Sema4b

Summary

Gene Symbol: Sema4b
Description: sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B
Alias: SemC, Semac, mKIAA1745, sema C, semaphorin-4B, semaphorin-C
Species: mouse

Top Publications

  1. ncbi Murine semaphorin D/collapsin is a member of a diverse gene family and creates domains inhibitory for axonal extension
    A W Puschel
    Abteilung Neurochemie Max Planck Institut für Hirnforschung, Frankfurt am Main, Federal Republic of Germany
    Neuron 14:941-8. 1995
  2. ncbi Semaphorin 4C and 4G are ligands of Plexin-B2 required in cerebellar development
    Viola Maier
    Institute of Developmental Genetics, Helmholtz Center Munich, Neuherberg, Germany
    Mol Cell Neurosci 46:419-31. 2011
  3. ncbi Plexin-B2 controls the development of cerebellar granule cells
    Roland H Friedel
    Department of Biological Sciences, Howard Hughes Medical Institute, Stanford University, Stanford, California 94305, USA
    J Neurosci 27:3921-32. 2007
  4. ncbi Semaphorin 4B interacts with the post-synaptic density protein PSD-95/SAP90 and is recruited to synapses through a C-terminal PDZ-binding motif
    Constanze Burkhardt
    Abt Molekularbiologie, Institut fur Allgemeine Zoologie und Genetik, Westfalische Wilhelms Universitat, Schlossplatz 5, D 48149 Munster, Germany
    FEBS Lett 579:3821-8. 2005
  5. ncbi Neurites from trigeminal ganglion explants grown in vitro are repelled or attracted by tooth-related tissues depending on developmental stage
    C Lillesaar
    Division of Cell Biology, Department of Biomedicine and Surgery, Faculty of Health Sciences, Linkoping University, SE 581 85 Linkoping, Sweden
    Neuroscience 125:149-61. 2004
  6. ncbi A PDZ protein regulates the distribution of the transmembrane semaphorin, M-SemF
    L h Wang
    Department of Neurology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Biol Chem 274:14137-46. 1999
  7. ncbi Neuropilin is a receptor for the axonal chemorepellent Semaphorin III
    Z He
    Howard Hughes Medical Institute, Department of Anatomy, University of California, San Francisco 94143 0452, USA
    Cell 90:739-51. 1997
  8. ncbi Identification of a novel transmembrane semaphorin expressed on lymphocytes
    T Furuyama
    Department of Anatomy and Neuroscience, Osaka University Medical School, 2 2 Yamadaoka, Suita Shi, Osaka 565, Japan
    J Biol Chem 271:33376-81. 1996
  9. ncbi The sensory innervation of the mouse spinal cord may be patterned by differential expression of and differential responsiveness to semaphorins
    A W Puschel
    Abteilung Neurochemie, Max Planck Institut für Hirnforschung, Frankfurt Main, Germany
    Mol Cell Neurosci 7:419-31. 1996
  10. ncbi Semaphorin III can function as a selective chemorepellent to pattern sensory projections in the spinal cord
    E K Messersmith
    Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA
    Neuron 14:949-59. 1995

Scientific Experts

  • Roland H Friedel
  • Viola Maier
  • Atsushi Kumanogoh
  • Yukinobu Nakagawa
  • Marc Tessier-Lavigne
  • Helen Rayburn
  • Constanze Burkhardt
  • C Lillesaar
  • A W Puschel
  • Tatsuki R Kataoka
  • Sujin Kang
  • Noriko Takegahara
  • Hitoshi Kikutani
  • Christine Jolicoeur
  • Hyota Takamatsu
  • Satoshi Nojima
  • Wolfgang Wurst
  • Tetsuya Kimura
  • Toshihiko Toyofuku
  • Masahito Ikawa
  • Ichiro Katayama
  • Tatsusada Okuno
  • L h Wang
  • Ulrich Schüller
  • Constantino Sotelo
  • Alain Chedotal
  • Geraldine Kerjan
  • Eckart D Gundelfinger
  • Craig C Garner
  • Anja Badde
  • Myriam Müller
  • Andreas W Püschel
  • K Fried
  • Z He
  • M Tessier-Lavigne
  • T Furuyama
  • R H Adams
  • H Betz
  • E K Messersmith
  • R G Kalb
  • S M Strittmatter
  • A Kosugi
  • S Inagaki
  • M Tohyama
  • N Miyazaki
  • T Hamaoka
  • Y Iwahashi
  • S Saitoh
  • S Noda
  • M Ogata
  • C S Goodman
  • E D Leonardo
  • A L Kolodkin
  • C J Shatz

Detail Information

Publications12

  1. ncbi Murine semaphorin D/collapsin is a member of a diverse gene family and creates domains inhibitory for axonal extension
    A W Puschel
    Abteilung Neurochemie Max Planck Institut für Hirnforschung, Frankfurt am Main, Federal Republic of Germany
    Neuron 14:941-8. 1995
    ..Our data demonstrate that semaphorins are a diverse family of molecules that may provide local signals to specify territories nonaccessible for growing axons...
  2. ncbi Semaphorin 4C and 4G are ligands of Plexin-B2 required in cerebellar development
    Viola Maier
    Institute of Developmental Genetics, Helmholtz Center Munich, Neuherberg, Germany
    Mol Cell Neurosci 46:419-31. 2011
    ....
  3. ncbi Plexin-B2 controls the development of cerebellar granule cells
    Roland H Friedel
    Department of Biological Sciences, Howard Hughes Medical Institute, Stanford University, Stanford, California 94305, USA
    J Neurosci 27:3921-32. 2007
    ..Many differentiated granule cells migrate inside the cerebellum and keep proliferating. These results reveal that Plexin-B2 controls the balance between proliferation and differentiation in granule cells...
  4. ncbi Semaphorin 4B interacts with the post-synaptic density protein PSD-95/SAP90 and is recruited to synapses through a C-terminal PDZ-binding motif
    Constanze Burkhardt
    Abt Molekularbiologie, Institut fur Allgemeine Zoologie und Genetik, Westfalische Wilhelms Universitat, Schlossplatz 5, D 48149 Munster, Germany
    FEBS Lett 579:3821-8. 2005
    ..This sequence mediates the interaction with the post-synaptic density protein PSD-95/SAP90. Co-expression of Sema4B with PSD-95 in COS 7 cells results in the clustering of Sema4B...
  5. ncbi Neurites from trigeminal ganglion explants grown in vitro are repelled or attracted by tooth-related tissues depending on developmental stage
    C Lillesaar
    Division of Cell Biology, Department of Biomedicine and Surgery, Faculty of Health Sciences, Linkoping University, SE 581 85 Linkoping, Sweden
    Neuroscience 125:149-61. 2004
    ..We conclude that developing mandibular/dental mesenchyme can inhibit/repel neurite growth in vitro. Our results support the hypothesis that semaphorins may be involved in this interaction...
  6. ncbi A PDZ protein regulates the distribution of the transmembrane semaphorin, M-SemF
    L h Wang
    Department of Neurology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Biol Chem 274:14137-46. 1999
    ..While SEMCAP-1(GIPC) also interacts with SemC, it does not interact with other proteins containing a class I PDZ binding motif, nor does M-SemF interact with ..
  7. ncbi Neuropilin is a receptor for the axonal chemorepellent Semaphorin III
    Z He
    Howard Hughes Medical Institute, Department of Anatomy, University of California, San Francisco 94143 0452, USA
    Cell 90:739-51. 1997
    ..These results provide evidence that neuropilin is a receptor or a component of a receptor complex that mediates the effects of Sema III on these axons...
  8. ncbi Identification of a novel transmembrane semaphorin expressed on lymphocytes
    T Furuyama
    Department of Anatomy and Neuroscience, Osaka University Medical School, 2 2 Yamadaoka, Suita Shi, Osaka 565, Japan
    J Biol Chem 271:33376-81. 1996
    ..M-sema G is most closely related to M-sema F, which we previously reported, and semB and semC. These four members appear to constitute a transmembrane type subfamily in mouse semaphorins...
  9. ncbi The sensory innervation of the mouse spinal cord may be patterned by differential expression of and differential responsiveness to semaphorins
    A W Puschel
    Abteilung Neurochemie, Max Planck Institut für Hirnforschung, Frankfurt Main, Germany
    Mol Cell Neurosci 7:419-31. 1996
    ..5. This suggests that Sem D may be involved in preventing an early penetration of the spinal cord by sensory afferents and subsequently shaping their lamina-specific termination...
  10. ncbi Semaphorin III can function as a selective chemorepellent to pattern sensory projections in the spinal cord
    E K Messersmith
    Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA
    Neuron 14:949-59. 1995
    ..These results suggest that semaphorin III functions to pattern sensory projections by selectively repelling axons that normally terminate dorsally...
  11. ncbi Identification of semaphorin 4B as a negative regulator of basophil-mediated immune responses
    Yukinobu Nakagawa
    Department of Immunopathology, World Premier International Immunology Frontier Research Center, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 565 0871, Japan
    J Immunol 186:2881-8. 2011
    ..In this article, we show that a class IV semaphorin, Sema4B, negatively regulates basophil functions through T cell-basophil contacts...