Gene Symbol: Shisa9
Description: shisa family member 9
Alias: 2700045P11Rik, Ckamp44, protein shisa-9, cystine-knot AMPAR modulating protein of 44 kDa, shisa homolog 9
von Engelhardt J, Mack V, Sprengel R, Kavenstock N, Li K, Stern Bach Y, et al
. CKAMP44: a brain-specific protein attenuating short-term synaptic plasticity in the dentate gyrus. Science. 2010;327:1518-22 pubmed publisher
b>CKAMP44, identified here by a proteomic approach, is a brain-specific type I transmembrane protein that associates with AMPA receptors in synaptic spines...
Schwenk J, Harmel N, Brechet A, Zolles G, Berkefeld H, Müller C, et al
. High-resolution proteomics unravel architecture and molecular diversity of native AMPA receptor complexes. Neuron. 2012;74:621-33 pubmed publisher
..6 and 1 MDa. The additional constituents change the gating properties of AMPARs and provide links to the protein dynamics fundamental for the complex role of AMPARs in formation and operation of glutamatergic synapses. ..
Khodosevich K, Jacobi E, Farrow P, Schulmann A, Rusu A, Zhang L, et al
. Coexpressed auxiliary subunits exhibit distinct modulatory profiles on AMPA receptor function. Neuron. 2014;83:601-15 pubmed publisher
..We focused on TARP ?-8 and CKAMP44 in dentate gyrus (DG) granule cells, since both subunits are highly expressed in this cell type...
Chen X, Aslam M, Gollisch T, Allen K, von Engelhardt J. CKAMP44 modulates integration of visual inputs in the lateral geniculate nucleus. Nat Commun. 2018;9:261 pubmed publisher
..Here we identify CKAMP44 as a crucial auxiliary subunit of AMPARs in dLGN relay neurons, where it increases AMPAR-mediated current ..
Karataeva A, Klaassen R, Ströder J, Ruiperez Alonso M, Hjorth J, Van Nierop P, et al
. C-terminal interactors of the AMPA receptor auxiliary subunit Shisa9. PLoS ONE. 2014;9:e87360 pubmed publisher
Shisa9 (initially named CKAMP44) has been identified as auxiliary subunit of the AMPA-type glutamate receptors and was shown to modulate its physiological properties...
Yang B, Dormann C, Vogt M, Sprengel R, Gass P, Inta D. Facilitated c-Fos Induction in Mice Deficient for the AMPA Receptor-Associated Protein Ckamp44. Cell Mol Neurobiol. 2016;36:1215-8 pubmed publisher
The recently identified Cystine-knot containing AMPAR-associated protein (Ckamp44) represents a novel AMPAR-related protein that critically controls AMPAR-mediated currents and short-term plasticity...