Shc1

Summary

Gene Symbol: Shc1
Description: src homology 2 domain-containing transforming protein C1
Alias: Shc, ShcA, p66, p66shc, SHC-transforming protein 1, SH2 domain protein C1, SHC-transforming protein A, Src homology 2 domain-containing transforming protein 1 isoform p66
Species: mouse
Products:     Shc1

Top Publications

  1. Kavanaugh W, Pot D, Chin S, Deuter Reinhard M, Jefferson A, Norris F, et al. Multiple forms of an inositol polyphosphate 5-phosphatase form signaling complexes with Shc and Grb2. Curr Biol. 1996;6:438-45 pubmed
    b>Shc and Grb2 form a complex in cells in response to growth factor stimulation and link tyrosine kinases to Ras during the resulting signaling process...
  2. Camici G, Schiavoni M, Francia P, Bachschmid M, Martin Padura I, Hersberger M, et al. Genetic deletion of p66(Shc) adaptor protein prevents hyperglycemia-induced endothelial dysfunction and oxidative stress. Proc Natl Acad Sci U S A. 2007;104:5217-22 pubmed
    ..The p66(Shc) adaptor protein controls cellular responses to oxidative stress...
  3. Capitani N, Lucherini O, Sozzi E, Ferro M, Giommoni N, Finetti F, et al. Impaired expression of p66Shc, a novel regulator of B-cell survival, in chronic lymphocytic leukemia. Blood. 2010;115:3726-36 pubmed publisher
    ..Here, we show that the Shc family adapter p66Shc uncouples the B-cell receptor (BCR) from the Erk- and Akt-dependent survival pathways, thereby enhancing B-cell ..
  4. Berniakovich I, Trinei M, Stendardo M, Migliaccio E, Minucci S, Bernardi P, et al. p66Shc-generated oxidative signal promotes fat accumulation. J Biol Chem. 2008;283:34283-93 pubmed publisher
    ..We investigated the effects of ROS on insulin signaling using as model system the p66(Shc)-null mice. p66(Shc) is a redox enzyme that generates mitochondrial ROS and promotes aging in mammals...
  5. Koch O, Fusco S, Ranieri S, Maulucci G, Palozza P, Larocca L, et al. Role of the life span determinant P66(shcA) in ethanol-induced liver damage. Lab Invest. 2008;88:750-60 pubmed publisher
    ..was much more pronounced in p66KO versus wild-type isolated liver cells, and blunted in HepG2 cells overexpressing p66shc. p66 overexpression also prevented the activation of a luciferase reporter gene controlled by the SOD2 promoter, ..
  6. Arany I, Faisal A, Nagamine Y, Safirstein R. p66shc inhibits pro-survival epidermal growth factor receptor/ERK signaling during severe oxidative stress in mouse renal proximal tubule cells. J Biol Chem. 2008;283:6110-7 pubmed publisher
    ..Studies have shown that the tyrosine-phosphorylated p46/52 isoforms of the ShcA family of adaptor proteins connect the activated EGFR to activation of Ras and ERK, whereas the p66(shc) isoform ..
  7. Martin Padura I, de Nigris F, Migliaccio E, Mansueto G, Minardi S, Rienzo M, et al. p66Shc deletion confers vascular protection in advanced atherosclerosis in hypercholesterolemic apolipoprotein E knockout mice. Endothelium. 2008;15:276-87 pubmed publisher
    ..Here, the authors have used hypercholesterolemic apolipoprotein E (ApoE(-/-)) mice to investigate the role of p66Shc deletion in advanced atheroma...
  8. Paneni F, Mocharla P, Akhmedov A, Costantino S, Osto E, Volpe M, et al. Gene silencing of the mitochondrial adaptor p66(Shc) suppresses vascular hyperglycemic memory in diabetes. Circ Res. 2012;111:278-89 pubmed publisher
    ..The present study investigated the role of mitochondrial adaptor p66(Shc) in this setting...
  9. Albiero M, Poncina N, Tjwa M, Ciciliot S, Menegazzo L, Ceolotto G, et al. Diabetes causes bone marrow autonomic neuropathy and impairs stem cell mobilization via dysregulated p66Shc and Sirt1. Diabetes. 2014;63:1353-65 pubmed publisher
    ..DAN increased the expression of the 66-kDa protein from the src homology and collagen homology domain (p66Shc) and reduced the expression of sirtuin 1 (Sirt1) in mice and humans...

More Information

Publications62

  1. Migliaccio E, Mele S, Salcini A, Pelicci G, Lai K, Superti Furga G, et al. Opposite effects of the p52shc/p46shc and p66shc splicing isoforms on the EGF receptor-MAP kinase-fos signalling pathway. EMBO J. 1997;16:706-16 pubmed
    ..We have isolated cDNAs encoding for a third Shc isoform, p66shc. The predicted amino acid sequence of p66shc overlaps that of p52shc and contains a unique N-terminal region which ..
  2. Woldt E, Matz R, Terrand J, Mlih M, Gracia C, Foppolo S, et al. Differential signaling by adaptor molecules LRP1 and ShcA regulates adipogenesis by the insulin-like growth factor-1 receptor. J Biol Chem. 2011;286:16775-82 pubmed publisher
    ..Its cytoplasmic domain serves as docking sites for several adaptor proteins such as the Src homology 2/?-collagen (ShcA), which also binds to several tyrosine kinase receptors such as the insulin-like growth factor 1 (IGF-1) receptor...
  3. Pinton P, Rimessi A, Marchi S, Orsini F, Migliaccio E, Giorgio M, et al. Protein kinase C beta and prolyl isomerase 1 regulate mitochondrial effects of the life-span determinant p66Shc. Science. 2007;315:659-63 pubmed
    The 66-kilodalton isoform of the growth factor adapter Shc (p66Shc) translates oxidative damage into cell death by acting as reactive oxygen species (ROS) producer within mitochondria...
  4. Trinei M, Giorgio M, Cicalese A, Barozzi S, Ventura A, Migliaccio E, et al. A p53-p66Shc signalling pathway controls intracellular redox status, levels of oxidation-damaged DNA and oxidative stress-induced apoptosis. Oncogene. 2002;21:3872-8 pubmed
    ..We investigated their mechanistic connections in p66Shc knockout mice, which are characterized by increased resistance to oxidative stress and extended life span...
  5. Di Stefano V, Cencioni C, Zaccagnini G, Magenta A, Capogrossi M, Martelli F. p66ShcA modulates oxidative stress and survival of endothelial progenitor cells in response to high glucose. Cardiovasc Res. 2009;82:421-9 pubmed publisher
    ..p66ShcA deletion rescues the BM-derived EPCs defect induced by HG, indicating p66ShcA as a potential therapeutic target in diabetic vasculopathy. ..
  6. Tomilov A, Ramsey J, Hagopian K, Giorgio M, Kim K, Lam A, et al. The Shc locus regulates insulin signaling and adiposity in mammals. Aging Cell. 2011;10:55-65 pubmed publisher
    Longevity of a p66Shc knockout strain (ShcP) was previously attributed to increased stress resistance and altered mitochondria. Microarrays of ShcP tissues indicated alterations in insulin signaling...
  7. Ranieri S, Fusco S, Panieri E, Labate V, Mele M, Tesori V, et al. Mammalian life-span determinant p66shcA mediates obesity-induced insulin resistance. Proc Natl Acad Sci U S A. 2010;107:13420-5 pubmed publisher
    ..Biochemical studies revealed that p66shc promotes the signal-inhibitory phosphorylation of the major insulin transducer IRS-1, by bridging IRS-1 and the ..
  8. McFarland K, Wilkes S, Koss S, Ravichandran K, Mandell J. Neural-specific inactivation of ShcA results in increased embryonic neural progenitor apoptosis and microencephaly. J Neurosci. 2006;26:7885-97 pubmed
    ..another approach with the same nestin-Cre transgene, conditional deletion of ShcA in mice with a homozygous floxed shc1 locus also showed a similar microencephaly phenotype...
  9. Smith W, Norton D, Gorospe M, Jiang H, Nemoto S, Holbrook N, et al. Phosphorylation of p66Shc and forkhead proteins mediates Abeta toxicity. J Cell Biol. 2005;169:331-9 pubmed
    ..Given the lessened susceptibility to oxidative stress exhibited by mice lacking p66Shc, we investigated the role of p66Shc in Abeta toxicity...
  10. Gertz M, Fischer F, Wolters D, Steegborn C. Activation of the lifespan regulator p66Shc through reversible disulfide bond formation. Proc Natl Acad Sci U S A. 2008;105:5705-9 pubmed publisher
    ..An important protection against these failures is cellular apoptosis, which can be induced by p66(Shc) in response to cellular stress...
  11. Hardy W, Li L, Wang Z, Sedy J, Fawcett J, Frank E, et al. Combinatorial ShcA docking interactions support diversity in tissue morphogenesis. Science. 2007;317:251-6 pubmed
    Changes in protein-protein interactions may allow polypeptides to perform unexpected regulatory functions. Mammalian ShcA docking proteins have amino-terminal phosphotyrosine (pTyr) binding (PTB) and carboxyl-terminal Src homology 2 (SH2) ..
  12. Francia P, Delli Gatti C, Bachschmid M, Martin Padura I, Savoia C, Migliaccio E, et al. Deletion of p66shc gene protects against age-related endothelial dysfunction. Circulation. 2004;110:2889-95 pubmed
    ..The p66shc protein controls cellular responses to oxidative stress...
  13. Schmandt R, Liu S, McGlade C. Cloning and characterization of mPAL, a novel Shc SH2 domain-binding protein expressed in proliferating cells. Oncogene. 1999;18:1867-79 pubmed
    b>Shc adaptor proteins play a role in linking activated cell surface receptors to the Ras signaling pathway in response to receptor mediated tyrosine kinase activation...
  14. Arany I, Faisal A, Clark J, Vera T, Baliga R, Nagamine Y. p66SHC-mediated mitochondrial dysfunction in renal proximal tubule cells during oxidative injury. Am J Physiol Renal Physiol. 2010;298:F1214-21 pubmed publisher
    ..The p66shc adaptor protein is a newly recognized mediator of mitochondrial dysfunction, which might play a role in AKI-..
  15. Tomilov A, Bicocca V, Schoenfeld R, Giorgio M, Migliaccio E, Ramsey J, et al. Decreased superoxide production in macrophages of long-lived p66Shc knock-out mice. J Biol Chem. 2010;285:1153-65 pubmed publisher
    ..Mice deficient in the p66Shc gene are long-lived, and their cells are both resistant to oxidative stress and produce less ROS...
  16. Zaccagnini G, Martelli F, Fasanaro P, Magenta A, Gaetano C, Di Carlo A, et al. p66ShcA modulates tissue response to hindlimb ischemia. Circulation. 2004;109:2917-23 pubmed
    Oxidative stress plays a pivotal role in ischemia and ischemia/reperfusion injury. Because p66(ShcA)-null (p66(ShcA)-/-) mice exhibit both lower levels of intracellular reactive oxygen species and increased resistance to cell death ..
  17. Trampont P, Zhang L, Ravichandran K. ShcA mediates the dominant pathway to extracellular signal-regulated kinase activation during early thymic development. Mol Cell Biol. 2006;26:9035-44 pubmed
    ..Here, using mice with a conditional loss of the shc1 gene or expressing mutants of ShcA, we demonstrate that the adapter protein ShcA is responsible for up to 70% of ..
  18. Ramshaw H, Guthridge M, Stomski F, Barry E, Ooms L, Mitchell C, et al. The Shc-binding site of the betac subunit of the GM-CSF/IL-3/IL-5 receptors is a negative regulator of hematopoiesis. Blood. 2007;110:3582-90 pubmed
    ..We show here that despite the known action of Tyr577 in beta(c) to recruit Shc-PI-3 kinase (PI3K) pathway members, Tyr577 plays, surprisingly, a negative regulatory role in cell function, and ..
  19. Nemoto S, Finkel T. Redox regulation of forkhead proteins through a p66shc-dependent signaling pathway. Science. 2002;295:2450-2 pubmed
    ..of longevity include the forkhead-related transcription factor DAF-16 in the worm Caenorhabditis elegans and the p66shc locus in mice...
  20. Luzi L, Confalonieri S, Di Fiore P, Pelicci P. Evolution of Shc functions from nematode to human. Curr Opin Genet Dev. 2000;10:668-74 pubmed
    ..indicates that the mammalian Shc isoforms regulate functions as diverse as growth (p52/p46Shc), apoptosis (p66Shc) and life-span (p66Shc)...
  21. Kao A, Waters S, Okada S, Pessin J. Insulin stimulates the phosphorylation of the 66- and 52-kilodalton Shc isoforms by distinct pathways. Endocrinology. 1997;138:2474-80 pubmed
    In contrast to the 52-kDa Shc isoform, insulin stimulation caused a quantitative, time-dependent decrease in the SDS-PAGE mobility of 66-kDa Shc in both Chinese hamster ovary/IR cells and 3T3L1 adipocytes...
  22. Zheng Y, Zhang C, Croucher D, Soliman M, St Denis N, Pasculescu A, et al. Temporal regulation of EGF signalling networks by the scaffold protein Shc1. Nature. 2013;499:166-71 pubmed publisher
    ..Activated receptor tyrosine kinases, for example, engage scaffolds such as Shc1 that contain phosphotyrosine (pTyr)-binding (PTB) domains...
  23. Finetti F, Pellegrini M, Ulivieri C, Savino M, Paccagnini E, Ginanneschi C, et al. The proapoptotic and antimitogenic protein p66SHC acts as a negative regulator of lymphocyte activation and autoimmunity. Blood. 2008;111:5017-27 pubmed publisher
    ..Among these, p66Shc inhibits TCR coupling to the Ras/MAPK pathway and primes T cells to undergo apoptotic death...
  24. Haga S, Terui K, Fukai M, Oikawa Y, Irani K, Furukawa H, et al. Preventing hypoxia/reoxygenation damage to hepatocytes by p66(shc) ablation: up-regulation of anti-oxidant and anti-apoptotic proteins. J Hepatol. 2008;48:422-32 pubmed publisher
    ..Major mechanisms for this certainly include oxidative stress. The effects of ablating the p66 isoform of ShcA (p66(shc)) on hypoxia/reoxygenation (H/R)-induced oxidative stress and cell injury in hepatocytes were investigated...
  25. Giorgio M, Berry A, Berniakovich I, Poletaeva I, Trinei M, Stendardo M, et al. The p66Shc knocked out mice are short lived under natural condition. Aging Cell. 2012;11:162-8 pubmed publisher
    Deletion of the p66(Shc) gene results in lean and healthy mice, retards aging, and protects from aging-associated diseases, raising the question of why p66(Shc) has been selected, and what is its physiological role...
  26. Ulivieri C, Fanigliulo D, Masi G, Savino M, Gamberucci A, Pelicci P, et al. p66Shc is a negative regulator of Fc?RI-dependent signaling in mast cells. J Immunol. 2011;186:5095-106 pubmed publisher
    ..Conversely, p66Shc was shown to uncouple the TCR for the Ras-MAPK pathway and prime T cells to undergo apoptotic death...
  27. Orsini F, Moroni M, Contursi C, Yano M, Pelicci P, Giorgio M, et al. Regulatory effects of the mitochondrial energetic status on mitochondrial p66Shc. Biol Chem. 2006;387:1405-10 pubmed
    b>p66(Shc) promotes apoptosis and controls the intracellular redox balance...
  28. Berry A, Capone F, Giorgio M, Pelicci P, de Kloet E, Alleva E, et al. Deletion of the life span determinant p66Shc prevents age-dependent increases in emotionality and pain sensitivity in mice. Exp Gerontol. 2007;42:37-45 pubmed
    ..Previous studies have determined that mice with a targeted mutation of the p66(Shc) gene show reduced oxidative stress and extended life span...
  29. Nemoto S, Combs C, French S, Ahn B, Fergusson M, Balaban R, et al. The mammalian longevity-associated gene product p66shc regulates mitochondrial metabolism. J Biol Chem. 2006;281:10555-60 pubmed
    Previous studies have determined that mice with a homozygous deletion in the adapter protein p66(shc) have an extended life span and that cells derived from these mice exhibit lower levels of reactive oxygen species...
  30. Capitani N, Patrussi L, Trentin L, Lucherini O, Cannizzaro E, Migliaccio E, et al. S1P1 expression is controlled by the pro-oxidant activity of p66Shc and is impaired in B-CLL patients with unfavorable prognosis. Blood. 2012;120:4391-9 pubmed publisher
    ..We provide evidence herein that p66Shc, a Shc adaptor family member the deficiency of which is implicated in the apoptosis defects of CLL B cells, ..
  31. Carpi A, Menabò R, Kaludercic N, Pelicci P, Di Lisa F, Giorgio M. The cardioprotective effects elicited by p66(Shc) ablation demonstrate the crucial role of mitochondrial ROS formation in ischemia/reperfusion injury. Biochim Biophys Acta. 2009;1787:774-80 pubmed publisher
    ..Besides a dysfunctional respiratory chain, other mitochondrial components, such as monoamine oxidase and p66(Shc), might be involved in oxidative stress...
  32. Su K, Savino C, Marracci G, Chaudhary P, Yu X, Morris B, et al. Genetic inactivation of the p66 isoform of ShcA is neuroprotective in a murine model of multiple sclerosis. Eur J Neurosci. 2012;35:562-71 pubmed publisher
    ..In this context, the role of the p66 isoform of ShcA protein (p66) may be significant...
  33. Ruff Jamison S, McGlade J, Pawson T, Chen K, Cohen S. Epidermal growth factor stimulates the tyrosine phosphorylation of SHC in the mouse. J Biol Chem. 1993;268:7610-2 pubmed
    ..We now report the identification of this receptor-associated protein as SHC. Immunoprecipitation and Western blotting analyses have revealed that SHC associates only with the activated EGFR...
  34. Rota M, LeCapitaine N, Hosoda T, Boni A, De Angelis A, Padin Iruegas M, et al. Diabetes promotes cardiac stem cell aging and heart failure, which are prevented by deletion of the p66shc gene. Circ Res. 2006;99:42-52 pubmed
    ..However, ablation of the p66shc gene prevents these negative adaptations of the CPC compartment, interfering with the acquisition of the heart ..
  35. Menini S, Amadio L, Oddi G, Ricci C, Pesce C, Pugliese F, et al. Deletion of p66Shc longevity gene protects against experimental diabetic glomerulopathy by preventing diabetes-induced oxidative stress. Diabetes. 2006;55:1642-50 pubmed
    p66(Shc) regulates both steady-state and environmental stress-dependent reactive oxygen species (ROS) generation. Its deletion was shown to confer resistance to oxidative stress and protect mice from aging-associated vascular disease...
  36. Khanday F, Santhanam L, Kasuno K, Yamamori T, Naqvi A, Dericco J, et al. Sos-mediated activation of rac1 by p66shc. J Cell Biol. 2006;172:817-22 pubmed
    ..We show that p66shc, an adaptor protein that promotes oxidative stress, increases the rac1-specific GEF activity of sos1, resulting in ..
  37. Napoli C, Martin Padura I, de Nigris F, Giorgio M, Mansueto G, Somma P, et al. Deletion of the p66Shc longevity gene reduces systemic and tissue oxidative stress, vascular cell apoptosis, and early atherogenesis in mice fed a high-fat diet. Proc Natl Acad Sci U S A. 2003;100:2112-6 pubmed
    ..Here, we have used p66(Shc-/-) and WT mice to investigate the effects of high-fat diet on both systemic and tissue oxidative stress and the ..
  38. Zhang L, Camerini V, Bender T, Ravichandran K. A nonredundant role for the adapter protein Shc in thymic T cell development. Nat Immunol. 2002;3:749-55 pubmed
    ..The role played by the adapter protein Shc in T cells has remained controversial, and its role in pre-TCR signaling has not been addressed...
  39. Menini S, Iacobini C, Ricci C, Oddi G, Pesce C, Pugliese F, et al. Ablation of the gene encoding p66Shc protects mice against AGE-induced glomerulopathy by preventing oxidant-dependent tissue injury and further AGE accumulation. Diabetologia. 2007;50:1997-2007 pubmed publisher
    ..ROS generation is regulated by the Src homology 2 domain-containing transforming protein C1 (Shc1) isoform p66(Shc), whose deletion has been shown to protect from tissue injury induced by ageing, diabetes, ..
  40. Lai K, Pawson T. The ShcA phosphotyrosine docking protein sensitizes cardiovascular signaling in the mouse embryo. Genes Dev. 2000;14:1132-45 pubmed
    The ShcA gene products have served as a model for the analysis of phosphotyrosine-recognition domains, and for the functions of docking proteins during tyrosine kinase signaling...
  41. Pelicci G, Lanfrancone L, McGlade J, Cavallo F, Forni G, Nicoletti I, et al. A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction. Cell. 1992;70:93-104 pubmed
    A new SH2-containing sequence, SHC, was isolated by screening cDNA libraries with SH2 representative DNA probes. The SHC cDNA is predicted to encode overlapping proteins of 46.8 and 51...
  42. Graiani G, Lagrasta C, Migliaccio E, Spillmann F, Meloni M, Madeddu P, et al. Genetic deletion of the p66Shc adaptor protein protects from angiotensin II-induced myocardial damage. Hypertension. 2005;46:433-40 pubmed
    ..In cultured vascular smooth muscle cells, this downstream mechanism comprises the p66Shc adaptor protein, previously recognized to play a role in vascular cell senescence and death...
  43. Pacini S, Pellegrini M, Migliaccio E, Patrussi L, Ulivieri C, Ventura A, et al. p66SHC promotes apoptosis and antagonizes mitogenic signaling in T cells. Mol Cell Biol. 2004;24:1747-57 pubmed
    Of the three Shc isoforms, p66Shc is responsible for fine-tuning p52/p46Shc signaling to Ras and has been implicated in apoptotic responses to oxidative stress...
  44. Lee M, Smith S, Banerjee M, Li C, Minoo P, Volpe M, et al. The p66Shc adapter protein regulates the morphogenesis and epithelial maturation of fetal mouse lungs. Am J Physiol Lung Cell Mol Physiol. 2014;306:L316-25 pubmed publisher
    ..The p66(Shc) isoform antagonizes proliferation, regulates oxidative stress, and mediates apoptosis...
  45. Migliaccio E, Giorgio M, Mele S, Pelicci G, Reboldi P, Pandolfi P, et al. The p66shc adaptor protein controls oxidative stress response and life span in mammals. Nature. 1999;402:309-13 pubmed
    ..Here we report that targeted mutation of the mouse p66shc gene induces stress resistance and prolongs life span. p66shc is a splice variant of p52shc/p46shc (ref...
  46. Ramsey J, Tran D, Giorgio M, Griffey S, Koehne A, Laing S, et al. The influence of Shc proteins on life span in mice. J Gerontol A Biol Sci Med Sci. 2014;69:1177-85 pubmed publisher
    The signaling molecule p66Shc is often described as a longevity protein. This conclusion is based on a single life span study that used a small number of mice...
  47. Borkowska A, Sielicka Dudzin A, Herman Antosiewicz A, Halon M, Wozniak M, Antosiewicz J. P66Shc mediated ferritin degradation--a novel mechanism of ROS formation. Free Radic Biol Med. 2011;51:658-63 pubmed publisher
    ..In this paper we demonstrate that DATS-induced ROS formation depends on p66Shc. In cells stably expressing a dominant negative mutant of p66Shc (p66ShcS36A), DATS did not induce ROS formation...
  48. Kumar S, Vikram A, Kim Y, S Jacobs J, Irani K. P66Shc mediates increased platelet activation and aggregation in hypercholesterolemia. Biochem Biophys Res Commun. 2014;449:496-501 pubmed publisher
    ..Platelet hyperactivity associated with hypercholesterolemia has been attributed, in part, to oxidative stress. P66Shc is a well-known determinant of cellular and organismal oxidative stress...
  49. Segatto O, Pelicci G, Giuli S, Digiesi G, Di Fiore P, McGlade J, et al. Shc products are substrates of erbB-2 kinase. Oncogene. 1993;8:2105-12 pubmed
    The shc genes encodes three widely expressed proteins of 46, 52 and 66 kDa. Overexpression of p46shc and p52shc in NIH3T3 fibroblasts induces a tumorigenic phenotype...
  50. Lucas D, Rohrschneider L. A novel spliced form of SH2-containing inositol phosphatase is expressed during myeloid development. Blood. 1999;93:1922-33 pubmed
    ..both 145 and 135 kD SHIP forms were tyrosine phosphorylated and could be coimmunoprecipitated with antibodies to Shc and Grb2. However, experiments showed only a weak association of 135 kD SHIP with p85...
  51. Kojima T, Yoshikawa Y, Takada S, Sato M, Nakamura T, Takahashi N, et al. Genomic organization of the Shc-related phosphotyrosine adapters and characterization of the full-length Sck/ShcB: specific association of p68-Sck/ShcB with pp135. Biochem Biophys Res Commun. 2001;284:1039-47 pubmed
    The Shc gene family is an emerging family, containing at least three members designated Shc/ShcA, Sck/Sli/ShcB, N-Shc/Rai/ShcC in mammals. In this study, we determined the genomic organization of the mouse Shc family...
  52. Artemenko Y, Gagnon A, Ibrahim S, Sorisky A. Regulation of PDGF-stimulated SHIP2 tyrosine phosphorylation and association with Shc in 3T3-L1 preadipocytes. J Cell Physiol. 2007;211:598-607 pubmed
    ..PDGF, but not insulin, stimulates SHIP2 tyrosine phosphorylation and its association with Shc in human and 3T3-L1 preadipocytes...
  53. Bock F, Shahzad K, Wang H, Stoyanov S, Wolter J, Dong W, et al. Activated protein C ameliorates diabetic nephropathy by epigenetically inhibiting the redox enzyme p66Shc. Proc Natl Acad Sci U S A. 2013;110:648-53 pubmed publisher
    ..and exogenous aPC prevents glomerular accumulation of oxidative stress markers and of the redox-regulating protein p66(Shc) in experimental diabetic nephropathy. These effects were predominately observed in podocytes...