Gene Symbol: Scn3a
Description: sodium channel, voltage-gated, type III, alpha
Alias: Gm1000, Nav1.3, sodium channel protein type 3 subunit alpha, sodium channel, voltage-gated, type III, alpha polypeptide, voltage-gated sodium channel Nav1.3 variant a, voltage-gated sodium channel Nav1.3 variant b
Species: mouse
Products:     Scn3a

Top Publications

  1. Nassar M, Baker M, Levato A, Ingram R, Mallucci G, McMahon S, et al. Nerve injury induces robust allodynia and ectopic discharges in Nav1.3 null mutant mice. Mol Pain. 2006;2:33 pubmed
    ..3 in global knock-out mice. Our data demonstrate that Nav1.3 is neither necessary nor sufficient for the development of nerve-injury related pain. ..
  2. Minett M, Falk S, Santana Varela S, Bogdanov Y, Nassar M, Heegaard A, et al. Pain without nociceptors? Nav1.7-independent pain mechanisms. Cell Rep. 2014;6:301-12 pubmed publisher
    ..8-positive nociceptors. Thus, similar pain phenotypes arise through distinct cellular and molecular mechanisms. Therefore, rational analgesic drug therapy requires patient stratification in terms of mechanisms and not just phenotype. ..
  3. Haufe V, Camacho J, Dumaine R, Günther B, Bollensdorff C, von Banchet G, et al. Expression pattern of neuronal and skeletal muscle voltage-gated Na+ channels in the developing mouse heart. J Physiol. 2005;564:683-96 pubmed
    ..Our data suggest that neuronal and skeletal muscle Na(+) channels contribute to the action potential of cardiomyocytes in the adult mammalian heart. ..
  4. Minett M, Eijkelkamp N, Wood J. Significant determinants of mouse pain behaviour. PLoS ONE. 2014;9:e104458 pubmed publisher
    ..Failure to conduct behavioural tests at different anatomical locations, stimulus intensities, and at different points in the circadian cycle may lead to a pain behavioural phenotype being misinterpreted, or missed altogether. ..
  5. Gao N, Lu M, Echeverri F, Laita B, Kalabat D, Williams M, et al. Voltage-gated sodium channels in taste bud cells. BMC Neurosci. 2009;10:20 pubmed publisher
    ..The molecular identity of the voltage-gated sodium channels that sense depolarizing signals and subsequently initiate action potentials coding taste information to gustatory nerve fibers is unknown...
  6. Zhang M, Green B, Catlin P, Fiedler B, Azam L, Chadwick A, et al. Structure/function characterization of micro-conotoxin KIIIA, an analgesic, nearly irreversible blocker of mammalian neuronal sodium channels. J Biol Chem. 2007;282:30699-706 pubmed
    ..2 and that further engineering of micro-conopeptides belonging to the KIIIA group may provide subtype-selective pharmacological compounds for mammalian neuronal sodium channels and potential therapeutics for the treatment of pain. ..
  7. Albrieux M, Platel J, Dupuis A, Villaz M, Moody W. Early expression of sodium channel transcripts and sodium current by cajal-retzius cells in the preplate of the embryonic mouse neocortex. J Neurosci. 2004;24:1719-25 pubmed
    ..These results raise the possibility that populations of pioneer neurons of the PP, including Cajal-Retzius cells, gain neuronal physiological properties early in development via expression of the Na(v)1.3 (SCN3) Na channel isoform. ..
  8. Valenzuela J, Francischetti I, Pham V, Garfield M, Mather T, Ribeiro J. Exploring the sialome of the tick Ixodes scapularis. J Exp Biol. 2002;205:2843-64 pubmed
    ..scapularis saliva and identifies novel vaccine targets that may be used in Lyme disease prevention. ..
  9. Crabbe J, Belknap J, Buck K, Metten P. Use of recombinant inbred strains for studying genetic determinants of responses to alcohol. Alcohol Alcohol Suppl. 1994;2:67-71 pubmed
    ..A cluster of genes (Scn1, Scn2, Scn3) code for voltage-sensitive sodium channel proteins. These genes are plausible candidates for affecting withdrawal HIC. ..

More Information


  1. Kozak C, Sangameswaran L. Genetic mapping of the peripheral sodium channel genes, Scn9a and Scn10a, in the mouse. Mamm Genome. 1996;7:787-8 pubmed
  2. Hao M, Lomax A, McKeown S, Reid C, Young H, Bornstein J. Early development of electrical excitability in the mouse enteric nervous system. J Neurosci. 2012;32:10949-60 pubmed publisher
    ..Spontaneous depolarizations resembling excitatory postsynaptic potentials were observed at E12.5. The ENS is one of the earliest parts of the developing nervous system to exhibit mature forms of electrical activity. ..
  3. Li H, Wan R, Tang L, Liu S, Zhao Q, Gao M, et al. Alteration of Scn3a expression is mediated via CpG methylation and MBD2 in mouse hippocampus during postnatal development and seizure condition. Biochim Biophys Acta. 2015;1849:1-9 pubmed publisher
    Increased expression of sodium channel SCN3A, an embryonic-expressed gene, has been identified in epileptic tissues, which is believed to contribute to the development of epilepsy...
  4. Zhang Q, Chibalina M, Bengtsson M, Groschner L, Ramracheya R, Rorsman N, et al. Na+ current properties in islet α- and β-cells reflect cell-specific Scn3a and Scn9a expression. J Physiol. 2014;592:4677-96 pubmed publisher
    ..7 and α-cells Nav1.3. In α-cells, genetically ablating Scn3a reduces the Na(+) current by 80%...
  5. Ogiwara I, Miyamoto H, Morita N, Atapour N, Mazaki E, Inoue I, et al. Nav1.1 localizes to axons of parvalbumin-positive inhibitory interneurons: a circuit basis for epileptic seizures in mice carrying an Scn1a gene mutation. J Neurosci. 2007;27:5903-14 pubmed
    ..Our data indicate that Nav1.1 plays critical roles in the spike output from PV interneurons and, furthermore, that the specifically altered function of these inhibitory circuits may contribute to epileptic seizures in the mice. ..
  6. Tsunozaki M, Lennertz R, Vilceanu D, Katta S, Stucky C, Bautista D. A 'toothache tree' alkylamide inhibits A? mechanonociceptors to alleviate mechanical pain. J Physiol. 2013;591:3325-40 pubmed publisher
    ..These results suggest that sanshool targets voltage-gated sodium channels on A? mechanosensory nociceptors to dampen excitability and thus induce 'fast pain' analgesia. ..
  7. Beckers M, Ernst E, Belcher S, Howe J, Levenson R, Gros P. A new sodium channel alpha-subunit gene (Scn9a) from Schwann cells maps to the Scn1a, Scn2a, Scn3a cluster of mouse chromosome 2. Genomics. 1996;36:202-5 pubmed
  8. Malo M, Srivastava K, Andresen J, Chen X, Korenberg J, Ingram V. Targeted gene walking by low stringency polymerase chain reaction: assignment of a putative human brain sodium channel gene (SCN3A) to chromosome 2q24-31. Proc Natl Acad Sci U S A. 1994;91:2975-9 pubmed
    ..assign this sequence as a part of a gene coding the alpha-subunit of a human brain type III sodium channel (SCN3A)...
  9. Malo D, Schurr E, Dorfman J, Canfield V, Levenson R, Gros P. Three brain sodium channel alpha-subunit genes are clustered on the proximal segment of mouse chromosome 2. Genomics. 1991;10:666-72 pubmed
    ..Physical mapping by pulsed-field gel electrophoresis has established that Scn2a and Scn3a (genes encoding type II and type III sodium channel alpha-subunit isoforms) are physically linked and are ..
  10. Martin M, Tang B, Ta N, Escayg A. Characterization of 5' untranslated regions of the voltage-gated sodium channels SCN1A, SCN2A, and SCN3A and identification of cis-conserved noncoding sequences. Genomics. 2007;90:225-35 pubmed
    The human voltage-gated sodium channel gene cluster on chromosome 2q24 contains three paralogs, SCN1A, SCN2A, and SCN3A, which are expressed in the central nervous system...
  11. Chen Y, Shi Y, Xu H, Chen M, Gao M, Sun W, et al. Electrophysiological Differences between the Same Pore Region Mutation in SCN1A and SCN3A. Mol Neurobiol. 2015;51:1263-70 pubmed publisher
    ..b>SCN3A mutations have also been identified in patients with epilepsy; however, mutations in this pore region maintain ..
  12. Lamar T, Vanoye C, Calhoun J, Wong J, Dutton S, Jorge B, et al. SCN3A deficiency associated with increased seizure susceptibility. Neurobiol Dis. 2017;102:38-48 pubmed publisher
    Mutations in voltage-gated sodium channels expressed highly in the brain (SCN1A, SCN2A, SCN3A, and SCN8A) are responsible for an increasing number of epilepsy syndromes...
  13. Deng G, Qin J, Sun X, Kuang Z, Su T, Zhao Q, et al. Promoter analysis of mouse Scn3a gene and regulation of the promoter activity by GC box and CpG methylation. J Mol Neurosci. 2011;44:115-21 pubmed publisher
    ..The expression of mouse Scn3a product (Na(v)1.3) mainly occurs in embryonic and early postnatal brain but not in adult brain...
  14. Fotia A, Ekberg J, Adams D, Cook D, Poronnik P, Kumar S. Regulation of neuronal voltage-gated sodium channels by the ubiquitin-protein ligases Nedd4 and Nedd4-2. J Biol Chem. 2004;279:28930-5 pubmed
    ..Interestingly, Nedd4 suppressed the activity of Na(v)1.2 and Na(v)1.7 but was a poor inhibitor of Na(v)1.8. Our results provide evidence that Nedd4 and Nedd4-2 are likely to be key regulators of specific neuronal Na(v) channels in vivo. ..
  15. Cheah C, Westenbroek R, Roden W, Kalume F, Oakley J, Jansen L, et al. Correlations in timing of sodium channel expression, epilepsy, and sudden death in Dravet syndrome. Channels (Austin). 2013;7:468-72 pubmed publisher
    ..1 channels in DS, defines a tipping point that leads to disinhibition of neural circuits, intractable seizures, co-morbidities, and premature death in this disease. ..
  16. Castillo S, Xiao Q, Lyu M, Kozak C, Nikodem V. Organization, sequence, chromosomal localization, and promoter identification of the mouse orphan nuclear receptor Nurr1 gene. Genomics. 1997;41:250-7 pubmed
    ..These data help to explain the different response characteristics of two closely related early response genes, Nurr1 and Nur77. ..
  17. Hessel E, van Lith H, Wolterink Donselaar I, de Wit M, Groot Koerkamp M, Holstege F, et al. Mapping of a FEB3 homologous febrile seizure locus on mouse chromosome 2 containing candidate genes Scn1a and Scn3a. Eur J Neurosci. 2016;44:2950-2957 pubmed publisher
    ..Ifih1) contained a non-synonymous SNP comparing CSS2 and C57BL/6J, six genes (March7, Nr4a2, Gpd2, Grb14, Scn1a, Scn3a) were differentially expressed between these strains...
  18. Chin H, Kwon O, Jung H, Kim D, Kozak C. Genetic mapping of the mouse genes encoding the voltage-sensitive calcium channel subunits. Genomics. 1995;28:592-5 pubmed
    ..These results together with previous mapping data indicate that the calcium channel genes are dispersed in the mouse genome, unlike the sodium channel genes, which are clustered. ..