Sgkl

Summary

Gene Symbol: Sgkl
Description: serum/glucocorticoid regulated kinase 2
Alias: AI098171, AW146006, Sgkl, serine/threonine-protein kinase Sgk2, serum/glucocorticoid-regulated kinase 2
Species: mouse

Top Publications

  1. pmc Expression and role of serum and glucocorticoid-regulated kinase 2 in the regulation of Na+/H+ exchanger 3 in the mammalian kidney
    Alan C Pao
    Div of Nephrology, Dept of Medicine, Stanford Univ, 780 Welch Rd, Suite 106, Palo Alto, CA 94304, USA
    Am J Physiol Renal Physiol 299:F1496-506. 2010
  2. pmc Placental PPARγ regulates spatiotemporally diverse genes and a unique metabolic network
    Tali Shalom-Barak
    Magee Womens Research Institute, Department of OBGYN and Reproductive Sciences, University of Pittsburgh, 204 Craft Avenue, Pittsburgh, PA 15213, USA
    Dev Biol 372:143-55. 2012
  3. pmc Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinase
    T Kobayashi
    MRC Protein Phosphorylation Unit, Department of Biochemistry, MSI WTB complex, Dow Street, University of Dundee, Dundee DD1 5EH, Scotland, U K
    Biochem J 344:189-97. 1999
  4. ncbi A mutation in the serum and glucocorticoid-inducible kinase-like kinase (Sgkl) gene is associated with defective hair growth in mice
    Kentaro Masujin
    Graduate School of Natural Science and Technology, Okayama University, Tsushima Naka, Okayama, 700 8530, Japan
    DNA Res 11:371-9. 2004
  5. ncbi Sgk kinases and their role in epithelial transport
    Johannes Loffing
    Department of Medicine Unit of Anatomy, University of Fribourg, CH 1700 Fribourg, Switzerland
    Annu Rev Physiol 68:461-90. 2006

Scientific Experts

  • Johannes Loffing
  • Alan C Pao
  • Tali Shalom-Barak
  • Kentaro Masujin
  • Xiaowen Zhang
  • Tianjiao Chu
  • Janardan K Reddy
  • W Timothy Schaiff
  • Jianming Xu
  • Yoel Sadovsky
  • Yaacov Barak
  • T Kobayashi
  • Junichiro Matsuda
  • Atsuo Ogura
  • Tetsuo Kunieda
  • Taro Okada
  • Takehito Tsuji
  • Kaoru Takano
  • Yoshiyuki Ishii
  • P Cohen
  • N Morrice
  • M Deak

Detail Information

Publications5

  1. pmc Expression and role of serum and glucocorticoid-regulated kinase 2 in the regulation of Na+/H+ exchanger 3 in the mammalian kidney
    Alan C Pao
    Div of Nephrology, Dept of Medicine, Stanford Univ, 780 Welch Rd, Suite 106, Palo Alto, CA 94304, USA
    Am J Physiol Renal Physiol 299:F1496-506. 2010
    ....
  2. pmc Placental PPARγ regulates spatiotemporally diverse genes and a unique metabolic network
    Tali Shalom-Barak
    Magee Womens Research Institute, Department of OBGYN and Reproductive Sciences, University of Pittsburgh, 204 Craft Avenue, Pittsburgh, PA 15213, USA
    Dev Biol 372:143-55. 2012
    ..These findings offer insights not only into the placental functions of PPARγ, but also into unique, previously unsuspected biosynthetic functions of trophoblasts...
  3. pmc Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinase
    T Kobayashi
    MRC Protein Phosphorylation Unit, Department of Biochemistry, MSI WTB complex, Dow Street, University of Dundee, Dundee DD1 5EH, Scotland, U K
    Biochem J 344:189-97. 1999
    ..Like PKB and SGK1, SGK2 and SGK3 preferentially phosphorylate Ser and Thr residues that lie in Arg-Xaa-Arg-Xaa-Xaa-Ser/Thr motifs...
  4. ncbi A mutation in the serum and glucocorticoid-inducible kinase-like kinase (Sgkl) gene is associated with defective hair growth in mice
    Kentaro Masujin
    Graduate School of Natural Science and Technology, Okayama University, Tsushima Naka, Okayama, 700 8530, Japan
    DNA Res 11:371-9. 2004
    ..Sequence analysis revealed a single C-to-A nucleotide substitution at nucleotide 1382 in the Sgkl gene, causing a nonsense mutation at codon 461...
  5. ncbi Sgk kinases and their role in epithelial transport
    Johannes Loffing
    Department of Medicine Unit of Anatomy, University of Fribourg, CH 1700 Fribourg, Switzerland
    Annu Rev Physiol 68:461-90. 2006
    ..In this review we first discuss the molecular, cellular, and regulatory aspects of Sgk1 and its paralogs. We then discuss its roles in the physiology and pathophysiology of epithelial ion transport...

Research Grants2

  1. The Functional Role of the PXL Domain of SGK1 in Epithelial Sodium Transport
    ALAN PAO; Fiscal Year: 2007
    ..UCSF offers the scientific expertise and the technical resources to provide an ideal environment for preparing this candidate for a successful career as a physician-scientist. ..