Gene Symbol: Sgkl
Description: serum/glucocorticoid regulated kinase 2
Alias: AI098171, AW146006, Sgkl, serine/threonine-protein kinase Sgk2
Pao A, Bhargava A, Di Sole F, Quigley R, Shao X, Wang J, et al
. Expression and role of serum and glucocorticoid-regulated kinase 2 in the regulation of Na+/H+ exchanger 3 in the mammalian kidney. Am J Physiol Renal Physiol. 2010;299:F1496-506 pubmed publisher
Masujin K, Okada T, Tsuji T, Ishii Y, Takano K, Matsuda J, et al
. A mutation in the serum and glucocorticoid-inducible kinase-like kinase (Sgkl) gene is associated with defective hair growth in mice. DNA Res. 2004;11:371-9 pubmed
..Sequence analysis revealed a single C-to-A nucleotide substitution at nucleotide 1382 in the Sgkl gene, causing a nonsense mutation at codon 461...
Loffing J, Flores S, Staub O. Sgk kinases and their role in epithelial transport. Annu Rev Physiol. 2006;68:461-90 pubmed
..In this review we first discuss the molecular, cellular, and regulatory aspects of Sgk1 and its paralogs. We then discuss its roles in the physiology and pathophysiology of epithelial ion transport. ..
Shalom Barak T, Zhang X, Chu T, Timothy Schaiff W, Reddy J, Xu J, et al
. Placental PPAR? regulates spatiotemporally diverse genes and a unique metabolic network. Dev Biol. 2012;372:143-55 pubmed publisher
..These findings offer insights not only into the placental functions of PPAR?, but also into unique, previously unsuspected biosynthetic functions of trophoblasts. ..
Kobayashi T, Deak M, Morrice N, Cohen P. Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinase. Biochem J. 1999;344 Pt 1:189-97 pubmed
..Like PKB and SGK1, SGK2 and SGK3 preferentially phosphorylate Ser and Thr residues that lie in Arg-Xaa-Arg-Xaa-Xaa-Ser/Thr motifs. ..