke Yun Chen
  • Douglas R Spitz
  • David A Sinclair
  • Yu Li
  • Randa Tao
  • Seong Hoon Park
  • Yumiko Kawamura
  • Min Joon Han
  • Angela V Hafner
  • Ozkan Ozden
  • Phuongmai Nguyen
  • J Daniel Pennington
  • Hasan Koc
  • Madhu Gupta
  • Ayman Isbatan
  • Gene Kim
  • Helen M Cooper
  • Takashi Nakagawa
  • Athanassios Vassilopoulos
  • Jakob Bunkenborg
  • Yasuhiko Nakamura
  • Bong Hyun Ahn
  • Marco Tonelli
  • Marta Simonatto
  • Min Huang
  • Alan J Higbee
  • Mary Mohrin

Detail Information

Publications55

  1. pmc SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation
    Matthew D Hirschey
    Gladstone Institute of Virology and Immunology, San Francisco, California 94158, USA
    Nature 464:121-5. 2010
    ..Sirtuin 3 (SIRT3) is localized in the mitochondrial matrix, where it regulates the acetylation levels of metabolic enzymes, ..
  2. pmc SIRT3 is a mitochondria-localized tumor suppressor required for maintenance of mitochondrial integrity and metabolism during stress
    Hyun Seok Kim
    Genetics of Development and Disease Branch, NIDDK, NIH, Bethesda, MD 20892, USA
    Cancer Cell 17:41-52. 2010
    ..This work demonstrates that SIRT3(-/-) mouse embryonic fibroblasts (MEFs) exhibit abnormal mitochondrial physiology as well as increases in stress-..
  3. pmc Sirt3-mediated deacetylation of evolutionarily conserved lysine 122 regulates MnSOD activity in response to stress
    Randa Tao
    Howard Hughes Medical Institute and Molecular Radiation Oncology, Radiation Oncology Branch, Center for Cancer Research, NCI, NIH, Bethesda, MD 20892, USA
    Mol Cell 40:893-904. 2010
    Genetic deletion of the mitochondrial deacetylase sirtuin-3 (Sirt3) results in increased mitochondrial superoxide, a tumor-permissive environment, and mammary tumor development...
  4. pmc A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis
    Bong Hyun Ahn
    Translational Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 105:14447-52. 2008
    Here, we demonstrate a role for the mitochondrial NAD-dependent deacetylase Sirt3 in the maintenance of basal ATP levels and as a regulator of mitochondrial electron transport...
  5. pmc Sirt3 promotes the urea cycle and fatty acid oxidation during dietary restriction
    William C Hallows
    Department of Biomolecular Chemistry, University of Wisconsin, Madison, WI 53706, USA
    Mol Cell 41:139-49. 2011
    ..Here we utilize acetyl-peptide arrays and metabolomic analyses to identify substrates of mitochondrial deacetylase Sirt3. We identified ornithine transcarbamoylase (OTC) from the urea cycle, and enzymes involved in β-oxidation...
  6. pmc SIRT3 deacetylates mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase 2 and regulates ketone body production
    Tadahiro Shimazu
    Gladstone Institute of Virology and Immunology, San Francisco, CA 94158, USA
    Cell Metab 12:654-61. 2010
    The mitochondrial sirtuin SIRT3 regulates metabolic homeostasis during fasting and calorie restriction...
  7. pmc Diet and exercise signals regulate SIRT3 and activate AMPK and PGC-1alpha in skeletal muscle
    Orsolya M Palacios
    USDA ARS Children s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
    Aging (Albany NY) 1:771-83. 2009
    b>SIRT3 is a member of the sirtuin family of NAD(+)-dependent deacetylases, which is localized to the mitochondria and is enriched in kidney, brown adipose tissue, heart, and other metabolically active tissues...
  8. pmc Neuronal Sirt3 protects against excitotoxic injury in mouse cortical neuron culture
    Sun Hee Kim
    Department of Neurology, Veterans Affairs Medical Center, San Francisco, California, United States of America
    PLoS ONE 6:e14731. 2011
    ..Among the known Sirt isoforms (Sirt1-7), Sirt3 was identified as a stress responsive deacetylase recently shown to play a role in protecting cells under stress ..
  9. pmc Sirtuin-3 (Sirt3) regulates skeletal muscle metabolism and insulin signaling via altered mitochondrial oxidation and reactive oxygen species production
    Enxuan Jing
    Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 108:14608-13. 2011
    b>Sirt3 is a member of the sirtuin family of protein deacetylases that is localized in mitochondria and regulates mitochondrial function...
  10. pmc SIRT5 Deacetylates carbamoyl phosphate synthetase 1 and regulates the urea cycle
    Takashi Nakagawa
    Department of Biology, Massachusetts Institute of Technology, Cambridge, 02139, USA
    Cell 137:560-70. 2009
    ..Similar effects occur during long-term calorie restriction or a high protein diet. These findings demonstrate SIRT5 plays a pivotal role in ammonia detoxification and disposal by activating CPS1...
  11. pmc Regulation of succinate dehydrogenase activity by SIRT3 in mammalian mitochondria
    Huseyin Cimen
    Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Biochemistry 49:304-11. 2010
    A member of the sirtuin family of NAD(+)-dependent deacetylases, SIRT3, is identified as one of the major mitochondrial deacetylases located in mammalian mitochondria responsible for deacetylation of several metabolic enzymes and ..
  12. pmc A new splice variant of the mouse SIRT3 gene encodes the mitochondrial precursor protein
    Helen M Cooper
    University of Tampere, Institute of Medical Technology and Tampere University Hospital, Tampere, Finland
    PLoS ONE 4:e4986. 2009
    ..Three mammalian sirtuins, SIRT3-5 are mitochondrial...
  13. ncbi SIRT3, a mitochondrial sirtuin deacetylase, regulates mitochondrial function and thermogenesis in brown adipocytes
    Tong Shi
    United States Department of Agriculture Agricultural Research Service Children s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 280:13560-7. 2005
    b>SIRT3 is one of the seven mammalian sirtuin homologs of the yeast Sir2 gene, which mediates the effect of caloric restriction on life span extension in yeast and Caenorhabditis elegans...
  14. pmc Characterization of the murine SIRT3 mitochondrial localization sequence and comparison of mitochondrial enrichment and deacetylase activity of long and short SIRT3 isoforms
    Jianjun Bao
    Translational Medicine Branch, NHLBI, NIH, Bethesda, Maryland, USA
    J Cell Biochem 110:238-47. 2010
    b>SIRT3 is identified as the major mitochondrial deacetylase...
  15. pmc Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation
    David B Lombard
    Howard Hughes Medical Institute, The Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Mol Cell Biol 27:8807-14. 2007
    ..Studies of the sirtuin SIRT3 have so far been limited to cell culture systems...
  16. pmc Succinate dehydrogenase is a direct target of sirtuin 3 deacetylase activity
    Lydia W S Finley
    Department of Pathology, The Paul F Glenn Labs for the Biological Mechanisms of Aging, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 6:e23295. 2011
    ..b>SIRT3 is localized to mitochondria, where it deacetylates and activates a number of enzymes involved in fuel oxidation ..
  17. pmc Peroxisome proliferator-activated receptor-gamma coactivator-1alpha controls transcription of the Sirt3 gene, an essential component of the thermogenic brown adipocyte phenotype
    Albert Giralt
    Departament de Bioquimica i Biologia Molecular, Institut de Biomedicina de la Universitat de Barcelona, Universitat de Barcelona, and CIBER Fisiopatologia de la Obesidad y Nutricion, 08028 Barcelona, Spain
    J Biol Chem 286:16958-66. 2011
    b>Sirt3 (silent mating type information regulation 2, homolog 3), a member of the sirtuin family of protein deacetylases with multiple actions on metabolism and gene expression is expressed in association with brown adipocyte ..
  18. ncbi Localization of mouse mitochondrial SIRT proteins: shift of SIRT3 to nucleus by co-expression with SIRT5
    Yasuhiko Nakamura
    Department of Diabetes and Clinical Nutrition, Graduate School of Medicine, Kyoto University, 54 Kawahara cho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Biochem Biophys Res Commun 366:174-9. 2008
    Yeast silent information regulator 2 (SIR2) is involved in extension of yeast longevity by calorie restriction, and SIRT3, SIRT4, and SIRT5 are mammalian homologs of SIR2 localized in mitochondria...
  19. pmc Regulation of the mPTP by SIRT3-mediated deacetylation of CypD at lysine 166 suppresses age-related cardiac hypertrophy
    Angela V Hafner
    Harvard Medical School, Department of Pathology and Glenn Labs for Aging Research, Boston, MA 02115, USA
    Aging (Albany NY) 2:914-23. 2010
    ..Here we report that the NAD+-dependent deacetylase SIRT3 deacetylates the regulatory component of the mPTP, cyclophilin D (CypD) on lysine 166, adjacent to the binding ..
  20. pmc SIRT3 is a stress-responsive deacetylase in cardiomyocytes that protects cells from stress-mediated cell death by deacetylation of Ku70
    Nagalingam R Sundaresan
    University of Chicago Medical Center, Committee on Cellular and Molecular Physiology, Biological Science Division, University of Chicago, Chicago, Illinois 60637, USA
    Mol Cell Biol 28:6384-401. 2008
    ..Among them, SIRT3 is the only sirtuin whose increased expression has been shown to correlate with an extended life span in humans...
  21. pmc Biochemical characterization, localization, and tissue distribution of the longer form of mouse SIRT3
    Lei Jin
    Sirtris, a GSK Company, 200 Technology Square, Cambridge, MA 02139, USA
    Protein Sci 18:514-25. 2009
    b>SIRT3 is a key mitochondrial protein deacetylase proposed to play key roles in regulating mitochondrial metabolism but there has been considerable debate about its actual size, the sequences required for activity, and its subcellular ..
  22. pmc Where in the cell is SIRT3?--functional localization of an NAD+-dependent protein deacetylase
    William C Hallows
    Department of Biomolecular Chemistry, School of Medicine and Public Health, University of Wisconsin, Madison, WI 53706, USA
    Biochem J 411:e11-3. 2008
    ..b>SIRT3 (sirtuin 3), a human homologue of Sir2 (silent information regulator 2), has been genetically linked to lifespan ..
  23. pmc Sirt3 blocks the cardiac hypertrophic response by augmenting Foxo3a-dependent antioxidant defense mechanisms in mice
    Nagalingam R Sundaresan
    Department of Surgery, University of Chicago, Chicago, Illinois 60637, USA
    J Clin Invest 119:2758-71. 2009
    Sirtuin 3 (SIRT3) is a member of the sirtuin family of proteins that promote longevity in many organisms. Increased expression of SIRT3 has been linked to an extended life span in humans...
  24. pmc Characterization of murine SIRT3 transcript variants and corresponding protein products
    Yongjie Yang
    USDA ARS Children s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, USA
    J Cell Biochem 111:1051-8. 2010
    b>SIRT3 is one of the seven mammalian sirtuin homologs of the yeast SIR2 gene. SIRT3 possesses NAD(+)-dependent protein deacetylase activity...
  25. pmc Exogenous NAD blocks cardiac hypertrophic response via activation of the SIRT3-LKB1-AMP-activated kinase pathway
    Vinodkumar B Pillai
    Department of Surgery, University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 285:3133-44. 2010
    ..By using gene knock-out and transgenic mouse models of SIRT3 and SIRT1, we showed that the anti-hypertrophic effects of exogenous NAD are mediated through activation of SIRT3, ..
  26. ncbi Cloning and characterization of two mouse genes with homology to the yeast Sir2 gene
    Y H Yang
    Department of Genetics, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut, 06536, USA
    Genomics 69:355-69. 2000
    ..Our results revealed that the two mouse Sir2-like proteins (mSIR2L2 and mSIR2L3) are most similar to the human Sir2-like proteins SIR2L2 and SIR2L3, respectively...
  27. pmc Muscle or liver-specific Sirt3 deficiency induces hyperacetylation of mitochondrial proteins without affecting global metabolic homeostasis
    Pablo J Fernandez-Marcos
    Laboratory of Integrative and Systems Physiology LISP NCEM, School of Life Sciences, Ecole Polytechnique Federale de Lausanne EPFL, 1015 Lausanne, Switzerland
    Sci Rep 2:425. 2012
    b>Sirt3 is a mitochondrial sirtuin, predominantly expressed in highly metabolic tissues...
  28. pmc SIRT3 protein deacetylates isocitrate dehydrogenase 2 (IDH2) and regulates mitochondrial redox status
    Wei Yu
    Department of Biomolecular Chemistry and the Wisconsin Institute for Discovery, University of Wisconsin Madison, Madison, Wisconsin 53715, USA
    J Biol Chem 287:14078-86. 2012
    ..Previously, we demonstrated that the NAD(+)-dependent deacetylase SIRT3 was essential for the prevention of age-related hearing loss in mice fed a calorically restricted diet...
  29. pmc Friedreich's ataxia reveals a mechanism for coordinate regulation of oxidative metabolism via feedback inhibition of the SIRT3 deacetylase
    Gregory R Wagner
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Hum Mol Genet 21:2688-97. 2012
    ..phenotype develops concurrently with cardiac hypertrophy and is caused by inhibition of the NAD(+)-dependent SIRT3 deacetylase...
  30. pmc Integration of β-catenin, sirtuin, and FOXO signaling protects from mutant huntingtin toxicity
    J Alex Parker
    INSERM, Unit 894, Laboratory of Neuronal Cell Biology and Pathology, 75014 Paris, France
    J Neurosci 32:12630-40. 2012
    ..Taken together, these results suggest that integration of β-catenin, sirtuin and FOXO signaling protects from the early phases of mutant huntingtin toxicity...
  31. doi ANG II causes insulin resistance and induces cardiac metabolic switch and inefficiency: a critical role of PDK4
    Jun Mori
    Department of Pediatrics, University of Alberta, Edmonton, Canada
    Am J Physiol Heart Circ Physiol 304:H1103-13. 2013
    ..ANG II-induced reduction in the levels of the deacetylase, SIRT3, was associated with increased acetylation of pyruvate dehydrogenase (PDH) and a reduced PDH activity...
  32. pmc Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways
    Matthew J Rardin
    Buck Institute for Research on Aging, Novato, CA 94945, USA
    Proc Natl Acad Sci U S A 110:6601-6. 2013
    ..Sirtuin 3 (SIRT3) is an NAD(+)-dependent mitochondrial protein deacetylase that has been shown to regulate a limited number of ..
  33. pmc SIRT3 opposes reprogramming of cancer cell metabolism through HIF1α destabilization
    Lydia W S Finley
    Department of Pathology, The Paul F Glenn Labs for the Biological Mechanisms of Aging, Harvard Medical School, Boston, MA 02115, USA
    Cancer Cell 19:416-28. 2011
    ..Here, we show that the mitochondrial NAD-dependent deacetylase SIRT3 is a crucial regulator of the Warburg effect...
  34. pmc SIRT3 reverses aging-associated degeneration
    Katharine Brown
    Program in Metabolic Biology, Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, CA 94720, USA
    Cell Rep 3:319-27. 2013
    ..We show that SIRT3, a mammalian sirtuin that regulates the global acetylation landscape of mitochondrial proteins and reduces ..
  35. pmc Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome
    Alexander S Hebert
    Department of Biomolecular Chemistry, University of Wisconsin, Madison, WI 53706, USA
    Mol Cell 49:186-99. 2013
    ..acetyl-proteome during CR versus control diet in mice that were wild-type or lacked the protein deacetylase SIRT3. Quantification of 3,285 acetylation sites-2,193 from mitochondrial proteins-rendered a comprehensive atlas of the ..
  36. pmc CNS SIRT3 expression is altered by reactive oxygen species and in Alzheimer's disease
    Heather J M Weir
    School of Biochemistry, University of Bristol, Bristol, United Kingdom
    PLoS ONE 7:e48225. 2012
    ..An essential regulator of mitochondrial function is the deacetylase, sirtuin 3 (SIRT3)...
  37. pmc Activation of the aryl hydrocarbon receptor sensitizes mice to nonalcoholic steatohepatitis by deactivating mitochondrial sirtuin deacetylase Sirt3
    Jinhan He
    Department of Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy, Pittsburgh, PA, USA
    Mol Cell Biol 33:2047-55. 2013
    ..polymerase (TiPARP) gene expression, depleted NAD(+), deactivated the mitochondrial sirtuin deacetylase 3 (Sirt3), increased SOD2 acetylation, and thereby decreased SOD2 activity...
  38. doi A novel AMPK-dependent FoxO3A-SIRT3 intramitochondrial complex sensing glucose levels
    Alessia Peserico
    Laboratory of Signal dependent Transcription, Department of Translational Pharmacology DTP, Consorzio Mario Negri Sud, 66030, Santa Maria Imbaro CH, Italy
    Cell Mol Life Sci 70:2015-29. 2013
    ..A low-glucose regimen induces the formation of a protein complex containing FoxO3A, SIRT3, and mitochondrial RNA polymerase (mtRNAPol) at mitochondrial DNA-regulatory regions causing activation of the ..
  39. ncbi [Inhibitory effect of Sirt3 on proliferation of vascular smooth muscle cells induced by angiotensin II]
    Xinning Wu
    Department of Cardiology, Shandong University, Jinan, China w_
    Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 29:237-41. 2013
    To detect the expression of Sirtuin3 (Sirt3) in mice vascular smooth muscle cells (VSMCs) and explore the effect of Sirt3 on VSMCs proliferation induced by angiotensin II (AngII).
  40. pmc Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3
    Eri Maria Sol
    Department of Proteomics, The Novo Nordisk Foundation Center for Protein Research, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    PLoS ONE 7:e50545. 2012
    ..we apply quantitative proteomics to identify endogenous substrates of the mitochondrial deacetylase Sirtuin 3 (Sirt3) by comparing site-specific acetylation in wild-type murine embryonic fibroblasts to Sirt3 knockout cells...
  41. pmc SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome
    Matthew D Hirschey
    Gladstone Institute of Virology and Immunology, San Francisco, CA 94158, USA
    Mol Cell 44:177-90. 2011
    ..mitochondrial protein hyperacetylation in mice and downregulation of the major mitochondrial protein deacetylase SIRT3. Mice lacking SIRT3 (SIRT3KO) placed on a HFD show accelerated obesity, insulin resistance, hyperlipidemia, and ..
  42. doi HDAC family: What are the cancer relevant targets?
    Olaf Witt
    CCU Pediatric Oncology G340, German Cancer Research Center, Im Neuenheimer Feld 280, Heidelberg, Germany
    Cancer Lett 277:8-21. 2009
    ..The aim of this review is to discuss individual HDAC family members as drug targets in cancer taking into consideration their function under physiological conditions and their oncogenic potential in malignant disease...
  43. ncbi Molecular evolution of mammalian lactate dehydrogenase-A genes and pseudogenes: association of a mouse processed pseudogene with a B1 repetitive sequence
    K M Fukasawa
    Laboratory of Genetics, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709
    Mol Biol Evol 3:330-42. 1986
    ..20 X 10(-9), which is considerably lower than the average rate of 0.88 X 10(-9) for 35 mammalian genes. Thus, the mammalian LDH-A gene appears to be highly conserved in evolution...
  44. pmc NAD+-dependent deacetylase SIRT3 regulates mitochondrial protein synthesis by deacetylation of the ribosomal protein MRPL10
    Yongjie Yang
    Children s Nutrition Research Center, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 285:7417-29. 2010
    A member of the sirtuin family of NAD(+)-dependent deacetylases, SIRT3, is located in mammalian mitochondria and is important for regulation of mitochondrial metabolism, cell survival, and longevity...
  45. pmc Sirtuin 3, a new target of PGC-1alpha, plays an important role in the suppression of ROS and mitochondrial biogenesis
    Xingxing Kong
    The National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    PLoS ONE 5:e11707. 2010
    Sirtuin 3 (SIRT3) is one of the seven mammalian sirtuins, which are homologs of the yeast Sir2 gene. SIRT3 is the only sirtuin with a reported association with the human life span...
  46. pmc Fatty liver is associated with reduced SIRT3 activity and mitochondrial protein hyperacetylation
    Agnieszka A Kendrick
    Nutrition and Obesity Research Center, Department of Anesthesiology, University of Colorado School of Medicine, Aurora, 80045, USA
    Biochem J 433:505-14. 2011
    ..Livers of mice fed on the HFD had reduced SIRT3 activity, a 3-fold decrease in hepatic NAD(+) levels and increased mitochondrial protein oxidation...
  47. doi Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation
    Xiaolei Qiu
    Department of Nutritional Science and Toxicology, University of California, Berkeley, CA 94720, USA
    Cell Metab 12:662-7. 2010
    ..Here, we show that the protective effects of CR on oxidative stress and damage are diminished in mice lacking SIRT3, a mitochondrial deacetylase...
  48. pmc Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction
    Shinichi Someya
    Departments of Genetics and Medical Genetics, University of Wisconsin, Madison, 53706, USA
    Cell 143:802-12. 2010
    ..prevents AHL in wild-type mice but fails to modify these phenotypes in mice lacking the mitochondrial deacetylase Sirt3, a member of the sirtuin family...
  49. doi Genomic organization and localization of the NAD-dependent histone deacetylase gene sirtuin 3 (Sirt3) in the mouse
    Ulrich Mahlknecht
    Saarland University Medical Center, Department of Internal Medicine, Homburg Saar, Germany
    Int J Oncol 38:813-22. 2011
    Sirtuin 3 (SIRT3) is a nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase, which belongs to the Silent information regulator 2 (Sir2) family of histone deacetylases (sirtuin HDACs)...
  50. pmc Sirt3 protects in vitro-fertilized mouse preimplantation embryos against oxidative stress-induced p53-mediated developmental arrest
    Yumiko Kawamura
    Department of Physiological Chemistry and Metabolism, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    J Clin Invest 120:2817-28. 2010
    ..These effects were recapitulated by siRNA-induced knockdown of Sirt3, which is involved in mitochondrial energy metabolism, and in Sirt3-/- embryos...
  51. pmc 4-Hydroxynonenal inhibits SIRT3 via thiol-specific modification
    Kristofer S Fritz
    Department of Pharmaceutical Sciences, Graduate Program in Toxicology, School of Pharmacy, University of Colorado Denver, Aurora, USA
    Chem Res Toxicol 24:651-62. 2011
    ..In the present study, a greater than 2-fold increase in protein carbonylation of sirtuin 3 (SIRT3), a mitochondrial class III histone deacetylase, is reported in liver mitochondrial extracts of ethanol-consuming ..
  52. doi SIRT3 attenuates palmitate-induced ROS production and inflammation in proximal tubular cells
    Tetsuro Koyama
    Department of Medicine, Shiga University of Medical Science, Otsu, Shiga 520 2192, Japan
    Free Radic Biol Med 51:1258-67. 2011
    ..b>SIRT3 is an antiaging molecule regulated by calorie restriction and mitochondria-localized NAD(+)-dependent deacetylase...
  53. pmc SIRT3-dependent deacetylation exacerbates acetaminophen hepatotoxicity
    Zhongping Lu
    Center for Molecular Medicine, NHLBI, National Institutes of Health, Building 10 CRC, Room 5 3150, 10 Center Drive, Bethesda, Maryland 20892, USA
    EMBO Rep 12:840-6. 2011
    ..As fasting promotes SIRT3-mediated mitochondrial-protein deacetylation and acetaminophen metabolites bind to lysine residues, we ..
  54. pmc Murine Sirt3 protein isoforms have variable half-lives
    Yongjie Yang
    Children s Nutrition Research Center, Baylor College of Medicine, 1100 Bates Street, Houston, TX 77030, USA
    Gene 488:46-51. 2011
    b>Sirt3 is a NAD+-dependent protein deacetylase mainly localized in mitochondria...
  55. pmc New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure
    Yu Hua Tseng
    Section on Obesity and Hormone Action, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Nature 454:1000-4. 2008
    ..These data reveal an important role of BMP7 in promoting brown adipocyte differentiation and thermogenesis in vivo and in vitro, and provide a potential new therapeutic approach for the treatment of obesity...

Research Grants8

  1. ROLE OF INSULIN AND IGF-1 ON BROWN ADIPOCYTES
    Yu Hua Tseng; Fiscal Year: 2003
    ..Accomplishment of the proposed studies will further our understanding on hormonal controls of metabolism and survival of brown adipocytes. ..
  2. Role of BMPs on Brown Adipogenesis and Thermogenesis
    Yu Hua Tseng; Fiscal Year: 2006
    ..abstract_text> ..
  3. Role of BMPs in Adipogenesis, Mitochondrial Function and Energy Homeostasis
    Yu Hua Tseng; Fiscal Year: 2010
    ..These studies will increase our understanding of adipocyte differentiation, energy balance, and BMP actions, and may help to develop potential therapeutic approaches for obesity and related diseases. ..
  4. Role of BMPs in Adipogenesis, Mitochondrial Function and Energy Homeostasis
    Yu Hua Tseng; Fiscal Year: 2010
    ..These studies will increase our understanding of adipocyte differentiation, energy balance, and BMP actions, and may help to develop potential therapeutic approaches for obesity and related diseases. ..