Gene Symbol: Setd7
Description: SET domain containing (lysine methyltransferase) 7
Alias: 1600028F23Rik, H3K4MT, KMT7, Set7, Set7/9, mKIAA1717, histone-lysine N-methyltransferase SETD7, H3-K4 methyltransferase, H3-K4-HMTase SETD7, SET domain-containing protein 7, histone H3-K4 methyltransferase SETD7
Species: mouse
Products:     Setd7

Top Publications

  1. Wang H, Cao R, Xia L, Erdjument Bromage H, Borchers C, Tempst P, et al. Purification and functional characterization of a histone H3-lysine 4-specific methyltransferase. Mol Cell. 2001;8:1207-17 pubmed
    ..identification, and functional characterization of an H3-lysine 4-specific methyltransferase (H3-K4-HMTase), SET7. We demonstrate that SET7 methylates H3-K4 in vitro and in vivo...
  2. Kurash J, Lei H, Shen Q, Marston W, Granda B, Fan H, et al. Methylation of p53 by Set7/9 mediates p53 acetylation and activity in vivo. Mol Cell. 2008;29:392-400 pubmed publisher
    The protein methyltransferase Set7/9 was recently shown to regulate p53 activity in cancer cells. However, the impact of Set7/9 on p53 function in vivo is unclear. To explore these issues, we created a null allele of Set7/9 in mice...
  3. Li Y, Reddy M, Miao F, Shanmugam N, Yee J, Hawkins D, et al. Role of the histone H3 lysine 4 methyltransferase, SET7/9, in the regulation of NF-kappaB-dependent inflammatory genes. Relevance to diabetes and inflammation. J Biol Chem. 2008;283:26771-81 pubmed publisher
    ..We report here that the chromatin histone H3-lysine 4 methyltransferase, SET7/9, is a novel coactivator of NF-kappaB...
  4. Oudhoff M, Braam M, Freeman S, Wong D, Rattray D, Wang J, et al. SETD7 Controls Intestinal Regeneration and Tumorigenesis by Regulating Wnt/?-Catenin and Hippo/YAP Signaling. Dev Cell. 2016;37:47-57 pubmed publisher
    ..We have previously shown that methylation of the Hippo transducer YAP by the lysine methyltransferase SETD7 controls its subcellular localization and function...
  5. Fujimaki K, Ogihara T, Morris D, Oda H, Iida H, Fujitani Y, et al. SET7/9 Enzyme Regulates Cytokine-induced Expression of Inducible Nitric-oxide Synthase through Methylation of Lysine 4 at Histone 3 in the Islet β Cell. J Biol Chem. 2015;290:16607-18 pubmed publisher
    b>SET7/9 is an enzyme that methylates histone 3 at lysine 4 (H3K4) to maintain euchromatin architecture...
  6. Maganti A, Maier B, Tersey S, Sampley M, Mosley A, Özcan S, et al. Transcriptional activity of the islet β cell factor Pdx1 is augmented by lysine methylation catalyzed by the methyltransferase Set7/9. J Biol Chem. 2015;290:9812-22 pubmed publisher
    ..b>Set7/9 is a Lys methyltransferase that interacts with Pdx1...
  7. Shao G, Chen J, Zhang L, Huang P, Lu H, Jin J, et al. Dynamic patterns of histone H3 lysine 4 methyltransferases and demethylases during mouse preimplantation development. In Vitro Cell Dev Biol Anim. 2014;50:603-13 pubmed publisher
    ..authors examined the dynamic changes of H3K4me and its key regulators (Ash1l, Ash2l, Kmt2a, Kmt2b, Kmt2c, Setd1a, Setd7, Kdm1a, Kdm1b, Kdm5a, Kdm5b, Kdm5c, and Kdm5d) in mouse oocytes and preimplantation embryos...
  8. Oda H, Okamoto I, Murphy N, Chu J, Price S, Shen M, et al. Monomethylation of histone H4-lysine 20 is involved in chromosome structure and stability and is essential for mouse development. Mol Cell Biol. 2009;29:2278-95 pubmed publisher
    PR-Set7/Set8/KMT5A is the sole enzyme known to catalyze monomethylation of histone H4 lysine 20 (H4K20) and is present only in multicellular organisms that compact a large fraction of their DNA...
  9. Campaner S, Spreafico F, Burgold T, Doni M, Rosato U, Amati B, et al. The methyltransferase Set7/9 (Setd7) is dispensable for the p53-mediated DNA damage response in vivo. Mol Cell. 2011;43:681-8 pubmed publisher
    ..defined as a critical layer of p53 regulation in human cell lines, p53 lysine methylation by Set7/9 (also called Setd7) was proposed to fulfill a similar function in vivo in the mouse, promoting p53 acetylation, stabilization, and ..

More Information


  1. Okabe J, Orlowski C, Balcerczyk A, Tikellis C, Thomas M, Cooper M, et al. Distinguishing hyperglycemic changes by Set7 in vascular endothelial cells. Circ Res. 2012;110:1067-76 pubmed publisher
    ..We have studied the molecular and functional mechanism whereby the Set7 methyltransferase associates with chromatin formation and histone methylation in vascular cells in response to ..
  2. Wang D, Zhou J, Liu X, Lu D, Shen C, Du Y, et al. Methylation of SUV39H1 by SET7/9 results in heterochromatin relaxation and genome instability. Proc Natl Acad Sci U S A. 2013;110:5516-21 pubmed publisher
    ..In this study, we identified SET domain-containing protein 7 (SET7/9), a protein methyltransferase, as a unique regulator of SUV39H1 activity...
  3. Elkouris M, Kontaki H, Stavropoulos A, Antonoglou A, Nikolaou K, Samiotaki M, et al. SET9-Mediated Regulation of TGF-? Signaling Links Protein Methylation to Pulmonary Fibrosis. Cell Rep. 2016;15:2733-44 pubmed publisher
    ..These results uncover a complex regulatory interplay among multiple Smad7 modifications and highlight the possibility that protein methyltransferases may represent promising therapeutic targets for treating lung fibrosis. ..
  4. Barsyte Lovejoy D, Li F, Oudhoff M, Tatlock J, Dong A, Zeng H, et al. (R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells. Proc Natl Acad Sci U S A. 2014;111:12853-8 pubmed publisher
    SET domain containing (lysine methyltransferase) 7 (SETD7) is implicated in multiple signaling and disease related pathways with a broad diversity of reported substrates...
  5. Tuano N, Okabe J, Ziemann M, Cooper M, El Osta A. Set7 mediated interactions regulate transcriptional networks in embryonic stem cells. Nucleic Acids Res. 2016;44:9206-9217 pubmed
    ..While it is known that Set7 catalyzes mono-methylation of histone and non-histone proteins, the functional importance of this enzyme in stem ..
  6. Wang J, Hevi S, Kurash J, Lei H, Gay F, Bajko J, et al. The lysine demethylase LSD1 (KDM1) is required for maintenance of global DNA methylation. Nat Genet. 2009;41:125-9 pubmed publisher
    ..Furthermore, Dnmt1 can be methylated by Set7/9 (also known as KMT7) and demethylated by LSD1 in vitro...
  7. Yang Y, Thorel F, Boyer D, Herrera P, Wright C. Context-specific ?- to-?-cell reprogramming by forced Pdx1 expression. Genes Dev. 2011;25:1680-5 pubmed publisher
    ..Our findings reveal that Pdx1 can work single-handedly as a potent context-dependent autonomous reprogramming agent, and suggest a postnatal differentiation evaluation stage involved in normal endocrine maturation. ..
  8. Lehnertz B, Rogalski J, Schulze F, Yi L, Lin S, Kast J, et al. p53-dependent transcription and tumor suppression are not affected in Set7/9-deficient mice. Mol Cell. 2011;43:673-80 pubmed publisher
    ..In particular, Set7/9 (KMT7)-mediated monomethylation of human p53 at lysine 372 (p53K372me1) was suggested to be essential for p53 ..
  9. Chen L, Fulcoli F, Ferrentino R, Martucciello S, Illingworth E, Baldini A. Transcriptional control in cardiac progenitors: Tbx1 interacts with the BAF chromatin remodeling complex and regulates Wnt5a. PLoS Genet. 2012;8:e1002571 pubmed publisher
    ..It also interacts with the Setd7 histone H3K4 monomethyltransferase...
  10. Ogihara T, Vanderford N, Maier B, Stein R, Mirmira R. Expression and function of Set7/9 in pancreatic islets. Islets. 2009;1:269-72 pubmed publisher
    ..In this brief report, we follow up on a recent study in which we identified the islet enriched factor Set7/9 as a potentially important histone methyltransferase in ?-cells (Deering, et al. Diabetes 2009; 58:185-93)...
  11. Tao Y, Neppl R, Huang Z, Chen J, Tang R, Cao R, et al. The histone methyltransferase Set7/9 promotes myoblast differentiation and myofibril assembly. J Cell Biol. 2011;194:551-65 pubmed publisher
    ..We report in this paper that expression of the H3-K4 histone methyltransferase Set7 is increased when myoblasts differentiate into myotubes and is required for skeletal muscle development, expression ..
  12. Lee J, Saha P, Yang Q, Lee S, Park J, Suh Y, et al. Targeted inactivation of MLL3 histone H3-Lys-4 methyltransferase activity in the mouse reveals vital roles for MLL3 in adipogenesis. Proc Natl Acad Sci U S A. 2008;105:19229-34 pubmed publisher
    ..receptor gamma (PPARgamma) and C/EBPalpha, is associated with histone H3-Lys-4-methyltransferase (H3K4MT) MLL3 or its paralogue MLL4 in a complex named ASCOM (ASC-2 complex)...
  13. Hang L, Xu Z, Wei S, Shu W, Luo H, Chen J. Spinal SET7/9 may contribute to the maintenance of cancer-induced bone pain in mice. Clin Exp Pharmacol Physiol. 2017;44:1001-1007 pubmed publisher
    ..SET domain containing lysine methyltransferase 7/9 (SET7/9) may modulate the expression of NF-κB-dependent proinflammatory genes in vitro...
  14. Oudhoff M, Freeman S, Couzens A, Antignano F, Kuznetsova E, Min P, et al. Control of the hippo pathway by Set7-dependent methylation of Yap. Dev Cell. 2013;26:188-94 pubmed publisher
    Methylation of nonhistone proteins is emerging as a regulatory mechanism to control protein function. Set7 (Setd7) is a SET-domain-containing lysine methyltransferase that methylates and alters function of a variety of proteins in vitro, ..
  15. Deering T, Ogihara T, Trace A, Maier B, Mirmira R. Methyltransferase Set7/9 maintains transcription and euchromatin structure at islet-enriched genes. Diabetes. 2009;58:185-93 pubmed publisher
    ..that this modification is maintained in islet beta-cells by the action of the histone methyltransferase Set7/9...
  16. Lee S, Lee D, Dou Y, Lee J, Lee B, Kwak E, et al. Coactivator as a target gene specificity determinant for histone H3 lysine 4 methyltransferases. Proc Natl Acad Sci U S A. 2006;103:15392-7 pubmed
    ..In contrast, RAR-beta2 expression is intact in MEFs devoid of menin, a component of MLL1 and MLL2 H3K4MT complexes...
  17. Jeong K, Park J, Lee S. The analysis of X-chromosome inactivation-related gene expression from single mouse embryo with sex-determination. Biochem Biophys Res Commun. 2005;333:803-7 pubmed
    ..An analysis of the XCI-related gene (Xist, Tsix, SUV39H1, SET7, and DNMT1) expression was performed to investigate the initiation process of XCI from early mouse single embryo (1-..
  18. Oudhoff M, Antignano F, Chenery A, Burrows K, Redpath S, Braam M, et al. Intestinal Epithelial Cell-Intrinsic Deletion of Setd7 Identifies Role for Developmental Pathways in Immunity to Helminth Infection. PLoS Pathog. 2016;12:e1005876 pubmed publisher
    ..Lysine methyltransferases are part of a family of novel attractive targets for drug discovery. SETD7 is a member of the Suppressor of variegation 3-9-Enhancer of zeste-Trithorax (SET) domain-containing family of ..