Serpine1

Summary

Gene Symbol: Serpine1
Description: serine (or cysteine) peptidase inhibitor, clade E, member 1
Alias: PAI-1, PAI1, Planh1, plasminogen activator inhibitor 1, PAI, Plasminogen activator inhibitor-1 precursor (PAI-1) (Endothelial plasminogen activator inhibitor) (PAI), endothelial plasminogen activator inhibitor, nexin, plasminogen activator inhibitor type 1, plasminogen activator inhibitor, type I, serine (or cysteine) proteinase inhibitor, clade E, member 1, serpin E1
Species: mouse

Top Publications

  1. pmc Bleomycin-induced pulmonary fibrosis in transgenic mice that either lack or overexpress the murine plasminogen activator inhibitor-1 gene
    D T Eitzman
    Division of Cardiology, University of Michigan Medical Center, Ann Arbor 48109, USA
    J Clin Invest 97:232-7. 1996
  2. ncbi Lack of plasminogen activator inhibitor-1 effect in a transgenic mouse model of metastatic melanoma
    D T Eitzman
    Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, USA
    Blood 87:4718-22. 1996
  3. ncbi Absence of host plasminogen activator inhibitor 1 prevents cancer invasion and vascularization
    K Bajou
    Laboratory of Tumor and Developmental Biology, University of Liege, Belgium
    Nat Med 4:923-8. 1998
  4. ncbi Atherosclerosis progression in LDL receptor-deficient and apolipoprotein E-deficient mice is independent of genetic alterations in plasminogen activator inhibitor-1
    H Sjöland
    Division of Cardiology, Department of Internal Medicine, Howard Hughes Medical Institute, University of Michigan Medical Center, Ann Arbor 48109 0644, USA
    Arterioscler Thromb Vasc Biol 20:846-52. 2000
  5. pmc Activin receptor-like kinase 1 modulates transforming growth factor-beta 1 signaling in the regulation of angiogenesis
    S P Oh
    Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Proc Natl Acad Sci U S A 97:2626-31. 2000
  6. ncbi Tumor development is retarded in mice lacking the gene for urokinase-type plasminogen activator or its inhibitor, plasminogen activator inhibitor-1
    L S Gutierrez
    Walther Cancer Center, University of Notre Dame, Indiana 46556, USA
    Cancer Res 60:5839-47. 2000
  7. pmc Bleomycin-induced pulmonary fibrosis in fibrinogen-null mice
    N Hattori
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan School of Medicine, Ann Arbor, Michigan, USA
    J Clin Invest 106:1341-50. 2000
  8. ncbi Plasminogen activator inhibitor-1 deficiency protects against atherosclerosis progression in the mouse carotid artery
    D T Eitzman
    Divisions of Cardiology, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, MI, USA
    Blood 96:4212-5. 2000
  9. ncbi Influence of plasminogen activator inhibitor type 1 on choroidal neovascularization
    V Lambert
    Laboratory of Tumor and Development Biology, University of Liege, B 4000 Liege, Belgium
    FASEB J 15:1021-7. 2001
  10. ncbi Plasminogen activator inhibitor-1 regulates tumor growth and angiogenesis
    G A McMahon
    Department of Vascular Biology, The Holland Laboratory, American Red Cross, Rockville, Maryland 20855, USA
    J Biol Chem 276:33964-8. 2001

Research Grants

  1. PATHOLOGICAL CONSEQUENCES OF THE PLASMINOGEN SYSTEM
    Victoria Ploplis; Fiscal Year: 2010
  2. Glutathione deficiency & immune dysfunction during aging
    Rui Ming Liu; Fiscal Year: 2006
  3. SYSTEMATIC EVALUATION OF THE PLASMINOGEN SYSTEM
    Jane Hoover Plow; Fiscal Year: 2003
  4. Vascular Cell Regulation of Connexins
    Brant Isakson; Fiscal Year: 2005
  5. BARI II - FIBRINOLYSIS AND COAGULATION CORE
    Burton Sobel; Fiscal Year: 2006
  6. Cyclic RGD Peptide in the Treatment of DMGS
    Susanne Nicholas; Fiscal Year: 2005
  7. Inflammation, Procoagulation, and Plaque Vulnerability
    Burton Sobel; Fiscal Year: 2005
  8. Vanderbilt Mentored Clinical Research Scholar Program
    Nancy Brown; Fiscal Year: 2006
  9. Genetics of Diabetic Nephropathy in Mexican-Americans a*
    Susanne Nicholas; Fiscal Year: 2006
  10. RAAS, Inflammation & Post-Operative Atrial Fibrillation
    Nancy Brown; Fiscal Year: 2009

Detail Information

Publications127 found, 100 shown here

  1. pmc Bleomycin-induced pulmonary fibrosis in transgenic mice that either lack or overexpress the murine plasminogen activator inhibitor-1 gene
    D T Eitzman
    Division of Cardiology, University of Michigan Medical Center, Ann Arbor 48109, USA
    J Clin Invest 97:232-7. 1996
    ..transgenic mice that either overexpressed or were completely deficient in murine plasminogen activator inhibitor-1 (PAI-1). 2 wk after 0...
  2. ncbi Lack of plasminogen activator inhibitor-1 effect in a transgenic mouse model of metastatic melanoma
    D T Eitzman
    Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, USA
    Blood 87:4718-22. 1996
    ..Plasminogen activator inhibitor-1 (PAI-1), a rapid inhibitor of both uPA and tissue-type plasminogen activator (tPA) is the major physiologic regulator of ..
  3. ncbi Absence of host plasminogen activator inhibitor 1 prevents cancer invasion and vascularization
    K Bajou
    Laboratory of Tumor and Developmental Biology, University of Liege, Belgium
    Nat Med 4:923-8. 1998
    ..of the plasminogen activation system, including urokinase, but paradoxically also its inhibitor, plasminogen activator inhibitor 1 (PAI1), have been correlated with a poor prognosis for some cancers...
  4. ncbi Atherosclerosis progression in LDL receptor-deficient and apolipoprotein E-deficient mice is independent of genetic alterations in plasminogen activator inhibitor-1
    H Sjöland
    Division of Cardiology, Department of Internal Medicine, Howard Hughes Medical Institute, University of Michigan Medical Center, Ann Arbor 48109 0644, USA
    Arterioscler Thromb Vasc Biol 20:846-52. 2000
    ..Plasminogen activator inhibitor type 1 (PAI-1) is the primary inhibitor of plasminogen activation and has been proposed to promote atherosclerosis by ..
  5. pmc Activin receptor-like kinase 1 modulates transforming growth factor-beta 1 signaling in the regulation of angiogenesis
    S P Oh
    Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Proc Natl Acad Sci U S A 97:2626-31. 2000
    ..Taken together, our results suggest that the balance between the ALK1 and ALK5 signaling pathways in endothelial cells plays a crucial role in determining vascular endothelial properties during angiogenesis...
  6. ncbi Tumor development is retarded in mice lacking the gene for urokinase-type plasminogen activator or its inhibitor, plasminogen activator inhibitor-1
    L S Gutierrez
    Walther Cancer Center, University of Notre Dame, Indiana 46556, USA
    Cancer Res 60:5839-47. 2000
    ..deficiencies in urokinase-type plasminogen activator (UPA-/-) and its inhibitor, plasminogen activator inhibitor-1 (PAI-1-/-), was studied using a fibrosarcoma tumor model. Murine T241 fibrosarcoma cells were s.c...
  7. pmc Bleomycin-induced pulmonary fibrosis in fibrinogen-null mice
    N Hattori
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan School of Medicine, Ann Arbor, Michigan, USA
    J Clin Invest 106:1341-50. 2000
    Mice deleted for the plasminogen activator inhibitor-1 (PAI-1) gene are relatively protected from developing pulmonary fibrosis induced by bleomycin...
  8. ncbi Plasminogen activator inhibitor-1 deficiency protects against atherosclerosis progression in the mouse carotid artery
    D T Eitzman
    Divisions of Cardiology, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, MI, USA
    Blood 96:4212-5. 2000
    Dissolution of the fibrin blood clot is regulated in large part by plasminogen activator inhibitor-1 (PAI-1)...
  9. ncbi Influence of plasminogen activator inhibitor type 1 on choroidal neovascularization
    V Lambert
    Laboratory of Tumor and Development Biology, University of Liege, B 4000 Liege, Belgium
    FASEB J 15:1021-7. 2001
    High levels of the plasminogen activators, but also their inhibitor, plasminogen activator inhibitor 1 (PAI-1), have been documented in neovascularization of severe ocular pathologies such as diabetic retinopathy or age-related macular ..
  10. ncbi Plasminogen activator inhibitor-1 regulates tumor growth and angiogenesis
    G A McMahon
    Department of Vascular Biology, The Holland Laboratory, American Red Cross, Rockville, Maryland 20855, USA
    J Biol Chem 276:33964-8. 2001
    Elevated expression of plasminogen activator inhibitor-1 (PAI-1) in tumors is associated with a poor prognosis in many cancers. Reduced tumor growth and angiogenesis have also been reported in mice deficient in PAI-1...
  11. ncbi The pro- or antiangiogenic effect of plasminogen activator inhibitor 1 is dose dependent
    Laetitia Devy
    Laboratory of Tumor and Developmental Biology, University of Liege, Tour de Pathologie B23, Sart Tilman, B 4000 Liege, Belgium
    FASEB J 16:147-54. 2002
    b>Plasminogen activator inhibitor 1 (PAI-1) is believed to control proteolytic activity and cell migration during angiogenesis...
  12. ncbi PAI-1 promotes extracellular matrix deposition in the airways of a murine asthma model
    Chad K Oh
    Division of Allergy and Immunology, Department of Pediatrics, UCLA School of Medicine, Harbor UCLA Medical Center, School of Medicine, University of California, Bldg N25, 1000 W Carson St, Los Angeles, Torrance, CA 90509, USA
    Biochem Biophys Res Commun 294:1155-60. 2002
    ..We hypothesized that elevated plasminogen activator inhibitor (PAI)-1 promotes ECM deposition in the asthmatic airway by inhibiting MMP-9 activity and fibrinolysis...
  13. pmc Aging accelerates endotoxin-induced thrombosis : increased responses of plasminogen activator inhibitor-1 and lipopolysaccharide signaling with aging
    Koji Yamamoto
    First Department of Internal Medicine, Nagoya University School of Medicine, Showa, Japan
    Am J Pathol 161:1805-14. 2002
    ..Since elevated plasminogen activator inhibitor-1 (PAI-1) primarily contributes to endotoxin-induced thrombosis, we first compared the induction of PAI-1 by ..
  14. ncbi Nutritionally induced obesity is attenuated in transgenic mice overexpressing plasminogen activator inhibitor-1
    H Roger Lijnen
    Center for Molecular and Vascular Biology, University of Leuven, Belgium
    Arterioscler Thromb Vasc Biol 23:78-84. 2003
    The objective of this study was to investigate the role of plasminogen activator inhibitor-1 (PAI-1) in adipose tissue development in vivo.
  15. ncbi Plasminogen activator inhibitor-1 is a significant determinant of renal injury in experimental crescentic glomerulonephritis
    A Richard Kitching
    Centre for Inflammatory Diseases, and Department of Medicine, Monash Medical Centre, Monash University, Clayton, Victoria, Australia
    J Am Soc Nephrol 14:1487-95. 2003
    ..Plasminogen activator inhibitor-1 (PAI-1) inhibits fibrinolysis by inhibiting plasminogen activators and has effects on leukocyte recruitment and matrix ..
  16. ncbi Metastasis of transgenic breast cancer in plasminogen activator inhibitor-1 gene-deficient mice
    Kasper Almholt
    The Finsen Laboratory, Rigshospitalet, Strandboulevarden 49, DK 2100 Copenhagen, Denmark
    Oncogene 22:4389-97. 2003
    The plasminogen activator inhibitor-1 (PAI-1) blocks the activation of plasmin(ogen), an extracellular protease vital to cancer invasion...
  17. pmc Reduction in fibrotic tissue formation in mice genetically deficient in plasminogen activator inhibitor-1
    Sheila Chuang-Tsai
    Department of Internal Medicine, Pulmonary and Critical Care Medicine Division, University of Michigan Health Sciences Center, Ann Arbor, Michigan 48109, USA
    Am J Pathol 163:445-52. 2003
    Mice with homozygous deletion of the plasminogen activator inhibitor-1 gene (PAI-1(-/-)) are relatively protected from bleomycin-induced pulmonary fibrosis...
  18. ncbi Enhanced in vitro proliferation of aortic endothelial cells from plasminogen activator inhibitor-1-deficient mice
    Victoria A Ploplis
    W M Keck Center for Transgene Research and the Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, USA
    J Biol Chem 279:6143-51. 2004
    A number of studies have identified a role for plasminogen activator inhibitor-1 (PAI-1) in regulating angiogenesis, although results from these investigations have been controversial...
  19. ncbi Prevention of obesity and insulin resistance in mice lacking plasminogen activator inhibitor 1
    Li Jun Ma
    Department of Pathology, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    Diabetes 53:336-46. 2004
    Increased plasminogen activator inhibitor 1 (PAI-1) has been linked to not only thrombosis and fibrosis but also to obesity and insulin resistance. Increased PAI-1 levels have been presumed to be consequent to obesity...
  20. ncbi Host-derived plasminogen activator inhibitor-1 (PAI-1) concentration is critical for in vivo tumoral angiogenesis and growth
    Khalid Bajou
    Laboratory of Tumor and Development Biology, CRCE, University of Liege, Tour de Pathologie B23, Sart Tilman, B 4000 Liege, Belgium
    Oncogene 23:6986-90. 2004
    Plasminogen activator inhibitor type 1 (PAI-1) plays a key role in tumor progression and is believed to control proteolytic activity and cell migration during angiogenesis...
  21. ncbi Overexpression of urokinase by macrophages or deficiency of plasminogen activator inhibitor type 1 causes cardiac fibrosis in mice
    Hideaki Moriwaki
    Department of Medicine, University of Washington, Seattle, WA 98195 7710, USA
    Circ Res 95:637-44. 2004
    ..we hypothesized that elevated activity of uPA or deficiency of the uPA inhibitor plasminogen activator inhibitor-1 (PAI-1) might cause cardiac fibrosis...
  22. pmc Pivotal role of PAI-1 in a murine model of hepatic vein thrombosis
    Layton H Smith
    Division of Cardiovascular Medicine, Vanderbilt University Medical Center, 2220 Pierce Ave, Nashville, TN 37232, USA
    Blood 107:132-4. 2006
    ..While the pathogenesis of VOD is uncertain, plasminogen activator inhibitor-1 (PAI-1) has emerged as a diagnostic marker and predictor of VOD in humans...
  23. ncbi Transforming growth factor beta 1 induces neointima formation through plasminogen activator inhibitor-1-dependent pathways
    Goro Otsuka
    Department of Medicine, University of Washington, Seattle, WA 98195 7710, USA
    Arterioscler Thromb Vasc Biol 26:737-43. 2006
    ..We used a mouse model to investigate mechanisms of TGF-beta1-induced intimal growth...
  24. ncbi Plasminogen activator inhibitor-1 potentiates LPS-induced neutrophil activation through a JNK-mediated pathway
    Sang Hyun Kwak
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Colorado, USA
    Thromb Haemost 95:829-35. 2006
    Plasminogen activator inhibitor-1 (PAI-1), a member of the serine protease inhibitor superfamily, modulates fibrinolysis by interacting with proteolytic mediators, including urokinase plasminogen activator (uPA)...
  25. ncbi A novel function of plasminogen activator inhibitor-1 in modulation of the AKT pathway in wild-type and plasminogen activator inhibitor-1-deficient endothelial cells
    Rashna D Balsara
    W M Keck Center for Transgene Research, University of Notre Dame, Notre Dame, IN 46556, USA
    J Biol Chem 281:22527-36. 2006
    ..The role of plasminogen activator inhibitor-1 (PAI-1) in angiogenesis remains controversial...
  26. ncbi CLOCK is involved in obesity-induced disordered fibrinolysis in ob/ob mice by regulating PAI-1 gene expression
    K Oishi
    Clock Cell Biology Research Group, Institute for Biological Resources and Functions, National Institute of Advanced Industrial Science and Technology, Higashi, Tsukuba, Ibaraki, Japan
    J Thromb Haemost 4:1774-80. 2006
    An increased level of obesity-induced plasma plasminogen activator inhibitor-1 (PAI-1) is considered a risk factor for cardiovascular disease.
  27. ncbi Bone marrow plasminogen activator inhibitor-1 influences the development of obesity
    Bart M De Taeye
    Department of Medicine, Division of Cardiovascular Medicine, Vanderbilt University, 2220 Pierce Avenue, Nashville, TN 37232, USA
    J Biol Chem 281:32796-805. 2006
    Plasma levels of plasminogen activator inhibitor-1 (PAI-1) are elevated in obesity and correlate with body mass index...
  28. ncbi Effects on coagulation and fibrinolysis induced by influenza in mice with a reduced capacity to generate activated protein C and a deficiency in plasminogen activator inhibitor type 1
    Tymen T Keller
    Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Circ Res 99:1261-9. 2006
    ..Thrombin generation was not changed in hyperfibrinolytic mice, deficient in plasminogen activator inhibitor type-1 (PAI-1(-/-)); however, increased fibrin degradation was seen...
  29. ncbi Modulation of angiotensin II and norepinephrine-induced plasminogen activator inhibitor-1 expression by AT1a receptor deficiency
    N J Brown
    Vanderbilt University Medical Center, Nashville, Tennessee 37232 6602, USA
    Kidney Int 72:72-81. 2007
    Angiotensin (Ang) II stimulates plasminogen activator inhibitor-1 (PAI-1) expression in many cell types by mechanisms that are cell-type specific...
  30. ncbi PAI-1 deficiency reduces liver fibrosis after bile duct ligation in mice through activation of tPA
    Hongtao Wang
    Division of Gastroenterology and Nutrition, Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA
    FEBS Lett 581:3098-104. 2007
    Plasminogen activator inhibitor-1 (PAI-1) increases injury in several liver, lung and kidney disease models...
  31. pmc Tumoral and choroidal vascularization: differential cellular mechanisms involving plasminogen activator inhibitor type I
    Maud Jost
    Laboratory of Tumor and Developmental Biology, University of Liege, Tour de Pathologie, CHU B23, Sart Tilman B 4000 Liège, Belgium
    Am J Pathol 171:1369-80. 2007
    An adequate balance between serine proteases and their plasminogen activator inhibitor-1 (PAI-1) is critical for pathological angiogenesis...
  32. pmc Transgenic over-expression of plasminogen activator inhibitor-1 results in age-dependent and gender-specific increases in bone strength and mineralization
    S M Nordstrom
    Department of Medicine, Vanderbilt University, Nashville, Tennessee, USA
    Bone 41:995-1004. 2007
    The plasminogen activation system (PAS) and its principal inhibitor, plasminogen activator inhibitor-1 (PAI-1), are recognized modulators of matrix...
  33. pmc TGF-beta1-induced plasminogen activator inhibitor-1 expression in vascular smooth muscle cells requires pp60(c-src)/EGFR(Y845) and Rho/ROCK signaling
    Rohan Samarakoon
    Albany Medical College, Center for Cell Biology and Cancer Research, MC 165, 47 New Scotland Avenue, Albany, NY 12208, USA
    J Mol Cell Cardiol 44:527-38. 2008
    TGF-beta1 and its target gene encoding plasminogen activator inhibitor-1 (PAI-1) are major causative factors in the pathology of tissue fibrosis and vascular disease...
  34. pmc Essential role of plasminogen activator inhibitor type-1 in radiation enteropathy
    Fabien Milliat
    Laboratory of Radiopathology, Institute for Radiological Protection and Nuclear Safety, Fontenay aux Roses Unité Propre de Recherche et de l Enseignement Supérieur, Equipe d Accueil 2710, France
    Am J Pathol 172:691-701. 2008
    ..involved in radiation-induced damage, we hypothesized that its target gene, plasminogen activator inhibitor type 1 (PAI-1), is an essential mediator of intestinal radiation toxicity...
  35. pmc PAI-1 inhibits neutrophil efferocytosis
    Young Jun Park
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Proc Natl Acad Sci U S A 105:11784-9. 2008
    ..Plasma and tissue levels of plasminogen activator inhibitor-1 (PAI-1), an inhibitor of fibrinolysis, are elevated in inflammatory conditions, including sepsis and acute lung injury, ..
  36. doi Reduction of brain metastases in plasminogen activator inhibitor-1-deficient mice with transgenic ocular tumors
    C M Maillard
    Laboratory of Tumor and Development Biology, GIGA Cancer, Tour de Pathologie B23, University of Liege, Sart Tilman, B 4000 Liege, Belgium
    Carcinogenesis 29:2236-42. 2008
    ..We studied the impact of plasminogen activator inhibitor (PAI)-1 deficiency in a transgenic mouse model of ocular tumors originating from retinal epithelial cells and leading to ..
  37. doi Fracture healing in mice deficient in plasminogen activator inhibitor-1
    Charles H Rundle
    Musculoskeletal Disease Center, Jerry L Pettis Memorial Veterans Administration Medical Center, 11201 Benton Street, Loma Linda, CA 92357, USA
    Calcif Tissue Int 83:276-84. 2008
    To evaluate the role of plasminogen activator inhibitor (PAI)-1, a key negative regulator of the plasmin system of extracellular matrix proteases in developmental bone growth and fracture repair, the bone phenotype of male adult PAI-1-..
  38. pmc Plasminogen activator inhibitor-1 protects endothelial cells from FasL-mediated apoptosis
    Khalid Bajou
    Division of Hematology Oncology, Department of Pediatrics, University of Southern California and The Saban Research Institute of Childrens Hospital Los Angeles, Los Angeles, CA 90027, USA
    Cancer Cell 14:324-34. 2008
    Plasminogen activator inhibitor-1 (PAI-1) paradoxically enhances tumor progression and angiogenesis; however, the mechanism supporting this role is not known...
  39. pmc Plasminogen activator inhibitor-1 regulates integrin alphavbeta3 expression and autocrine transforming growth factor beta signaling
    Benjamin S Pedroja
    Department of Ophthalmology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 284:20708-17. 2009
    ..transforming growth factor beta (TGFbeta) signaling, resulting in extracellular matrix accumulation and increased PAI-1 (plasminogen activator inhibitor) expression...
  40. ncbi Inhibition by fibrates of plasminogen activator inhibitor type-1 expression in human adipocytes and preadipocytes
    Andreas Zirlik
    Dept of Cardiology and Angiology, University of Freiburg, Hugstetterstrasse 55, 79106 Freiburg, Germany
    Thromb Haemost 101:1060-9. 2009
    Plasminogen activator inhibitor type-1 (PAI-1), an established marker and mediator of cardiovascular risk, is produced extensively in adipose tissue...
  41. pmc Plasminogen activator inhibitor-1 (PAI-1) is cardioprotective in mice by maintaining microvascular integrity and cardiac architecture
    Zhi Xu
    The W M Keck Center for Transgene Research, 230 Raclin Carmichael Hall, University of Notre Dame, Notre Dame, IN 46556, USA
    Blood 115:2038-47. 2010
    Although the involvement of plasminogen activator inhibitor-1 (PAI-1) in fibrotic diseases is well documented, its role in cardiac fibrosis remains controversial...
  42. pmc Oxidative modification of nuclear mitogen-activated protein kinase phosphatase 1 is involved in transforming growth factor beta1-induced expression of plasminogen activator inhibitor 1 in fibroblasts
    Rui Ming Liu
    Department of Environmental Health Sciences, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Biol Chem 285:16239-47. 2010
    ..RNA enhances TGF-beta1-induced phosphorylation of JNK and p38 as well as the expression of plasminogen activator inhibitor 1 (PAI-1), a TGF-beta-responsive gene involved in the pathogenesis of many diseases...
  43. pmc Plasminogen activator inhibitor-1 is a transcriptional target of the canonical pathway of Wnt/beta-catenin signaling
    Weichun He
    Department of Medicine, The First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, China
    J Biol Chem 285:24665-75. 2010
    Plasminogen activator inhibitor-1 (PAI-1) is a multifunctional glycoprotein that plays a critical role in the pathogenesis of chronic kidney and cardiovascular diseases...
  44. doi Genetic deficiency of plasminogen activator inhibitor-1 promotes cardiac fibrosis in aged mice: involvement of constitutive transforming growth factor-beta signaling and endothelial-to-mesenchymal transition
    Asish K Ghosh
    Feinberg Cardiovascular Research Institute, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Circulation 122:1200-9. 2010
    Elevated levels of plasminogen activator inhibitor-1 (PAI-1), a potent inhibitor of urokinase plasminogen activator and tissue plasminogen activator, are implicated in the pathogenesis of tissue fibrosis...
  45. doi PPARα deficiency augments a ketogenic diet-induced circadian PAI-1 expression possibly through PPARγ activation in the liver
    Katsutaka Oishi
    Biological Clock Research Group, Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology AIST, Tsukuba, Ibaraki, Japan
    Biochem Biophys Res Commun 401:313-8. 2010
    An increased level of plasminogen activator inhibitor-1 (PAI-1) is considered a risk factor for cardiovascular diseases, and PAI-1 gene expression is under the control of molecular circadian clocks in mammals...
  46. doi Transient reduction of placental angiogenesis in PAI-1-deficient mice
    Soraya Labied
    Laboratory of Tumour and Development Biology, University of Liege, Tour de Pathologie B23, Groupe Interdisciplinaire de Génoprotéomique Appliquée Cancer GIGA Cancer, Liege, Belgium
    Physiol Genomics 43:188-98. 2011
    ..Plasminogen activator inhibitor-1 (PAI-1) is transiently produced by spongiotrophoblasts and trophoblast giant cells at 10.5-11.5 days postcoitum (dpc)...
  47. pmc The anti-fibrinolytic SERPIN, plasminogen activator inhibitor 1 (PAI-1), is targeted to and released from catecholamine storage vesicles
    Qijiao Jiang
    Department of Medicine, University of California, San Diego, La Jolla, CA 92161, USA
    Blood 117:7155-63. 2011
    Recent studies suggest a crucial role for plasminogen activator inhibitor-1 (PAI-1) in mediating stress-induced hypercoagulability and thrombosis. However, the mechanisms by which PAI-1 is released by stress are not well-delineated...
  48. pmc Increased PAI-1 in females compared with males is protective for abdominal aortic aneurysm formation in a rodent model
    Paul D DiMusto
    Jobst Vascular Research Laboratory, Department of Surgery, University of Michigan, Ann Arbor, USA
    Am J Physiol Heart Circ Physiol 302:H1378-86. 2012
    The serine proteases, along with their inhibitor plasmin activator inhibitor-1 (PAI-1), have been shown to play a role in abdominal aortic aneurysm (AAA) formation...
  49. pmc PAI-1-dependent endothelial cell death determines severity of radiation-induced intestinal injury
    Rym Abderrahmani
    Laboratory of Radiopathology and Experimental Therapeutics, Institute for Radiological Protection and Nuclear Safety, Fontenay aux Roses, France
    PLoS ONE 7:e35740. 2012
    ..Recently, plasminogen activator inhibitor type 1 (SERPINE1/PAI-1) was reported as an essential mediator of late radiation-induced intestinal injury...
  50. pmc The vitronectin-binding domain of plasminogen activator inhibitor-1 plays an important functional role in lipopolysaccharide-induced lethality in mice
    R Narasaki
    W M Keck Center for Transgene Research Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN, USA
    J Thromb Haemost 10:2618-21. 2012
    ..The vitronectin-binding domain of plasminogen activator inhibitor-1 plays an important functional role in lipopolysaccharide-induced lethality in mice. J Thromb Haemost 2012; 10: 2678-21...
  51. pmc Gastric expression of plasminogen activator inhibitor (PAI)-1 is associated with hyperphagia and obesity in mice
    Susan Kenny
    Departments of Cell and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Liverpool L69 3BX, United Kingdom
    Endocrinology 154:718-26. 2013
    The adipokine plasminogen activator inhibitor (PAI)-1 is increased in plasma of obese individuals and exhibits increased expression in the stomachs of individuals infected with Helicobacter...
  52. pmc Plasminogen activator inhibitor-1 is involved in streptozotocin-induced bone loss in female mice
    Yukinori Tamura
    Department of Physiology and Regenerative Medicine, Kinki University Faculty of Medicine, Osaka, Japan
    Diabetes 62:3170-9. 2013
    ..In the current study, we investigated the role of plasminogen activator inhibitor (PAI)-1 in the pathogenesis of type 1 diabetic osteoporosis by using PAI-1-deficient mice...
  53. pmc Plasminogen activator inhibitor-1 gene-deficient mice. I. Generation by homologous recombination and characterization
    P Carmeliet
    Whitehead Institute for Biomedical Sciences, Cambridge, Massachusetts 02139 4307
    J Clin Invest 92:2746-55. 1993
    Homozygous plasminogen activator inhibitor-1 (PAI-1)-deficient (PAI-1-/-) mice were generated by homologous recombination in D3 embryonic stem cells...
  54. ncbi PAI-1 deficiency attenuates the fibrogenic response to ureteral obstruction
    T Oda
    Children s Hospital and Regional Medical Center, Department of Pediatrics, University of Washington, Seattle, Washington 98105, USA
    Kidney Int 60:587-96. 2001
    Progressive renal disease is characterized by the induction of plasminogen activator inhibitor-1 (PAI-1), suggesting that impaired activity of the renal plasmin cascade may play a role in renal fibrosis.
  55. ncbi Enhanced thrombosis in atherosclerosis-prone mice is associated with increased arterial expression of plasminogen activator inhibitor-1
    Katrin Schafer
    Department of Cardiology and Pulmonary Medicine, Georg August University of Goettingen, Germany
    Arterioscler Thromb Vasc Biol 23:2097-103. 2003
    This study was undertaken to investigate the origin and pathophysiological importance of plasminogen activator inhibitor (PAI-1) in atherosclerosis.
  56. pmc Plasminogen activator inhibitor-1 gene-deficient mice. II. Effects on hemostasis, thrombosis, and thrombolysis
    P Carmeliet
    Center for Molecular and Vascular Biology, University of Leuven, Belgium
    J Clin Invest 92:2756-60. 1993
    The effects of plasminogen activator inhibitor-1 (PAI-1) gene inactivation on hemostasis, thrombosis and thrombolysis were studied in homozygous PAI-1-deficient (PAI-1-/-) mice, generated by homologous recombination in D3 embryonic stem ..
  57. pmc Coordinated induction of plasminogen activator inhibitor-1 (PAI-1) and inhibition of plasminogen activator gene expression by hypoxia promotes pulmonary vascular fibrin deposition
    D J Pinsky
    Columbia University College of Physicians and Surgeons, New York 10032, USA
    J Clin Invest 102:919-28. 1998
    ..Plasma levels of plasminogen activator inhibitor-1 (PAI-1) antigen, detected by ELISA, increased in a time-dependent fashion after hypoxic exposure (increased as early as ..
  58. pmc Remodeling of the vessel wall after copper-induced injury is highly attenuated in mice with a total deficiency of plasminogen activator inhibitor-1
    V A Ploplis
    W M Keck Center for Transgene Research and Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, USA
    Am J Pathol 158:107-17. 2001
    ..system on both early and late stages of this disease, mice deficient for plasminogen activator inhibitor-1 (PAI-1(-/-)) were used in a model of vascular injury/repair, and the resulting phenotype compared to that of wild-type (..
  59. ncbi Transcriptional profiling after bile duct ligation identifies PAI-1 as a contributor to cholestatic injury in mice
    Hongtao Wang
    Division of Gastroenterology and Nutrition, Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA
    Hepatology 42:1099-108. 2005
    ..The most upregulated gene identified encodes plasminogen activator inhibitor 1 (PAI-1, Serpine 1), a protease inhibitor that blocks urokinase plasminogen activator (uPA) and ..
  60. ncbi Food deprivation induces adipose plasminogen activator inhibitor-1 (PAI-1) expression without accumulation of plasma PAI-1 in genetically obese and diabetic db/db mice
    Katsutaka Oishi
    Clock Cell Biology Research Group, National Institute of Advanced Industrial Science and Technology, Central 6, 1 1 1, Higashi, Tsukuba, Ibaraki 305 8566, Japan
    Thromb Haemost 98:864-70. 2007
    ..Twelve hours of FD induced considerable gene expression of plasminogen activator inhibitor-1 (PAI-1) in both epididymal (3.8-fold, p < 0.05) and intestinal (2.4-fold, p < 0...
  61. pmc Tissue-type plasminogen activator is not necessary for platelet-derived growth factor-c activation
    Kimberly J Riehle
    Department of Pathology, University of Washington School of Medicine, Seattle, WA 98195, USA Department of Surgery, University of Washington School of Medicine, Seattle, WA 98195, USA
    Biochim Biophys Acta 1842:318-25. 2014
    ..Our ELISA data suggest a difference between in vitro and in vivo activation of this growth factor, and our mouse model confirms that multiple proteases cleave and activate PDGF-C in vivo. ..
  62. pmc Histone H3 lysine 36 methyltransferase Hypb/Setd2 is required for embryonic vascular remodeling
    Ming Hu
    State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
    Proc Natl Acad Sci U S A 107:2956-61. 2010
    ..Taken together, these results indicate that Hypb is required for embryonic vascular remodeling and provide a tool to study the function of H3K36 methylation in vasculogenesis/angiogenesis...
  63. pmc Mitogen-activated protein kinase kinase kinase 1 (MAP3K1) integrates developmental signals for eyelid closure
    Esmond Geh
    Department of Environmental Health, University of Cincinnati Medical Center, Cincinnati, OH 45267, USA
    Proc Natl Acad Sci U S A 108:17349-54. 2011
    ..and activates a JNK-c-Jun module, leading to AP-1 transactivation and induction of its downstream genes, such as Pai-1. MAP3K1 inactivation reduces AP-1 activity and PAI-1 expression both in cells and developing eyelids...
  64. doi Gender-specific role of HDAC11 in kidney ischemia- and reperfusion-induced PAI-1 expression and injury
    Jee In Kim
    Department of Anatomy and BK21, Kyungpook National University School of Medicine, Daegu, Republic of Korea
    Am J Physiol Renal Physiol 305:F61-70. 2013
    ..We investigated the gender-specific role of HDACs in plasminogen activator inhibitor type-1 (PAI-1) expression and I/R injury...
  65. pmc Regulation of lung injury and fibrosis by p53-mediated changes in urokinase and plasminogen activator inhibitor-1
    Yashodhar P Bhandary
    Texas Lung Injury Institute, Center for Biomedical Research, University of Texas Health Science Center at Tyler, Tyler, Texas 75708, USA
    Am J Pathol 183:131-43. 2013
    ..of p53-mediated changes in urokinase-type plasminogen activator (uPA) and plasminogen activator inhibitor-1 (PAI-1) levels in the regulation of alveolar epithelial injury...
  66. doi Lack of both α2-antiplasmin and plasminogen activator inhibitor type-1 induces high IgE production
    Kiyotaka Okada
    Department of Physiology, Kinki University, Faculty of Medicine, Osakasayama, Japan
    Life Sci 93:89-95. 2013
    We investigated the pathophysiological changes in mice lacking α2-antiplasmin (α2-AP) and plasminogen activator inhibitor type-1 (PAI-1) genes, and elucidated the involvement of these inhibitors for fibrinolysis in immune response.
  67. pmc Cellular localization of type 1 plasminogen activator inhibitor messenger RNA and protein in murine renal tissue
    M Keeton
    Committee on Vascular Biology, Scripps Research Institute, La Jolla, CA 92037
    Am J Pathol 142:59-70. 1993
    Type 1 plasminogen activator inhibitor (PAI-1) may be markedly increased in the plasma of patients with endotoxemia and/or renal disease. To investigate renal PAI-1 production during acute endotoxemia, a murine model system was used...
  68. pmc Distribution and regulation of plasminogen activator inhibitor-1 in murine adipose tissue in vivo. Induction by tumor necrosis factor-alpha and lipopolysaccharide
    F Samad
    Scripps Research Institute, Department of Vascular Biology, La Jolla, California 92037, USA
    J Clin Invest 97:37-46. 1996
    Although elevated plasma plasminogen activator inhibitor 1 (PAI-1) is associated with obesity, very little is known about its tissue or cellular origin, or about the events that lead to increased PAI-1 levels under obese conditions...
  69. ncbi Inhibitory role of plasminogen activator inhibitor-1 in arterial wound healing and neointima formation: a gene targeting and gene transfer study in mice
    P Carmeliet
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, University of Leuven, Belgium
    Circulation 96:3180-91. 1997
    ..Therefore, we studied the consequences of plasminogen activator inhibitor-1 (PAI-1) gene inactivation and adenoviral PAI-1 gene transfer on arterial neointima formation.
  70. pmc The plasminogen activator inhibitor-2 gene is not required for normal murine development or survival
    K M Dougherty
    Howard Hughes Medical Institute, University of Michigan Medical School, Ann Arbor, MI 48109 0650, USA
    Proc Natl Acad Sci U S A 96:686-91. 1999
    Plasminogen activator inhibitor-2 (PAI-2), a member of the serpin gene family, is thought to serve as a primary regulator of plasminogen activation in the extravascular compartment...
  71. ncbi Role of plasminogen system components in focal cerebral ischemic infarction: a gene targeting and gene transfer study in mice
    N Nagai
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, Center for Molecular and Vascular Biology, KU Leuven, Belgium
    Circulation 99:2440-4. 1999
    ..ischemic infarction (FCI) was studied in mice deficient in plasminogen (Plg-/-), in tissue or urokinase plasminogen activator (tPA-/- or uPA-/-), or in plasminogen activator inhibitor-1 or alpha2-antiplasmin (PAI-1(-/-) or alpha2-AP-/-).
  72. ncbi Impaired migration and delayed differentiation of pancreatic islet cells in mice lacking EGF-receptors
    P J Miettinen
    Department of Pathology and Transplantation Laboratory, The Haartman Institute, and Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland
    Development 127:2617-27. 2000
    ..Furthermore, the levels of secreted plasminogen activator inhibitor-1 (PAI-1) were markedly higher, while no apparent differences were seen in the levels of active uPA and tPa between EGF-R (..
  73. ncbi Restricted feeding induces daily expression of clock genes and Pai-1 mRNA in the heart of Clock mutant mice
    Yoichi Minami
    Department of Pharmacology and Brain Science, School of Human Sciences, Waseda University, Tokorozawa, Saitama 359 1192, Japan
    FEBS Lett 526:115-8. 2002
    Plasminogen activator inhibitor-1 (PAI-1) is a key factor of fibrinolytic activity. The activity and mRNA abundance show a daily rhythm...
  74. ncbi Fibrinolysis in LPS-induced chronic airway disease
    Jordan D Savov
    Duke Univ Medical Center, P O Box 2629, Durham, NC 27710, USA
    Am J Physiol Lung Cell Mol Physiol 285:L940-8. 2003
    ..Subepithelial fibrin deposition was prevalent in WT mice but diminished in C57BL/6JPAI-1-/-. PAI-1 expression by nonciliated bronchial epithelial cells was enhanced in LPS-exposed WT mice compared with the saline-..
  75. ncbi Type 1 plasminogen activator inhibitor deficiency aggravates the course of experimental glomerulonephritis through overactivation of transforming growth factor beta
    Alexandre Hertig
    Institut National de la Santé et de la Recherche Médicale U489, Paris, France
    FASEB J 17:1904-6. 2003
    Type 1 plasminogen activator inhibitor (PAI-1) is the primary inhibitor of tissue-type plasminogen activator (tPA) and urokinase-type plasminogen activator (uPA)...
  76. ncbi Evidence for similar expression of protein C inhibitor and the urokinase-type plasminogen activator system during mouse testis development
    Fanny Odet
    Institut National de la Sante et de la Recherche Medicale, Unité 329, Hopital Debrousse, 69322 Lyon cedex 05, France
    Endocrinology 145:1481-9. 2004
    ..We here demonstrate that PAI-3 or protein C (PC) inhibitor (PCI) was expressed in a sexually dimorphic fashion during mouse gonad genesis, ..
  77. ncbi PPARalpha deficiency does not modify age dependency but prevents high fat diet increase in plasma PAI-1 as well as insulin resistance
    Alenka Mavri
    Thromb Haemost 91:1051-2. 2004
  78. ncbi Cholesterol diet enhances daily rhythm of Pai-1 mRNA in the mouse liver
    Takashi Kudo
    Department of Pharmacology, School of Science and Engineering, Waseda University, Higashifushimi 2 7 5, Nishitokyo shi, Tokyo 202 0021, Japan
    Am J Physiol Endocrinol Metab 287:E644-51. 2004
    ..Plasminogen activator inhibitor-1 (PAI-1) is a key factor behind fibrinolytic activity, and its gene expression is controlled under the circadian clock ..
  79. pmc Plasminogen activator inhibitor-1 is elevated, but not essential, in the development of bleomycin-induced murine scleroderma
    M Matsushita
    Department of Dermatology, Tokyo Medical and Dental University, School of Medicine, Tokyo, Japan
    Clin Exp Immunol 139:429-38. 2005
    Accumulative data have demonstrated that plasminogen activator inhibitor-1 (PAI-1) plays an important role in the extracellular matrix metabolism; however, the involvement of PAI-1 in scleroderma has not been fully elucidated...
  80. ncbi Protection of plasminogen activator inhibitor-1-deficient mice from nasal allergy
    Takayuki Sejima
    Department of Otorhinolaryngology Head and Neck Surgery, and Division of Cell and Molecular Medicine, Center for Molecular Medicine, Jichi Medical School, International University of Health and Welfare Hospital, Tochigi, Japan
    J Immunol 174:8135-43. 2005
    ..excess subepithelial collagen deposition in wild-type (WT) C57BL/6J mice than in plasminogen activator inhibitor (PAI)-1-deficient (PAI-1(-/-)) mice...
  81. ncbi Regulation of lipopolysaccharide-induced lung inflammation by plasminogen activator Inhibitor-1 through a JNK-mediated pathway
    Patrick G Arndt
    Division of Pulmonary and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, CO 80206, USA
    J Immunol 175:4049-59. 2005
    ..As plasminogen activator inhibitor-1 (PAI-1) accentuates cell migration, with JNK activation recently shown to up-regulate PAI-1 expression, this suggested ..
  82. ncbi Evidence for a pre-latent form of the serpin plasminogen activator inhibitor-1 with a detached beta-strand 1C
    Daniel M Dupont
    Laboratory of Cellular Protein Science, Department of Molecular Biology, University of Aarhus, Gustav Wieds Vej 10C, DK 8000 Arhus C, Denmark
    J Biol Chem 281:36071-81. 2006
    Latency transition of plasminogen activator inhibitor-1 (PAI-1) occurs spontaneously in the absence of proteases and results in stabilization of the molecule through insertion of its reactive center loop (RCL) as a strand in beta-sheet A ..
  83. pmc Genetic background determines response to hemostasis and thrombosis
    Jane Hoover-Plow
    Department of Cardiovascular Medicine, Joseph J Jacobs Center for Thrombosis and Vascular Biology, Ohio, USA
    BMC Blood Disord 6:6. 2006
    ..The objective of this study was to evaluate thrombosis and hemostasis in these two inbred strains and determine the phenotypic response of A/J chromosomes in the C57BL/6J background...
  84. ncbi Reactive site-dependent phenotypic alterations in plasminogen activator inhibitor-1 transgenic mice
    M Eren
    Division of Cardiovascular Medicine, Department of Medicine and Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    J Thromb Haemost 5:1500-8. 2007
    Plasminogen activator inhibitor-1 (PAI-1) is the major physiological inhibitor of plasminogen activators (PAs) and plays a role in the regulation of a number of physiological processes including the degradation of extracellular matrix ..
  85. ncbi Plasminogen activator inhibitor-1 contributes to the deleterious effect of obesity on the outcome of thrombotic ischemic stroke in mice
    N Nagai
    Center for Molecular and Vascular Biology, KU Leuven, Leuven, Belgium
    J Thromb Haemost 5:1726-31. 2007
    ..Adipose tissue is an important source of plasminogen activator inhibitor-1 (PAI-1), the main inhibitor of plasminogen activation.
  86. ncbi Gender-dependent physiological implications of combined PAI-1 and TIMP-1 gene deficiency characterized in a mouse model
    Jakob Harslund
    1Section of Biomedicine, Dept of Veterinary Pathobiology, Faculty of Life Sciences, Univ of Copenhagen, Ridebanevej 9, DK 1870 Frederiksberg C, Denmark
    Am J Physiol Regul Integr Comp Physiol 293:R1630-9. 2007
    The endogenous proteinase inhibitors plasminogen activator inhibitor type 1 (PAI-1) and tissue inhibitor of metalloproteinase type 1 (TIMP-1) are two distinct proteins with separate molecular pathways...
  87. ncbi Adiponectin mediates the suppressive effect of rosiglitazone on plasminogen activator inhibitor-1 production
    Ruby L C Hoo
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong, China
    Arterioscler Thromb Vasc Biol 27:2777-82. 2007
    ..sulfonylureas, on circulating levels of adiponectin and the prothrombotic factor, plasminogen activator inhibitor (PAI)-1, in type 2 diabetic patients, and to investigate, in animal models, whether the antithrombotic action of ..
  88. ncbi TGF-beta signaling is dynamically regulated during the alveolarization of rodent and human lungs
    Miguel A Alejandre-Alcázar
    Department of Internal Medicine, University of Giessen Lung Center, Justus Liebig University, Giessen, Germany
    Dev Dyn 237:259-69. 2008
    ..These data suggest that active TGF-beta signaling is required for normal late lung development...
  89. pmc Plasmin therapy enhances mobilization of HPCs after G-CSF
    Marc Tjwa
    Vesalius Research Center, Leuven, Belgium
    Blood 112:4048-50. 2008
    ..Here we report that genetic loss of the plasminogen activator inhibitor Pai-1 or of the plasmin inhibitor alpha2-antiplasmin increases HPC mobilization in response to G-CSF...
  90. pmc Plasminogen activator inhibitor 1 protects fibrosarcoma cells from etoposide-induced apoptosis through activation of the PI3K/Akt cell survival pathway
    Maria U Rømer
    Department of Veterinary Pathobiology, Section for Biomedicine, Faculty of Life Sciences, University of Copenhagen, Ridebanevej 9, DK 1870 Frederiksberg C, Copenhagen, Denmark
    Neoplasia 10:1083-91. 2008
    ..b>Plasminogen activator inhibitor 1 has been suggested to contribute to tumor growth by protecting cancer cells from apoptosis, and we ..
  91. doi A profibrotic effect of plasminogen activator inhibitor type-1 (PAI-1) in the heart
    A K M Tarikuz Zaman
    University of Vermont, Colchester Research Facility, 208 South Park Drive, Colchester, VT 05446, USA
    Exp Biol Med (Maywood) 234:246-54. 2009
    Increased expression of PAI-1 is profibrotic in several organs. However, its potentially profibrotic effects in the heart subjected to infarction have not been elucidated...
  92. pmc Plasminogen activator inhibitor-1 (PAI-1) facilitates retinal angiogenesis in a model of oxygen-induced retinopathy
    Anupam Basu
    Department of Cell Biology and Physiology, University of New Mexico School of Medicine, Albuquerque, New Mexico 87131, USA
    Invest Ophthalmol Vis Sci 50:4974-81. 2009
    ..The aim of the present study was to investigate the role of the serine proteinase inhibitor plasminogen activator inhibitor -1 (PAI-1) in facilitating retinal angiogenesis.
  93. pmc The urokinase receptor (uPAR) facilitates clearance of Borrelia burgdorferi
    Joppe W R Hovius
    Center for Experimental and Molecular Medicine CEMM, Academic Medical Center, University of Amsterdam, AMC, Amsterdam, The Netherlands
    PLoS Pathog 5:e1000447. 2009
    ..numbers in vivo, and phagocytotic capacity in vitro, were unaltered in uPA, tPA (low fibrinolytic activity) and PAI-1 (high fibrinolytic activity) knock-out mice compared to WT controls...
  94. doi Anticoagulant and antithrombotic properties of platelet protease nexin-1
    Yacine Boulaftali
    INSERM, U698, Universite Paris 7, Paris, France
    Blood 115:97-106. 2010
    ..Platelet PN-1 is thus a key player in the thrombotic process, whose negative regulatory role has been, up to now, markedly underestimated...
  95. pmc Regulation of plasminogen activator inhibitor-1 expression in endothelial cells with exposure to metal nanoparticles
    Min Yu
    Department of Environmental and Occupational Health Sciences, School of Public Health and Information Sciences, University of Louisville, 485 E Gray Street, Louisville, KY 40209, USA
    Toxicol Lett 195:82-9. 2010
    ..Plasminogen activator inhibitor-1 (PAI-1) is the most potent endogenous inhibitor of fibrinolysis and is involved in the pathogenesis of several ..
  96. pmc Unimpeded skin carcinogenesis in K14-HPV16 transgenic mice deficient for plasminogen activator inhibitor
    Anne Masset
    Laboratory of Biology of Tumor and Development, Groupe Interdisciplinaire de Génoprotéomique Appliqué GIGA Cancer, Tour de Pathologie B23, Sart Tilman, Liege, University of Liege, Liege, Belgium
    Int J Cancer 128:283-93. 2011
    ..the plasminogen activating system and its main physiological inhibitor, the plasminogen activator inhibitor-1 (PAI-1)...
  97. pmc Placenta growth factor (PlGF), a novel inducer of plasminogen activator inhibitor-1 (PAI-1) in sickle cell disease (SCD)
    Nitin Patel
    Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA
    J Biol Chem 285:16713-22. 2010
    Sickle cell disease (SCD) is characterized by a prothrombotic state. Plasminogen activator inhibitor-1 (PAI-1) is known to modulate fibrinolysis, lung injury/fibrosis, and angiogenesis...
  98. pmc Plasminogen activator inhibitor-1 and vitronectin expression level and stoichiometry regulate vascular smooth muscle cell migration through physiological collagen matrices
    N Garg
    Department of Internal Medicine, University of Missouri School of Medicine and Research Service, Harry S Truman Memorial Veterans Affairs Hospital, Columbia, MO, USA
    J Thromb Haemost 8:1847-54. 2010
    Vascular smooth muscle cell (VSMC) migration is a critical process in arterial remodeling. Purified plasminogen activator inhibitor-1 (PAI-1) is reported to both promote and inhibit VSMC migration on two-dimensional (D) surfaces.
  99. pmc HDL3, but not HDL2, stimulates plasminogen activator inhibitor-1 release from adipocytes: the role of sphingosine-1-phosphate
    Mi Hye Lee
    Division of Endocrinology, Metabolism, and Medical Genetics, Department of Medicine, Medical University of South Carolina, Charleston, SC, USA
    J Lipid Res 51:2619-28. 2010
    ..decreased fibrinolytic capacity may result from increased circulating levels of plasminogen activator inhibitor-1 (PAI-1). We examined the effect of S1P associated with HDL subfractions on PAI-1 secretion from 3T3 adipocytes...

Research Grants11

  1. PATHOLOGICAL CONSEQUENCES OF THE PLASMINOGEN SYSTEM
    Victoria Ploplis; Fiscal Year: 2010
    ..Studies have indicated that a PAI-1 deficiency diminishes angiogenesis in tumor models...
  2. Glutathione deficiency & immune dysfunction during aging
    Rui Ming Liu; Fiscal Year: 2006
    ....
  3. SYSTEMATIC EVALUATION OF THE PLASMINOGEN SYSTEM
    Jane Hoover Plow; Fiscal Year: 2003
    ..End of Abstract.) ..
  4. Vascular Cell Regulation of Connexins
    Brant Isakson; Fiscal Year: 2005
    ..These results will be compared to similar experiments on in situ wild type and connexin KO animals. Combined, these methods will help delineate the physiological role of connexins between EC and SMC. ..
  5. BARI II - FIBRINOLYSIS AND COAGULATION CORE
    Burton Sobel; Fiscal Year: 2006
    ..the effect of glycemic control strategy on the progression and mechanism of vasculopathy, including changes in PAI-1 activity and gene expression...
  6. Cyclic RGD Peptide in the Treatment of DMGS
    Susanne Nicholas; Fiscal Year: 2005
    ..The successful completion of this study can provide a novel and feasible target for treatment in DN. ..
  7. Inflammation, Procoagulation, and Plaque Vulnerability
    Burton Sobel; Fiscal Year: 2005
    ..abstract_text> ..
  8. Vanderbilt Mentored Clinical Research Scholar Program
    Nancy Brown; Fiscal Year: 2006
    ..The VCRS program will train successful new clinical investigators who will serve as leaders role in the post-genomic era. [unreadable] [unreadable] [unreadable]..
  9. Genetics of Diabetic Nephropathy in Mexican-Americans a*
    Susanne Nicholas; Fiscal Year: 2006
    ..The final year of the project will focus more heavily on manuscript preparation. Dr. Nicholas will be directly involved in all aspects of the project. ..
  10. RAAS, Inflammation & Post-Operative Atrial Fibrillation
    Nancy Brown; Fiscal Year: 2009
    ..abstract_text> ..
  11. PAI-1 and The Vascular Toxicity of Aldosterone
    Nancy Brown; Fiscal Year: 2005
    ..Ang II stimulates expression of plasminogen activator inhibitor-1 (PAI-1) both in vitro and in humans...