Gene Symbol: Sdha
Description: succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
Alias: 1500032O14Rik, 2310034D06Rik, 4921513A11, C81073, SDH2, SDHF, succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial, flavoprotein subunit of complex II
Species: mouse
Products:     Sdha

Top Publications

  1. Ge J, Gong Y, Xu Y, Shao F. Preventing bacterial DNA release and absent in melanoma 2 inflammasome activation by a Legionella effector functioning in membrane trafficking. Proc Natl Acad Sci U S A. 2012;109:6193-8 pubmed publisher
    ..Dot/Icm-translocated effector SdhA is critical for L. pneumophila intracellular growth and functions to prevent host cell death...
  2. Xiao M, Yang H, Xu W, Ma S, Lin H, Zhu H, et al. Inhibition of ?-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors. Genes Dev. 2012;26:1326-38 pubmed publisher
    ..These epigenetic alterations associated with mutations of FH and SDH likely contribute to tumorigenesis. ..
  3. Rastetter R, Bernard P, Palmer J, Chassot A, Chen H, Western P, et al. Marker genes identify three somatic cell types in the fetal mouse ovary. Dev Biol. 2014;394:242-52 pubmed publisher
  4. Svingen T, Spiller C, Kashimada K, Harley V, Koopman P. Identification of suitable normalizing genes for quantitative real-time RT-PCR analysis of gene expression in fetal mouse gonads. Sex Dev. 2009;3:194-204 pubmed publisher
    ..5 to 14.5 dpc irrespective of sex. Based on our analysis, we suggest that Rn18s, Rps29, Tbp and Sdha are suitable reference genes for qRT-PCR expression studies during early gonad differentiation in the mouse.
  5. Forner F, Kumar C, Luber C, Fromme T, Klingenspor M, Mann M. Proteome differences between brown and white fat mitochondria reveal specialized metabolic functions. Cell Metab. 2009;10:324-35 pubmed publisher
    ..In vivo comparison of organellar proteomes can thus directly address functional questions in metabolism. ..
  6. Yang H, Brosel S, Acin Perez R, Slavkovich V, Nishino I, Khan R, et al. Analysis of mouse models of cytochrome c oxidase deficiency owing to mutations in Sco2. Hum Mol Genet. 2010;19:170-80 pubmed publisher
    ..These mouse models should be of use in further studies of Sco2 function, as well as in testing therapeutic approaches to treat the human disorder. ..
  7. Sun W, Lu Y, Zhang X, Tang W, Huang Q. [Effects of cocaine on activities of ATPase, LDH and SDH in mouse splenocytes]. Fa Yi Xue Za Zhi. 2010;26:81-3 pubmed
    ..The present study demonstrated that cocaine could inhibit the activities of ATPase, LDH and SDH in cultured splenocytes in vitro. ..
  8. Baris O, Klose A, Kloepper J, Weiland D, Neuhaus J, Schauen M, et al. The mitochondrial electron transport chain is dispensable for proliferation and differentiation of epidermal progenitor cells. Stem Cells. 2011;29:1459-68 pubmed publisher
    ..In conclusion, we here provide unequivocal evidence that EPSCs, and probably tissue stem cells in general, are independent of the mitochondrial respiratory chain, but still require a functional dynamic mitochondrial compartment. ..
  9. Acin Perez R, Carrascoso I, Baixauli F, Roche Molina M, Latorre Pellicer A, Fernandez Silva P, et al. ROS-triggered phosphorylation of complex II by Fgr kinase regulates cellular adaptation to fuel use. Cell Metab. 2014;19:1020-33 pubmed publisher

More Information


  1. Ishihara T, Ban Ishihara R, Maeda M, Matsunaga Y, Ichimura A, Kyogoku S, et al. Dynamics of mitochondrial DNA nucleoids regulated by mitochondrial fission is essential for maintenance of homogeneously active mitochondria during neonatal heart development. Mol Cell Biol. 2015;35:211-23 pubmed publisher
    ..Thus, the dynamics of mtDNA nucleoids regulated by mitochondrial fission is required for neonatal cardiomyocyte development by promoting homogeneous distribution of active mitochondria throughout the cardiomyocytes. ..
  2. Lee K, Singh M, Ussar S, Wetzel P, Hirshman M, Goodyear L, et al. Tbx15 controls skeletal muscle fibre-type determination and muscle metabolism. Nat Commun. 2015;6:8054 pubmed publisher
    ..Thus, Tbx15 is one of a limited number of transcription factors to be identified with a critical role in regulating glycolytic fibre identity and muscle metabolism. ..
  3. Chen H, Chen W, Yan W, Huang Y, Chang S, Fu W, et al. NRIP is newly identified as a Z-disc protein, activating calmodulin signaling for skeletal muscle contraction and regeneration. J Cell Sci. 2015;128:4196-209 pubmed publisher
    ..In conclusion, NRIP is a novel Z-disc protein that is important for skeletal muscle strength and regenerative capacity. ..
  4. Hilander T, Zhou X, Konovalova S, Zhang F, Euro L, Chilov D, et al. Editing activity for eliminating mischarged tRNAs is essential in mammalian mitochondria. Nucleic Acids Res. 2018;46:849-860 pubmed publisher
    ..These results indicate that tRNA proofreading is essential in mammalian mitochondria, and cannot be overcome by other quality control mechanisms. ..
  5. Schilling B, Murray J, Yoo C, Row R, Cusack M, Capaldi R, et al. Proteomic analysis of succinate dehydrogenase and ubiquinol-cytochrome c reductase (Complex II and III) isolated by immunoprecipitation from bovine and mouse heart mitochondria. Biochim Biophys Acta. 2006;1762:213-22 pubmed
    ..The identification of several posttranslational modifications, including the covalent FAD modification of flavoprotein subunit 1 from Complex II, was possible due to high mass spectrometric sequence coverage. ..
  6. Finley L, Haas W, Desquiret Dumas V, Wallace D, Procaccio V, Gygi S, et al. Succinate dehydrogenase is a direct target of sirtuin 3 deacetylase activity. PLoS ONE. 2011;6:e23295 pubmed publisher
    ..Two subunits of complex II (also known as succinate dehydrogenase, or SDH), SDHA and SDHB, interacted specifically with SIRT3...