Gene Symbol: Scgb1b27
Description: secretoglobin, family 1B, member 27
Alias: Abp, Abpa, Abpa27, Sal-1, Tcp, secretoglobin, family 1B, member 27, androgen binding protein alpha, androgen-binding protein, major allergen 1-like; lacrimal gland protein, salivary androgen-binding alpha subunit, salivary androgen-binding protein alpha subunit
Species: mouse
Products:     Scgb1b27

Top Publications

  1. Dlouhy S, Taylor B, Karn R. The genes for mouse salivary androgen-binding protein (ABP) subunits alpha and gamma are located on chromosome 7. Genetics. 1987;115:535-43 pubmed
    ..binding protein (Abp; Dlouhy and Karn, 1984) codes for the Alpha subunit of ABP and rename the locus Androgen binding protein alpha (Abpa)...
  2. Ryan A, Womack J, Yu J, Lin J, Wu X, Sun T, et al. Chromosomal localization of uroplakin genes of cattle and mice. Mamm Genome. 1993;4:656-61 pubmed
    ..Our results also suggest likely positions for two human uroplakin genes and should facilitate further analysis of their possible involvement in disease. ..
  3. Laukaitis C, Heger A, Blakley T, Munclinger P, Ponting C, Karn R. Rapid bursts of androgen-binding protein (Abp) gene duplication occurred independently in diverse mammals. BMC Evol Biol. 2008;8:46 pubmed publisher
    ..Further investigation of 14 alpha-like (Abpa) and 13 beta- or gamma-like (Abpbg) undisrupted gene sequences revealed a rich diversity of developmental stage-, ..
  4. Karn R, Dlouhy S. Salivary androgen-binding protein variation in Mus and other rodents. J Hered. 1991;82:453-8 pubmed
    We have searched for genetic variation in the expression of salivary androgen-binding protein (ABP) in a wide variety of mice and other rodents. ABP was present in the salivas of mice of all species and subspecies studied...
  5. Dlouhy S, Nichols W, Karn R. Production of an antibody to mouse salivary androgen binding protein (ABP) and its use in identifying a prostate protein produced by a gene distinct from Abp. Biochem Genet. 1986;24:743-63 pubmed
    ..polymorphism of a mouse salivary protein which, because of its ability to bind androgen, we designated androgen binding protein (ABP) and its structural gene, Androgen binding protein (Abp)...
  6. Laukaitis C, Dlouhy S, Emes R, Ponting C, Karn R. Diverse spatial, temporal, and sexual expression of recently duplicated androgen-binding protein genes in Mus musculus. BMC Evol Biol. 2005;5:40 pubmed
    ..We observed expression of six Abpa paralogues and five Abpbg paralogues in ten glands and other organs located predominantly in the head and neck (..
  7. Karn R. Steroid binding by mouse salivary proteins. Biochem Genet. 1998;36:105-17 pubmed
    ..of this study were to determine the steroid-binding specificity of the mouse salivary androgen-binding protein (ABP) family and to ascertain whether there might be other proteins in mouse saliva capable of binding steroids...
  8. Emes R, Riley M, Laukaitis C, Goodstadt L, Karn R, Ponting C. Comparative evolutionary genomics of androgen-binding protein genes. Genome Res. 2004;14:1516-29 pubmed
    Allelic variation within the mouse androgen-binding protein (ABP) alpha subunit gene (Abpa) has been suggested to promote assortative mating and thus prezygotic isolation...
  9. Karn R. The mouse salivary androgen-binding protein (ABP) alpha subunit closely resembles chain 1 of the cat allergen Fel dI. Biochem Genet. 1994;32:271-7 pubmed
    Androgen-binding protein (ABP) is found in the salivas of a wide variety of rodents and it has been proposed that ABP functions in sex and/or subspecies recognition (Karn and Dlouhy, J. Hered. 82, 453, 1991)...

More Information


  1. Karn R, Russell R. The amino acid sequence of the alpha subunit of mouse salivary androgen-binding protein (ABP), with a comparison to the partial sequence of the beta subunit and to other ligand-binding proteins. Biochem Genet. 1993;31:307-19 pubmed
    It has been suggested that three distinct genes, Abpa, Abpb, and Abpg, determine the three subunits of mouse salivary androgen-binding protein (ABP) (Dlouhy, S. R., et al., Genetics 115, 535, 1987)...
  2. Karn R, Orth A, Bonhomme F, Boursot P. The complex history of a gene proposed to participate in a sexual isolation mechanism in house mice. Mol Biol Evol. 2002;19:462-71 pubmed
    ..The pattern of evolution of Abpa, the gene for the alpha subunit of ABP, was found to be consistent with this hypothesis...
  3. Hwang J, Hofstetter J, Bonhomme F, Karn R. The microevolution of mouse salivary androgen-binding protein (ABP) paralleled subspeciation of Mus musculus. J Hered. 1997;88:93-7 pubmed
    ..sequences and putative amino acid sequences they determine for the three common alleles of the Alpha subunit gene (Abpa), alleles that appear to be diagnostic for the three subspecies of Mus musculus...
  4. Karn R, Laukaitis C. Characterization of two forms of mouse salivary androgen-binding protein (ABP): implications for evolutionary relationships and ligand-binding function. Biochemistry. 2003;42:7162-70 pubmed
    Mouse salivary androgen-binding protein (ABP) is a member of the secretoglobin family produced in the submaxillary glands of house mice (Mus musculus)...
  5. Dlouhy S, Karn R. The tissue source and cellular control of the apparent size of androgen binding protein (Abp), a mouse salivary protein whose electrophoretic mobility is under the control of sex-limited saliva pattern (Ssp). Biochem Genet. 1983;21:1057-70 pubmed
    ..We discuss the possible causes of the increase in molecular weight. ..
  6. Karn R, Nachman M. Reduced nucleotide variability at an androgen-binding protein locus (Abpa) in house mice: evidence for positive natural selection. Mol Biol Evol. 1999;16:1192-7 pubmed
    Previous work has shown that the gene for the alpha subunit of androgen-binding protein, Abpa, may be involved in premating isolation between different subspecies of the house mouse, Mus musculus...
  7. Laukaitis C, Mauss C, Karn R. Congenic strain analysis reveals genes that are rapidly evolving components of a prezygotic isolation mechanism mediating incipient reinforcement. PLoS ONE. 2012;7:e35898 pubmed publisher
    ..ago, we developed a congenic strain of Mus musculus, called b-congenic, by replacing the androgen-binding protein Abpa27(a) allele in the C3H/HeJ genome with the Abpa27(b) allele from DBA/2J...
  8. Dlouhy S, Karn R. Multiple gene action determining a mouse salivary protein phenotype: identification of the structural gene for androgen binding protein (Abp). Biochem Genet. 1984;22:657-67 pubmed
    A novel variation in electrophoretic phenotype is described for a mouse salivary androgen binding protein (Abp)...
  9. Grover A, Sairam M, Smith C, Hermo L. Structural and functional modifications of sertoli cells in the testis of adult follicle-stimulating hormone receptor knockout mice. Biol Reprod. 2004;71:117-29 pubmed
    ..Functionally, androgen-binding protein (ABP), a major secretory protein of Sertoli cells, was dramatically reduced in FORKO mice...
  10. Malo D, Gros P, Bergmann A, Trask B, Mohrenweiser H, Canfield V, et al. Genes encoding the H,K-ATPase alpha and Na,K-ATPase alpha 3 subunits are linked on mouse chromosome 7 and human chromosome 19. Mamm Genome. 1993;4:644-9 pubmed
    ..1 region, and proximal to ATP1A3, which maps to the q13.2 region, of Chr 19. These results indicate that ATP4A and ATP1A3 are linked in both the mouse and human genomes. ..
  11. Karn R, Dlouhy S, Springer K, Hjorth J, Nielsen J. Sex-limited genetic variation in a mouse salivary protein. Biochem Genet. 1982;20:493-504 pubmed
    ..Thus it appears that the observed strain-specific differences reflect a genetic variation in androgen levels and/or androgen sensitivity rather than variation in a structural gene. ..
  12. Taylor B, Rowe L. Genes for serum amyloid A proteins map to Chromosome 7 in the mouse. Mol Gen Genet. 1984;195:491-9 pubmed
    ..A survey of inbred strains revealed a single common Saa haplotype and eight rare haplotypes. The complex distribution of 14 different variants suggests that recombination may have played a role in haplotype evolution. ..
  13. D EUSTACHIO P, Colman D, Salzer J. Chromosomal location of the mouse gene that encodes the myelin-associated glycoproteins. J Neurochem. 1988;50:589-93 pubmed
    ..5 centimorgans from the locus Abpa (androgen binding protein alpha) on proximal chromosome 7...
  14. Yabe D, Nakamura T, Kanazawa N, Tashiro K, Honjo T. Calumenin, a Ca2+-binding protein retained in the endoplasmic reticulum with a novel carboxyl-terminal sequence, HDEF. J Biol Chem. 1997;272:18232-9 pubmed
    ..Calumenin is expressed most strongly in heart of adult and 18.5-day embryos. The calumenin gene (Calu) was mapped at the proximal portion of mouse chromosome 7. ..
  15. Karn R, Young J, Laukaitis C. A candidate subspecies discrimination system involving a vomeronasal receptor gene with different alleles fixed in M. m. domesticus and M. m. musculus. PLoS ONE. 2010;5: pubmed publisher
    ..m. domesticus and M. m. musculus. We observed substantial linkage disequilibrium (LD) between Vmn1r67 and Abpa27, a mouse salivary androgen-binding protein gene that encodes a proteinaceous pheromone (ABP) capable of mediating ..
  16. Jeyaraj D, Grossman G, Petrusz P. Dynamics of testicular germ cell apoptosis in normal mice and transgenic mice overexpressing rat androgen-binding protein. Reprod Biol Endocrinol. 2003;1:48 pubmed
    ..and compared in age-matched wild type (WT) control and in a transgenic (TG) mice homozygous to rat androgen binding protein (ABP) using flow cytometry...
  17. Nelson D, Manhardt C, Kamath V, Sui Y, Santamaria Pang A, Can A, et al. Quantitative single cell analysis of cell population dynamics during submandibular salivary gland development and differentiation. Biol Open. 2013;2:439-47 pubmed publisher
    ..The data suggest that there are temporally and spatially discreet progenitor populations that contribute to salivary gland development and homeostasis. ..