Gene Symbol: Sept4
Description: septin 4
Alias: ARTS, Bh5, Pnutl2, septin-4, M-Septin, brain protein H5, cell division control-related protein 2b, peanut-like 2 homolog, peanut-like protein 2, septin H5
Species: mouse
Products:     Sept4

Top Publications

  1. Kissel H, Georgescu M, Larisch S, Manova K, Hunnicutt G, Steller H. The Sept4 septin locus is required for sperm terminal differentiation in mice. Dev Cell. 2005;8:353-64 pubmed
    The murine septin4 gene (Sept4) has been implicated in diverse cellular functions, including cytokinesis, apoptosis, and tumor suppression...
  2. Ihara M, Yamasaki N, Hagiwara A, Tanigaki A, Kitano A, Hikawa R, et al. Sept4, a component of presynaptic scaffold and Lewy bodies, is required for the suppression of alpha-synuclein neurotoxicity. Neuron. 2007;53:519-33 pubmed
    In Parkinson disease (PD), alpha-synuclein aggregates called Lewy bodies often involve and sequester Septin4 (Sept4), a polymerizing scaffold protein. However, the pathophysiological significance of this phenomenon is unclear...
  3. Peng X, Jia Z, Zhang Y, Ware J, Trimble W. The septin CDCrel-1 is dispensable for normal development and neurotransmitter release. Mol Cell Biol. 2002;22:378-87 pubmed
    ..Together, these data suggest that CDCrel-1 is not essential for neuronal development or function, and that changes in expression of other septins may account for its functional redundancy. ..
  4. Ihara M, Kinoshita A, Yamada S, Tanaka H, Tanigaki A, Kitano A, et al. Cortical organization by the septin cytoskeleton is essential for structural and mechanical integrity of mammalian spermatozoa. Dev Cell. 2005;8:343-52 pubmed
    ..A mammalian septin gene Sept4 is expressed mainly in postmitotic neural cells and postmeiotic male germ cells...
  5. Kinoshita A, Noda M, Kinoshita M. Differential localization of septins in the mouse brain. J Comp Neurol. 2000;428:223-39 pubmed
  6. Iwaisako K, Hatano E, Taura K, Nakajima A, Tada M, Seo S, et al. Loss of Sept4 exacerbates liver fibrosis through the dysregulation of hepatic stellate cells. J Hepatol. 2008;49:768-78 pubmed publisher
    ..We disclose the quiescent hepatic stellate cells (HSCs)-specific expression of a septin subunit Sept4 in the liver, and explore the significance of the septin system in liver fibrosis...
  7. Bornstein B, Gottfried Y, Edison N, Shekhtman A, Lev T, Glaser F, et al. ARTS binds to a distinct domain in XIAP-BIR3 and promotes apoptosis by a mechanism that is different from other IAP-antagonists. Apoptosis. 2011;16:869-81 pubmed publisher
    b>ARTS (Sept4_i2), is a pro-apoptotic protein localized at the mitochondria of living cells. In response to apoptotic signals, ARTS rapidly translocates to the cytosol where it binds and antagonizes XIAP to promote caspase activation...
  8. Ono R, Ihara M, Nakajima H, Ozaki K, Kataoka Fujiwara Y, Taki T, et al. Disruption of Sept6, a fusion partner gene of MLL, does not affect ontogeny, leukemogenesis induced by MLL-SEPT6, or phenotype induced by the loss of Sept4. Mol Cell Biol. 2005;25:10965-78 pubmed
    ..quantitative changes in any of the septins evaluated in this study, nor did it cause any additional changes in the Sept4-deficient mice...
  9. Kim J, Kim S, Kim B, Lee H, Kim I, Yun J, et al. Identification of a novel anti-apoptotic E3 ubiquitin ligase that ubiquitinates antagonists of inhibitor of apoptosis proteins SMAC, HtrA2, and ARTS. J Biol Chem. 2013;288:12014-21 pubmed publisher
    ..AREL1 interacted with and ubiquitinated IAP antagonists such as SMAC, HtrA2, and ARTS. However, AREL1 was cytosolic and did not localize to nuclei or mitochondria...

Scientific Experts

More Information


  1. Kato K. A Collection of cDNA Clones with Specific Expression Patterns in Mouse Brain. Eur J Neurosci. 1990;2:704-711 pubmed
    ..Among them seven clones were especially abundant in specific nuclei, and three in specific fibre bundles. These clones will be useful in defining new subpopulations of brain cells characterized by different gene expression. ..
  2. Takahashi S, Inatome R, Yamamura H, Yanagi S. Isolation and expression of a novel mitochondrial septin that interacts with CRMP/CRAM in the developing neurones. Genes Cells. 2003;8:81-93 pubmed
    ..Our results suggest that M-septin has a role which is distinct from H5, and together with CRMP/CRAM, may play an important role in the neuronal differentiation and axon guidance through the control of mitochondrial function. ..
  3. Ageta Ishihara N, Yamakado H, Morita T, Hattori S, Takao K, Miyakawa T, et al. Chronic overload of SEPT4, a parkin substrate that aggregates in Parkinson's disease, causes behavioral alterations but not neurodegeneration in mice. Mol Brain. 2013;6:35 pubmed publisher
    ..Parkin substrates include two septins; SEPT4/CDCrel-2 which coaggregates with ?-synuclein as Lewy bodies in Parkinson's disease, and its closest homolog SEPT5/..
  4. Zhu D, Song K, Chen J, Wang J, Sun X, Qian H, et al. Expression of Septin4 in Schistosoma japonicum-infected mouse livers after praziquantel treatment. Parasit Vectors. 2015;8:19 pubmed publisher
    Septin4 (SEPT4) exists widely in human tissues and is related to mechanical stability, actin dynamics, membrane trafficking, viral replication and apoptosis...
  5. Paavola P, Horelli Kuitunen N, Palotie A, Peltonen L. Characterization of a novel gene, PNUTL2, on human chromosome 17q22-q23 and its exclusion as the Meckel syndrome gene. Genomics. 1999;55:122-5 pubmed
    We assigned two human expressed sequence tags (ESTs), WI-15444 and SGC32067, homologous to mouse brain protein h5, to the critical region for Meckel syndrome (MKS) on 17q22-q23...
  6. Duan Y, Qian H, Qin Y, Zhu D, He X, Zhou Q, et al. Dynamics of Sept4 expression in fibrotic livers of mice infected with Schistosoma japonicum. Parasitology. 2011;138:1003-10 pubmed publisher
    n order to investigate the dynamics of Septin4 (Sept4) expression and its function in the formation of fibrotic livers in mice infected with Schistosoma japonicum, we constructed the mouse model of S...
  7. Kwitny S, Klaus A, Hunnicutt G. The annulus of the mouse sperm tail is required to establish a membrane diffusion barrier that is engaged during the late steps of spermiogenesis. Biol Reprod. 2010;82:669-78 pubmed publisher
    ..We tested this premise directly on septin 4 knockout mice, whose sperm are viable but lack an annulus, by following the diffusing membrane protein basigin...
  8. Garcia Fernandez M, Kissel H, Brown S, Gorenc T, Schile A, Rafii S, et al. Sept4/ARTS is required for stem cell apoptosis and tumor suppression. Genes Dev. 2010;24:2282-93 pubmed publisher
    ..Here we show that deletion of the mouse Sept4 gene, which encodes the IAP antagonist ARTS, promotes tumor development...
  9. Kinoshita N, Kimura K, Matsumoto N, Watanabe M, Fukaya M, Ide C. Mammalian septin Sept2 modulates the activity of GLAST, a glutamate transporter in astrocytes. Genes Cells. 2004;9:1-14 pubmed
    ..Thus Sept2 may regulate GLAST-mediated glutamate uptake by astrocytes, which is important for appropriate transmitter signalling in the cerebellum. ..
  10. Fuchs Y, Brown S, Gorenc T, Rodriguez J, Fuchs E, Steller H. Sept4/ARTS regulates stem cell apoptosis and skin regeneration. Science. 2013;341:286-9 pubmed publisher
    ..We found that mice deficient for the proapoptotic Sept4/ARTS gene have elevated numbers of hair follicle stem cells (HFSCs) that are protected against apoptosis...
  11. Colley S, Wintle L, Searles R, Russell V, Firman R, Smith S, et al. Loss of the nuclear receptor corepressor SLIRP compromises male fertility. PLoS ONE. 2013;8:e70700 pubmed publisher
    ..In sum, our data implicates SLIRP in regulating male fertility, wherein its loss results in asthenozoospermia associated with compromised sperm structure and mitochondrial morphology. ..
  12. He X, Bao J, Chen J, Sun X, Wang J, Zhu D, et al. Adenovirus-mediated over-expression of Septin4 ameliorates hepatic fibrosis in mouse livers infected with Schistosoma japonicum. Parasitol Int. 2015;64:487-92 pubmed publisher
    Septin4 (Sept4) belongs to Septin family and may be involved in apoptosis, vesicle trafficking and other cell processes. In this study, we attempted to investigate the effect of Sept4 in hepatic fibrosis induced by Schistosoma japonicum...
  13. Yanagida A, Iwaisako K, Hatano E, Taura K, Sato F, Narita M, et al. Downregulation of the Wnt antagonist Dkk2 links the loss of Sept4 and myofibroblastic transformation of hepatic stellate cells. Biochim Biophys Acta. 2011;1812:1403-11 pubmed publisher
    b>Sept4, a subunit of the septin cytoskeleton specifically expressed in quiescent hepatic stellate cells (HSCs), is downregulated through transdifferentiation to fibrogenic and contractile myofibroblastic cells...
  14. Yoshida A, Yamamoto N, Kinoshita M, Hiroi N, Hiramoto T, Kang G, et al. Localization of septin proteins in the mouse cochlea. Hear Res. 2012;289:40-51 pubmed publisher
    ..To identify the roles of septins in the cochlea, we analyzed the localization of three septin proteins, septin 4 (SEPT4), septin 5 (SEPT5), and septin 7 (SEPT7) that are abundantly expressed in brain tissues, and also examined ..
  15. Guan J, Kinoshita M, Yuan L. Spatiotemporal association of DNAJB13 with the annulus during mouse sperm flagellum development. BMC Dev Biol. 2009;9:23 pubmed publisher
    ..Although ultrastructural abnormalities and functional importance of the annulus have been addressed in Sept4-null mutant mice and a subset of human patients with asthenospermia syndrome, little is known about how the ..
  16. Shinoda T, Ito H, Sudo K, Iwamoto I, Morishita R, Nagata K. Septin 14 is involved in cortical neuronal migration via interaction with Septin 4. Mol Biol Cell. 2010;21:1324-34 pubmed publisher
    ..Biochemical analyses revealed that C-terminal coiled-coil region of Sept14 interacts with Septin 4 (Sept4). Knockdown experiments showed that Sept4 is also involved in cortical neuronal migration in vivo...
  17. Sitz J, Baumgärtel K, Hämmerle B, Papadopoulos C, Hekerman P, Tejedor F, et al. The Down syndrome candidate dual-specificity tyrosine phosphorylation-regulated kinase 1A phosphorylates the neurodegeneration-related septin 4. Neuroscience. 2008;157:596-605 pubmed publisher
    ..searched for novel proteins interacting with the kinase domain of DYRK1A in the adult mouse brain and identified septin 4 (SEPT4, also known as Pnutl2/CDCrel-2)...