Serpinb5

Summary

Gene Symbol: Serpinb5
Description: serine (or cysteine) peptidase inhibitor, clade B, member 5
Alias: 1110036M19Rik, AI462524, AI646751, Maspin, PI-5, Spi7, ovalbumin, serpin B5, peptidase inhibitor 5, protease inhibitor 5, serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 5, serine (or cysteine) proteinase inhibitor, clade B, member 5, serine protease inhibitor 7
Species: mouse
Products:     Serpinb5

Top Publications

  1. Gao F, Shi H, Daughty C, Cella N, Zhang M. Maspin plays an essential role in early embryonic development. Development. 2004;131:1479-89 pubmed
    b>Maspin (Mp) is a member of the serpin family with inhibitory functions against cell migration, metastasis and angiogenesis. To identify its role in embryonic development in vivo, we generated maspin knockout mice by gene targeting...
  2. Luo J, Tan W, Ricono J, Korchynskyi O, Zhang M, Gonias S, et al. Nuclear cytokine-activated IKKalpha controls prostate cancer metastasis by repressing Maspin. Nature. 2007;446:690-4 pubmed
    ..Decreased metastasis correlated with elevated expression of the metastasis suppressor Maspin, the ablation of which restored metastatic activity...
  3. Sheng S, Truong B, Fredrickson D, Wu R, Pardee A, Sager R. Tissue-type plasminogen activator is a target of the tumor suppressor gene maspin. Proc Natl Acad Sci U S A. 1998;95:499-504 pubmed
    The maspin protein has tumor suppressor activity in breast and prostate cancers. It inhibits cell motility and invasion in vitro and tumor growth and metastasis in nude mice...
  4. Zhang M, Magit D, Botteri F, Shi H, He K, Li M, et al. Maspin plays an important role in mammary gland development. Dev Biol. 1999;215:278-87 pubmed
    b>Maspin is a unique member of the serpin family, which functions as a class II tumor suppressor gene...
  5. Cher M, Biliran H, Bhagat S, Meng Y, Che M, Lockett J, et al. Maspin expression inhibits osteolysis, tumor growth, and angiogenesis in a model of prostate cancer bone metastasis. Proc Natl Acad Sci U S A. 2003;100:7847-52 pubmed
    ..Previously, we showed that maspin, a serine protease inhibitor, specifically inhibits PC-associated uPA and PC cell invasion and motility in vitro...
  6. Qin L, Zhang M. Maspin regulates endothelial cell adhesion and migration through an integrin signaling pathway. J Biol Chem. 2010;285:32360-9 pubmed publisher
    b>Maspin has been identified as a potent angiogenesis inhibitor. However, the molecular mechanism responsible for its anti-angiogenic property is unclear...
  7. Goulet B, Kennette W, Ablack A, Postenka C, Hague M, Mymryk J, et al. Nuclear localization of maspin is essential for its inhibition of tumor growth and metastasis. Lab Invest. 2011;91:1181-7 pubmed publisher
    Maspin (mammary serine protease inhibitor or SerpinB5) acts as a tumor suppressor when overexpressed in aggressive cancer cell lines. However, its role in human cancer is controversial...
  8. Ngamkitidechakul C, Burke J, O Brien W, Twining S. Maspin: synthesis by human cornea and regulation of in vitro stromal cell adhesion to extracellular matrix. Invest Ophthalmol Vis Sci. 2001;42:3135-41 pubmed
    b>Maspin, a tumor-suppressor protein that regulates cell migration, invasion, and adhesion, is synthesized by many normal epithelial cells, but downregulated in invasive epithelial tumor cells...
  9. Dzinic S, Bernardo M, Li X, Fernandez Valdivia R, Ho Y, Mi Q, et al. An Essential Role of Maspin in Embryogenesis and Tumor Suppression. Cancer Res. 2017;77:886-896 pubmed publisher
    Maspin (SerpinB5) is an epithelial-specific tumor suppressor gene product that displays context-dependent cellular functions...

More Information

Publications25

  1. Srivastava U, Paigen B, Korstanje R. Differences in health status affect susceptibility and mapping of genetic loci for atherosclerosis (fatty streak) in inbred mice. Arterioscler Thromb Vasc Biol. 2012;32:2380-6 pubmed publisher
  2. Askew D, Askew Y, Kato Y, Turner R, Dewar K, Lehoczky J, et al. Comparative genomic analysis of the clade B serpin cluster at human chromosome 18q21: amplification within the mouse squamous cell carcinoma antigen gene locus. Genomics. 2004;84:176-84 pubmed
  3. Labbadia J, Novoselov S, Bett J, Weiss A, Paganetti P, Bates G, et al. Suppression of protein aggregation by chaperone modification of high molecular weight complexes. Brain. 2012;135:1180-96 pubmed publisher
    ..Furthermore, our findings represent an important proof of principle that DNAJ manipulation is a valid therapeutic approach for intervention in Huntington's disease. ..
  4. Zhang M, Sheng S, Maass N, Sager R. mMaspin: the mouse homolog of a human tumor suppressor gene inhibits mammary tumor invasion and motility. Mol Med. 1997;3:49-59 pubmed
    The human maspin gene encodes a protein in the serine proteinase inhibitor (serpin) family with tumor-suppressing functions in cell culture and in nude mice...
  5. Villares G, Zigler M, Dobroff A, Wang H, Song R, Melnikova V, et al. Protease activated receptor-1 inhibits the Maspin tumor-suppressor gene to determine the melanoma metastatic phenotype. Proc Natl Acad Sci U S A. 2011;108:626-31 pubmed publisher
    ..Gene expression profiling identified a 40-fold increase in expression of Maspin in PAR-1-silenced metastatic melanoma cell lines...
  6. Shao L, Shi H, Ayala G, Rowley D, Zhang M. Haploinsufficiency of the maspin tumor suppressor gene leads to hyperplastic lesions in prostate. Cancer Res. 2008;68:5143-51 pubmed publisher
    b>Maspin is a key tumor suppressor gene in prostate and breast cancers with diverse biological functions. However, how maspin regulates prostate tumor progression is not fully understood...
  7. Shi H, Lydon J, Zhang M. Hormonal defect in maspin heterozygous mice reveals a role of progesterone in pubertal ductal development. Mol Endocrinol. 2004;18:2196-207 pubmed
    ..This conclusion derived from our analysis of maspin heterozygous (Mp+/-) mice that showed defective ductal development at puberty...
  8. Denk A, Bettstetter M, Wild P, Hoek K, Bataille F, Dietmaier W, et al. Loss of maspin expression contributes to a more invasive potential in malignant melanoma. Pigment Cell Res. 2007;20:112-9 pubmed
    ..The serpin maspin, a tumour suppressor in breast and prostate cancer was described as an inhibitor of cell migration and inducer of ..
  9. Landin M, Shabestari M, Babaie E, Reseland J, Osmundsen H. Gene Expression Profiling during Murine Tooth Development. Front Genet. 2012;3:139 pubmed publisher
    ..Bioinformatic analysis associated the 87 genes with multiple biological functions. Around 35 genes were associated with 15 transcription factors. ..
  10. Mardin W, Petrov K, Enns A, Senninger N, Haier J, Mees S. SERPINB5 and AKAP12 - expression and promoter methylation of metastasis suppressor genes in pancreatic ductal adenocarcinoma. BMC Cancer. 2010;10:549 pubmed publisher
    ..05) and invasion scores (P < 0.01) while higher SERPINB5 mRNA expression was correlated with increased metastasis scores (P < 0.05)...
  11. Huang Y, Cai L, Yang R. Expression of maspin in the early pregnant mouse endometrium and its role during embryonic implantation. Comp Med. 2012;62:179-84 pubmed
    Maspin (serpin B5), a tumor-suppressing member of the serine protease inhibitor family, participates in cell migration, adhesion, invasion, and apoptosis...
  12. Mahajan N, Shi H, Lukas T, Zhang M. Tumor-suppressive maspin functions as a reactive oxygen species scavenger: importance of cysteine residues. J Biol Chem. 2013;288:11611-20 pubmed publisher
    b>Maspin is a member of the serine protease inhibitor (serpin) superfamily and displays tumor-suppressing activity by controlling cell migration, proliferation, apoptosis, and adhesion...
  13. Dzinic S, Kaplun A, Li X, Bernardo M, Meng Y, Dean I, et al. Identification of an intrinsic determinant critical for maspin subcellular localization and function. PLoS ONE. 2013;8:e74502 pubmed publisher
    b>Maspin, a multifaceted tumor suppressor, belongs to the serine protease inhibitor superfamily, but only inhibits serine protease-like enzymes such as histone deacetylase 1 (HDAC1)...
  14. Teoh S, Vieusseux J, Prakash M, Berkowicz S, Luu J, Bird C, et al. Maspin is not required for embryonic development or tumour suppression. Nat Commun. 2014;5:3164 pubmed publisher
    Maspin (SERPINB5) is accepted as an important tumour suppressor lost in many cancers...
  15. Zhang W, Shi H, Zhang M. Maspin overexpression modulates tumor cell apoptosis through the regulation of Bcl-2 family proteins. BMC Cancer. 2005;5:50 pubmed
    b>Maspin is a member of serpin family with tumor suppressing activity. Recent studies of maspin in animal models strongly support maspin's role as an inhibitor against the growth of primary tumor sand the process of metastasis...
  16. Tamazato Longhi M, Magalhães M, Reina J, Morais Freitas V, Cella N. EGFR Signaling Regulates Maspin/SerpinB5 Phosphorylation and Nuclear Localization in Mammary Epithelial Cells. PLoS ONE. 2016;11:e0159856 pubmed publisher
    Maspin (SerpinB5) is a non-inhibitory serpin (serine protease inhibitor) with very diverse biological activities including regulation of cell adhesion, migration, death, control of gene expression and oxidative stress response...