Gene Symbol: Shb
Description: src homology 2 domain-containing transforming protein B
Alias: BC028832, SH2 domain-containing adapter protein B
Species: mouse
Products:     Shb

Top Publications

  1. Welsh M, Mares J, Karlsson T, Lavergne C, Breant B, Claesson Welsh L. Shb is a ubiquitously expressed Src homology 2 protein. Oncogene. 1994;9:19-27 pubmed
    ..containing a motif with strong homology to Src homology 2 (SH2) domains was found using this procedure and called Shb. The Shb cDNA contains two methionine codons in its N-terminus and thus may code for two proteins of 67 and 56 kDa, ..
  2. Calounova G, Livera G, Zhang X, Liu K, Gosden R, Welsh M. The Src homology 2 domain-containing adapter protein B (SHB) regulates mouse oocyte maturation. PLoS ONE. 2010;5:e11155 pubmed publisher
    b>SHB (Src homology 2 domain-containing adapter protein B) is involved in receptor tyrosine kinase signaling...
  3. Gustafsson K, Heffner G, Wenzel P, Curran M, Grawe J, McKinney Freeman S, et al. The Src homology 2 protein Shb promotes cell cycle progression in murine hematopoietic stem cells by regulation of focal adhesion kinase activity. Exp Cell Res. 2013;319:1852-64 pubmed publisher
    The widely expressed adaptor protein Shb has previously been reported to contribute to T cell function due to its association with the T cell receptor and furthermore, several of Shb's known interaction partners are established ..
  4. Akerblom B, Barg S, Calounova G, Mokhtari D, Jansson L, Welsh M. Impaired glucose homeostasis in Shb-/- mice. J Endocrinol. 2009;203:271-9 pubmed publisher
    Src homology 2 domain-containing protein B (SHB) is an adapter protein involved in the regulation of beta-cell and endothelial cell function...
  5. Funa N, Kriz V, Zang G, Calounova G, Akerblom B, Mares J, et al. Dysfunctional microvasculature as a consequence of shb gene inactivation causes impaired tumor growth. Cancer Res. 2009;69:2141-8 pubmed publisher
    b>Shb (Src homology 2 protein B) is an adapter protein downstream of the vascular endothelial growth factor receptor receptor-2 (VEGFR-2). Previous experiments have suggested a role for Shb in endothelial cell function...
  6. Kriz V, Agren N, Lindholm C, Lenell S, Saldeen J, Mares J, et al. The SHB adapter protein is required for normal maturation of mesoderm during in vitro differentiation of embryonic stem cells. J Biol Chem. 2006;281:34484-91 pubmed
    ..b>SHB (Src homology 2 protein in beta-cells) is an adapter protein previously found to be involved in ES cell ..
  7. Kriz V, Mares J, Wentzel P, Funa N, Calounova G, Zhang X, et al. Shb null allele is inherited with a transmission ratio distortion and causes reduced viability in utero. Dev Dyn. 2007;236:2485-92 pubmed
    b>SHB is an Src homology 2 domain-containing adapter protein that has been found to be involved in numerous cellular responses. We have generated an Shb knockout mouse...
  8. Funa N, Saldeen J, Akerblom B, Welsh M. Interdependent fibroblast growth factor and activin A signaling promotes the expression of endodermal genes in differentiating mouse embryonic stem cells expressing Src Homology 2-domain inactive Shb. Differentiation. 2008;76:443-53 pubmed
    ..b>Shb is a Src homology 2 (SH2) domain-containing adapter protein that has been implicated in FGF receptor 1 (FGFR1) ..
  9. Gustafsson K, Calounova G, Hjelm F, Kriz V, Heyman B, Grönvik K, et al. Shb deficient mice display an augmented TH2 response in peripheral CD4+ T cells. BMC Immunol. 2011;12:3 pubmed publisher
    b>Shb, a ubiquitously expressed Src homology 2 domain-containing adaptor protein has previously been implicated in the signaling of various tyrosine kinase receptors including the TCR...

More Information


  1. Mokhtari D, Kerblom B, Mehmeti I, Wang X, Funa N, Olerud J, et al. Increased Hsp70 expression attenuates cytokine-induced cell death in islets of Langerhans from Shb knockout mice. Biochem Biophys Res Commun. 2009;387:553-7 pubmed publisher
    ..beta-cell death and therefore the current investigation was performed in order to elucidate this response in Shb-deficient islets...
  2. Rolny C, Lu L, Agren N, Nilsson I, Roe C, Webb G, et al. Shb promotes blood vessel formation in embryoid bodies by augmenting vascular endothelial growth factor receptor-2 and platelet-derived growth factor receptor-beta signaling. Exp Cell Res. 2005;308:381-93 pubmed
    ..b>Shb is an adaptor protein previously implicated in the angiogenic response to vascular endothelial growth factor (VEGF)...
  3. Funa N, Reddy K, Bhandarkar S, Kurenova E, Yang L, Cance W, et al. Shb gene knockdown increases the susceptibility of SVR endothelial tumor cells to apoptotic stimuli in vitro and in vivo. J Invest Dermatol. 2008;128:710-6 pubmed
    The Shb adapter protein is an Src homology 2-domain containing signaling intermediate operating downstream of several tyrosine kinase receptors, including vascular endothelial growth factor receptor-2...
  4. Annerén C. Dual role of the tyrosine kinase GTK and the adaptor protein SHB in beta-cell growth: enhanced beta-cell replication after 60% pancreatectomy and increased sensitivity to streptozotocin. J Endocrinol. 2002;172:145-53 pubmed
    Transgenic CBA mice expressing either the tyrosine kinase GTK (gut tyrosine kinase) or the adaptor protein SHB (Src homology 2 protein of beta-cells) under the control of the rat insulin promoter exhibited an increased beta-cell mass, ..
  5. Christoffersson G, Zang G, Zhuang Z, Vågesjö E, Simons M, Phillipson M, et al. Vascular adaptation to a dysfunctional endothelium as a consequence of Shb deficiency. Angiogenesis. 2012;15:469-80 pubmed publisher
    ..The Shb adapter protein has previously been found to relay certain VEGFR-2 dependent signals and consequently vascular ..
  6. Xu J, Yu W, Jan Y, Jan L, Li M. Assembly of voltage-gated potassium channels. Conserved hydrophilic motifs determine subfamily-specific interactions between the alpha-subunits. J Biol Chem. 1995;270:24761-8 pubmed
    ..These subfamily-specific associations suggest a molecular basis for the selective formation of heteromultimeric channels in vivo. ..
  7. Gustafsson K, Willebrand E, Welsh M. Absence of the adaptor protein Shb potentiates the T helper type 2 response in a mouse model of atopic dermatitis. Immunology. 2014;143:33-41 pubmed publisher
    ..The Src homology domain protein B (Shb) adaptor protein was recently implicated as a regulator of Th cell differentiation...
  8. Lavergne C, Mares J, Karlsson T, Breant B, Welsh M. Control of SHB gene expression by protein phosphorylation. Cell Signal. 1996;8:55-8 pubmed
    To increase our understanding of the role of the Src homology 2 (SH2) domain-containing protein Shb in the mitogenic signal transduction, Shb mRNA contents were determined in the fibroblast-like NIH3T3 cells and the insulin producing ..
  9. Zang G, Gustafsson K, Jamalpour M, Hong J, Genové G, Welsh M. Vascular dysfunction and increased metastasis of B16F10 melanomas in Shb deficient mice as compared with their wild type counterparts. BMC Cancer. 2015;15:234 pubmed publisher
    b>Shb is a signaling protein downstream of vascular endothelial growth factor receptor-2 and Shb deficiency has been found to restrict tumor angiogenesis...
  10. Akerblom B, Zang G, Zhuang Z, Calounova G, Simons M, Welsh M. Heterogeneity among RIP-Tag2 insulinomas allows vascular endothelial growth factor-A independent tumor expansion as revealed by studies in Shb mutant mice: implications for tumor angiogenesis. Mol Oncol. 2012;6:333-46 pubmed publisher
    The Shb adapter protein is a signaling intermediate that operates downstream of vascular endothelial growth factor receptor-2 (VEGFR-2) in endothelial cells...
  11. Nikpour M, Gustafsson K, Vågesjö E, Seignez C, Giraud A, Phillipson M, et al. Shb deficiency in endothelium but not in leucocytes is responsible for impaired vascular performance during hindlimb ischaemia. Acta Physiol (Oxf). 2015;214:200-9 pubmed publisher
    Myeloid cells have been suggested to participate in angiogenesis and regulation of vascular function. Shb-deficient mice display both vascular and myeloid cell abnormalities with possible consequences for recovery after hindlimb ..
  12. Holmqvist K, Cross M, Riley D, Welsh M. The Shb adaptor protein causes Src-dependent cell spreading and activation of focal adhesion kinase in murine brain endothelial cells. Cell Signal. 2003;15:171-9 pubmed
    ..We have investigated the role of the adaptor protein Shb in cell spreading and the regulation of FAK phosphorylation in immortalised brain endothelial (IBE) cells...
  13. Cross M, Lu L, Magnusson P, Nyqvist D, Holmqvist K, Welsh M, et al. The Shb adaptor protein binds to tyrosine 766 in the FGFR-1 and regulates the Ras/MEK/MAPK pathway via FRS2 phosphorylation in endothelial cells. Mol Biol Cell. 2002;13:2881-93 pubmed
    ..We report that the adaptor protein Shb is also able to bind tyrosine 766 in the FGFR-1, via its SH2 domain, resulting in its subsequent phosphorylation...
  14. Gustafsson K, Jamalpour M, Trinh C, Kharas M, Welsh M. The Src homology-2 protein Shb modulates focal adhesion kinase signaling in a BCR-ABL myeloproliferative disorder causing accelerated progression of disease. J Hematol Oncol. 2014;7:45 pubmed publisher
    The Src homology-2 domain protein B (Shb) is an adapter protein operating downstream of several tyrosine kinase receptors and consequently Shb regulates various cellular responses...
  15. Alenkvist I, Dyachok O, Tian G, Li J, Mehrabanfar S, Jin Y, et al. Absence of Shb impairs insulin secretion by elevated FAK activity in pancreatic islets. J Endocrinol. 2014;223:267-75 pubmed publisher
    The Src homology-2 domain containing protein B (SHB) has previously been shown to function as a pleiotropic adapter protein, conveying signals from receptor tyrosine kinases to intracellular signaling intermediates...