Selplg

Summary

Gene Symbol: Selplg
Description: selectin, platelet (p-selectin) ligand
Alias: CD162, Psgl-1, Psgl1, Selp1, Selpl, P-selectin glycoprotein ligand 1, selectin P ligand
Species: mouse
Products:     Selplg

Top Publications

  1. Yang J, Hirata T, Croce K, Merrill Skoloff G, Tchernychev B, Williams E, et al. Targeted gene disruption demonstrates that P-selectin glycoprotein ligand 1 (PSGL-1) is required for P-selectin-mediated but not E-selectin-mediated neutrophil rolling and migration. J Exp Med. 1999;190:1769-82 pubmed
    ..These kinetics are consistent with a model in which PSGL-1 is the predominant neutrophil P-selectin ligand but is not a required counterreceptor for E-selectin under in vivo physiological conditions. ..
  2. Norman K, Katopodis A, Thoma G, Kolbinger F, Hicks A, Cotter M, et al. P-selectin glycoprotein ligand-1 supports rolling on E- and P-selectin in vivo. Blood. 2000;96:3585-91 pubmed
    ..The results suggest that P-selectin-PSGL-1 interaction alone is sufficient to mediate rolling in vivo and that E-selectin-PSGL-1 interaction supports slow rolling. ..
  3. Haddad W, Cooper C, Zhang Z, Brown J, Zhu Y, Issekutz A, et al. P-selectin and P-selectin glycoprotein ligand 1 are major determinants for Th1 cell recruitment to nonlymphoid effector sites in the intestinal lamina propria. J Exp Med. 2003;198:369-77 pubmed
    ..These data suggest that IL-12-induced functional PSGL-1 expression is a major determinant for the recruitment of Th1 effector cells to noninflamed as well as inflamed intestine. ..
  4. Atarashi K, Hirata T, Matsumoto M, Kanemitsu N, Miyasaka M. Rolling of Th1 cells via P-selectin glycoprotein ligand-1 stimulates LFA-1-mediated cell binding to ICAM-1. J Immunol. 2005;174:1424-32 pubmed
    ..These results support the idea that PSGL-1-mediated rolling interactions induce intracellular signals leading to integrin activation, facilitating Th1 cell arrest and subsequent migration into target tissues. ..
  5. Yago T, Shao B, Miner J, Yao L, Klopocki A, Maeda K, et al. E-selectin engages PSGL-1 and CD44 through a common signaling pathway to induce integrin alphaLbeta2-mediated slow leukocyte rolling. Blood. 2010;116:485-94 pubmed publisher
    ..Thus, E-selectin triggers common signals through distinct neutrophil glycoproteins to induce alpha(L)beta(2)-dependent slow rolling. ..
  6. Xia L, Sperandio M, Yago T, McDaniel J, Cummings R, Pearson White S, et al. P-selectin glycoprotein ligand-1-deficient mice have impaired leukocyte tethering to E-selectin under flow. J Clin Invest. 2002;109:939-50 pubmed
    ..The residual PSGL-1-/- leukocytes that tethered rolled with slow velocities equivalent to those of PSGL-1+/+ leukocytes. These results reveal a novel function for PSGL-1 in tethering leukocytes to E-selectin under flow. ..
  7. Thatte A, Ficarro S, Snapp K, Wild M, Vestweber D, Hunt D, et al. Binding of function-blocking mAbs to mouse and human P-selectin glycoprotein ligand-1 peptides with and without tyrosine sulfation. J Leukoc Biol. 2002;72:470-7 pubmed
    ..Our data show, in three independent assay systems, that function-blocking antibodies to mouse or human PSGL-1 do not require sulfation of N-terminal tyrosines for binding. ..
  8. Sundd P, Gutierrez E, Koltsova E, Kuwano Y, Fukuda S, Pospieszalska M, et al. 'Slings' enable neutrophil rolling at high shear. Nature. 2012;488:399-403 pubmed publisher
    ..Each sling effectively lays out a cell-autonomous adhesive substrate in front of neutrophils rolling at high shear stress during inflammation. ..
  9. Xia L, Ramachandran V, McDaniel J, Nguyen K, Cummings R, McEver R. N-terminal residues in murine P-selectin glycoprotein ligand-1 required for binding to murine P-selectin. Blood. 2003;101:552-9 pubmed
    ..Because it uses only one tyrosine, murine PSGL-1 may rely more on other peptide components and O-glycosylation to bind to P-selectin than does human PSGL-1. ..

More Information

Publications84

  1. Wang H, Wang J, Zhang L, Geng Z, Xu W, Xu T, et al. P-selectin primes leukocyte integrin activation during inflammation. Nat Immunol. 2007;8:882-92 pubmed
    ..Our data demonstrate the functional importance of this newly identified signaling pathway mediated by P-selectin glycoprotein ligand 1. ..
  2. Zarbock A, Lowell C, Ley K. Spleen tyrosine kinase Syk is necessary for E-selectin-induced alpha(L)beta(2) integrin-mediated rolling on intercellular adhesion molecule-1. Immunity. 2007;26:773-83 pubmed
    ..Neutrophil recruitment in a thioglycollate-induced peritonitis model was almost completely inhibited in Selplg(-/-) mice or Syk(-/-) bone-marrow chimeras treated with pertussis toxin...
  3. Hidalgo A, Peired A, Wild M, Vestweber D, Frenette P. Complete identification of E-selectin ligands on neutrophils reveals distinct functions of PSGL-1, ESL-1, and CD44. Immunity. 2007;26:477-489 pubmed publisher
    ..These results suggest distinct and dynamic contributions of these three glycoproteins in selectin-mediated neutrophil adhesion and signaling. ..
  4. Rossi F, Corbel S, Merzaban J, Carlow D, Gossens K, Duenas J, et al. Recruitment of adult thymic progenitors is regulated by P-selectin and its ligand PSGL-1. Nat Immunol. 2005;6:626-34 pubmed
    ..Furthermore, the number of resident thymic progenitors controls thymic expression of P-selectin, suggesting that regulation of P-selectin expression by a thymic 'niche occupancy sensor' may be used to direct progenitor access. ..
  5. Mori M, Salter J, Vowinkel T, Krieglstein C, Stokes K, Granger D. Molecular determinants of the prothrombogenic phenotype assumed by inflamed colonic venules. Am J Physiol Gastrointest Liver Physiol. 2005;288:G920-6 pubmed
    ..Our findings indicate that colonic inflammation is associated with the induction of a prothrombogenic phenotype in the colonic microcirculation, with P-selectin and its ligand PSGL-1 playing a major role in the recruitment of platelets. ..
  6. Smith M, Olson T, Ley K. CXCR2- and E-selectin-induced neutrophil arrest during inflammation in vivo. J Exp Med. 2004;200:935-9 pubmed
    ..These data show that E-selectin- and chemokine-mediated arrest mechanisms are overlapping in this model and identify CXCR2 as an important neutrophil arrest chemokine in vivo. ..
  7. Alcaide P, King S, Dimitroff C, Lim Y, Fuhlbrigge R, Luscinskas F. The 130-kDa glycoform of CD43 functions as an E-selectin ligand for activated Th1 cells in vitro and in delayed-type hypersensitivity reactions in vivo. J Invest Dermatol. 2007;127:1964-72 pubmed
    ..These results demonstrate that both PSGL-1 and CD43 are major E-selectin ligands and are likely to be important during leukocyte recruitment in the development of inflammatory reactions. ..
  8. Kawar Z, Johnson T, Natunen S, Lowe J, Cummings R. PSGL-1 from the murine leukocytic cell line WEHI-3 is enriched for core 2-based O-glycans with sialyl Lewis x antigen. Glycobiology. 2008;18:441-6 pubmed publisher
    ..These results demonstrate that WEHI-3 cells selectively fucosylate PSGL-1 to generate functionally important core 2-based O-glycans containing the SLe(x) antigen. ..
  9. Sperandio M, Smith M, Forlow S, Olson T, Xia L, McEver R, et al. P-selectin glycoprotein ligand-1 mediates L-selectin-dependent leukocyte rolling in venules. J Exp Med. 2003;197:1355-63 pubmed
    ..L-selectin binding to PSGL-1 initiates tethering events that enable L-selectin-independent leukocyte-endothelial interactions. These findings provide a molecular mechanism for the inflammatory defects seen in L-selectin-deficient mice. ..
  10. Katayama Y, Hidalgo A, Furie B, Vestweber D, Furie B, Frenette P. PSGL-1 participates in E-selectin-mediated progenitor homing to bone marrow: evidence for cooperation between E-selectin ligands and alpha4 integrin. Blood. 2003;102:2060-7 pubmed
    ..Our results thus underscore a major difference between mature myeloid cells and immature stem/progenitor cells in that E-selectin ligands cooperate with alpha4 integrin rather than P-selectin ligands. ..
  11. Hirata T, Furie B, Furie B. P-, E-, and L-selectin mediate migration of activated CD8+ T lymphocytes into inflamed skin. J Immunol. 2002;169:4307-13 pubmed
    ..P- and E-selectin-independent migration of Tc1 cells into the inflamed skin was predominantly mediated by L-selectin. These observations indicate that all three selectins can mediate Tc1 cell migration into the inflamed skin. ..
  12. Hirata T, Merrill Skoloff G, Aab M, Yang J, Furie B, Furie B. P-Selectin glycoprotein ligand 1 (PSGL-1) is a physiological ligand for E-selectin in mediating T helper 1 lymphocyte migration. J Exp Med. 2000;192:1669-76 pubmed
    ..These data provide evidence that PSGL-1 on Th1 cells functions as one of the E-selectin ligands in vivo. ..
  13. Zarbock A, Abram C, Hundt M, Altman A, Lowell C, Ley K. PSGL-1 engagement by E-selectin signals through Src kinase Fgr and ITAM adapters DAP12 and FcR gamma to induce slow leukocyte rolling. J Exp Med. 2008;205:2339-47 pubmed publisher
  14. Xu H, Manivannan A, Jiang H, Liversidge J, Sharp P, Forrester J, et al. Recruitment of IFN-gamma-producing (Th1-like) cells into the inflamed retina in vivo is preferentially regulated by P-selectin glycoprotein ligand 1:P/E-selectin interactions. J Immunol. 2004;172:3215-24 pubmed
    ..We suggest that random trafficking of activated T cells (both Th1 and Th2) across the blood-retina barrier is mediated by CD44:CD44R and LFA-1:ICAM-1, whereas preferential recruitment of Th1 cells is mediated by PSGL-1:P/E-selectin...
  15. Miner J, Xia L, Yago T, Kappelmayer J, Liu Z, Klopocki A, et al. Separable requirements for cytoplasmic domain of PSGL-1 in leukocyte rolling and signaling under flow. Blood. 2008;112:2035-45 pubmed publisher
    ..These data demonstrate that the PSGL-1 cytoplasmic domain is dispensable for leukocyte rolling on P-selectin but is essential to activate beta2 integrins to slow rolling on ICAM-1. ..
  16. Veerman K, Williams M, Uchimura K, Singer M, Merzaban J, Naus S, et al. Interaction of the selectin ligand PSGL-1 with chemokines CCL21 and CCL19 facilitates efficient homing of T cells to secondary lymphoid organs. Nat Immunol. 2007;8:532-9 pubmed
    ..Our data show involvement of PSGL-1 in facilitating the entry of T cells into secondary lymphoid organs, thereby demonstrating the bifunctional nature of this molecule. ..
  17. Rivera Nieves J, Burcin T, Olson T, Morris M, McDuffie M, Cominelli F, et al. Critical role of endothelial P-selectin glycoprotein ligand 1 in chronic murine ileitis. J Exp Med. 2006;203:907-17 pubmed
    ..Thus, the multiple roles of PSGL-1 may explain why targeting this single adhesion molecule results in attenuation of chronic murine ileitis, a disease previously resistant to antiadhesion molecule strategies. ..
  18. Ostanin D, Furr K, Pavlick K, Gray L, Kevil C, Shukla D, et al. T cell-associated CD18 but not CD62L, ICAM-1, or PSGL-1 is required for the induction of chronic colitis. Am J Physiol Gastrointest Liver Physiol. 2007;292:G1706-14 pubmed
    ..We conclude that T cell-associated CD18, but not CD62L, ICAM-1, or PSGL-1, is required for the development of chronic colitis. ..
  19. An G, Wang H, Tang R, Yago T, McDaniel J, McGee S, et al. P-selectin glycoprotein ligand-1 is highly expressed on Ly-6Chi monocytes and a major determinant for Ly-6Chi monocyte recruitment to sites of atherosclerosis in mice. Circulation. 2008;117:3227-37 pubmed publisher
    ..These data indicate that PSGL-1 is a new marker for Ly-6C(hi) monocytes and a major determinant for Ly-6C(hi) cell recruitment to sites of atherosclerosis in mice. ..
  20. Yang J, Galipeau J, Kozak C, Furie B, Furie B. Mouse P-selectin glycoprotein ligand-1: molecular cloning, chromosomal localization, and expression of a functional P-selectin receptor. Blood. 1996;87:4176-86 pubmed
    ..The mouse PSGL-1 gene, Selpl, was mapped to a position on mouse chromosome 5 (Chr 5)...
  21. Chen S, Huang C, Chien C, Jeng C, Su H, Chiang E, et al. Cross-linking of P-selectin glycoprotein ligand-1 induces death of activated T cells. Blood. 2004;104:3233-42 pubmed
    ..Here, we demonstrate for the first time that P-selectin glycoprotein ligand-1 (PSGL-1) or CD162 molecules cross-linked by an anti-PSGL-1 monoclonal antibody, TAB4, can trigger a death signal in activated T ..
  22. Sato C, Shikata K, Hirota D, Sasaki M, Nishishita S, Miyamoto S, et al. P-selectin glycoprotein ligand-1 deficiency is protective against obesity-related insulin resistance. Diabetes. 2011;60:189-99 pubmed publisher
  23. Miszti Blasius K, Felszeghy S, Kiss C, Benko I, Géresi K, Megyeri A, et al. P-selectin glycoprotein ligand-1 deficiency augments G-CSF induced myeloid cell mobilization. Naunyn Schmiedebergs Arch Pharmacol. 2014;387:109-18 pubmed publisher
  24. Liou J, Lee C, Lin Y, Chen C, Liao C, Lee H, et al. P-selectin is required for neutrophils and macrophage infiltration into injured site and contributes to generation of behavioral hypersensitivity following peripheral nerve injury in mice. Pain. 2013;154:2150-9 pubmed publisher
  25. Mazo I, Honczarenko M, Leung H, Cavanagh L, Bonasio R, Weninger W, et al. Bone marrow is a major reservoir and site of recruitment for central memory CD8+ T cells. Immunity. 2005;22:259-70 pubmed
    ..Thus, the BM functions as a major reservoir for TCMs by providing specific recruitment signals that act in sequence to mediate the constitutive recruitment of TCMs from the blood. ..
  26. Liu G, Liang B, Song X, Bai R, Qin W, Sun X, et al. P?selectin increases angiotensin II?induced cardiac inflammation and fibrosis via platelet activation. Mol Med Rep. 2016;13:5021-8 pubmed publisher
    ..The results from the present study suggest that activated platelets secrete P?selectin to promote cardiac inflammation and fibrosis in Ang II?induced hypertension. ..
  27. Hoffmann U, Pink M, Lauer U, Heimesaat M, Winsauer C, Kruglov A, et al. Regulation and migratory role of P-selectin ligands during intestinal inflammation. PLoS ONE. 2013;8:e62055 pubmed publisher
    ..While RA impeded the induction of fucosyltransferase-VII it did not affect IL-12-dependent C2GlcNAcT-I induction suggesting that C2GlcNAcT-I can support P-lig expression even if fucosyltransferase-VII mRNA upregulation is dampened. ..
  28. Harakawa N, Shigeta A, Wato M, Merrill Skoloff G, Furie B, Furie B, et al. P-selectin glycoprotein ligand-1 mediates L-selectin-independent leukocyte rolling in high endothelial venules of peripheral lymph nodes. Int Immunol. 2007;19:321-9 pubmed
    ..Taken together, these results indicate that the interaction of PSGL-1 with P-selectin constitutes a second mechanism of leukocyte rolling in the HEVs of peripheral LNs. ..
  29. Eom H, Rubio M, Means T, Luster A, Sykes M. T-cell P/E-selectin ligand alpha(1,3)fucosylation is not required for graft-vs-host disease induction. Exp Hematol. 2005;33:1564-73 pubmed
    ..These results suggest that donor T cells, including Th1, are capable of trafficking to GVHD target tissues independently of P- and E- selectin ligand in conditioned hosts. ..
  30. Piccio L, Rossi B, Colantonio L, Grenningloh R, Gho A, Ottoboni L, et al. Efficient recruitment of lymphocytes in inflamed brain venules requires expression of cutaneous lymphocyte antigen and fucosyltransferase-VII. J Immunol. 2005;174:5805-13 pubmed
    ..These observations allow us to conclude that efficient recruitment of activated lymphocytes to the brain in the contexts mimicking EAE is controlled by FucT-VII and its cognate cell surface Ag CLA. ..
  31. Luo W, Wang H, Ohman M, Guo C, Shi K, Wang J, et al. P-selectin glycoprotein ligand-1 deficiency leads to cytokine resistance and protection against atherosclerosis in apolipoprotein E deficient mice. Atherosclerosis. 2012;220:110-7 pubmed publisher
    ..This study suggests that Psgl-1 deficiency leads to reduced atherosclerosis and adhesive interactions between endothelial cells and leukocytes by indirectly regulating endothelial responses to cytokine stimulation. ..
  32. Westmuckett A, Thacker K, Moore K. Tyrosine sulfation of native mouse Psgl-1 is required for optimal leukocyte rolling on P-selectin in vivo. PLoS ONE. 2011;6:e20406 pubmed publisher
    ..These findings provide direct and convincing evidence that tyrosine sulfation is required for optimal function of mouse Psgl-1 in vivo and suggests that tyrosine sulfation of Psgl-1 contributes to the development of atherosclerosis. ..
  33. Raes G, Ghassabeh G, Brys L, Mpofu N, Verschueren H, Vanhecke D, et al. The metastatic T-cell hybridoma antigen/P-selectin glycoprotein ligand 1 is required for hematogenous metastasis of lymphomas. Int J Cancer. 2007;121:2646-52 pubmed
  34. He X, Schoeb T, Panoskaltsis Mortari A, Zinn K, Kesterson R, Zhang J, et al. Deficiency of P-selectin or P-selectin glycoprotein ligand-1 leads to accelerated development of glomerulonephritis and increased expression of CC chemokine ligand 2 in lupus-prone mice. J Immunol. 2006;177:8748-56 pubmed
  35. Shigeta A, Matsumoto M, Tedder T, Lowe J, Miyasaka M, Hirata T. An L-selectin ligand distinct from P-selectin glycoprotein ligand-1 is expressed on endothelial cells and promotes neutrophil rolling in inflammation. Blood. 2008;112:4915-23 pubmed publisher
    ..These results provide evidence for the existence of an L-selectin ligand distinct from PSGL-1 in inflammation and indicate that such a ligand is expressed on endothelial cells, promoting neutrophil rolling in vivo. ..
  36. Foubert P, Silvestre J, Souttou B, Barateau V, Martin C, Ebrahimian T, et al. PSGL-1-mediated activation of EphB4 increases the proangiogenic potential of endothelial progenitor cells. J Clin Invest. 2007;117:1527-37 pubmed
    ..Therefore, activation of EphB4 is an innovative and potentially valuable therapeutic strategy for improving the recruitment of EPCs to sites of neovascularization and thereby the efficiency of cell-based proangiogenic therapy. ..
  37. Chu Y, Schmitz S, Choudhury B, Telford W, Kapoor V, Garfield S, et al. Exogenous insulin-like growth factor 1 enhances thymopoiesis predominantly through thymic epithelial cell expansion. Blood. 2008;112:2836-46 pubmed publisher
    ..These results indicate the critical point thymic function regulation by IGF-1 involves TEC expansion regulating thymocyte precursor entry and facilitating thymocyte development. ..
  38. Yago T, Fu J, McDaniel J, Miner J, McEver R, Xia L. Core 1-derived O-glycans are essential E-selectin ligands on neutrophils. Proc Natl Acad Sci U S A. 2010;107:9204-9 pubmed publisher
  39. Sultana D, Zhang S, Todd S, Bhandoola A. Expression of functional P-selectin glycoprotein ligand 1 on hematopoietic progenitors is developmentally regulated. J Immunol. 2012;188:4385-93 pubmed publisher
    ..These studies provide insight into the developmentally regulated expression of a critical determinant involved in progenitor homing to the thymus. ..
  40. Dold S, Laschke M, Zhau Y, Schilling M, Menger M, Jeppsson B, et al. P-selectin glycoprotein ligand-1-mediated leukocyte recruitment regulates hepatocellular damage in acute obstructive cholestasis in mice. Inflamm Res. 2010;59:291-8 pubmed publisher
    ..Consequently, interference with PSGL-1 attenuates cholestasis-provoked leukocyte adhesion and extravasation in the liver. Thus, inhibition of PSGL-1 may help to protect against hepatocellular damage in cholestatic diseases. ..
  41. Shao B, Wahrenbrock M, Yao L, David T, Coughlin S, Xia L, et al. Carcinoma mucins trigger reciprocal activation of platelets and neutrophils in a murine model of Trousseau syndrome. Blood. 2011;118:4015-23 pubmed publisher
    ..Thus, carcinoma mucins promote thrombosis through adhesion-dependent, bidirectional signaling in neutrophils and platelets. ..
  42. Krause D, Lazarides K, Lewis J, von Andrian U, Van Etten R. Selectins and their ligands are required for homing and engraftment of BCR-ABL1+ leukemic stem cells in the bone marrow niche. Blood. 2014;123:1361-71 pubmed publisher
    ..Selectin blockade is a novel strategy to exploit differences between normal and leukemic stem cells that may be beneficial in autologous transplantation for CML and perhaps other leukemias. ..
  43. Matsumoto M, Shigeta A, Miyasaka M, Hirata T. CD43 plays both antiadhesive and proadhesive roles in neutrophil rolling in a context-dependent manner. J Immunol. 2008;181:3628-35 pubmed
  44. Zanardo R, Bonder C, Hwang J, Andonegui G, Liu L, Vestweber D, et al. A down-regulatable E-selectin ligand is functionally important for PSGL-1-independent leukocyte-endothelial cell interactions. Blood. 2004;104:3766-73 pubmed
    ..In conclusion, E-selectin mediates PSGL-1-dependent and independent rolling and the latter can be down-regulated by systemic activation and can replace PSGL-1 to support the development of inflammation. ..
  45. Zlotoff D, Zhang S, De Obaldia M, Hess P, Todd S, Logan T, et al. Delivery of progenitors to the thymus limits T-lineage reconstitution after bone marrow transplantation. Blood. 2011;118:1962-70 pubmed publisher
    ..Finally, we show that thymic recovery is limited by the number of progenitors entering the thymus after BMT. Hence, T-lineage reconstitution after BMT is limited by progenitor supply to the thymus. ..
  46. Tinoco R, Carrette F, Barraza M, Otero D, Magaña J, Bosenberg M, et al. PSGL-1 Is an Immune Checkpoint Regulator that Promotes T Cell Exhaustion. Immunity. 2016;44:1190-203 pubmed publisher
    ..Thus, PSGL-1 plays a fundamental role in balancing viral control and immunopathology and also functions to regulate T cell responses in the tumor microenvironment. ..
  47. Looney M, Nguyen J, Hu Y, Van Ziffle J, Lowell C, Matthay M. Platelet depletion and aspirin treatment protect mice in a two-event model of transfusion-related acute lung injury. J Clin Invest. 2009;119:3450-61 pubmed publisher
    ..Furthermore, our data offer an explanation for the increased incidence of TRALI in patients with immune priming conditions, and we suggest what we believe to be a novel therapeutic approach. ..
  48. Santen S, Schramm R, Menger M, Wang Y, Jeppsson B, Thorlacius H. P-selectin glycoprotein ligand-1 regulates chemokine-dependent leukocyte recruitment in colonic ischemia-reperfusion. Inflamm Res. 2007;56:452-8 pubmed
    ..These findings suggest that targeting PSGL-1 may be an effective strategy to prevent I/R-induced inflammation in the colon. ..
  49. Gainers M, Descheny L, Barthel S, Liu L, Wurbel M, Dimitroff C. Skin-homing receptors on effector leukocytes are differentially sensitive to glyco-metabolic antagonism in allergic contact dermatitis. J Immunol. 2007;179:8509-18 pubmed
  50. Carlyon J, Akkoyunlu M, Xia L, Yago T, Wang T, Cummings R, et al. Murine neutrophils require alpha1,3-fucosylation but not PSGL-1 for productive infection with Anaplasma phagocytophilum. Blood. 2003;102:3387-95 pubmed
    ..However, murine infection does not require neutrophil PSGL-1 expression, which has important implications for understanding how A phagocytophilum binds and infects neutrophils. ..
  51. Bae S, Shimizu K, Yozaki M, Yamaoka T, Akiyama Y, Yoshizaki A, et al. Involvement of L-selectin in contact hypersensitivity responses augmented by auditory stress. Am J Pathol. 2010;176:187-97 pubmed publisher
    ..Our results indicated that auditory stress enhances CH response and that the augmentation of this CH response might be mediated through L-selectin, but not through P- or E-selectin pathways. ..
  52. Bai X, Weitz J, Gross P. Leukocyte urokinase plasminogen activator receptor and PSGL1 play a role in endogenous arterial fibrinolysis. Thromb Haemost. 2009;102:1212-8 pubmed publisher
    ..Thus, fibrin loss from microarteriolar thrombi is mediated, at least in part, by leukocyte-associated uPA in a process that requires leukocyte uPAR and PSGL-1. ..
  53. Dole V, Bergmeier W, Mitchell H, Eichenberger S, Wagner D. Activated platelets induce Weibel-Palade-body secretion and leukocyte rolling in vivo: role of P-selectin. Blood. 2005;106:2334-9 pubmed
    ..We conclude that the presence of activated platelets in circulation promotes acute inflammation by stimulating secretion of Weibel-Palade bodies and P-selectin-mediated leukocyte rolling...
  54. Tchernychev B, Furie B, Furie B. Peritoneal macrophages express both P-selectin and PSGL-1. J Cell Biol. 2003;163:1145-55 pubmed
    ..This is the first description of a leukocyte shown to express both P-selectin and PSGL-1. ..
  55. Nacher M, Blazquez A, Shao B, Matesanz A, Prophete C, Berin M, et al. Physiological contribution of CD44 as a ligand for E-Selectin during inflammatory T-cell recruitment. Am J Pathol. 2011;178:2437-46 pubmed publisher
    ..Our results identify additional mechanisms by which CD44 modulates the inflammatory response. ..
  56. Zhao C, Su E, Yang X, Gao Z, Li L, Wu H, et al. Important role of platelets in modulating endotoxin-induced lung inflammation in CFTR-deficient mice. PLoS ONE. 2013;8:e82683 pubmed publisher
    ..As such, targeting platelets might be an emerging strategy for dampening recurrent lung inflammation in cystic fibrosis patients. ..
  57. Han X, Wang S. Deficiency of Psgl-1 accelerates bleomycin (BLM)-induced lung fibrosis and inflammation in mice through activating PI3K/AKT. Biochem Biophys Res Commun. 2017;491:558-565 pubmed publisher
    ..However, further experiments are still necessary to characterize the precise molecular mechanism of Psgl-1 in mice fibrosis. ..
  58. Shao B, Yago T, Setiadi H, Wang Y, Mehta D souza P, Fu J, et al. O-glycans direct selectin ligands to lipid rafts on leukocytes. Proc Natl Acad Sci U S A. 2015;112:8661-6 pubmed publisher
    ..Preassociation of these glycoproteins with rafts is required for signaling but not for movement to uropods. ..
  59. Becker K, Beckmann N, Adams C, Hessler G, Krämer M, Gulbins E, et al. Melanoma cell metastasis via P-selectin-mediated activation of acid sphingomyelinase in platelets. Clin Exp Metastasis. 2017;34:25-35 pubmed publisher
    ..The data suggest that p38 MAPK acts downstream from P-selectin and is necessary for the secretion of Asm. ..
  60. Miszti Blasius K, Debreceni I, Felszeghy S, Dezso B, Kappelmayer J. Lack of P-selectin glycoprotein ligand-1 protects mice from thrombosis after collagen/epinephrine challenge. Thromb Res. 2011;127:228-34 pubmed publisher
    ..Our aim was to establish the role of PSGL-1 in thrombus formation by evaluating the response to thrombotic stimuli in wild type and PSGL-1 knockout mice...
  61. Urzainqui A, Martinez del Hoyo G, Lamana A, de la Fuente H, Barreiro O, Olazabal I, et al. Functional role of P-selectin glycoprotein ligand 1/P-selectin interaction in the generation of tolerogenic dendritic cells. J Immunol. 2007;179:7457-65 pubmed
    ..Our data reveal an unexpected role of PSGL-1 on the tolerogenic function of DCs, and the regulation of the immune response. ..
  62. van Genderen H, Wielders S, Lindhout T, Reutelingsperger C. Rolling and adhesion of apoptotic monocytes is impaired by loss of functional cell surface-expressed P-selectin glycoprotein ligand-1. J Thromb Haemost. 2006;4:1611-7 pubmed
    ..However, in contrast to TF, PSGL-1 shedding and loss of function, makes that apoptotic monocytes are unlikely involved in a thrombotic action because of their inability to adhere to an injured vessel wall or developing thrombus. ..
  63. Nuñez Andrade N, Lamana A, Sancho D, Gisbert J, Gonzalez Amaro R, Sanchez Madrid F, et al. P-selectin glycoprotein ligand-1 modulates immune inflammatory responses in the enteric lamina propria. J Pathol. 2011;224:212-21 pubmed publisher
  64. Shao B, Yago T, Coghill P, Klopocki A, Mehta D souza P, Schmidtke D, et al. Signal-dependent slow leukocyte rolling does not require cytoskeletal anchorage of P-selectin glycoprotein ligand-1 (PSGL-1) or integrin ?L?2. J Biol Chem. 2012;287:19585-98 pubmed publisher
    ..The cytoskeletal independence of PSGL-1-initiated, ?(L)?(2)-mediated slow rolling differs markedly from the cytoskeletal dependence of chemokine-initiated, ?(L)?(2)-mediated arrest. ..
  65. Gossens K, Naus S, Corbel S, Lin S, Rossi F, Kast J, et al. Thymic progenitor homing and lymphocyte homeostasis are linked via S1P-controlled expression of thymic P-selectin/CCL25. J Exp Med. 2009;206:761-78 pubmed publisher
    ..Our findings suggest a model whereby thymic TCP importation is controlled by both early thymic niche occupancy and the peripheral lymphocyte pool via S1P. ..
  66. Ryzhov S, Solenkova N, Goldstein A, Lamparter M, Fleenor T, Young P, et al. Adenosine receptor-mediated adhesion of endothelial progenitors to cardiac microvascular endothelial cells. Circ Res. 2008;102:356-63 pubmed
    ..Our results suggest a role for adenosine in vasculogenesis and its potential use to stimulate engraftment in cell-based therapies. ..
  67. Matsumoto M, Shigeta A, Furukawa Y, Tanaka T, Miyasaka M, Hirata T. CD43 collaborates with P-selectin glycoprotein ligand-1 to mediate E-selectin-dependent T cell migration into inflamed skin. J Immunol. 2007;178:2499-506 pubmed
    ..Collectively, these results demonstrate that the CD43 expressed on activated T cells functions as an E-selectin ligand and thereby mediates T cell migration to inflamed sites, in collaboration with PSGL-1. ..
  68. Pruenster M, Kurz A, Chung K, Cao Ehlker X, Bieber S, Nussbaum C, et al. Extracellular MRP8/14 is a regulator of β2 integrin-dependent neutrophil slow rolling and adhesion. Nat Commun. 2015;6:6915 pubmed publisher
    ..This extracellular activation loop reduces leukocyte rolling velocity and stimulates adhesion. Thus, we identify Mrp8/14 and TLR4 as important modulators of the leukocyte recruitment cascade during inflammation in vivo. ..
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    ..We propose that PSGL-1 plays a role in blood coagulation in addition to its known role in leukocyte trafficking. ..
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    ..These results reveal a novel regulatory role for PSGL-1 in T cell adhesion and proliferation and suggest that PSGL-1 negatively regulates T cell immune responses in vivo. ..
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    ..The temporal overlap between PSGL-1 and P-selectin up-regulation reveals an as yet unrecognized collaboration between this receptor-ligand pair, increasing efficiency of the first steps of the leukocyte recruitment cascade. ..
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