Gene Symbol: Sema3a
Description: sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
Alias: Hsema-I, SEMA1, SemD, Semad, coll-1, semaphorin-3A, collapsin-1, sema D, sema III, semaphorin III, semaphorin-D
Species: mouse
Products:     Sema3a

Top Publications

  1. Huber A, Kania A, Tran T, Gu C, De Marco Garcia N, Lieberam I, et al. Distinct roles for secreted semaphorin signaling in spinal motor axon guidance. Neuron. 2005;48:949-64 pubmed
    ..We show here that motor axon growth and guidance are impaired in the absence of Sema3A-Npn-1 signaling...
  2. Maden C, Gomes J, Schwarz Q, Davidson K, Tinker A, Ruhrberg C. NRP1 and NRP2 cooperate to regulate gangliogenesis, axon guidance and target innervation in the sympathetic nervous system. Dev Biol. 2012;369:277-85 pubmed publisher
    ..By comparing the phenotypes of mice lacking NRP1 or its ligand SEMA3A with mice lacking NRP1 in the sympathetic versus vascular endothelial cell lineages, we demonstrate that SEMA3A ..
  3. Bouzioukh F, Daoudal G, Falk J, Debanne D, Rougon G, Castellani V. Semaphorin3A regulates synaptic function of differentiated hippocampal neurons. Eur J Neurosci. 2006;23:2247-54 pubmed
    ..We investigated the functional properties of semaphorin3A (Sema3A) in adult hippocampal neurons, and report that exogenous application of this cue decreases the efficacy of ..
  4. Maione F, Molla F, Meda C, Latini R, Zentilin L, Giacca M, et al. Semaphorin 3A is an endogenous angiogenesis inhibitor that blocks tumor growth and normalizes tumor vasculature in transgenic mouse models. J Clin Invest. 2009;119:3356-72 pubmed publisher
    ..By analyzing 3 different mouse models of multistep carcinogenesis, we show here that during angiogenesis, semaphorin 3A (Sema3A) is expressed in ECs, where it serves as an endogenous inhibitor of angiogenesis that is present in ..
  5. Schwarz Q, Vieira J, Howard B, Eickholt B, Ruhrberg C. Neuropilin 1 and 2 control cranial gangliogenesis and axon guidance through neural crest cells. Development. 2008;135:1605-13 pubmed publisher
    ..their class 3 semaphorin (SEMA3) ligands play well-established roles in axon guidance, with loss of NRP1, NRP2, SEMA3A or SEMA3F causing defasciculation and errors in growth cone guidance of peripherally projecting nerves...
  6. Lerman O, Ben Zvi A, Yagil Z, Behar O. Semaphorin3A accelerates neuronal polarity in vitro and in its absence the orientation of DRG neuronal polarity in vivo is distorted. Mol Cell Neurosci. 2007;36:222-34 pubmed
    ..Taken together, our findings suggest that Semaphorin3A plays a role in the formation of neuronal polarity, in addition to its classic repellent role. ..
  7. Messersmith E, Leonardo E, Shatz C, Tessier Lavigne M, Goodman C, Kolodkin A. Semaphorin III can function as a selective chemorepellent to pattern sensory projections in the spinal cord. Neuron. 1995;14:949-59 pubmed
    ..We also provide evidence implicating semaphorin III/collapsin, a diffusible guidance molecule expressed by ventral spinal cord cells, in mediating this effect...
  8. Gu C, Rodriguez E, Reimert D, Shu T, Fritzsch B, Richards L, et al. Neuropilin-1 conveys semaphorin and VEGF signaling during neural and cardiovascular development. Dev Cell. 2003;5:45-57 pubmed
    ..Therefore, Npn-1 is a multifunctional receptor that mediates the activities of structurally distinct ligands during development of the heart, vasculature, and nervous system. ..
  9. Marin O, Yaron A, Bagri A, Tessier Lavigne M, Rubenstein J. Sorting of striatal and cortical interneurons regulated by semaphorin-neuropilin interactions. Science. 2001;293:872-5 pubmed
    ..interneurons avoid entering the striatum because of a chemorepulsive signal composed at least in part of semaphorin 3A and semaphorin 3F...

More Information


  1. Castellani V, Chedotal A, Schachner M, Faivre Sarrailh C, Rougon G. Analysis of the L1-deficient mouse phenotype reveals cross-talk between Sema3A and L1 signaling pathways in axonal guidance. Neuron. 2000;27:237-49 pubmed
    ..Using coculture assays, we report that Sema3A secreted from the ventral spinal cord repels cortical axons from wild-type but not from L1-deficient mice...
  2. Niisato E, Nagai J, Yamashita N, Abe T, Kiyonari H, Goshima Y, et al. CRMP4 suppresses apical dendrite bifurcation of CA1 pyramidal neurons in the mouse hippocampus. Dev Neurobiol. 2012;72:1447-57 pubmed publisher
    ..CRMP2 also mediates the growth cone collapse response to the repulsive guidance molecule semaphorin-3A (Sema3A). However, the role of CRMP4 in Sema3A signaling and its function in the developing mouse brain remain unclear...
  3. Jiang S, Whitehead S, Aylsworth A, Slinn J, Zurakowski B, Chan K, et al. Neuropilin 1 directly interacts with Fer kinase to mediate semaphorin 3A-induced death of cortical neurons. J Biol Chem. 2010;285:9908-18 pubmed publisher
    ..The interaction of Sema3A/NRP1 during development leads to the collapse of growth cones...
  4. Wright A, Demyanenko G, Powell A, Schachner M, Enriquez Barreto L, Tran T, et al. Close homolog of L1 and neuropilin 1 mediate guidance of thalamocortical axons at the ventral telencephalon. J Neurosci. 2007;27:13667-79 pubmed
    We report a cooperation between the neural adhesion molecule close homolog of L1 (CHL1) and the semaphorin 3A (Sema3A) receptor, neuropilin 1 (Npn1), important for establishment of area-specific thalamocortical projections...
  5. Takamatsu H, Takegahara N, Nakagawa Y, Tomura M, Taniguchi M, Friedel R, et al. Semaphorins guide the entry of dendritic cells into the lymphatics by activating myosin II. Nat Immunol. 2010;11:594-600 pubmed publisher
    ..Additionally, we show that the semaphorin Sema3A, but not Sema6C or Sema6D, was required for DC transmigration and that Sema3A produced by the lymphatics promoted ..
  6. Appleton B, Wu P, Maloney J, Yin J, Liang W, Stawicki S, et al. Structural studies of neuropilin/antibody complexes provide insights into semaphorin and VEGF binding. EMBO J. 2007;26:4902-12 pubmed
    ..Based upon our structural and functional data, we propose possible models for ligand binding to neuropilins. ..
  7. Erskine L, Reijntjes S, Pratt T, Denti L, Schwarz Q, Vieira J, et al. VEGF signaling through neuropilin 1 guides commissural axon crossing at the optic chiasm. Neuron. 2011;70:951-65 pubmed publisher
    ..These findings have identified a permissive midline signal for axons at the chiasm midline and provide in vivo evidence that VEGF-A is an essential axon guidance cue. ..
  8. Pekcec A, Yigitkanli K, Jung J, Pallast S, Xing C, Antipenko A, et al. Following experimental stroke, the recovering brain is vulnerable to lipoxygenase-dependent semaphorin signaling. FASEB J. 2013;27:437-45 pubmed publisher
    ..endothelial cells, and a mouse model of ischemic stroke, we show that signaling from the axon guidance molecule Sema3A via eicosanoid second messengers can contribute to this inhibitory environment...
  9. Ranganathan P, Jayakumar C, Mohamed R, Weintraub N, Ramesh G. Semaphorin 3A inactivation suppresses ischemia-reperfusion-induced inflammation and acute kidney injury. Am J Physiol Renal Physiol. 2014;307:F183-94 pubmed publisher
    ..One such molecule, semaphorin3A (sema3A), is highly expressed after acute kidney injury (AKI) in mice and humans, but its pathophysiological role is ..
  10. Cohen S, Funkelstein L, Livet J, Rougon G, Henderson C, Castellani V, et al. A semaphorin code defines subpopulations of spinal motor neurons during mouse development. Eur J Neurosci. 2005;21:1767-76 pubmed
    ..Finally, we found that a secreted semaphorin, Sema3A, elicits differential collapse responses in topologically distinct subpopulations of spinal MNs...
  11. Kagoshima M, Ito T. Diverse gene expression and function of semaphorins in developing lung: positive and negative regulatory roles of semaphorins in lung branching morphogenesis. Genes Cells. 2001;6:559-71 pubmed
    Previously, we reported that Sema3A, one of the secreted repulsive axon guidance molecules, CRMP (collapsin response mediator protein)-2, a putative intracellular signalling molecule for Sema3A and Sema3A receptor neuropilin-1 are ..
  12. Takahashi T, Fournier A, Nakamura F, Wang L, Murakami Y, Kalb R, et al. Plexin-neuropilin-1 complexes form functional semaphorin-3A receptors. Cell. 1999;99:59-69 pubmed
    ..Plex 1 alone does not bind semaphorin-3A (Sema3A), but the NP-1/Plex 1 complex has a higher affinity for Sema3A than does NP-1 alone...
  13. Bagnard D, Lohrum M, Uziel D, Puschel A, Bolz J. Semaphorins act as attractive and repulsive guidance signals during the development of cortical projections. Development. 1998;125:5043-53 pubmed
    ..The present findings show that recombinant Semaphorin D has similar effects on cortical axons and, in addition, inhibits axonal branching...
  14. Imai T, Yamazaki T, Kobayakawa R, Kobayakawa K, Abe T, Suzuki M, et al. Pre-target axon sorting establishes the neural map topography. Science. 2009;325:585-90 pubmed publisher
    ..Thus, pre-target axon sorting plays an important role in establishing the topographic order based on the relative levels of guidance molecules expressed by axons. ..
  15. Roffers Agarwal J, Gammill L. Neuropilin receptors guide distinct phases of sensory and motor neuronal segmentation. Development. 2009;136:1879-88 pubmed publisher
    ..We now expand these results to show that Nrp2 patterns initial motor axon outgrowth as well. Later, Nrp1/Sema3A signaling is essential for segmental dorsal root gangliogenesis and motor axonal fasciculation into ventral roots...
  16. Cariboni A, Davidson K, Dozio E, Memi F, Schwarz Q, Stossi F, et al. VEGF signalling controls GnRH neuron survival via NRP1 independently of KDR and blood vessels. Development. 2011;138:3723-33 pubmed publisher
    ..We previously reported that the class 3 semaphorin SEMA3A signals through its neuropilin receptors, NRP1 and NRP2, to organise the axons that guide migrating GnRH neurons ..
  17. Tran T, Rubio M, Clem R, Johnson D, Case L, Tessier Lavigne M, et al. Secreted semaphorins control spine distribution and morphogenesis in the postnatal CNS. Nature. 2009;462:1065-9 pubmed publisher
    ..In contrast, a distinct Sema3A-Npn-1/PlexA4 signalling cascade controls basal dendritic arborization in layer V cortical neurons, but does not ..
  18. Taniguchi M, Yuasa S, Fujisawa H, Naruse I, Saga S, Mishina M, et al. Disruption of semaphorin III/D gene causes severe abnormality in peripheral nerve projection. Neuron. 1997;19:519-30 pubmed
    ..b>Semaphorin III/D is a member of this family, has been shown to repel dorsal root ganglion (DRG) axons in vitro, and has been ..
  19. Le Guelte A, Galan Moya E, Dwyer J, Treps L, Kettler G, Hebda J, et al. Semaphorin 3A elevates endothelial cell permeability through PP2A inactivation. J Cell Sci. 2012;125:4137-46 pubmed publisher
    ..Although Semaphorin 3A has emerged as one of the few known anti-angiogenic factors to exhibit pro-permeability activity, little is ..
  20. Behar O, Golden J, Mashimo H, Schoen F, Fishman M. Semaphorin III is needed for normal patterning and growth of nerves, bones and heart. Nature. 1996;383:525-8 pubmed
    ..Some seem to guide neuronal growth cones, but otherwise their functions are unknown. Semaphorin III is a membrane-associated secreted protein with a developmentally dynamic pattern of expression, including ..
  21. Toyofuku T, Yoshida J, Sugimoto T, Zhang H, Kumanogoh A, Hori M, et al. FARP2 triggers signals for Sema3A-mediated axonal repulsion. Nat Neurosci. 2005;8:1712-9 pubmed
    b>Sema3A, a prototypical semaphorin, acts as a chemorepellent or a chemoattractant for axons by activating a receptor complex comprising neuropilin-1 as the ligand-binding subunit and plexin-A1 as the signal-transducing subunit...
  22. Suto F, Murakami Y, Nakamura F, Goshima Y, Fujisawa H. Identification and characterization of a novel mouse plexin, plexin-A4. Mech Dev. 2003;120:385-96 pubmed
    ..COS-7 cells coexpressing plexin-A4 with neuropilin-1 were induced to contract by Sema3A, a member of the class 3 semaphorin...
  23. Haupt C, Kloos K, Faus Kessler T, Huber A. Semaphorin 3A-Neuropilin-1 signaling regulates peripheral axon fasciculation and pathfinding but not developmental cell death patterns. Eur J Neurosci. 2010;31:1164-72 pubmed publisher
    ..b>Semaphorin 3A (Sema3A), in addition to its function as a guidance cue and mediator of timing and fasciculation of motor and ..
  24. Cheng H, Bagri A, Yaron A, Stein E, Pleasure S, Tessier Lavigne M. Plexin-A3 mediates semaphorin signaling and regulates the development of hippocampal axonal projections. Neuron. 2001;32:249-63 pubmed
    ..Analysis of plexin-A3 knockout mice shows that plexin-A3 contributes to Sema3F and Sema3A signaling and that plexin-A3 regulates the development of hippocampal axonal projections in vivo.
  25. Tufro A, Teichman J, Woda C, Villegas G. Semaphorin3a inhibits ureteric bud branching morphogenesis. Mech Dev. 2008;125:558-68 pubmed publisher
    ..Semaphorin3a (Sema3a) is expressed in renal epithelia throughout kidney development, including podocytes and ureteric bud cells...
  26. Serini G, Valdembri D, Zanivan S, Morterra G, Burkhardt C, Caccavari F, et al. Class 3 semaphorins control vascular morphogenesis by inhibiting integrin function. Nature. 2003;424:391-7 pubmed
    ..b>Sema3a null mice show vascular defects as well...
  27. Ito T, Kagoshima M, Sasaki Y, Li C, Udaka N, Kitsukawa T, et al. Repulsive axon guidance molecule Sema3A inhibits branching morphogenesis of fetal mouse lung. Mech Dev. 2000;97:35-45 pubmed
    b>Semaphorin III/collapsin-1 (Sema3A) guides a specific subset of neuronal growth cones as a repulsive molecule. In this study, we have investigated a possible role of non-neuronal Sema3A in lung morphogenesis...
  28. Cariboni A, Davidson K, Rakic S, Maggi R, Parnavelas J, Ruhrberg C. Defective gonadotropin-releasing hormone neuron migration in mice lacking SEMA3A signalling through NRP1 and NRP2: implications for the aetiology of hypogonadotropic hypogonadism. Hum Mol Genet. 2011;20:336-44 pubmed publisher
    ..mice with in vitro models, we demonstrate here that a secreted guidance cue of the class 3 semaphorin family, SEMA3A, is essential for the development of the GnRH neuron system: loss of SEMA3A signalling alters the targeting of ..
  29. Ieda M, Kanazawa H, Kimura K, Hattori F, Ieda Y, Taniguchi M, et al. Sema3a maintains normal heart rhythm through sympathetic innervation patterning. Nat Med. 2007;13:604-12 pubmed
    ..Here we show that a neural chemorepellent, Sema3a, establishes cardiac sympathetic innervation patterning...
  30. Hayashi M, Nakashima T, Taniguchi M, Kodama T, Kumanogoh A, Takayanagi H. Osteoprotection by semaphorin 3A. Nature. 2012;485:69-74 pubmed publisher
    ..Here we show that semaphorin 3A (Sema3A) exerts an osteoprotective effect by both suppressing osteoclastic bone resorption and increasing ..
  31. Kettunen P, Løes S, Furmanek T, Fjeld K, Kvinnsland I, Behar O, et al. Coordination of trigeminal axon navigation and patterning with tooth organ formation: epithelial-mesenchymal interactions, and epithelial Wnt4 and Tgfbeta1 regulate semaphorin 3a expression in the dental mesenchyme. Development. 2005;132:323-34 pubmed
    ..By analyzing Sema3a and its receptor Npn1 knockout mouse embryos, we found that Sema3a regulates dental trigeminal axon navigation and ..
  32. Sasaki Y, Cheng C, Uchida Y, Nakajima O, Ohshima T, Yagi T, et al. Fyn and Cdk5 mediate semaphorin-3A signaling, which is involved in regulation of dendrite orientation in cerebral cortex. Neuron. 2002;35:907-20 pubmed
    Semaphorin-3A (Sema3A), a member of class 3 semaphorins, regulates axon and dendrite guidance in the nervous system. How Sema3A and its receptors plexin-As and neuropilins regulate neuronal guidance is unknown...
  33. Yamamoto M, Suzuki K, Okuno T, Ogata T, Takegahara N, Takamatsu H, et al. Plexin-A4 negatively regulates T lymphocyte responses. Int Immunol. 2008;20:413-20 pubmed publisher
    ..mutant (npn-1(Sema-)) mice, in which the binding site of class III semaphorins is disrupted, and T cells from Sema3A-deficient (Sema-3A-/-) mice...
  34. Merte J, Wang Q, Vander Kooi C, Sarsfield S, Leahy D, Kolodkin A, et al. A forward genetic screen in mice identifies Sema3A(K108N), which binds to neuropilin-1 but cannot signal. J Neurosci. 2010;30:5767-75 pubmed publisher
    ..Using this assay, we identified Sema3A(K108N), a novel loss-of-function allele of Sema3A...
  35. Puschel A, Adams R, Betz H. The sensory innervation of the mouse spinal cord may be patterned by differential expression of and differential responsiveness to semaphorins. Mol Cell Neurosci. 1996;7:419-31 pubmed
    ..5. This suggests that Sem D may be involved in preventing an early penetration of the spinal cord by sensory afferents and subsequently shaping their lamina-specific termination. ..
  36. Kitsukawa T, Shimizu M, Sanbo M, Hirata T, Taniguchi M, Bekku Y, et al. Neuropilin-semaphorin III/D-mediated chemorepulsive signals play a crucial role in peripheral nerve projection in mice. Neuron. 1997;19:995-1005 pubmed a neuronal cell surface protein and has been shown to function as a receptor for a secreted protein, semaphorin III/D, that can induce neuronal growth cone collapse and repulsion of neurites in vitro...
  37. Sibbe M, Taniguchi M, Schachner M, Bartsch U. Development of the corticospinal tract in Semaphorin3A- and CD24-deficient mice. Neuroscience. 2007;150:898-904 pubmed
    ..Our results indicate that elongation, collateralization, fasciculation and path finding of corticospinal axons in mice proceed normally in the absence of Semaphorin3A or CD24. ..
  38. Meléndez Herrera E, Varela Echavarria A. Expression of secreted semaphorins and their receptors in specific neuromeres, boundaries, and neuronal groups in the developing mouse and chick brain. Brain Res. 2006;1067:126-37 pubmed
    ..Comparison of the expression patterns between mouse and chick embryos showed large similarities, but important differences were also detected. ..
  39. Reidy K, Villegas G, Teichman J, Veron D, Shen W, Jimenez J, et al. Semaphorin3a regulates endothelial cell number and podocyte differentiation during glomerular development. Development. 2009;136:3979-89 pubmed publisher
    Semaphorin3a (Sema3a), a chemorepellant guidance protein, plays crucial roles in neural, cardiac and peripheral vascular patterning. Sema3a is expressed in the developing nephron, mature podocytes and collecting tubules...
  40. Acevedo L, Barillas S, Weis S, Gothert J, Cheresh D. Semaphorin 3A suppresses VEGF-mediated angiogenesis yet acts as a vascular permeability factor. Blood. 2008;111:2674-80 pubmed publisher
    b>Semaphorin 3A (Sema3A), a known inhibitor of axonal sprouting, also alters vascular patterning. Here we show that Sema3A selectively interferes with VEGF- but not bFGF-induced angiogenesis in vivo...
  41. Zimmer G, Schanuel S, Burger S, Weth F, Steinecke A, Bolz J, et al. Chondroitin sulfate acts in concert with semaphorin 3A to guide tangential migration of cortical interneurons in the ventral telencephalon. Cereb Cortex. 2010;20:2411-22 pubmed publisher
    ..We found that chondroitin-4-sulfate is coexpressed with semaphorin 3A (Sema 3A) in the striatal mantle zone (SMZ), a nontarget region of neuropilin (Nrp)-1-expressing cortical ..
  42. Fenstermaker V, Chen Y, Ghosh A, Yuste R. Regulation of dendritic length and branching by semaphorin 3A. J Neurobiol. 2004;58:403-12 pubmed
    The molecular mechanisms that control dendritic development are still unclear. Semaphorin 3A, a class III semaphorin, has been shown to regulate the radial orientation of pyramidal neurons in the developing neocortex...
  43. White F, Behar O. The development and subsequent elimination of aberrant peripheral axon projections in Semaphorin3A null mutant mice. Dev Biol. 2000;225:79-86 pubmed
    Semaphorin3A (previously known as Semaphorin III, Semaphorin D, or collapsin-1) is a member of the semaphorin gene family, many of which have been shown to guide axons during nervous system development...
  44. Yamashita N, Morita A, Uchida Y, Nakamura F, Usui H, Ohshima T, et al. Regulation of spine development by semaphorin3A through cyclin-dependent kinase 5 phosphorylation of collapsin response mediator protein 1. J Neurosci. 2007;27:12546-54 pubmed
    ..We show here evidence that CRMP1 is involved in semaphorin3A (Sema3A)-induced spine development in the cerebral cortex...
  45. Suto F, Ito K, Uemura M, Shimizu M, Shinkawa Y, Sanbo M, et al. Plexin-a4 mediates axon-repulsive activities of both secreted and transmembrane semaphorins and plays roles in nerve fiber guidance. J Neurosci. 2005;25:3628-37 pubmed
    ..The defects in peripheral sensory and SG axons were fundamentally related to those of neuropilin-1 or Sema3A mutant embryos reported but were more moderate than the phenotype in these mutants...
  46. Bechara A, Nawabi H, Moret F, Yaron A, Weaver E, Bozon M, et al. FAK-MAPK-dependent adhesion disassembly downstream of L1 contributes to semaphorin3A-induced collapse. EMBO J. 2008;27:1549-62 pubmed publisher
    ..Intriguingly, the genetic removal of L1 blocks axon responses of cortical neurons to Sema3A in vitro despite the expression of Plexin-As in the cortex, suggesting either that L1 substitutes for Plexin-As or ..
  47. Ben Zvi A, Manor O, Schachner M, Yaron A, Tessier Lavigne M, Behar O. The Semaphorin receptor PlexinA3 mediates neuronal apoptosis during dorsal root ganglia development. J Neurosci. 2008;28:12427-32 pubmed publisher
    ..Here we demonstrate that both Plexins contribute to Sema3A-induced cell death in vitro, albeit in a different hierarchy...
  48. Antipenko A, Himanen J, van Leyen K, Nardi Dei V, Lesniak J, Barton W, et al. Structure of the semaphorin-3A receptor binding module. Neuron. 2003;39:589-98 pubmed
    ..We report the crystal structure of a secreted 65 kDa form of Semaphorin-3A (Sema3A), containing the full semaphorin domain...
  49. Waimey K, Huang P, Chen M, Cheng H. Plexin-A3 and plexin-A4 restrict the migration of sympathetic neurons but not their neural crest precursors. Dev Biol. 2008;315:448-58 pubmed publisher
    ..They function cooperatively to regulate the migration of sympathetic neurons and then differentially to guide the sympathetic axons. ..
  50. Chung L, Yang T, Huang H, Hsu S, Cheng H, Huang P. Semaphorin signaling facilitates cleft formation in the developing salivary gland. Development. 2007;134:2935-45 pubmed
    ..This Npn1-dependent morphogenesis is mediated by Sema3A and Sema3C in an additive manner, and can be abolished by decreasing the expression of plexin A2 or plexin D1...
  51. Kaneko S, Iwanami A, Nakamura M, Kishino A, Kikuchi K, Shibata S, et al. A selective Sema3A inhibitor enhances regenerative responses and functional recovery of the injured spinal cord. Nat Med. 2006;12:1380-9 pubmed
    ..Recent research has demonstrated that semaphorin3A (Sema3A) is one of the major inhibitors of axonal regeneration...
  52. Schwarz Q, Maden C, Davidson K, Ruhrberg C. Neuropilin-mediated neural crest cell guidance is essential to organise sensory neurons into segmented dorsal root ganglia. Development. 2009;136:1785-9 pubmed publisher
    ..Specifically, SEMA3A/NRP1 signalling first directs one population of NCCs from the intersomitic path into the sclerotome, and SEMA3F/..
  53. Schwarz Q, Maden C, Vieira J, Ruhrberg C. Neuropilin 1 signaling guides neural crest cells to coordinate pathway choice with cell specification. Proc Natl Acad Sci U S A. 2009;106:6164-9 pubmed publisher
    ..Here we show that the repulsive guidance cue SEMA3A and its receptor neuropilin 1 (NRP1) are essential to direct the intermediate wave NCC precursors of peripheral ..
  54. Schwarz Q, Waimey K, Golding M, Takamatsu H, Kumanogoh A, Fujisawa H, et al. Plexin A3 and plexin A4 convey semaphorin signals during facial nerve development. Dev Biol. 2008;324:1-9 pubmed publisher
    ..Loss of either SEMA3A/NRP1 or SEMA3F/NRP2 caused defasciculation and ectopic projection of facial branchiomotor axons...
  55. Kawasaki T, Bekku Y, Suto F, Kitsukawa T, Taniguchi M, Nagatsu I, et al. Requirement of neuropilin 1-mediated Sema3A signals in patterning of the sympathetic nervous system. Development. 2002;129:671-80 pubmed
    Neuropilin 1 is the specific receptor for Sema3A and plays a role in nerve fiber guidance...
  56. Cobos I, Borello U, Rubenstein J. Dlx transcription factors promote migration through repression of axon and dendrite growth. Neuron. 2007;54:873-88 pubmed
  57. Schwarz Q, Gu C, Fujisawa H, Sabelko K, Gertsenstein M, Nagy A, et al. Vascular endothelial growth factor controls neuronal migration and cooperates with Sema3A to pattern distinct compartments of the facial nerve. Genes Dev. 2004;18:2822-34 pubmed
    ..regulated independently by two secreted ligands for the transmembrane receptor neuropilin 1 (Nrp1), the semaphorin Sema3A and the VEGF164 isoform of Vascular Endothelial Growth Factor...
  58. Casazza A, Laoui D, Wenes M, Rizzolio S, Bassani N, Mambretti M, et al. Impeding macrophage entry into hypoxic tumor areas by Sema3A/Nrp1 signaling blockade inhibits angiogenesis and restores antitumor immunity. Cancer Cell. 2013;24:695-709 pubmed publisher
    ..Here, we report that hypoxia-induced Semaphorin 3A (Sema3A) acts as an attractant for TAMs by triggering vascular endothelial growth factor receptor 1 ..
  59. Puschel A, Adams R, Betz H. Murine semaphorin D/collapsin is a member of a diverse gene family and creates domains inhibitory for axonal extension. Neuron. 1995;14:941-8 pubmed
    ..Our data demonstrate that semaphorins are a diverse family of molecules that may provide local signals to specify territories nonaccessible for growing axons. ..