Gene Symbol: Sdhc
Description: succinate dehydrogenase complex, subunit C, integral membrane protein
Alias: 0610010E03Rik, AI316496, AU019277, succinate dehydrogenase cytochrome b560 subunit, mitochondrial, QPs-1, QPs1, integral membrane protein CII-3
Species: mouse
Products:     Sdhc

Top Publications

  1. Ishii T, Yasuda K, Akatsuka A, Hino O, Hartman P, Ishii N. A mutation in the SDHC gene of complex II increases oxidative stress, resulting in apoptosis and tumorigenesis. Cancer Res. 2005;65:203-9 pubmed
    ..In this study, a transgenic mouse cell line (SDHC E69) with a mutated SDHC gene (a subunit of complex II in the electron transport chain) was constructed to test ..
  2. Ishii T, Miyazawa M, Onouchi H, Yasuda K, Hartman P, Ishii N. Model animals for the study of oxidative stress from complex II. Biochim Biophys Acta. 2013;1827:588-97 pubmed publisher
    ..We have previously demonstrated that mutations in complex II can result in excessive ROS (specifically in SDHC: G71E in Caenorhabditis elegans, I71E in Drosophila and V69E in mouse)...
  3. Schilling B, Murray J, Yoo C, Row R, Cusack M, Capaldi R, et al. Proteomic analysis of succinate dehydrogenase and ubiquinol-cytochrome c reductase (Complex II and III) isolated by immunoprecipitation from bovine and mouse heart mitochondria. Biochim Biophys Acta. 2006;1762:213-22 pubmed
    ..The identification of several posttranslational modifications, including the covalent FAD modification of flavoprotein subunit 1 from Complex II, was possible due to high mass spectrometric sequence coverage. ..
  4. Sharma S, Wang J, Cortes Gomez E, TAGGART R, Baysal B. Mitochondrial complex II regulates a distinct oxygen sensing mechanism in monocytes. Hum Mol Genet. 2017;26:1328-1339 pubmed publisher
    ..Accordingly, compound germline heterozygosity of mouse Sdhb/Sdhc/Sdhd null alleles blunts chronic hypoxia-induced increases in hemoglobin levels, an adaptive response mainly ..
  5. Forner F, Kumar C, Luber C, Fromme T, Klingenspor M, Mann M. Proteome differences between brown and white fat mitochondria reveal specialized metabolic functions. Cell Metab. 2009;10:324-35 pubmed publisher
    ..In vivo comparison of organellar proteomes can thus directly address functional questions in metabolism. ..
  6. Paddenberg R, Ishaq B, Goldenberg A, Faulhammer P, Rose F, Weissmann N, et al. Essential role of complex II of the respiratory chain in hypoxia-induced ROS generation in the pulmonary vasculature. Am J Physiol Lung Cell Mol Physiol. 2003;284:L710-9 pubmed
    ..Presumably, its catalytic activity switches from succinate dehydrogenase to fumarate reductase at reduced oxygen tension, thereby modulating the directionality of the electron flow. ..
  7. Albayrak T, Scherhammer V, Schoenfeld N, Braziulis E, Mund T, Bauer M, et al. The tumor suppressor cybL, a component of the respiratory chain, mediates apoptosis induction. Mol Biol Cell. 2003;14:3082-96 pubmed
    ..One of the isolated genes is cytochrome bL (cybL also known as SDHC, CII-3, or QPs-1), a component of the respiratory chain complex II...
  8. Hitzemann R, Reed C, Malmanger B, Lawler M, Hitzemann B, Cunningham B, et al. On the integration of alcohol-related quantitative trait loci and gene expression analyses. Alcohol Clin Exp Res. 2004;28:1437-48 pubmed
    ..Although improvements are needed in the expression databases, the integration of QTL and gene expression analyses seems to have potential as a high-throughput strategy for moving from QTL to QTG. ..
  9. Jones K, Corbin J, Huntsman M. Neonatal NMDA receptor blockade disrupts spike timing and glutamatergic synapses in fast spiking interneurons in a NMDA receptor hypofunction model of schizophrenia. PLoS ONE. 2014;9:e109303 pubmed publisher
    ..Overall, we propose these physiological disturbances represent a general impairment to the physiological maturation of FSIs which may contribute to schizophrenia-like behaviors produced by this model. ..

More Information


  1. Her Y, Nelson Holte M, MAHER L. Oxygen concentration controls epigenetic effects in models of familial paraganglioma. PLoS ONE. 2015;10:e0127471 pubmed publisher
    ..Increasing oxygen suppresses succinate inhibition of α-KG-dependent dioxygenases. This result provides a possible explanation for the association between hypoxia and PGL, and suggests hyperoxia as a potential novel therapy. ..
  2. Ishii T, Takanashi Y, Sugita K, Miyazawa M, Yanagihara R, Yasuda K, et al. Endogenous reactive oxygen species cause astrocyte defects and neuronal dysfunctions in the hippocampus: a new model for aging brain. Aging Cell. 2017;16:39-51 pubmed publisher
    ..we demonstrate that astrocyte defects occur in the hippocampal area of middle-aged Tet-mev-1 mice with the SDHCV69E mutation. These mice are characterized by chronic oxidative stress...