Gene Symbol: Selenot
Description: selenoprotein T
Alias: 2810407C02Rik, 5730408P04Rik, Selt, thioredoxin reductase-like selenoprotein T, thioredoxin reductase-like enzyme
Kryukov G, Kryukov V, Gladyshev V. New mammalian selenocysteine-containing proteins identified with an algorithm that searches for selenocysteine insertion sequence elements. J Biol Chem. 1999;274:33888-97 pubmed
..When SECISearch was applied to search human dbEST, two new mammalian selenoproteins, designated SelT and SelR, were identified...
Sengupta A, Carlson B, Labunskyy V, Gladyshev V, Hatfield D. Selenoprotein T deficiency alters cell adhesion and elevates selenoprotein W expression in murine fibroblast cells. Biochem Cell Biol. 2009;87:953-61 pubmed publisher
..The cellular role of selenoprotein T (SelT), manifesting a CxxU motif in a thioredoxin-like fold and localized to Golgi and the endoplasmic reticulum, is not ..
Rederstorff M, Castets P, Arbogast S, Laine J, Vassilopoulos S, Beuvin M, et al
. Increased muscle stress-sensitivity induced by selenoprotein N inactivation in mouse: a mammalian model for SEPN1-related myopathy. PLoS ONE. 2011;6:e23094 pubmed publisher
Prévost G, Arabo A, Jian L, Quelennec E, Cartier D, Hassan S, et al
. The PACAP-regulated gene selenoprotein T is abundantly expressed in mouse and human ?-cells and its targeted inactivation impairs glucose tolerance. Endocrinology. 2013;154:3796-806 pubmed publisher
..Here, we found that selenoprotein T (SelT), a new thioredoxin-like protein of the endoplasmic reticulum, is present at high levels in human and mouse ..
Castex M, Arabo A, Benard M, Roy V, Le Joncour V, Prévost G, et al
. Selenoprotein T Deficiency Leads to Neurodevelopmental Abnormalities and Hyperactive Behavior in Mice. Mol Neurobiol. 2016;53:5818-5832 pubmed publisher
Selenoprotein T (SelT) is a newly discovered thioredoxin-like protein, which is abundantly but transiently expressed in the neural lineage during brain ontogenesis...
Boukhzar L, Hamieh A, Cartier D, Tanguy Y, Alsharif I, Castex M, et al
. Selenoprotein T Exerts an Essential Oxidoreductase Activity That Protects Dopaminergic Neurons in Mouse Models of Parkinson's Disease. Antioxid Redox Signal. 2016;24:557-74 pubmed publisher
..We demonstrated first that selenoprotein T (SelT) whose gene disruption is lethal during embryogenesis, exerts a potent oxidoreductase activity...
Gladyshev V, Arnér E, Berry M, Brigelius Flohe R, Bruford E, Burk R, et al
. Selenoprotein Gene Nomenclature. J Biol Chem. 2016;291:24036-24040 pubmed
..O, SELO), SELENOP (selenoprotein P, SeP, SEPP1, SELP), SELENOS (selenoprotein S, SELS, SEPS1, VIMP), SELENOT (selenoprotein T, SELT), SELENOV (selenoprotein V, SELV), and SELENOW (selenoprotein W, SELW, SEPW1)...
Sasaki N, Nagaoka S, Itoh M, Izawa M, Konno H, Carninci P, et al
. Characterization of gene expression in mouse blastocyst using single-pass sequencing of 3995 clones. Genomics. 1998;49:167-79 pubmed
..Although the human EST project is considered to represent roughly half of all genes, our findings indicate that many early stage developmental genes remain to be identified. ..