Sgk1

Summary

Gene Symbol: Sgk1
Description: serum/glucocorticoid regulated kinase 1
Alias: Sgk, serine/threonine-protein kinase Sgk1, serum and glucocorticoid-dependent protein kinase
Species: mouse
Products:     Sgk1

Top Publications

  1. Rexhepaj R, Artunc F, Grahammer F, Nasir O, Sandu C, Friedrich B, et al. SGK1 is not required for regulation of colonic ENaC activity. Pflugers Arch. 2006;453:97-105 pubmed
    The serum and glucocorticoid-inducible kinase SGK1 is known to be upregulated by mineralocorticoids and to enhance ENaC activity in several expression systems...
  2. Arteaga M, Alvarez de la Rosa D, Alvarez J, Canessa C. Multiple translational isoforms give functional specificity to serum- and glucocorticoid-induced kinase 1. Mol Biol Cell. 2007;18:2072-80 pubmed
    ..We report that a single SGK1 mRNA produces isoforms with different N-termini owing to alternative translation initiation...
  3. Wang K, Gu S, Nasir O, Foller M, Ackermann T, Klingel K, et al. SGK1-dependent intestinal tumor growth in APC-deficient mice. Cell Physiol Biochem. 2010;25:271-8 pubmed publisher
    ..beta-catenin upregulates the serum- and glucocorticoid-inducible kinase Sgk1, which inhibits GSK3beta. The present study explored the role of SGK1 in tumor growth of apc(Min/+)mice...
  4. Sakoda H, Gotoh Y, Katagiri H, Kurokawa M, Ono H, Onishi Y, et al. Differing roles of Akt and serum- and glucocorticoid-regulated kinase in glucose metabolism, DNA synthesis, and oncogenic activity. J Biol Chem. 2003;278:25802-7 pubmed
    Serum- and glucocorticoid-regulated kinase (SGK) is a serine kinase that has a catalytic domain homologous to that of Akt, but lacks the pleckstrin homology domain present in Akt...
  5. Miranda P, Cadaveira Mosquera A, González Montelongo R, Villarroel A, Gonzalez Hernandez T, Lamas J, et al. The neuronal serum- and glucocorticoid-regulated kinase 1.1 reduces neuronal excitability and protects against seizures through upregulation of the M-current. J Neurosci. 2013;33:2684-96 pubmed publisher
    ..In Xenopus laevis oocytes, an increase in Kv7.2/3 function by the serum- and glucocorticoid-regulated kinase 1 (SGK1) has been reported previously (Schuetz et al., 2008). We now show that the neuronal isoform of this kinase (SGK1...
  6. Arteaga M, Wang L, Ravid T, Hochstrasser M, Canessa C. An amphipathic helix targets serum and glucocorticoid-induced kinase 1 to the endoplasmic reticulum-associated ubiquitin-conjugation machinery. Proc Natl Acad Sci U S A. 2006;103:11178-83 pubmed
    Serum- and glucocorticoid-induced kinase 1 (Sgk1) regulates many ion channels and transporters in epithelial cells and promotes cell survival under stress conditions...
  7. Fejes Toth G, Frindt G, NARAY FEJES TOTH A, Palmer L. Epithelial Na+ channel activation and processing in mice lacking SGK1. Am J Physiol Renal Physiol. 2008;294:F1298-305 pubmed publisher
    Amiloride-sensitive Na(+) channel activity was examined in the cortical collecting ducts of a mouse line (SGK1(-/-)) deficient in the serum- and glucocorticoid-dependent protein kinase SGK1...
  8. Hong F, LARREA M, Doughty C, Kwiatkowski D, Squillace R, Slingerland J. mTOR-raptor binds and activates SGK1 to regulate p27 phosphorylation. Mol Cell. 2008;30:701-11 pubmed publisher
    The cell-cycle effects of mTORC1 are not fully understood. We provide evidence that mTOR-raptor phosphorylates SGK1 to modulate p27 function...
  9. Murray J, Campbell D, Morrice N, Auld G, Shpiro N, Marquez R, et al. Exploitation of KESTREL to identify NDRG family members as physiological substrates for SGK1 and GSK3. Biochem J. 2004;384:477-88 pubmed
    We detected a protein in rabbit skeletal muscle extracts that was phosphorylated rapidly by SGK1 (serum- and glucocorticoid-induced kinase 1), but not by protein kinase Ba, and identified it as NDRG2 (N-myc downstream-regulated gene 2)...

More Information

Publications88

  1. Wulff P, Vallon V, Huang D, Volkl H, Yu F, Richter K, et al. Impaired renal Na(+) retention in the sgk1-knockout mouse. J Clin Invest. 2002;110:1263-8 pubmed
    The serum- and glucocorticoid-regulated kinase (sgk1) is induced by mineralocorticoids and, in turn, upregulates heterologously expressed renal epithelial Na(+) channel (ENaC) activity in Xenopus oocytes...
  2. Catela C, Kratsios P, Hede M, Lang F, Rosenthal N. Serum and glucocorticoid-inducible kinase 1 (SGK1) is necessary for vascular remodeling during angiogenesis. Dev Dyn. 2010;239:2149-60 pubmed publisher
    ..Serum and glucocorticoid-inducible kinase 1 (SGK1) is a serine/threonine kinase lying downstream of the phosphoinositide 3 (PI3) kinase pathway, whose embryonic ..
  3. Naray Fejes Toth A, Canessa C, Cleaveland E, Aldrich G, Fejes Toth G. sgk is an aldosterone-induced kinase in the renal collecting duct. Effects on epithelial na+ channels. J Biol Chem. 1999;274:16973-8 pubmed
    ..We report here that aldosterone rapidly increases mRNA levels of a putative Ser/Thr kinase, sgk (or serum- and glucocorticoid-regulated kinase), in its native target cells, i.e. in cortical collecting duct cells...
  4. Lu M, Wang J, Ives H, Pearce D. mSIN1 protein mediates SGK1 protein interaction with mTORC2 protein complex and is required for selective activation of the epithelial sodium channel. J Biol Chem. 2011;286:30647-54 pubmed publisher
    ..b>SGK1 is an mTORC2 substrate, which is a key regulator of epithelial Na(+) transport mediated by the epithelial sodium ..
  5. García Martínez J, Alessi D. mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1). Biochem J. 2008;416:375-85 pubmed publisher
    b>SGK1 (serum- and glucocorticoid-induced protein kinase 1) is a member of the AGC (protein kinase A/protein kinase G/protein kinase C) family of protein kinases and is activated by agonists including growth factors...
  6. Strutz Seebohm N, Seebohm G, Shumilina E, Mack A, Wagner H, Lampert A, et al. Glucocorticoid adrenal steroids and glucocorticoid-inducible kinase isoforms in the regulation of GluR6 expression. J Physiol. 2005;565:391-401 pubmed
    ..The glucocorticoid-dependent genes include the serum- and glucocorticoid-inducible kinase SGK1. SGK1 is activated through the phosphatidylinositol 3 kinase (PI3-kinase) pathway by growth factors such as insulin-..
  7. Arteaga M, Coric T, Straub C, Canessa C. A brain-specific SGK1 splice isoform regulates expression of ASIC1 in neurons. Proc Natl Acad Sci U S A. 2008;105:4459-64 pubmed publisher
    ..diseases and noxious stimuli to the brain enhance transcription of serum- and glucocorticoid-induced kinase-1 (SGK1). Here, we report that the SGK1 gene encodes a brain-specific additional isoform, SGK1...
  8. Di Pietro N, Panel V, Hayes S, Bagattin A, Meruvu S, Pandolfi A, et al. Serum- and glucocorticoid-inducible kinase 1 (SGK1) regulates adipocyte differentiation via forkhead box O1. Mol Endocrinol. 2010;24:370-80 pubmed publisher
    The serum and glucocorticoid-inducible kinase 1 (SGK1) is an inducible kinase the physiological function of which has been characterized primarily in the kidney...
  9. Gao D, Wan L, Inuzuka H, Berg A, Tseng A, Zhai B, et al. Rictor forms a complex with Cullin-1 to promote SGK1 ubiquitination and destruction. Mol Cell. 2010;39:797-808 pubmed publisher
    ..Rictor, but not Raptor or mTOR alone, promotes SGK1 ubiquitination...
  10. Mo J, Ann E, Yoon J, Jung J, Choi Y, Kim H, et al. Serum- and glucocorticoid-inducible kinase 1 (SGK1) controls Notch1 signaling by downregulation of protein stability through Fbw7 ubiquitin ligase. J Cell Sci. 2011;124:100-12 pubmed publisher
    ..Here, we report that the serum- and glucocorticoid-inducible protein kinase SGK1 remarkably reduced the protein stability of the active form of Notch1 through Fbw7...
  11. Debonneville C, Flores S, Kamynina E, Plant P, Tauxe C, Thomas M, et al. Phosphorylation of Nedd4-2 by Sgk1 regulates epithelial Na(+) channel cell surface expression. EMBO J. 2001;20:7052-9 pubmed
    ..Here we show by expression studies in Xenopus laevis oocytes that the aldosterone-induced Sgk1 kinase interacts with the ubiquitin protein ligase Nedd4-2 in a PY motif-dependent manner and phosphorylates Nedd4-..
  12. Li L, Wingo C, Xia S. Downregulation of SGK1 by nucleotides in renal tubular epithelial cells. Am J Physiol Renal Physiol. 2007;293:F1751-7 pubmed
    ..to purinergic receptors (P2R) regulate the expression or function of serum- and glucocorticoid-inducible kinase-1 (SGK1) in mouse renal inner medullar collecting duct cells (mIMCD-3). The SGK1 protein was detected by Western blotting...
  13. Schmidt E, Kraemer B, Borst O, Münzer P, Schonberger T, Schmidt C, et al. SGK1 sensitivity of platelet migration. Cell Physiol Biochem. 2012;30:259-68 pubmed publisher
    ..PI3K-sensitive kinases include the serum- and glucocorticoid-inducible kinase 1 (SGK1)...
  14. Palmada M, Boehmer C, Akel A, Rajamanickam J, Jeyaraj S, Keller K, et al. SGK1 kinase upregulates GLUT1 activity and plasma membrane expression. Diabetes. 2006;55:421-7 pubmed
    ..The serum- and glucocorticoid-inducible kinase SGK1, a further kinase downstream of PI3 kinase, regulates several transporters by enhancing their plasma membrane ..
  15. Yang X, Yao G, Chen W, Tang X, Feng X, Sun L. Exacerbation of lupus nephritis by high sodium chloride related to activation of SGK1 pathway. Int Immunopharmacol. 2015;29:568-573 pubmed publisher
    ..T cells from Systemic Lupus Erythematosus (SLE) patients and healthy donors were treated by NaCl with or without SGK1 inhibitor. Then, Th17 and Treg cells were detected...
  16. Chang C, Wu M, Tian Y, Chen K, Yu C, Liao C, et al. Enhancement of epithelial sodium channel expression in renal cortical collecting ducts cells by advanced glycation end products. Nephrol Dial Transplant. 2007;22:722-31 pubmed
    ..a luciferase reporter and plasmids expressing wild-type or mutant serum- and glucocorticoid-induced kinase 1 (Sgk1) mRNA were stimulated with AGE to identify the signalling pathway...
  17. Sheth R, Barozzi I, Langlais D, Osterwalder M, Nemec S, Carlson H, et al. Distal Limb Patterning Requires Modulation of cis-Regulatory Activities by HOX13. Cell Rep. 2016;17:2913-2926 pubmed publisher
    ..Our results show that proper termination of the early limb transcriptional program and activation of the late-distal limb program are coordinated by the dual action of HOX13 on cis-regulatory modules. ..
  18. Nonogaki K, Ohashi Nozue K, Oka Y. Induction of hypothalamic serum- and glucocorticoid-induced protein kinase-1 gene expression and its relation to plasma des-acyl ghrelin in energy homeostasis in mice. Biochem Biophys Res Commun. 2006;344:696-9 pubmed
    Serum- and glucocorticoid-induced protein kinase (SGK) is a serine/threonine-specific protein kinase that is transcriptionally regulated by serum, glucocorticoids, and mineral corticoids...
  19. Artunc F, Nasir O, Amann K, Boini K, Haring H, Risler T, et al. Serum- and glucocorticoid-inducible kinase 1 in doxorubicin-induced nephrotic syndrome. Am J Physiol Renal Physiol. 2008;295:F1624-34 pubmed publisher
    ..The aldosterone-sensitive serum- and glucocorticoid-inducible kinase SGK1 has been shown to participate in the stimulation of ENaC and to mediate renal fibrosis following mineralocorticoid ..
  20. Masujin K, Okada T, Tsuji T, Ishii Y, Takano K, Matsuda J, et al. A mutation in the serum and glucocorticoid-inducible kinase-like kinase (Sgkl) gene is associated with defective hair growth in mice. DNA Res. 2004;11:371-9 pubmed
  21. Ullrich S, Berchtold S, Ranta F, Seebohm G, Henke G, Lupescu A, et al. Serum- and glucocorticoid-inducible kinase 1 (SGK1) mediates glucocorticoid-induced inhibition of insulin secretion. Diabetes. 2005;54:1090-9 pubmed
    ..that dexamethasone upregulates transcription and expression of the serum- and glucocorticoid-inducible kinase 1 (SGK1) in insulin-secreting cells, an effect reversed by mifepristone (RU486), an antagonist of the nuclear ..
  22. You H, Jang Y, You Ten A, Okada H, Liepa J, Wakeham A, et al. p53-dependent inhibition of FKHRL1 in response to DNA damage through protein kinase SGK1. Proc Natl Acad Sci U S A. 2004;101:14057-62 pubmed
    ..By contrast, serum- and glucocorticoid-inducible kinase 1 (SGK1) was significantly induced in a p53-dependent manner after DNA damage, and this induction was through extracellular ..
  23. Nasir O, Wang K, Foller M, Gu S, Bhandaru M, Ackermann T, et al. Relative resistance of SGK1 knockout mice against chemical carcinogenesis. IUBMB Life. 2009;61:768-76 pubmed publisher
    The serum and glucocorticoid inducible kinase SGK1 was originally cloned from mammary tumor cells. SGK1 was found to be up-regulated in a variety of tumors, but down-regulated in several distinct tumors...
  24. Borst O, Schaub M, Walker B, Schmid E, Münzer P, Voelkl J, et al. Pivotal role of serum- and glucocorticoid-inducible kinase 1 in vascular inflammation and atherogenesis. Arterioscler Thromb Vasc Biol. 2015;35:547-57 pubmed publisher
    ..Regulators of nuclear factor-κB include serum- and glucocorticoid-inducible kinase 1 (SGK1). The present study explored involvement of SGK1 in vascular inflammation and atherogenesis...
  25. Kaji T, Nonogaki K. Contribution of central SGK-1 to the acute phase responses of mice to social isolation. Front Biosci (Elite Ed). 2010;2:1355-61 pubmed
    ..The serum- and glucocorticoid-inducible kinase 1 (SGK-1) is a member of the AGC family of serine/threonine protein kinase...
  26. Schoenebeck B, Bader V, Zhu X, Schmitz B, Lübbert H, Stichel C. Sgk1, a cell survival response in neurodegenerative diseases. Mol Cell Neurosci. 2005;30:249-64 pubmed
    Serum and glucocorticoid-regulated kinase 1 (sgk1) belongs to a family of serine/threonine kinases that is under acute transcriptional control by serum and glucocorticoids...
  27. Michalick L, Erfinanda L, Weichelt U, van der Giet M, Liedtke W, Kuebler W. Transient Receptor Potential Vanilloid 4 and Serum Glucocorticoid-regulated Kinase 1 Are Critical Mediators of Lung Injury in Overventilated Mice In Vivo. Anesthesiology. 2017;126:300-311 pubmed publisher
    ..Genetic deficiency or pharmacologic inhibition of TRPV4 or SGK1 protected mice from overventilation-induced vascular leakage (reduction in alveolar protein concentration from 0...
  28. Bertog M, Cuffe J, Pradervand S, Hummler E, Hartner A, Porst M, et al. Aldosterone responsiveness of the epithelial sodium channel (ENaC) in colon is increased in a mouse model for Liddle's syndrome. J Physiol. 2008;586:459-75 pubmed
    ..beta- and gamma-subunit (beta ENaC and gamma ENaC) and of the serum- and glucocorticoid-inducible kinase 1 (SGK1) was similar in colon tissue from Liddle and wild-type animals, while aldosterone had no transcriptional effect on ..
  29. Salker M, Steel J, Hosseinzadeh Z, Nautiyal J, Webster Z, Singh Y, et al. Activation of SGK1 in Endometrial Epithelial Cells in Response to PI3K/AKT Inhibition Impairs Embryo Implantation. Cell Physiol Biochem. 2016;39:2077-2087 pubmed
    Serum & Glucocorticoid Regulated Kinase 1 (SGK1) plays a fundamental role in ion and solute transport processes in epithelia...
  30. Cordón Barris L, Pascual Guiral S, Yang S, Gimenez Llort L, Lope Piedrafita S, Niemeyer C, et al. Mutation of the 3-phosphoinositide-dependent protein kinase-1 (PDK1) substrate-docking site in the developing brain causes microcephaly with abnormal brain morphogenesis independently of Akt, leading to impaired cognition and disruptive behaviors. Mol Cell Biol. 2016;: pubmed
  31. Boortz K, Syring K, Lee R, Dai C, Oeser J, McGuinness O, et al. G6PC2 Modulates the Effects of Dexamethasone on Fasting Blood Glucose and Glucose Tolerance. Endocrinology. 2016;157:4133-4145 pubmed
    ..These observations demonstrate that G6pc2 modulates the complex effects of Dex on both FBG and glucose tolerance. ..
  32. Salker M, Hosseinzadeh Z, Alowayed N, Zeng N, Umbach A, Webster Z, et al. LEFTYA Activates the Epithelial Na+ Channel (ENaC) in Endometrial Cells via Serum and Glucocorticoid Inducible Kinase SGK1. Cell Physiol Biochem. 2016;39:1295-306 pubmed publisher
    Serum & glucocorticoid inducible kinase (SGK1) regulates several ion channels, including amiloride sensitive epithelial Na+ channel (ENaC)...
  33. Bhalla V, Daidié D, Li H, Pao A, LaGrange L, Wang J, et al. Serum- and glucocorticoid-regulated kinase 1 regulates ubiquitin ligase neural precursor cell-expressed, developmentally down-regulated protein 4-2 by inducing interaction with 14-3-3. Mol Endocrinol. 2005;19:3073-84 pubmed
    Serum- and glucocorticoid-regulated kinase 1 (SGK1) is an aldosterone-regulated early response gene product that regulates the activity of several ion transport proteins, most notably that of the epithelial sodium channel (ENaC)...
  34. Loffing J, Flores S, Staub O. Sgk kinases and their role in epithelial transport. Annu Rev Physiol. 2006;68:461-90 pubmed
    The serum/glucocorticoid-induced kinase Sgk1 plays an important role in the regulation of epithelial ion transport...
  35. Ding L, Zhang L, Kim M, Byzova T, Podrez E. Akt3 kinase suppresses pinocytosis of low-density lipoprotein by macrophages via a novel WNK/SGK1/Cdc42 protein pathway. J Biol Chem. 2017;292:9283-9293 pubmed publisher
    ..We now report that Akt3 constitutively suppresses macropinocytosis in macrophages through a novel WNK1/SGK1/Cdc42 pathway...
  36. Marzook H, Deivendran S, George B, Reshmi G, Santhoshkumar T, Kumar R, et al. Cytoplasmic translocation of MTA1 coregulator promotes de-repression of SGK1 transcription in hypoxic cancer cells. Oncogene. 2017;36:5263-5273 pubmed publisher
    ..Here we have discovered that MTA1 is a novel corepressor of serum and glucocorticoid-inducible kinase 1 (SGK1)...
  37. Rauh R, Dinudom A, Fotia A, Paulides M, Kumar S, Korbmacher C, et al. Stimulation of the epithelial sodium channel (ENaC) by the serum- and glucocorticoid-inducible kinase (Sgk) involves the PY motifs of the channel but is independent of sodium feedback inhibition. Pflugers Arch. 2006;452:290-9 pubmed
    ..It has been proposed recently that the kinase Sgk activates the channel as a consequence of phosphorylating Nedd4-2, thus preventing it from inhibiting the channels...
  38. Maiyar A, Huang A, Phu P, Cha H, Firestone G. p53 stimulates promoter activity of the sgk. serum/glucocorticoid-inducible serine/threonine protein kinase gene in rodent mammary epithelial cells. J Biol Chem. 1996;271:12414-22 pubmed
    b>sgk is a novel member of the serine/threonine protein kinase gene family that is transcriptionally regulated by serum and glucocorticoids in mammary epithelial cells...
  39. Hallows K, Bhalla V, Oyster N, Wijngaarden M, Lee J, Li H, et al. Phosphopeptide screen uncovers novel phosphorylation sites of Nedd4-2 that potentiate its inhibition of the epithelial Na+ channel. J Biol Chem. 2010;285:21671-8 pubmed publisher
    ..identified Xenopus Nedd4-2 Ser/Thr phosphorylation sites corresponded to previously identified target sites for SGK1, whereas four were novel, including Ser-293, which matched the consensus for a MAPK target sequence...
  40. Reiter M, Vila G, Knosp E, Baumgartner Parzer S, Wagner L, Stalla G, et al. Opposite effects of serum- and glucocorticoid-regulated kinase-1 and glucocorticoids on POMC transcription and ACTH release. Am J Physiol Endocrinol Metab. 2011;301:E336-41 pubmed publisher
    Serum- and glucocorticoid-regulated kinase-1 (SGK1) is a glucocorticoid early-response gene; its function, however, has been elucidated mainly in the context of mineralocorticoid signaling...
  41. Borst O, Schmidt E, Münzer P, Schonberger T, Towhid S, Elvers M, et al. The serum- and glucocorticoid-inducible kinase 1 (SGK1) influences platelet calcium signaling and function by regulation of Orai1 expression in megakaryocytes. Blood. 2012;119:251-61 pubmed publisher
    ..Here, we show, for the first time, that the serum- and glucocorticoid-inducible kinase 1 (SGK1) is expressed in platelets and megakaryocytes...
  42. Raikwar N, Liu K, Thomas C. A regulated NH2-terminal Sgk1 variant with enhanced function is expressed in the collecting duct. Am J Physiol Renal Physiol. 2012;303:F1527-33 pubmed publisher
    b>Sgk1 is a relatively unstable kinase that regulates epithelial Na(+) transport in the distal nephron of the kidney...
  43. Huang D, Wulff P, Volkl H, Loffing J, Richter K, Kuhl D, et al. Impaired regulation of renal K+ elimination in the sgk1-knockout mouse. J Am Soc Nephrol. 2004;15:885-91 pubmed
    Serum- and glucocorticoid-regulated kinase 1 (Sgk1) contributes to Na+ reabsorption in the aldosterone-sensitive distal nephron...
  44. Voelkl J, Castor T, Musculus K, Viereck R, Mia S, Feger M, et al. SGK1-Sensitive Regulation of Cyclin-Dependent Kinase Inhibitor 1B (p27) in Cardiomyocyte Hypertrophy. Cell Physiol Biochem. 2015;37:603-14 pubmed
    The serum- and glucocorticoid-inducible kinase SGK1 participates in the orchestration of cardiac hypertrophy and remodeling. Signaling linking SGK1 activity to cardiac remodeling is, however, incompletely understood...
  45. Al Qusairi L, Basquin D, Roy A, Stifanelli M, Rajaram R, Debonneville A, et al. Renal tubular SGK1 deficiency causes impaired K+ excretion via loss of regulation of NEDD4-2/WNK1 and ENaC. Am J Physiol Renal Physiol. 2016;311:F330-42 pubmed publisher
    ..Germline inactivation of SGK1 suggests that this kinase is fundamental for K(+) excretion under conditions of K(+) load, but the specific role of ..
  46. Orlacchio A, Ranieri M, Brave M, Arciuch V, Forde T, De Martino D, et al. SGK1 Is a Critical Component of an AKT-Independent Pathway Essential for PI3K-Mediated Tumor Development and Maintenance. Cancer Res. 2017;77:6914-6926 pubmed publisher
    ..Instead, transformation requires the activity of the PDK1-regulated AGC family of protein kinases. In particular, SGK1 was found to be essential for proliferation and survival of thyroid cancer cells harboring PI3K-activating ..
  47. Shigaev A, Asher C, Latter H, Garty H, Reuveny E. Regulation of sgk by aldosterone and its effects on the epithelial Na(+) channel. Am J Physiol Renal Physiol. 2000;278:F613-9 pubmed
    ..Recently, it has been reported that aldosterone induces the serum- and glucocorticoid-dependent kinase sgk and that coexpressing ENaC with this kinase in Xenopus laevis oocytes increases the amiloride-sensitive Na(+) ..
  48. Rotte A, Mack A, Bhandaru M, Kempe D, Beier N, Scholz W, et al. Pioglitazone induced gastric acid secretion. Cell Physiol Biochem. 2009;24:193-200 pubmed publisher
    ..They enhance transcription of the serum and glucocorticoid inducible kinase SGK1, which could in turn enhance gastric acid secretion by stimulating KCNQ1 K+ channels...
  49. Flores S, Loffing Cueni D, Kamynina E, Daidié D, Gerbex C, Chabanel S, et al. Aldosterone-induced serum and glucocorticoid-induced kinase 1 expression is accompanied by Nedd4-2 phosphorylation and increased Na+ transport in cortical collecting duct cells. J Am Soc Nephrol. 2005;16:2279-87 pubmed
    ..Part of the effects of aldosterone is mediated by serum and glucocorticoid-induced kinase 1 (Sgk1), a Ser/Thr kinase whose expression is rapidly induced by aldosterone and that increases in heterologous expression ..
  50. Grahammer F, Artunc F, Sandulache D, Rexhepaj R, Friedrich B, Risler T, et al. Renal function of gene-targeted mice lacking both SGK1 and SGK3. Am J Physiol Regul Integr Comp Physiol. 2006;290:R945-50 pubmed
    ..Whereas SGK1 is under genomic control of mineralocorticoids and glucocorticoids, SGK3 is constitutively expressed...
  51. Ackermann T, Kempe D, Lang F, Lang U. Hyperactivity and enhanced curiosity of mice expressing PKB/SGK-resistant glycogen synthase kinase-3 (GSK-3). Cell Physiol Biochem. 2010;25:775-86 pubmed publisher
    ..is phosphorylated and thus inhibited by protein kinase B (PKB/Akt) and serum and glucocorticoid inducible kinase (SGK) isoforms. The present study explored, whether PKB/SGK-dependent GSK-3 regulation influences the behavior of mice...
  52. Rexhepaj R, Alesutan I, Gu S, Pelzl L, Eichenmüller M, Pathare G, et al. SGK1-dependent stimulation of intestinal SGLT1 activity by vitamin D. Pflugers Arch. 2011;462:489-94 pubmed publisher
    The serum- and glucocorticoid-inducible kinase SGK1 has previously been shown to mediate the glucocorticoid-dependent stimulation of several intestinal transport systems including the electrogenic glucose transporter SGLT1...
  53. BelAiba R, Djordjevic T, Bonello S, Artunc F, Lang F, Hess J, et al. The serum- and glucocorticoid-inducible kinase Sgk-1 is involved in pulmonary vascular remodeling: role in redox-sensitive regulation of tissue factor by thrombin. Circ Res. 2006;98:828-36 pubmed
    ..was diminished by kinase-deficient Sgk-1 and was not detectable in fibroblasts from mice deficient in sgk-1 (sgk1(-/-))...
  54. Zhang W, Xia X, Reisenauer M, Rieg T, Lang F, Kuhl D, et al. Aldosterone-induced Sgk1 relieves Dot1a-Af9-mediated transcriptional repression of epithelial Na+ channel alpha. J Clin Invest. 2007;117:773-83 pubmed
    ..Here we provide evidence from renal collecting duct cells and serum- and glucocorticoid-induced kinase-1 (Sgk1) WT and knockout mice that Sgk1 phosphorylated Af9, thereby impairing the Dot1a-Af9 interaction and leading to ..
  55. Lu M, Wang J, Jones K, Ives H, Feldman M, Yao L, et al. mTOR complex-2 activates ENaC by phosphorylating SGK1. J Am Soc Nephrol. 2010;21:811-8 pubmed publisher
    The serum- and glucocorticoid-induced kinase 1 (SGK1) plays a central role in hormone regulation of epithelial sodium (Na+) channel (ENaC)-dependent Na+ transport in the distal nephron...
  56. Leong M, Maiyar A, Kim B, O Keeffe B, Firestone G. Expression of the serum- and glucocorticoid-inducible protein kinase, Sgk, is a cell survival response to multiple types of environmental stress stimuli in mammary epithelial cells. J Biol Chem. 2003;278:5871-82 pubmed
    ..of multiple stress stimuli on the cellular utilization of the serum- and glucocorticoid-inducible protein kinase (Sgk) were examined in NMuMg mammary epithelial cells exposed to hyperosmotic stress induced by the organic osmolyte ..
  57. Chen S, McCormick J, Prabaker K, Wang J, Pearce D, Gardner D. Sgk1 mediates osmotic induction of NPR-A gene in rat inner medullary collecting duct cells. Hypertension. 2004;43:866-71 pubmed
    ..75 mmol/L NaCl in culture media (final osmolality 475 mosm/kg) resulted in an approximately 4-fold increase in Sgk1 protein levels after 7 hours...
  58. Cobb J, Duboule D. Comparative analysis of genes downstream of the Hoxd cluster in developing digits and external genitalia. Development. 2005;132:3055-67 pubmed
    ..e. the digits and the penis/clitoris. ..
  59. Binger K, Gebhardt M, Heinig M, Rintisch C, Schroeder A, Neuhofer W, et al. High salt reduces the activation of IL-4- and IL-13-stimulated macrophages. J Clin Invest. 2015;125:4223-38 pubmed publisher
    ..Collectively, this study provides evidence that high salt reduces noninflammatory innate immune cell activation and may thus lead to an overall imbalance in immune homeostasis. ..
  60. Rozansky D, Cornwall T, Subramanya A, Rogers S, Yang Y, David L, et al. Aldosterone mediates activation of the thiazide-sensitive Na-Cl cotransporter through an SGK1 and WNK4 signaling pathway. J Clin Invest. 2009;119:2601-12 pubmed publisher
    ..sodium uptake in a Xenopus oocyte expression system and found that serum and glucocorticoid-induced kinase 1 (SGK1), an aldosterone-responsive gene expressed in the DN, attenuated the inhibitory effect of WNK4 on NCC activity...
  61. Pelzl L, Fakhri H, Umbach A, Gawaz M, Paulmichl M, Lang F. Sgk1 sensitive pendrin expression in murine platelets. Cell Physiol Biochem. 2013;32:210-20 pubmed publisher
    ..the Na(+)/H(+) exchanger are regulated by the mineralocorticoid-sensitive serum and glucocorticoid inducible kinase SGK1. The present study utilized i) quantitative reverse transcription polymerase chain reaction (RT-qPCR) to quantify ..
  62. Schmid E, Xuan N, Zahir N, Russo A, Yang W, Kuhl D, et al. Serum- and glucocorticoid-inducible kinase 1 sensitive NF-κB signaling in dendritic cells. Cell Physiol Biochem. 2014;34:943-54 pubmed publisher
    ..Downstream signaling elements of PI3K include serum- and glucocorticoid-inducible kinase 1 (SGK1) and its phosphorylation target N-myc downstream regulated gene 1 (NDRG1)...
  63. Yang M, Zheng J, Miao Y, Wang Y, Cui W, Guo J, et al. Serum-glucocorticoid regulated kinase 1 regulates alternatively activated macrophage polarization contributing to angiotensin II-induced inflammation and cardiac fibrosis. Arterioscler Thromb Vasc Biol. 2012;32:1675-86 pubmed publisher
    ..Although serum-glucocorticoid regulated kinase 1 (SGK1) is a key mediator of fibrosis, its role in regulating macrophage function leading to cardiac fibrosis has not been ..
  64. Rexhepaj R, Rotte A, Kempe D, Sopjani M, Foller M, Gehring E, et al. Stimulation of electrogenic intestinal dipeptide transport by the glucocorticoid dexamethasone. Pflugers Arch. 2009;459:191-202 pubmed publisher
    ..in vitro experiments, the peptide transporter PepT2 is stimulated by the serum- and glucocorticoid-inducible kinase SGK1. The present study explored the contribution of SGK1 to the regulation of electrogenic intestinal peptide transport...
  65. Roy A, Al Qusairi L, Donnelly B, Ronzaud C, Marciszyn A, Gong F, et al. Alternatively spliced proline-rich cassettes link WNK1 to aldosterone action. J Clin Invest. 2015;125:3433-48 pubmed publisher
    ..were efficiently degraded by the ubiquitin proteasome system, an effect reversed by the aldosterone-induced kinase SGK1. In gene-edited cells, WNK1 deficiency negated regulatory effects of NEDD4-2 and SGK1 on NCC, suggesting that WNK1 ..
  66. Miyata S, Yoshikawa K, Taniguchi M, Ishikawa T, Tanaka T, Shimizu S, et al. Sgk1 regulates desmoglein 1 expression levels in oligodendrocytes in the mouse corpus callosum after chronic stress exposure. Biochem Biophys Res Commun. 2015;464:76-82 pubmed publisher
    ..elevated plasma corticosterone levels show upregulation and activation of serum glucocorticoid-regulated kinase (Sgk1) in oligodendrocytes...
  67. Walker B, Schmid E, Russo A, Schmidt E, Burk O, Münzer P, et al. Impact of the serum- and glucocorticoid-inducible kinase 1 on platelet dense granule biogenesis and secretion. J Thromb Haemost. 2015;13:1325-34 pubmed publisher
    ..Nevertheless, biogenesis of platelet granules is poorly understood. Serum- and glucocorticoid-inducible kinase 1 (SGK1) has been shown to be highly expressed in platelets and megakaryocytes, but its role in the regulation of platelet ..
  68. Ackermann T, Boini K, Volkl H, Bhandaru M, Bareiss P, Just L, et al. SGK1-sensitive renal tubular glucose reabsorption in diabetes. Am J Physiol Renal Physiol. 2009;296:F859-66 pubmed publisher
    ..A candidate is the serum- and glucocorticoid-inducible kinase SGK1. The kinase has been shown to stimulate Na(+)-coupled glucose transport in vitro and mediate the stimulation of ..
  69. Ring A, Leng Q, Rinehart J, Wilson F, Kahle K, Hebert S, et al. An SGK1 site in WNK4 regulates Na+ channel and K+ channel activity and has implications for aldosterone signaling and K+ homeostasis. Proc Natl Acad Sci U S A. 2007;104:4025-9 pubmed
    ..We show that WNK4 is phosphorylated by SGK1, a mediator of aldosterone signaling...
  70. Zhou H, Gao S, Duan X, Liang S, Scott D, Lamont R, et al. Inhibition of serum- and glucocorticoid-inducible kinase 1 enhances TLR-mediated inflammation and promotes endotoxin-driven organ failure. FASEB J. 2015;29:3737-49 pubmed publisher
    ..However, the involvement and functional role of SGK1 in innate immune responses remain entirely unknown...
  71. Helms M, Yu L, Malik B, Kleinhenz D, Hart C, Eaton D. Role of SGK1 in nitric oxide inhibition of ENaC in Na+-transporting epithelia. Am J Physiol Cell Physiol. 2005;289:C717-26 pubmed
    ..inducible nitric oxide synthase (iNOS) coimmunoprecipitated with the serum- and glucocorticoid-inducible kinase (SGK1) and both proteins colocalized in the cytoplasm (as shown in our studies in mouse ATII cells), SGK1 may also be ..
  72. Salker M, Christian M, Steel J, Nautiyal J, Lavery S, Trew G, et al. Deregulation of the serum- and glucocorticoid-inducible kinase SGK1 in the endometrium causes reproductive failure. Nat Med. 2011;17:1509-13 pubmed publisher
    ..Analysis of midsecretory endometrial samples revealed that SGK1, a kinase involved in epithelial ion transport and cell survival, is upregulated in unexplained infertility, most ..
  73. Heikamp E, Patel C, Collins S, Waickman A, Oh M, Sun I, et al. The AGC kinase SGK1 regulates TH1 and TH2 differentiation downstream of the mTORC2 complex. Nat Immunol. 2014;15:457-64 pubmed publisher
    b>SGK1 is an AGC kinase that regulates the expression of membrane sodium channels in renal tubular cells in a manner dependent on the metabolic checkpoint kinase complex mTORC2...
  74. Inoue K, Sakuma E, Morimoto H, Asai H, Koide Y, Leng T, et al. Serum- and glucocorticoid-inducible kinases in microglia. Biochem Biophys Res Commun. 2016;478:53-59 pubmed publisher
    ..Here we, for the first time, report that SGK1 and SGK3 are expressed in multiple microglial cell lines. An SGK inhibitor, gsk650394, inhibits cell viability...
  75. Chen S, Grigsby C, Law C, Ni X, Nekrep N, Olsen K, et al. Tonicity-dependent induction of Sgk1 expression has a potential role in dehydration-induced natriuresis in rodents. J Clin Invest. 2009;119:1647-58 pubmed publisher
    ..Serum- and glucocorticoid-inducible kinase (Sgk1), which is expressed in the renal medulla, is regulated by extracellular tonicity...
  76. Grahammer F, Henke G, Sandu C, Rexhepaj R, Hussain A, Friedrich B, et al. Intestinal function of gene-targeted mice lacking serum- and glucocorticoid-inducible kinase 1. Am J Physiol Gastrointest Liver Physiol. 2006;290:G1114-23 pubmed
    In vitro experiments have revealed the ability of serum- and glucocorticoid-inducible kinase 1 (SGK1) to stimulate intestinal Na(+)-coupled glucose cotransporter 1 (SGLT1) and intestinal Na(+)/H(+) exchanger 3 (NHE3)...
  77. Rotte A, Bhandaru M, Foller M, Biswas R, Mack A, Friedrich B, et al. APC sensitive gastric acid secretion. Cell Physiol Biochem. 2009;23:133-42 pubmed publisher
    ..APC fosters degradation of beta-catenin, which in turn upregulates the serum- and glucocorticoid-inducible kinase SGK1. SGK1 stimulates KCNQ1, which is required for luminal K+ recycling and thus for gastric acid secretion...
  78. He P, Lee S, Lin S, Seidler U, Lang F, Fejes Toth G, et al. Serum- and glucocorticoid-induced kinase 3 in recycling endosomes mediates acute activation of Na+/H+ exchanger NHE3 by glucocorticoids. Mol Biol Cell. 2011;22:3812-25 pubmed publisher
    ..In this study, we compared short-term regulation of NHE3 by Dex in SGK1-null and NHERF2-null mice...
  79. Steinberger M, Föller M, Vogelgesang S, Krautwald M, Landsberger M, Winkler C, et al. Lack of the serum- and glucocorticoid-inducible kinase SGK1 improves muscle force characteristics and attenuates fibrosis in dystrophic mdx mouse muscle. Pflugers Arch. 2015;467:1965-74 pubmed publisher
    ..The serum- and glucocorticoid-inducible kinase SGK1 regulates a variety of physiological functions and participates in fibrosis stimulation...