Gene Symbol: Sept12
Description: septin 12
Alias: 1700028G04Rik, 4933413B09Rik, Septin12, septin-12
Lin Y, Chou C, Hung Y, Yu I, Pan H, Lin S, et al
. SEPT12 deficiency causes sperm nucleus damage and developmental arrest of preimplantation embryos. Fertil Steril. 2011;95:363-5 pubmed publisher
Oocytes fertilized with spermatozoa obtained from Septin 12+/- chimeric mice failed to develop beyond the morula stage after IVF and intracytoplasmic sperm injection because of significant DNA defects in the spermatozoa...
Yoshida A, Yamamoto N, Kinoshita M, Hiroi N, Hiramoto T, Kang G, et al
. Localization of septin proteins in the mouse cochlea. Hear Res. 2012;289:40-51 pubmed publisher
..Immunohistochemical analysis of Sept4 null mice showed that compensatory expression of SEPT5 in the phalangeal process of Deiters' cells may have caused functional compensation of hearing ability in Sept4 null mice...
Kuo Y, Shen Y, Chen H, Lin Y, Wang Y, Chen Y, et al
. SEPT12 orchestrates the formation of mammalian sperm annulus by organizing core octameric complexes with other SEPT proteins. J Cell Sci. 2015;128:923-34 pubmed publisher
Male infertility has become a worldwide health problem, but the etiologies of most cases are still unknown. SEPT12, a GTP-binding protein, is involved in male fertility...
Lai T, Wu Y, Wang Y, Chen M, Wang P, Chen T, et al
. SEPT12-NDC1 Complexes Are Required for Mammalian Spermiogenesis. Int J Mol Sci. 2016;17: pubmed
..Our knockout and knock-in mice models demonstrated that SEPTIN12 (SEPT12) is vital for the formation of sperm morphological characteristics during spermiogenesis...
Shen Y, Wang H, Kuo Y, Shih S, Hsu C, Chen Y, et al
. SEPT12 phosphorylation results in loss of the septin ring/sperm annulus, defective sperm motility and poor male fertility. PLoS Genet. 2017;13:e1006631 pubmed publisher
..Here, we showed that SEPT12 was phosphorylated on Ser198 using mass spectrometry, and we generated SEPT12 phosphomimetic knock-in (KI) mice to ..
Lin Y, Lin Y, Wang Y, Yu I, Lin Y, Wang Y, et al
. The expression level of septin12 is critical for spermiogenesis. Am J Pathol. 2009;174:1857-68 pubmed publisher
..One family member, septin12, is expressed specifically in the testis...