Gene Symbol: Sct
Description: secretin
Alias: secretin
Species: mouse
Products:     Sct

Top Publications

  1. Offield M, Jetton T, Labosky P, Ray M, Stein R, Magnuson M, et al. PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum. Development. 1996;122:983-95 pubmed
    ..These results offer additional insight into the role of pdx-1 in the determination and differentiation of the posterior foregut, particularly regarding the proliferation and differentiation of the pancreatic progenitors. ..
  2. Cheng C, Chu J, Chow B. Central and peripheral administration of secretin inhibits food intake in mice through the activation of the melanocortin system. Neuropsychopharmacology. 2011;36:459-71 pubmed publisher
    b>Secretin (Sct) is released into the circulation postprandially from the duodenal S-cells...
  3. Mellitzer G, Beucher A, Lobstein V, Michel P, Robine S, Kedinger M, et al. Loss of enteroendocrine cells in mice alters lipid absorption and glucose homeostasis and impairs postnatal survival. J Clin Invest. 2010;120:1708-21 pubmed publisher
    ..Our data help unravel the role of enteroendocrine cells and hormones in lipid absorption and maintenance of the intestinal epithelium. ..
  4. Lee V, Lee L, Chu J, Lam I, Siu F, Vaudry H, et al. An indispensable role of secretin in mediating the osmoregulatory functions of angiotensin II. FASEB J. 2010;24:5024-32 pubmed publisher
    ..In the present study, we show initially that the osmoregulatory functions of secretin (SCT) in the brain are similar to those of ANGII in mice and, more important, we discovered the role of SCT as ..
  5. Piccand J, Meunier A, Merle C, Jia Z, Barnier J, Gradwohl G. Pak3 promotes cell cycle exit and differentiation of ?-cells in the embryonic pancreas and is necessary to maintain glucose homeostasis in adult mice. Diabetes. 2014;63:203-15 pubmed publisher
    ..In the adult, Pak3 is required for the proper control of glucose homeostasis under challenging HFD. ..
  6. Egerod K, Engelstoft M, Grunddal K, Nøhr M, Secher A, Sakata I, et al. A major lineage of enteroendocrine cells coexpress CCK, secretin, GIP, GLP-1, PYY, and neurotensin but not somatostatin. Endocrinology. 2012;153:5782-95 pubmed publisher
    ..but also glucagon-like peptide 1 (GLP-1), gastric inhibitory peptide (GIP), peptide YY (PYY), neurotensin, and secretin, but not somatostatin. Immunohistochemistry confirmed this expression pattern...
  7. Lam I, Lee L, Choi H, Alpini G, Chow B. Bile acids inhibit duodenal secretin expression via orphan nuclear receptor small heterodimer partner (SHP). Am J Physiol Gastrointest Liver Physiol. 2009;297:G90-7 pubmed publisher
    ..the transcriptional activities of other nuclear receptors including NeuroD, which has been shown to regulate secretin gene expression...
  8. CHAO C, Loomis Z, Lee J, Sussel L. Genetic identification of a novel NeuroD1 function in the early differentiation of islet alpha, PP and epsilon cells. Dev Biol. 2007;312:523-32 pubmed
    ..Furthermore, this study reveals a previously unappreciated early function of NeuroD1 in regulating the specification of alpha, PP and epsilon cells. ..
  9. Lay J, Gillespie P, Samuelson L. Murine prenatal expression of cholecystokinin in neural crest, enteric neurons, and enteroendocrine cells. Dev Dyn. 1999;216:190-200 pubmed
    ..5, suggesting that CCK signaling is established early in mouse development. Dev Dyn 1999;216:190-200. ..

More Information


  1. Du A, McCracken K, Walp E, Terry N, Klein T, Han A, et al. Arx is required for normal enteroendocrine cell development in mice and humans. Dev Biol. 2012;365:175-88 pubmed publisher
    ..endoderm results in a decrease of enteroendocrine cell types including gastrin-, glucagon/GLP-1-, CCK-, secretin-producing cell populations and an increase of somatostatin-expressing cells...
  2. López Díaz L, Jain R, Keeley T, VanDussen K, Brunkan C, Gumucio D, et al. Intestinal Neurogenin 3 directs differentiation of a bipotential secretory progenitor to endocrine cell rather than goblet cell fate. Dev Biol. 2007;309:298-305 pubmed
    ..Thus, our data suggest that Neurogenin 3 can redirect the differentiation of bipotential secretory progenitors to endocrine rather than goblet cell fate. ..
  3. Rindi G, Ratineau C, Ronco A, Candusso M, Tsai M, Leiter A. Targeted ablation of secretin-producing cells in transgenic mice reveals a common differentiation pathway with multiple enteroendocrine cell lineages in the small intestine. Development. 1999;126:4149-56 pubmed
    ..The secretin-producing (S) cell is one of at least ten cell types belonging to the diffuse neuroendocrine system of the gut...
  4. Takayanagi Y, Yoshida M, Takashima A, Takanami K, Yoshida S, Nishimori K, et al. Activation of Supraoptic Oxytocin Neurons by Secretin Facilitates Social Recognition. Biol Psychiatry. 2017;81:243-251 pubmed publisher
    ..b>Secretin receptor-deficient mice show deficits in social behavior...
  5. Lam I, Lee L, Choi H, Chow B. Localization of small heterodimer partner (SHP) and secretin in mouse duodenal cells. Ann N Y Acad Sci. 2006;1070:371-5 pubmed
    ..NeuroD is a basic helix-loop-helix transcription factor that has also been shown to be important in modulating secretin gene expression...
  6. Sekar R, Chow B. Secretin receptor-knockout mice are resistant to high-fat diet-induced obesity and exhibit impaired intestinal lipid absorption. FASEB J. 2014;28:3494-505 pubmed publisher
    b>Secretin, a classical gastrointestinal hormone released from S cells in response to acid and dietary lipid, regulates pleiotropic physiological functions, such as exocrine pancreatic secretion and gastric motility...
  7. Huang Z, Wang T, Qi Q, Zuo R, Liang X, Zhao X, et al. Progesterone regulates secretin expression in mouse uterus during early pregnancy. Reprod Sci. 2014;21:724-32 pubmed publisher
    b>Secretin, a classical gastrointestinal and neuroendocrine peptide, plays an important role in maintaining the body fluid balance. However, the expression and regulation of secretin in the reproductive system are still unknown...
  8. Sundaresan S, Shahid R, Riehl T, Chandra R, Nassir F, Stenson W, et al. CD36-dependent signaling mediates fatty acid-induced gut release of secretin and cholecystokinin. FASEB J. 2013;27:1191-202 pubmed publisher
    ..We explored whether CD36 signaling influences FA-mediated secretion of cholecystokinin (CCK) and secretin, peptides released by enteroendocrine cells (EECs) in the duodenum/jejunum, which regulate events important for ..
  9. Kimura T, Nishizawa K, Oguma A, Nishimura Y, Sakasegawa Y, Teruya K, et al. Secretin receptor involvement in prion-infected cells and animals. FEBS Lett. 2015;589:2011-8 pubmed publisher
    The cellular mechanisms behind prion biosynthesis and metabolism remain unclear. Here we show that secretin signaling via the secretin receptor regulates abnormal prion protein formation in prion-infected cells...
  10. Pearton D, Smith C, Redgate E, van Leeuwen J, Donnison M, Pfeffer P. Elf5 counteracts precocious trophoblast differentiation by maintaining Sox2 and 3 and inhibiting Hand1 expression. Dev Biol. 2014;392:344-57 pubmed publisher
    ..This data thus suggest that Elf5 is a gatekeeper for the TS to differentiated trophoblast transition thereby preventing the precocious differentiation of the undifferentiated extraembryonic ectoderm. ..
  11. Jukkola P, Rogers J, Kaspar B, Weeber E, Nishijima I. Secretin deficiency causes impairment in survival of neural progenitor cells in mice. Hum Mol Genet. 2011;20:1000-7 pubmed publisher
    ..To understand the role of hippocampal neurogenesis in the postnatal developing period, we analyzed secretin, a neuropeptide, which is expressed significantly higher in the development stage...
  12. Yamagata T, Aradhya S, Mori M, Inoue K, Momoi M, Nelson D. The human secretin gene: fine structure in 11p15.5 and sequence variation in patients with autism. Genomics. 2002;80:185-94 pubmed
    b>Secretin is a peptide hormone involved in digestion that has been studied as a potential therapeutic agent in patients with autism...
  13. Yamagata T, Urano H, Weeber E, Nelson D, Nishijima I. Impaired hippocampal synaptic function in secretin deficient mice. Neuroscience. 2008;154:1417-22 pubmed publisher
    b>Secretin is a gut peptide hormone that is also expressed in the CNS. To explore the potential neuroactive role of secretin in the brain, we have generated secretin deficient mice...
  14. Siu F, Sham M, Chow B. Secretin, a known gastrointestinal peptide, is widely expressed during mouse embryonic development. Gene Expr Patterns. 2005;5:445-51 pubmed
    The gastrointestinal functions of the 27-amino acid secretin peptide have been well established...
  15. Edfalk S, Steneberg P, Edlund H. Gpr40 is expressed in enteroendocrine cells and mediates free fatty acid stimulation of incretin secretion. Diabetes. 2008;57:2280-7 pubmed publisher
    ..Moreover, our data suggest a conserved role for Ipf1/Pdx1 and Gpr40 in FFA-mediated secretion of hormones that regulate glucose and overall energy homeostasis. ..
  16. Vanhorenbeeck V, Jenny M, Cornut J, Gradwohl G, Lemaigre F, Rousseau G, et al. Role of the Onecut transcription factors in pancreas morphogenesis and in pancreatic and enteric endocrine differentiation. Dev Biol. 2007;305:685-94 pubmed
    ..In conclusion, our data reveal partially redundant roles for HNF-6 and OC-2 in developing pancreas and identify new markers for antero-posterior patterning of the gut and for enteroendocrine differentiation. ..
  17. Zhang L, Chung S, Chow B. The knockout of secretin in cerebellar Purkinje cells impairs mouse motor coordination and motor learning. Neuropsychopharmacology. 2014;39:1460-8 pubmed publisher
    b>Secretin (SCT) was first considered to be a gut hormone regulating gastrointestinal functions when discovered...
  18. Sekar R, Chow B. Lipolytic actions of secretin in mouse adipocytes. J Lipid Res. 2014;55:190-200 pubmed publisher
    b>Secretin (Sct), a classical gut hormone, is now known to play pleiotropic functions in the body including osmoregulation, digestion, and feeding control...
  19. Harikumar K, Lau S, Sexton P, Wootten D, Miller L. Coexpressed Class B G Protein-Coupled Secretin and GLP-1 Receptors Self- and Cross-Associate: Impact on Pancreatic Islets. Endocrinology. 2017;158:1685-1700 pubmed publisher
    ..TM4 is also the predominant determinant for formation of heteroreceptor complexes between two class B receptors, secretin receptor (SecR) and glucagonlike peptide-1 receptor (GLP-1R), which are expressed on pancreatic islet cells...
  20. Chang A, Dunham M, Jeffrey K, Reddel R. Molecular cloning and characterization of mouse stanniocalcin cDNA. Mol Cell Endocrinol. 1996;124:185-7 pubmed
    ..As in human, the mRNA is expressed in many mouse tissues, suggesting that mammalian stanniocalcin has a paracrine rather than endocrine role. ..
  21. Wang Y, Gallego Arteche E, Iezza G, Yuan X, Matli M, Choo S, et al. Homeodomain transcription factor NKX2.2 functions in immature cells to control enteroendocrine differentiation and is expressed in gastrointestinal neuroendocrine tumors. Endocr Relat Cancer. 2009;16:267-79 pubmed publisher
    ..hormones, such as serotonin, gastrin, cholecystokinin, somatostatin, glucagon-like peptide 1 (GLP-1), and secretin, but an increase in cells producing ghrelin. NKX2...
  22. Whitmore T, Holloway J, Lofton Day C, Maurer M, Chen L, Quinton T, et al. Human secretin (SCT): gene structure, chromosome location, and distribution of mRNA. Cytogenet Cell Genet. 2000;90:47-52 pubmed
    b>Secretin is an endocrine hormone that stimulates the secretion of bicarbonate-rich pancreatic fluids...
  23. Knox K, Leuenberger D, Penn A, Baker J. Global hormone profiling of murine placenta reveals Secretin expression. Placenta. 2011;32:811-6 pubmed publisher
    ..Our analysis identified Secretin, a novel placental hormone that is expressed specifically by the trophoblast at levels many times greater than in ..
  24. Sans M, Sabbatini M, Ernst S, D Alecy L, Nishijima I, Williams J. Secretin is not necessary for exocrine pancreatic development and growth in mice. Am J Physiol Gastrointest Liver Physiol. 2011;301:G791-8 pubmed publisher
    ..However, camostat has also been reported to stimulate secretin release and, because secretin often potentiates the action of CCK, it could participate in the growth response...
  25. Lan M, Kajiyama W, Donadel G, Lu J, Notkins A. cDNA sequence and genomic organization of mouse secretin. Biochem Biophys Res Commun. 1994;200:1066-71 pubmed
    ..sequence of one of the clones with sequences from the GenBank database showed that it was a member of the secretin family...
  26. Donnison M, Broadhurst R, Pfeffer P. Elf5 and Ets2 maintain the mouse extraembryonic ectoderm in a dosage dependent synergistic manner. Dev Biol. 2015;397:77-88 pubmed publisher
  27. Lossi L, Bottarelli L, Candusso M, Leiter A, Rindi G, Merighi A. Transient expression of secretin in serotoninergic neurons of mouse brain during development. Eur J Neurosci. 2004;20:3259-69 pubmed
    Existence of the gastro-intestinal peptide secretin in the CNS has been a matter of debate, and contrasting results have been reported, altogether indicating that the CNS is not a major site of production of this peptide...
  28. Hwang D, Givens B, Nishijima I. Ethanol-induced developmental neurodegeneration in secretin receptor-deficient mice. Neuroreport. 2009;20:698-701 pubmed publisher
    ..Several neuroactive peptides have been shown to protect against alcohol-induced cell death. Secretin is a peptide hormone, and the secretin receptor is expressed in the gut and the brain...