Sirt2

Summary

Gene Symbol: Sirt2
Description: sirtuin 2
Alias: 5730427M03Rik, SIR2L2, Sir2l, NAD-dependent protein deacetylase sirtuin-2, NAD-dependent deacetylase sirtuin-2, SIR2-like protein 2, mSIR2L2, regulatory protein SIR2 homolog 2, silent mating type information regulation 2, (S.cerevisiae, homolog)-like; sirtuin 2
Species: mouse
Products:     Sirt2

Top Publications

  1. Pais T, Szego E, Marques O, Miller Fleming L, Antas P, Guerreiro P, et al. The NAD-dependent deacetylase sirtuin 2 is a suppressor of microglial activation and brain inflammation. EMBO J. 2013;32:2603-16 pubmed publisher
    ..Here, we identified sirtuin 2 (SIRT2), an abundant deacetylase in the brain, as a major inhibitor of microglia-mediated inflammation and neurotoxicity...
  2. Lin J, Sun B, Jiang C, Hong H, Zheng Y. Sirt2 suppresses inflammatory responses in collagen-induced arthritis. Biochem Biophys Res Commun. 2013;441:897-903 pubmed publisher
    ..Here in this study, we demonstrate that Sirt2 inhibits collagen-induced arthritis (CIA) using in vivo and in vitro evidence...
  3. Serrano L, Martínez Redondo P, Marazuela Duque A, Vazquez B, Dooley S, Voigt P, et al. The tumor suppressor SirT2 regulates cell cycle progression and genome stability by modulating the mitotic deposition of H4K20 methylation. Genes Dev. 2013;27:639-53 pubmed publisher
    ..However, the mechanisms involved in the regulation of this event are not well understood. Here we show that SirT2 regulates H4K20me1 deposition through the deacetylation of H4K16Ac (acetylation of H4K16) and determines the ..
  4. Zhu H, Zhao L, Wang E, Dimova N, Liu G, Feng Y, et al. The QKI-PLP pathway controls SIRT2 abundance in CNS myelin. Glia. 2012;60:69-82 pubmed publisher
    Sirtuin 2 (SIRT2), a nicotinamide adenine dinucleotide (NAD)-dependent deacetylase expressed by oligodendrocytes (OLs), the myelin-producing cells of the central nervous system (CNS), is markedly up-regulated during active myelination (..
  5. Bobrowska A, Donmez G, Weiss A, Guarente L, Bates G. SIRT2 ablation has no effect on tubulin acetylation in brain, cholesterol biosynthesis or the progression of Huntington's disease phenotypes in vivo. PLoS ONE. 2012;7:e34805 pubmed publisher
    ..Previous studies in invertebrate and cell culture HD models have suggested that inhibition of SIRT2 could have beneficial consequences on disease progression...
  6. Beirowski B, Gustin J, Armour S, Yamamoto H, Viader A, North B, et al. Sir-two-homolog 2 (Sirt2) modulates peripheral myelination through polarity protein Par-3/atypical protein kinase C (aPKC) signaling. Proc Natl Acad Sci U S A. 2011;108:E952-61 pubmed publisher
    ..to examine peripheral nerve myelination and identified the NAD(+)-dependent deacetylase Sir-two-homolog 2 (Sirt2) as a protein likely to be involved in myelination...
  7. Wang Y, Zhou L, Zhao Y, Wang S, Chen L, Liu L, et al. Regulation of G6PD acetylation by SIRT2 and KAT9 modulates NADPH homeostasis and cell survival during oxidative stress. EMBO J. 2014;33:1304-20 pubmed publisher
    ..Moreover, we show that cells sense extracellular oxidative stimuli to decrease G6PD acetylation in a SIRT2-dependent manner...
  8. Kim M, Kim D, Park J, Kim S, Lee C, Yong J, et al. PEP-1-SIRT2 inhibits inflammatory response and oxidative stress-induced cell death via expression of antioxidant enzymes in murine macrophages. Free Radic Biol Med. 2013;63:432-45 pubmed publisher
    Sirtuin 2 (SIRT2), a member of the sirtuin family of proteins, plays an important role in cell survival. However, the biological function of SIRT2 protein is unclear with respect to inflammation and oxidative stress...
  9. Ji S, Doucette J, Nazarali A. Sirt2 is a novel in vivo downstream target of Nkx2.2 and enhances oligodendroglial cell differentiation. J Mol Cell Biol. 2011;3:351-9 pubmed publisher
    Although Sirt2 is primarily expressed in oligodendrocytes of the central nervous system, its role in oligodendroglial lineage differentiation is not fully understood. Our findings demonstrate that the transcription factor Nkx2...

More Information

Publications74

  1. Krishnan J, Danzer C, Simka T, Ukropec J, Walter K, Kumpf S, et al. Dietary obesity-associated Hif1? activation in adipocytes restricts fatty acid oxidation and energy expenditure via suppression of the Sirt2-NAD+ system. Genes Dev. 2012;26:259-70 pubmed publisher
    ..Hif1? is linked to its capacity to suppress ?-oxidation, in part, through transcriptional repression of sirtuin 2 (Sirt2) NAD(+)-dependent deacetylase...
  2. Maxwell M, Tomkinson E, Nobles J, Wizeman J, Amore A, Quinti L, et al. The Sirtuin 2 microtubule deacetylase is an abundant neuronal protein that accumulates in the aging CNS. Hum Mol Genet. 2011;20:3986-96 pubmed publisher
    Sirtuin 2 (SIRT2) is one of seven known mammalian protein deacetylases homologous to the yeast master lifespan regulator Sir2...
  3. Vaquero A, Scher M, Lee D, Sutton A, Cheng H, Alt F, et al. SirT2 is a histone deacetylase with preference for histone H4 Lys 16 during mitosis. Genes Dev. 2006;20:1256-61 pubmed
    The mammalian cytoplasmic protein SirT2 is a member of the Sir2 family of NAD+-dependent protein deacetylases involved in caloric restriction-dependent life span extension...
  4. Kim H, Vassilopoulos A, Wang R, Lahusen T, Xiao Z, Xu X, et al. SIRT2 maintains genome integrity and suppresses tumorigenesis through regulating APC/C activity. Cancer Cell. 2011;20:487-99 pubmed publisher
    ..To investigate the physiological functions of SIRT2 in development and tumorigenesis, we disrupted Sirt2 in mice...
  5. Jing E, Gesta S, Kahn C. SIRT2 regulates adipocyte differentiation through FoxO1 acetylation/deacetylation. Cell Metab. 2007;6:105-14 pubmed
    The family of mammalian Sirtuin proteins comprises seven members homologous to yeast Sir2. Here we show that SIRT2, a cytoplasmic sirtuin, is the most abundant sirtuin in adipocytes...
  6. Rothgiesser K, Erener S, Waibel S, Luscher B, Hottiger M. SIRT2 regulates NF-?B dependent gene expression through deacetylation of p65 Lys310. J Cell Sci. 2010;123:4251-8 pubmed publisher
    ..In this study, we identified SIRT2 as a deacetylase of the transcription factor p65...
  7. Li Y, Nie H, Wu D, Zhang J, Wei X, Ying W. Poly(ADP-ribose) polymerase mediates both cell death and ATP decreases in SIRT2 inhibitor AGK2-treated microglial BV2 cells. Neurosci Lett. 2013;544:36-40 pubmed publisher
    Sirtuin 2 (SIRT2), a sirtuin family protein, is a tubulin deacetylase...
  8. North B, Rosenberg M, Jeganathan K, Hafner A, Michan S, Dai J, et al. SIRT2 induces the checkpoint kinase BubR1 to increase lifespan. EMBO J. 2014;33:1438-53 pubmed publisher
    ..Here, we show that the loss of BubR1 levels with age is due to a decline in NAD(+) and the ability of SIRT2 to maintain lysine-668 of BubR1 in a deacetylated state, which is counteracted by the acetyltransferase CBP...
  9. Wang F, Tong Q. SIRT2 suppresses adipocyte differentiation by deacetylating FOXO1 and enhancing FOXO1's repressive interaction with PPARgamma. Mol Biol Cell. 2009;20:801-8 pubmed publisher
    ..have previously reported that caloric restriction increases the expression of one of the seven mammalian sirtuins, SIRT2, in tissues such as white adipose tissue...
  10. Wang F, Nguyen M, Qin F, Tong Q. SIRT2 deacetylates FOXO3a in response to oxidative stress and caloric restriction. Aging Cell. 2007;6:505-14 pubmed
    ..The mammalian ortholog of Hst2, SIRT2, was shown to co-localize with microtubules and functions as alpha-tubulin deacetylase...
  11. Suzuki K, Koike T. Resveratrol abolishes resistance to axonal degeneration in slow Wallerian degeneration (WldS) mice: activation of SIRT2, an NAD-dependent tubulin deacetylase. Biochem Biophys Res Commun. 2007;359:665-71 pubmed
    ..This promoting effect on tubulin deacetylation was mimicked by NAD, suggesting the involvement of SIRT2, an NAD-dependent tubulin deacetylase...
  12. Lo Sasso G, Menzies K, Mottis A, Piersigilli A, Perino A, Yamamoto H, et al. SIRT2 deficiency modulates macrophage polarization and susceptibility to experimental colitis. PLoS ONE. 2014;9:e103573 pubmed publisher
    b>SIRT2 belongs to a highly conserved family of NAD+-dependent deacylases, consisting of seven members (SIRT1-SIRT7), which vary in subcellular localizations and have substrates ranging from histones to transcription factors and enzymes...
  13. Eskandarian H, Impens F, Nahori M, Soubigou G, Coppee J, Cossart P, et al. A role for SIRT2-dependent histone H3K18 deacetylation in bacterial infection. Science. 2013;341:1238858 pubmed publisher
    ..We found that during infection with the bacterium Listeria monocytogenes, the host deacetylase sirtuin 2 (SIRT2) translocates to the nucleus, in a manner dependent on the bacterial factor InlB...
  14. Nagai T, Ikeda M, Chiba S, Kanno S, Mizuno K. Furry promotes acetylation of microtubules in the mitotic spindle by inhibition of SIRT2 tubulin deacetylase. J Cell Sci. 2013;126:4369-80 pubmed publisher
    ..We also found that Fry binds to the tubulin deacetylase SIRT2, preferentially in mitotic cells...
  15. Belman J, Bian R, Habtemichael E, Li D, Jurczak M, Alcázar Román A, et al. Acetylation of TUG protein promotes the accumulation of GLUT4 glucose transporters in an insulin-responsive intracellular compartment. J Biol Chem. 2015;290:4447-63 pubmed publisher
    ..Sirtuin 2 (SIRT2), a NAD(+)-dependent deacetylase, bound TUG and deacetylated the TUG peptide...
  16. Cardoso F, Castro F, Moreira Teixeira L, Sousa J, Torrado E, Silvestre R, et al. Myeloid Sirtuin 2 Expression Does Not Impact Long-Term Mycobacterium tuberculosis Control. PLoS ONE. 2015;10:e0131904 pubmed publisher
    ..Recently, Sirt2 was shown to prevent the development of inflammatory processes and its expression favors acute Listeria ..
  17. Buechler N, Wang X, Yoza B, McCall C, Vachharajani V. Sirtuin 2 Regulates Microvascular Inflammation during Sepsis. J Immunol Res. 2017;2017:2648946 pubmed publisher
    ..We have studied the roles of SIRTs 1, 3, and 6 in sepsis previously. In this project, we studied the role of SIRT2 on sepsis-related inflammation. Methods...
  18. Ramakrishnan G, Davaakhuu G, Kaplun L, Chung W, Rana A, Atfi A, et al. Sirt2 deacetylase is a novel AKT binding partner critical for AKT activation by insulin. J Biol Chem. 2014;289:6054-66 pubmed publisher
    ..Here, we identify the cytoplasmic NAD(+)-dependent deacetylase, Sirt2, as a novel AKT interactor, required for optimal AKT activation...
  19. Gal J, Bang Y, Choi H. SIRT2 interferes with autophagy-mediated degradation of protein aggregates in neuronal cells under proteasome inhibition. Neurochem Int. 2012;61:992-1000 pubmed publisher
    ..Sirtuin-2 (SIRT2) is a class III histone deacetylase that is expressed abundantly in aging brain tissue...
  20. Arora A, Dey C. SIRT2 negatively regulates insulin resistance in C2C12 skeletal muscle cells. Biochim Biophys Acta. 2014;1842:1372-8 pubmed publisher
    b>SIRT2 is primarily a cytoplasmic protein deacetylase and is abundantly expressed in metabolically active tissues like adipocytes and brain. However, its role, if any, in regulating insulin signaling in skeletal muscle cells, is not known...
  21. Parker J, Vázquez Manrique R, Tourette C, Farina F, Offner N, Mukhopadhyay A, et al. Integration of ?-catenin, sirtuin, and FOXO signaling protects from mutant huntingtin toxicity. J Neurosci. 2012;32:12630-40 pubmed publisher
    ..Taken together, these results suggest that integration of ?-catenin, sirtuin and FOXO signaling protects from the early phases of mutant huntingtin toxicity. ..
  22. Wang X, Buechler N, Martin A, Wells J, Yoza B, McCall C, et al. Sirtuin-2 Regulates Sepsis Inflammation in ob/ob Mice. PLoS ONE. 2016;11:e0160431 pubmed publisher
    ..Unlike WT mice that showed increased SIRT1 expression, we found that SIRT2 levels were increased in ob/ob mice during hypo-inflammation...
  23. Krey L, Lühder F, Kusch K, Czech Zechmeister B, Könnecke B, Fleming Outeiro T, et al. Knockout of silent information regulator 2 (SIRT2) preserves neurological function after experimental stroke in mice. J Cereb Blood Flow Metab. 2015;35:2080-8 pubmed publisher
    Sirtuin-2 (Sirt2) is a member of the NAD(+)-dependent protein deacetylase family. Various members of the sirtuin class have been found to be involved in processes related to longevity, regulation of inflammation, and neuroprotection...
  24. Yang W, Guo X, Thein S, Xu F, Sugii S, Baas P, et al. Regulation of adipogenesis by cytoskeleton remodelling is facilitated by acetyltransferase MEC-17-dependent acetylation of ?-tubulin. Biochem J. 2013;449:605-12 pubmed publisher
    ..Moreover, acetylation of ?-tubulin is under the control of the acetyltransferase MEC-17 and deacetylases SIRT2 (Sirtuin 2) and HDAC6 (histone deacetylase 6)...
  25. Misawa T, Takahama M, Kozaki T, Lee H, Zou J, Saitoh T, et al. Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome. Nat Immunol. 2013;14:454-60 pubmed publisher
    ..Therefore, in addition to direct activation of NLRP3, the creation of optimal sites for signal transduction by microtubules is required for activation of the entire NLRP3 inflammasome. ..
  26. Valle C, Salvatori I, Gerbino V, Rossi S, Palamiuc L, Rene F, et al. Tissue-specific deregulation of selected HDACs characterizes ALS progression in mouse models: pharmacological characterization of SIRT1 and SIRT2 pathways. Cell Death Dis. 2014;5:e1296 pubmed publisher
    ..We have then focused on class III histone deacetylases SIRT1 and SIRT2 that are considered relevant in neurodegenerative diseases...
  27. Fukui K, Masuda A, Hosono A, Suwabe R, Yamashita K, Shinkai T, et al. Changes in microtubule-related proteins and autophagy in long-term vitamin E-deficient mice. Free Radic Res. 2014;48:649-58 pubmed publisher
    ..These results indicate that the mechanisms of axonal injury in long-term vitamin E-deficient mice are related to dysfunction in microtubules assembly via alterations in microtubule-related proteins and autophagy. ..
  28. Erburu M, Muñoz Cobo I, Domínguez Andrés J, Beltran E, Suzuki T, Mai A, et al. Chronic stress and antidepressant induced changes in Hdac5 and Sirt2 affect synaptic plasticity. Eur Neuropsychopharmacol. 2015;25:2036-48 pubmed publisher
    ..CSDS increased Hdac5 and Sirt2 mRNA whereas repeated imipramine did the opposite...
  29. Shukla S, Shankavaram U, Nguyen P, Stanley B, Smart D. Radiation-Induced Alteration of the Brain Proteome: Understanding the Role of the Sirtuin 2 Deacetylase in a Murine Model. J Proteome Res. 2015;14:4104-17 pubmed publisher
    ..A deacetylase expressed in the central nervous system, Sirtuin 2 (SIRT2), has been linked to neurodegeneration...
  30. Seo K, Park J, Heo J, Jing K, Han J, Min K, et al. SIRT2 regulates tumour hypoxia response by promoting HIF-1? hydroxylation. Oncogene. 2015;34:1354-62 pubmed publisher
    ..In this study, it is shown that SIRT2-mediated deacetylation of HIF-1? regulates its stability in tumour cells...
  31. Watanabe H, Inaba Y, Kimura K, Matsumoto M, Kaneko S, Kasuga M, et al. Sirt2 facilitates hepatic glucose uptake by deacetylating glucokinase regulatory protein. Nat Commun. 2018;9:30 pubmed publisher
    ..Here, we show that diminished hepatic Sirt2 activity impairs HGU in obese diabetic mice...
  32. Liemburg Apers D, Wagenaars J, Smeitink J, Willems P, Koopman W. Acute stimulation of glucose influx upon mitoenergetic dysfunction requires LKB1, AMPK, Sirt2 and mTOR-RAPTOR. J Cell Sci. 2016;129:4411-4423 pubmed
    ..Stimulation of glucose uptake was greatly reduced by chemical inhibition of Sirt2 or mTOR-RAPTOR...
  33. Szego E, Gerhardt E, Outeiro T. Sirtuin 2 enhances dopaminergic differentiation via the AKT/GSK-3?/?-catenin pathway. Neurobiol Aging. 2017;56:7-16 pubmed publisher
    ..Here, we established that the nicotinamide adenine dinucleotide-dependent deacetylase sirtuin 2 (SIRT2) interacts with protein kinase B, and, via the glycogen synthase kinase 3?/?-catenin pathway, modulates the ..
  34. . AMPK and Sirt2 control compensatory glucose uptake. J Cell Sci. 2016;129:e2304 pubmed
  35. Tang X, Chen X, Wang N, Wang X, Liang S, Zheng W, et al. SIRT2 Acts as a Cardioprotective Deacetylase in Pathological Cardiac Hypertrophy. Circulation. 2017;136:2051-2067 pubmed publisher
    ..We aimed to investigate the roles of SIRT2 in aging-related and angiotensin II (Ang II)-induced pathological cardiac hypertrophy...
  36. Movahedi Naini S, Sheridan A, Force T, Shah J, Bonventre J. Group IVA Cytosolic Phospholipase A2 Regulates the G2-to-M Transition by Modulating the Activity of Tumor Suppressor SIRT2. Mol Cell Biol. 2015;35:3768-84 pubmed publisher
    The G2-to-M transition (or prophase) checkpoint of the cell cycle is a critical regulator of mitotic entry. SIRT2, a tumor suppressor gene, contributes to the control of this checkpoint by blocking mitotic entry under cellular stress...
  37. Ming M, Qiang L, Zhao B, He Y. Mammalian SIRT2 inhibits keratin 19 expression and is a tumor suppressor in skin. Exp Dermatol. 2014;23:207-9 pubmed publisher
    b>SIRT2 is a member of the mammalian sirtuin family (SIRT1-7). As compared with other sirtuins, SIRT2 is found primarily in the cytoplasm. It regulates multiple physiological processes...
  38. Park S, Ozden O, Liu G, Song H, Zhu Y, Yan Y, et al. SIRT2-Mediated Deacetylation and Tetramerization of Pyruvate Kinase Directs Glycolysis and Tumor Growth. Cancer Res. 2016;76:3802-12 pubmed publisher
    ..In this study, we identify the M2 isoform of pyruvate kinase (PKM2) as a critical target of the sirtuin SIRT2 implicated in cancer...
  39. Orpinell M, Fournier M, Riss A, Nagy Z, Krebs A, Frontini M, et al. The ATAC acetyl transferase complex controls mitotic progression by targeting non-histone substrates. EMBO J. 2010;29:2381-94 pubmed publisher
    ..mitotic function: ATAC/Gcn5-mediated acetylation targets Cyclin A for degradation, which in turn regulates the SIRT2 deacetylase activity...
  40. Fourcade S, Morató L, Parameswaran J, Ruiz M, Ruiz Cortés T, Jove M, et al. Loss of SIRT2 leads to axonal degeneration and locomotor disability associated with redox and energy imbalance. Aging Cell. 2017;16:1404-1413 pubmed publisher
    Sirtuin 2 (SIRT2) is a member of a family of NAD+ -dependent histone deacetylases (HDAC) that play diverse roles in cellular metabolism and especially for aging process...
  41. Li J, Flick F, Verheugd P, Carloni P, Lüscher B, Rossetti G. Insight into the Mechanism of Intramolecular Inhibition of the Catalytic Activity of Sirtuin 2 (SIRT2). PLoS ONE. 2015;10:e0139095 pubmed publisher
    Sirtuin 2 (SIRT2) is a NAD+-dependent deacetylase that has been associated with neurodegeneration and cancer...
  42. Newton K, Hildebrand J, Shen Z, Rodriguez D, Alvarez Diaz S, Petersen S, et al. Is SIRT2 required for necroptosis?. Nature. 2014;506:E4-6 pubmed publisher
    ..Recently Narayan et al., reported that SIRT2 was required for necroptosis based on their findings that SIRT2 inhibition, knock-down or knock-out prevented ..
  43. Ferguson D, Koo J, Feng J, Heller E, Rabkin J, Heshmati M, et al. Essential role of SIRT1 signaling in the nucleus accumbens in cocaine and morphine action. J Neurosci. 2013;33:16088-98 pubmed publisher
    ..Here, we establish an essential role for SIRT1 and SIRT2 in regulating behavioral responses to cocaine and morphine through actions in the nucleus accumbens (NAc), a key ..
  44. Song H, Biancucci M, Kang H, O Callaghan C, Park S, Principe D, et al. SIRT2 deletion enhances KRAS-induced tumorigenesis in vivo by regulating K147 acetylation status. Oncotarget. 2016;7:80336-80349 pubmed publisher
    ..Here we report that KrasG12D mice lacking Sirt2 show an aggressive tumorigenic phenotype as compared to KrasG12D mice...
  45. Sharma G, So S, Gupta A, Kumar R, Cayrou C, Avvakumov N, et al. MOF and histone H4 acetylation at lysine 16 are critical for DNA damage response and double-strand break repair. Mol Cell Biol. 2010;30:3582-95 pubmed publisher
    ..We propose that MOF, through H4K16ac (histone code), has a critical role at multiple stages in the cellular DNA damage response and DSB repair. ..
  46. Bouras T, Fu M, Sauve A, Wang F, Quong A, Perkins N, et al. SIRT1 deacetylation and repression of p300 involves lysine residues 1020/1024 within the cell cycle regulatory domain 1. J Biol Chem. 2005;280:10264-76 pubmed
    ..Because p300 is a limiting transcriptional cofactor, deacetylation and repression of p300 by SIRT1 may serve an important integration point during metabolism and cellular differentiation. ..
  47. Chen H, Wu D, Ding X, Ying W. SIRT2 is required for lipopolysaccharide-induced activation of BV2 microglia. Neuroreport. 2015;26:88-93 pubmed publisher
    It has been reported that inhibition of sirtuin 2 (SIRT2), a sirtuin family protein, can decrease cellular and tissue injuries in models of Parkinson's disease (PD) and Huntington's disease (HD); however, the mechanisms underlying these ..
  48. Zhou X, Fan L, Li K, Ramchandran R, Calvet J, Li X. SIRT2 regulates ciliogenesis and contributes to abnormal centrosome amplification caused by loss of polycystin-1. Hum Mol Genet. 2014;23:1644-55 pubmed publisher
    ..Here, we present for the first time that SIRT2, a nicotinamide adenine dinucleotide (NAD)-dependent deacetylase, regulates ciliogenesis and centrosome ..
  49. Arteaga M, Shang N, Ding X, Yong S, Cotler S, Denning M, et al. Inhibition of SIRT2 suppresses hepatic fibrosis. Am J Physiol Gastrointest Liver Physiol. 2016;310:G1155-68 pubmed publisher
    ..In this study, we found that blocking the activity of sirtuin 2 (SIRT2) by using inhibitors or shRNAs significantly suppressed fibrogenic gene expression in HSCs...
  50. Southwood C, Peppi M, Dryden S, Tainsky M, Gow A. Microtubule deacetylases, SirT2 and HDAC6, in the nervous system. Neurochem Res. 2007;32:187-95 pubmed
    ..Herein, we analyze two microtubule regulatory alpha-tubulin deacetylases, histone deacetylase-6 (HDAC6) and SirT2. HDAC6 is expressed by most neurons but is abundant in cerebellar Purkinje cells...
  51. Nguyen P, Lee S, Lorang Leins D, Trepel J, Smart D. SIRT2 interacts with β-catenin to inhibit Wnt signaling output in response to radiation-induced stress. Mol Cancer Res. 2014;12:1244-53 pubmed publisher
    ..Therefore, the hypothesis that sirtuin 2 (SIRT2) directly interacts with β-catenin and whether this interaction alters the expression of Wnt target genes to ..
  52. Wu G, Song C, Lu H, Jia L, Yang G, Shi X, et al. Sirt2 induces C2C12 myoblasts proliferation by activation of the ERK1/2 pathway. Acta Biochim Biophys Sin (Shanghai). 2014;46:342-5 pubmed publisher
  53. Taes I, Timmers M, Hersmus N, Bento Abreu A, Van Den Bosch L, Van Damme P, et al. Hdac6 deletion delays disease progression in the SOD1G93A mouse model of ALS. Hum Mol Genet. 2013;22:1783-90 pubmed publisher
    ..of the ?-tubulin deacetylating enzymes, histone deacetylase 6 (Hdac6) and silent information regulator 2 (Sirt2), is thought to be an interesting therapeutic strategy for these conditions...
  54. Zhang L, Hou X, Ma R, Moley K, Schedl T, Wang Q. Sirt2 functions in spindle organization and chromosome alignment in mouse oocyte meiosis. FASEB J. 2014;28:1435-45 pubmed publisher
    ..Here, by confocal scanning and quantitative analysis, we show that specific depletion of Sirt2 in mouse oocytes results in spindle defects and chromosome disorganization (35.5±8.7 vs. 9.6±3...
  55. Yang X, Park S, Chang H, Shapiro J, Vassilopoulos A, Sawicki K, et al. Sirtuin 2 regulates cellular iron homeostasis via deacetylation of transcription factor NRF2. J Clin Invest. 2017;127:1505-1516 pubmed publisher
    b>SIRT2 is a cytoplasmic sirtuin that plays a role in various cellular processes, including tumorigenesis, metabolism, and inflammation...
  56. Witt O, Deubzer H, Milde T, Oehme I. HDAC family: What are the cancer relevant targets?. Cancer Lett. 2009;277:8-21 pubmed publisher
    ..The aim of this review is to discuss individual HDAC family members as drug targets in cancer taking into consideration their function under physiological conditions and their oncogenic potential in malignant disease. ..
  57. Si X, Chen W, Guo X, Chen L, Wang G, Xu Y, et al. Activation of GSK3? by Sirt2 is required for early lineage commitment of mouse embryonic stem cell. PLoS ONE. 2013;8:e76699 pubmed publisher
    b>Sirt2, a member of the NAD(+)-dependent protein deacetylase family, is increasingly recognized as a critical regulator of the cell cycle, cellular necrosis and cytoskeleton organization...
  58. Zhang Z, Zhang P, Qi G, Jiao F, Wang Q, Yan J, et al. CDK5-mediated phosphorylation of Sirt2 contributes to depressive-like behavior induced by social defeat stress. Biochim Biophys Acta Mol Basis Dis. 2018;1864:533-541 pubmed publisher
    ..Histone deacetylases (HDACs) appear to play an essential role in depression. As the class III HDACs, Sirt1 and Sirt2 have attracted the most interest in the nervous system...
  59. Kawamura Y, Uchijima Y, Horike N, Tonami K, Nishiyama K, Amano T, et al. Sirt3 protects in vitro-fertilized mouse preimplantation embryos against oxidative stress-induced p53-mediated developmental arrest. J Clin Invest. 2010;120:2817-28 pubmed publisher
    ..These results indicate that Sirt3 plays a protective role in preimplantation embryos against stress conditions during in vitro fertilization and culture...
  60. Thangaraj M, Furber K, Gan J, Ji S, Sobchishin L, Doucette J, et al. RNA-binding Protein Quaking Stabilizes Sirt2 mRNA during Oligodendroglial Differentiation. J Biol Chem. 2017;292:5166-5182 pubmed publisher
    ..Sirtuin 2 (SIRT2), a NAD+-dependent deacetylase, plays a critical role in OL differentiation by promoting both ..
  61. Yang Y, Chen Y, Zhang C, Nimmakayalu M, Ward D, Weissman S. Cloning and characterization of two mouse genes with homology to the yeast Sir2 gene. Genomics. 2000;69:355-69 pubmed
    ..Our results revealed that the two mouse Sir2-like proteins (mSIR2L2 and mSIR2L3) are most similar to the human Sir2-like proteins SIR2L2 and SIR2L3, respectively...
  62. Turdi S, Li Q, Lopez F, Ren J. Catalase alleviates cardiomyocyte dysfunction in diabetes: role of Akt, Forkhead transcriptional factor and silent information regulator 2. Life Sci. 2007;81:895-905 pubmed
    ..blot analysis revealed that diabetes reduced Akt phosphorylation, enhanced the silent information regulator 2 (Sirt2), and upregulated Forkhead transcriptional factor Foxo3a as well as glycogen synthase kinase-3beta (GSK-3beta) and ..
  63. Snider N, Leonard J, Kwan R, Griggs N, Rui L, Omary M. Glucose and SIRT2 reciprocally mediate the regulation of keratin 8 by lysine acetylation. J Cell Biol. 2013;200:241-7 pubmed publisher
    ..The NAD-dependent deacetylase sirtuin 2 (SIRT2) associated with and deacetylated K8...
  64. Wang G, Li S, Gilbert J, Gritton H, Wang Z, Li Z, et al. Crucial Roles for SIRT2 and AMPA Receptor Acetylation in Synaptic Plasticity and Memory. Cell Rep. 2017;20:1335-1347 pubmed publisher
    ..We find that sirtuin 2 (SIRT2) acts as an AMPAR deacetylase regulating AMPAR trafficking and proteostasis...
  65. Martin J, Balmer M, Rajendran S, Maurhofer O, Dufour J, St Pierre M. Nutritional stress exacerbates hepatic steatosis induced by deletion of the histidine nucleotide-binding (Hint2) mitochondrial protein. Am J Physiol Gastrointest Liver Physiol. 2016;310:G497-509 pubmed publisher
    ..The absence of Hint2 deregulates the posttranslational modification of several mitochondrial proteins, which impedes the adaptation to episodes of nutritional stress. ..