Gene Symbol: Sdhd
Description: succinate dehydrogenase complex, subunit D, integral membrane protein
Alias: 3110001M13Rik, AVLL5809, C78570, PRO19626, succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial, CII-4, QPs3, cybS, succinate dehydrogenase complex subunit D, succinate-ubiquinone oxidoreductase cytochrome b small subunit, succinate-ubiquinone reductase membrane anchor subunit
Piruat J, Pintado C, Ortega Saenz P, Roche M, Lopez Barneo J. The mitochondrial SDHD gene is required for early embryogenesis, and its partial deficiency results in persistent carotid body glomus cell activation with full responsiveness to hypoxia. Mol Cell Biol. 2004;24:10933-40 pubmed
The SDHD gene encodes one of the two membrane-anchoring proteins of the succinate dehydrogenase (complex II) of the mitochondrial electron transport chain...
Bayley J, van Minderhout I, Hogendoorn P, Cornelisse C, van der Wal A, Prins F, et al
. Sdhd and SDHD/H19 knockout mice do not develop paraganglioma or pheochromocytoma. PLoS ONE. 2009;4:e7987 pubmed publisher
..Mutations of SDHD, the first protein of intermediary metabolism shown to be involved in tumorigenesis, lead to the human tumors ..
Diaz Castro B, Pintado C, García Flores P, Lopez Barneo J, Piruat J. Differential impairment of catecholaminergic cell maturation and survival by genetic mitochondrial complex II dysfunction. Mol Cell Biol. 2012;32:3347-57 pubmed publisher
The SDHD gene (subunit D of succinate dehydrogenase) has been shown to be involved in the generation of paragangliomas and pheochromocytomas...
Platero Luengo A, González Granero S, Durán R, Diaz Castro B, Piruat J, Garcia Verdugo J, et al
. An O2-sensitive glomus cell-stem cell synapse induces carotid body growth in chronic hypoxia. Cell. 2014;156:291-303 pubmed publisher
..Thus, glomus cells not only acutely activate the respiratory center but also induce NSC-dependent CB hypertrophy necessary for acclimatization to chronic hypoxemia. ..
Paddenberg R, Tiefenbach M, Faulhammer P, Goldenberg A, Gries B, Pfeil U, et al
. Mitochondrial complex II is essential for hypoxia-induced pulmonary vasoconstriction of intra- but not of pre-acinar arteries. Cardiovasc Res. 2012;93:702-10 pubmed publisher
..vascular bed and consequences for PAP and perfusion-to-ventilation matching, using mutant mice heterozygous for the SDHD subunit of complex II (SDHD(+/-))...
Lepoutre Lussey C, Thibault C, Buffet A, Morin A, Badoual C, BÃ©nit P, et al
. From Nf1 to Sdhb knockout: Successes and failures in the quest for animal models of pheochromocytoma. Mol Cell Endocrinol. 2016;421:40-8 pubmed publisher
..In this review, we present an overview of existing, successful or not, PPGL models, and a description of our own experience on the quest of Sdhb knockout mouse models of PPGL. ..
Sharma S, Wang J, Cortes Gomez E, TAGGART R, Baysal B. Mitochondrial complex II regulates a distinct oxygen sensing mechanism in monocytes. Hum Mol Genet. 2017;26:1328-1339 pubmed publisher
..Accordingly, compound germline heterozygosity of mouse Sdhb/Sdhc/Sdhd null alleles blunts chronic hypoxia-induced increases in hemoglobin levels, an adaptive response mainly regulated ..
Lussey Lepoutre C, Hollinshead K, Ludwig C, Menara M, Morin A, Castro Vega L, et al
. Loss of succinate dehydrogenase activity results in dependency on pyruvate carboxylation for cellular anabolism. Nat Commun. 2015;6:8784 pubmed publisher
..Our results demonstrate that the loss of SDH reduces the metabolic plasticity of cells, suggesting vulnerabilities that can be targeted therapeutically. ..
Millán Uclés Á, Diaz Castro B, García Flores P, Baez A, Perez Simon J, Lopez Barneo J, et al
. A conditional mouse mutant in the tumor suppressor SdhD gene unveils a link between p21(WAF1/Cip1) induction and mitochondrial dysfunction. PLoS ONE. 2014;9:e85528 pubmed publisher
..In this work, we made use of the inducible SDHD-ESR mouse, a conditional mutant in the SdhD gene, which encodes the small subunit of MCII, and that acts as a tumor ..