Scd1

Summary

Gene Symbol: Scd1
Description: stearoyl-Coenzyme A desaturase 1
Alias: AA589638, AI265570, Scd, Scd-1, acyl-CoA desaturase 1, asebia, delta(9)-desaturase 1, fatty acid desaturase 1, stearoyl-CoA desaturase 1
Species: mouse
Products:     Scd1

Top Publications

  1. Dobrzyn P, Dobrzyn A, Miyazaki M, Ntambi J. Loss of stearoyl-CoA desaturase 1 rescues cardiac function in obese leptin-deficient mice. J Lipid Res. 2010;51:2202-10 pubmed publisher
    ..In the present study, using an ob/ob;SCD1(-/-) mouse model, we tested the hypothesis that lack of SCD1 could improve steatosis and left ventricle (LV) ..
  2. Flowers J, Rabaglia M, Schueler K, Flowers M, Lan H, Keller M, et al. Loss of stearoyl-CoA desaturase-1 improves insulin sensitivity in lean mice but worsens diabetes in leptin-deficient obese mice. Diabetes. 2007;56:1228-39 pubmed
    ..we determined that insulin sensitivity was improved in heart, soleus muscle, adipose tissue, and liver of BTBR SCD1-deficient mice. We next determined whether SCD1 deficiency could prevent diabetes in leptin-deficient BTBR mice...
  3. Sampath H, Ntambi J. Role of stearoyl-CoA desaturase-1 in skin integrity and whole body energy balance. J Biol Chem. 2014;289:2482-8 pubmed publisher
    ..Mice with a deletion of the ?(9)-desaturase-1 isoform (SCD1) either globally (Scd1(-/-)) or specifically in the skin (skin-specific Scd1-knockout; SKO) present with marked ..
  4. Chen C, Shah Y, Morimura K, Krausz K, Miyazaki M, Richardson T, et al. Metabolomics reveals that hepatic stearoyl-CoA desaturase 1 downregulation exacerbates inflammation and acute colitis. Cell Metab. 2008;7:135-47 pubmed publisher
    ..mice compared to controls led to the identification of DSS-elicited inhibition of stearoyl-CoA desaturase 1 (SCD1) expression in liver...
  5. Biddinger S, Almind K, Miyazaki M, Kokkotou E, Ntambi J, Kahn C. Effects of diet and genetic background on sterol regulatory element-binding protein-1c, stearoyl-CoA desaturase 1, and the development of the metabolic syndrome. Diabetes. 2005;54:1314-23 pubmed
    ..Stearoyl-CoA desaturase 1 (SCD1), an enzyme that regulates monounsaturated fatty acid (MUFA) synthesis, was also increased at the mRNA and enzyme ..
  6. Zhang Y, Zhang X, Chen L, Wu J, Su D, Lu W, et al. Liver X receptor agonist TO-901317 upregulates SCD1 expression in renal proximal straight tubule. Am J Physiol Renal Physiol. 2006;290:F1065-73 pubmed
    ..Among them, the stearoyl-CoA desaturase-1 (SCD1) was upregulated most dramatically...
  7. Miyazaki M, Bruggink S, Ntambi J. Identification of mouse palmitoyl-coenzyme A Delta9-desaturase. J Lipid Res. 2006;47:700-4 pubmed
    ..Currently, there are four known enzymatic isoforms (SCD1-SCD4) in the mouse genome...
  8. Liu X, Miyazaki M, Flowers M, Sampath H, Zhao M, Chu K, et al. Loss of Stearoyl-CoA desaturase-1 attenuates adipocyte inflammation: effects of adipocyte-derived oleate. Arterioscler Thromb Vasc Biol. 2010;30:31-8 pubmed publisher
    ..This study aimed at identify the effects of stearoyl-CoA desaturase-1 (SCD1) on the inflammatory response of a paracrine network involving adipocytes, macrophages, and endothelial cells...
  9. Ntambi J, Miyazaki M, Stoehr J, Lan H, Kendziorski C, Yandell B, et al. Loss of stearoyl-CoA desaturase-1 function protects mice against adiposity. Proc Natl Acad Sci U S A. 2002;99:11482-6 pubmed
    ..Several SCD isoforms (SCD1-3) exist in the mouse...
  10. Sundberg J, Boggess D, Sundberg B, Eilertsen K, Parimoo S, Filippi M, et al. Asebia-2J (Scd1(ab2J)): a new allele and a model for scarring alopecia. Am J Pathol. 2000;156:2067-75 pubmed
    ..Because this mutant mouse showed genetic, anatomical, and laboratory similarities to the asebia mutation, crosses were done between the new mutant and mice carrying the asebia-J allele...

Detail Information

Publications80

  1. Dobrzyn P, Dobrzyn A, Miyazaki M, Ntambi J. Loss of stearoyl-CoA desaturase 1 rescues cardiac function in obese leptin-deficient mice. J Lipid Res. 2010;51:2202-10 pubmed publisher
    ..In the present study, using an ob/ob;SCD1(-/-) mouse model, we tested the hypothesis that lack of SCD1 could improve steatosis and left ventricle (LV) ..
  2. Flowers J, Rabaglia M, Schueler K, Flowers M, Lan H, Keller M, et al. Loss of stearoyl-CoA desaturase-1 improves insulin sensitivity in lean mice but worsens diabetes in leptin-deficient obese mice. Diabetes. 2007;56:1228-39 pubmed
    ..we determined that insulin sensitivity was improved in heart, soleus muscle, adipose tissue, and liver of BTBR SCD1-deficient mice. We next determined whether SCD1 deficiency could prevent diabetes in leptin-deficient BTBR mice...
  3. Sampath H, Ntambi J. Role of stearoyl-CoA desaturase-1 in skin integrity and whole body energy balance. J Biol Chem. 2014;289:2482-8 pubmed publisher
    ..Mice with a deletion of the ?(9)-desaturase-1 isoform (SCD1) either globally (Scd1(-/-)) or specifically in the skin (skin-specific Scd1-knockout; SKO) present with marked ..
  4. Chen C, Shah Y, Morimura K, Krausz K, Miyazaki M, Richardson T, et al. Metabolomics reveals that hepatic stearoyl-CoA desaturase 1 downregulation exacerbates inflammation and acute colitis. Cell Metab. 2008;7:135-47 pubmed publisher
    ..mice compared to controls led to the identification of DSS-elicited inhibition of stearoyl-CoA desaturase 1 (SCD1) expression in liver...
  5. Biddinger S, Almind K, Miyazaki M, Kokkotou E, Ntambi J, Kahn C. Effects of diet and genetic background on sterol regulatory element-binding protein-1c, stearoyl-CoA desaturase 1, and the development of the metabolic syndrome. Diabetes. 2005;54:1314-23 pubmed
    ..Stearoyl-CoA desaturase 1 (SCD1), an enzyme that regulates monounsaturated fatty acid (MUFA) synthesis, was also increased at the mRNA and enzyme ..
  6. Zhang Y, Zhang X, Chen L, Wu J, Su D, Lu W, et al. Liver X receptor agonist TO-901317 upregulates SCD1 expression in renal proximal straight tubule. Am J Physiol Renal Physiol. 2006;290:F1065-73 pubmed
    ..Among them, the stearoyl-CoA desaturase-1 (SCD1) was upregulated most dramatically...
  7. Miyazaki M, Bruggink S, Ntambi J. Identification of mouse palmitoyl-coenzyme A Delta9-desaturase. J Lipid Res. 2006;47:700-4 pubmed
    ..Currently, there are four known enzymatic isoforms (SCD1-SCD4) in the mouse genome...
  8. Liu X, Miyazaki M, Flowers M, Sampath H, Zhao M, Chu K, et al. Loss of Stearoyl-CoA desaturase-1 attenuates adipocyte inflammation: effects of adipocyte-derived oleate. Arterioscler Thromb Vasc Biol. 2010;30:31-8 pubmed publisher
    ..This study aimed at identify the effects of stearoyl-CoA desaturase-1 (SCD1) on the inflammatory response of a paracrine network involving adipocytes, macrophages, and endothelial cells...
  9. Ntambi J, Miyazaki M, Stoehr J, Lan H, Kendziorski C, Yandell B, et al. Loss of stearoyl-CoA desaturase-1 function protects mice against adiposity. Proc Natl Acad Sci U S A. 2002;99:11482-6 pubmed
    ..Several SCD isoforms (SCD1-3) exist in the mouse...
  10. Sundberg J, Boggess D, Sundberg B, Eilertsen K, Parimoo S, Filippi M, et al. Asebia-2J (Scd1(ab2J)): a new allele and a model for scarring alopecia. Am J Pathol. 2000;156:2067-75 pubmed
    ..Because this mutant mouse showed genetic, anatomical, and laboratory similarities to the asebia mutation, crosses were done between the new mutant and mice carrying the asebia-J allele...
  11. Biddinger S, Miyazaki M, Boucher J, Ntambi J, Kahn C. Leptin suppresses stearoyl-CoA desaturase 1 by mechanisms independent of insulin and sterol regulatory element-binding protein-1c. Diabetes. 2006;55:2032-41 pubmed
    ..b>SCD1 is suppressed by leptin but induced by insulin...
  12. Dobrzyn P, Dobrzyn A, Miyazaki M, Cohen P, Asilmaz E, Hardie D, et al. Stearoyl-CoA desaturase 1 deficiency increases fatty acid oxidation by activating AMP-activated protein kinase in liver. Proc Natl Acad Sci U S A. 2004;101:6409-14 pubmed
    ..Mice with a targeted disruption of the SCD1 isoform have reduced body adiposity, increased energy expenditure, and up-regulated expression of several genes ..
  13. Sampath H, Flowers M, Liu X, Paton C, Sullivan R, Chu K, et al. Skin-specific deletion of stearoyl-CoA desaturase-1 alters skin lipid composition and protects mice from high fat diet-induced obesity. J Biol Chem. 2009;284:19961-73 pubmed publisher
    Stearoyl-CoA desaturase-1 (SCD1) catalyzes the synthesis of monounsaturated fatty acids and is an important regulator of whole body energy homeostasis...
  14. Dobrzyn A, Dobrzyn P, Lee S, Miyazaki M, Cohen P, Asilmaz E, et al. Stearoyl-CoA desaturase-1 deficiency reduces ceramide synthesis by downregulating serine palmitoyltransferase and increasing beta-oxidation in skeletal muscle. Am J Physiol Endocrinol Metab. 2005;288:E599-607 pubmed
    ..Lack of SCD1 function significantly increases insulin sensitivity in skeletal muscles and corrects the hypometabolic phenotype ..
  15. Paton C, Ntambi J. Biochemical and physiological function of stearoyl-CoA desaturase. Am J Physiol Endocrinol Metab. 2009;297:E28-37 pubmed publisher
    ..regulated enzyme that is required for the biosynthesis of monounsaturated fatty acids is stearoyl-CoA desaturase (SCD), which catalyzes the D(9)-cis desaturation of a range of fatty acyl-CoA substrates...
  16. Binczek E, Jenke B, Holz B, Günter R, Thevis M, Stoffel W. Obesity resistance of the stearoyl-CoA desaturase-deficient (scd1-/-) mouse results from disruption of the epidermal lipid barrier and adaptive thermoregulation. Biol Chem. 2007;388:405-18 pubmed
    Targeted deletion of the stearoyl-CoA desaturase 1 gene (scd1) in mouse causes obesity resistance and a severe skin phenotype...
  17. Chu K, Miyazaki M, Man W, Ntambi J. Stearoyl-coenzyme A desaturase 1 deficiency protects against hypertriglyceridemia and increases plasma high-density lipoprotein cholesterol induced by liver X receptor activation. Mol Cell Biol. 2006;26:6786-98 pubmed
    ..In this study, we investigated the regulation of mouse SCD1 by liver X receptor (LXR) and its role in plasma lipoprotein metabolism upon LXR activation...
  18. Zheng Y, Prouty S, Harmon A, Sundberg J, Stenn K, Parimoo S. Scd3--a novel gene of the stearoyl-CoA desaturase family with restricted expression in skin. Genomics. 2001;71:182-91 pubmed
    ..Scd3 is expressed in the skin of young asebia mutant mice (Scd1(ab2J)/Scd1(ab2J)) in the absence of Scd1...
  19. Rahman S, Dobrzyn A, Lee S, Dobrzyn P, Miyazaki M, Ntambi J. Stearoyl-CoA desaturase 1 deficiency increases insulin signaling and glycogen accumulation in brown adipose tissue. Am J Physiol Endocrinol Metab. 2005;288:E381-7 pubmed
    ..Previously, we showed that SCD1 deficiency elevates insulin-signaling components and downregulates protein-tyrosine phosphatase-1B (PTP-1B) in ..
  20. Lee S, Dobrzyn A, Dobrzyn P, Rahman S, Miyazaki M, Ntambi J. Lack of stearoyl-CoA desaturase 1 upregulates basal thermogenesis but causes hypothermia in a cold environment. J Lipid Res. 2004;45:1674-82 pubmed
    ..Mice with a targeted disruption of the SCD1 isoform (SCD1-/-) exhibit reduced adiposity and increased energy expenditure...
  21. Miyazaki M, Man W, Ntambi J. Targeted disruption of stearoyl-CoA desaturase1 gene in mice causes atrophy of sebaceous and meibomian glands and depletion of wax esters in the eyelid. J Nutr. 2001;131:2260-8 pubmed
    ..Three well-characterized isoforms of SCD, SCD1, SCD2 and SCD3, exist in mice...
  22. Miyazaki M, Sampath H, Liu X, Flowers M, Chu K, Dobrzyn A, et al. Stearoyl-CoA desaturase-1 deficiency attenuates obesity and insulin resistance in leptin-resistant obese mice. Biochem Biophys Res Commun. 2009;380:818-22 pubmed publisher
    ..Mice deficient in the enzyme stearoyl-CoA desaturase-1 (SCD1) are lean and protected from diet-induced obesity and insulin resistance...
  23. Rahman S, Dobrzyn A, Dobrzyn P, Lee S, Miyazaki M, Ntambi J. Stearoyl-CoA desaturase 1 deficiency elevates insulin-signaling components and down-regulates protein-tyrosine phosphatase 1B in muscle. Proc Natl Acad Sci U S A. 2003;100:11110-5 pubmed
    We have shown previously that mice with a targeted disruption in the stearoyl-CoA desaturase 1 gene (SCD1-/-) have increased insulin sensitivity compared with control mice...
  24. Dobrzyn P, Sampath H, Dobrzyn A, Miyazaki M, Ntambi J. Loss of stearoyl-CoA desaturase 1 inhibits fatty acid oxidation and increases glucose utilization in the heart. Am J Physiol Endocrinol Metab. 2008;294:E357-64 pubmed
    ..Stearoyl-CoA desaturase (SCD) is a lipogenic enzyme that catalyzes the synthesis of monounsaturated fatty acids (FA). SCD1 deficiency activates metabolic pathways that promote FA beta-oxidation and decrease lipogenesis in liver...
  25. Miyazaki M, Kim Y, Gray Keller M, Attie A, Ntambi J. The biosynthesis of hepatic cholesterol esters and triglycerides is impaired in mice with a disruption of the gene for stearoyl-CoA desaturase 1. J Biol Chem. 2000;275:30132-8 pubmed
    ..We found that asebia mice homozygous for a natural mutation of the gene for SCD1 (SCD-/-) are deficient in hepatic cholesterol esters ..
  26. Ntambi J, Buhrow S, Kaestner K, Christy R, Sibley E, Kelly T, et al. Differentiation-induced gene expression in 3T3-L1 preadipocytes. Characterization of a differentially expressed gene encoding stearoyl-CoA desaturase. J Biol Chem. 1988;263:17291-300 pubmed
    ..acid sequences of both cDNA and genomic clones revealed that the gene encodes the mouse stearoyl-CoA desaturase (SCD), an enzyme known to be expressed upon differentiation of 3T3-L1 preadipocytes...
  27. Sampath H, Miyazaki M, Dobrzyn A, Ntambi J. Stearoyl-CoA desaturase-1 mediates the pro-lipogenic effects of dietary saturated fat. J Biol Chem. 2007;282:2483-93 pubmed
    ..that a diet high in the saturated fat stearate induces lipogenic genes in wild-type mice, with the induction of the Scd1 (stearoyl-CoA desaturase-1) gene preceding that of other lipogenic genes...
  28. Fluhr J, Mao Qiang M, Brown B, Wertz P, Crumrine D, Sundberg J, et al. Glycerol regulates stratum corneum hydration in sebaceous gland deficient (asebia) mice. J Invest Dermatol. 2003;120:728-37 pubmed
    ..We assessed here whether sebum influences stratum corneum hydration or permeability barrier function in asebia J1 and 2 J mice, with profound sebaceous gland hypoplasia...
  29. Flowers M, Keller M, Choi Y, Lan H, Kendziorski C, Ntambi J, et al. Liver gene expression analysis reveals endoplasmic reticulum stress and metabolic dysfunction in SCD1-deficient mice fed a very low-fat diet. Physiol Genomics. 2008;33:361-72 pubmed publisher
    We previously reported that mice deficient in stearoyl-CoA desaturase-1 (Scd1) and maintained on a very low-fat (VLF) diet for 10 days developed severe loss of body weight, hypoglycemia, hypercholesterolemia, and many cholestasis-like ..
  30. Miyazaki M, Flowers M, Sampath H, Chu K, Otzelberger C, Liu X, et al. Hepatic stearoyl-CoA desaturase-1 deficiency protects mice from carbohydrate-induced adiposity and hepatic steatosis. Cell Metab. 2007;6:484-96 pubmed
    Stearoyl-CoA desaturase-1 (SCD1), a critical regulator of energy metabolism, catalyzes the synthesis of monounsaturated fats...
  31. Oran A, Marshall J, Kondo S, Paglia D, McKenzie R. Cyclosporin inhibits intercellular adhesion molecule-1 expression and reduces mast cell numbers in the asebia mouse model of chronic skin inflammation. Br J Dermatol. 1997;136:519-26 pubmed
    The asebia mouse represents a spontaneous mutation in BALB/c mice leading to hyperplasia of the epidermis and chronic inflammatory dermal changes including enhanced cellularity, oedema and elevated mast cell numbers...
  32. Pinnamaneni S, Southgate R, Febbraio M, Watt M. Stearoyl CoA desaturase 1 is elevated in obesity but protects against fatty acid-induced skeletal muscle insulin resistance in vitro. Diabetologia. 2006;49:3027-37 pubmed
    b>Stearoyl CoA desaturase 1 (SCD1) is implicated in mediating obesity and insulin resistance. Paradoxically, SCD1 converts saturated fatty acids, the lipid species implicated in mediating insulin resistance, to monounsaturated fatty acids...
  33. Zheng Y, Eilertsen K, Ge L, Zhang L, Sundberg J, Prouty S, et al. Scd1 is expressed in sebaceous glands and is disrupted in the asebia mouse. Nat Genet. 1999;23:268-70 pubmed
  34. Repa J, Liang G, Ou J, Bashmakov Y, Lobaccaro J, Shimomura I, et al. Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta. Genes Dev. 2000;14:2819-30 pubmed
    ..Because this active form of SREBP-1c controls the transcription of genes involved in fatty acid biosynthesis, our results reveal a unique regulatory interplay between cholesterol and fatty acid metabolism. ..
  35. Miyazaki M, Dobrzyn A, Man W, Chu K, Sampath H, Kim H, et al. Stearoyl-CoA desaturase 1 gene expression is necessary for fructose-mediated induction of lipogenic gene expression by sterol regulatory element-binding protein-1c-dependent and -independent mechanisms. J Biol Chem. 2004;279:25164-71 pubmed
    ..Mice with a targeted disruption of the SCD1 gene are deficient in tissue oleate and have reduced expression of the sterol regulatory element-binding protein (..
  36. Attie A, Krauss R, Gray Keller M, Brownlie A, Miyazaki M, Kastelein J, et al. Relationship between stearoyl-CoA desaturase activity and plasma triglycerides in human and mouse hypertriglyceridemia. J Lipid Res. 2002;43:1899-907 pubmed
    ..Mice with a targeted disruption of the SCD1 gene have very low levels of VLDL and impaired triglyceride and cholesterol ester biosynthesis...
  37. Schwenk R, Jonas W, Ernst S, Kammel A, Jähnert M, Schurmann A. Diet-dependent alterations of hepatic Scd1 expression are accompanied by differences in promoter methylation. Horm Metab Res. 2013;45:786-94 pubmed publisher
    ..Expression of stearoyl-CoA desaturase 1 (Scd1) was lower in livers from HFD-fed C57BL/6 J mice compared to HCD-fed animals and correlated inversely with the ..
  38. Stamatikos A, Paton C. Role of stearoyl-CoA desaturase-1 in skeletal muscle function and metabolism. Am J Physiol Endocrinol Metab. 2013;305:E767-75 pubmed publisher
    Stearoyl-CoA desaturase-1 (SCD1) converts saturated fatty acids (SFA) into monounsaturated fatty acids and is necessary for proper liver, adipose tissue, and skeletal muscle lipid metabolism...
  39. Myöhänen S, Wahlfors J, Alhonen L, Janne J. Nucleotide sequence of mouse spermidine synthase cDNA. DNA Seq. 1994;4:343-6 pubmed
    ..The open reading frame encoded a polypeptide of 302 amino acids, displaying 95% similarity to human and 33% similarity to E. coli spermidine synthase. The 3' flanking region contained an unusual polyadenylation signal AATACA. ..
  40. Bojanic D, Tarr P, Gale G, Smith D, Bok D, Chen B, et al. Differential expression and function of ABCG1 and ABCG4 during development and aging. J Lipid Res. 2010;51:169-81 pubmed publisher
    ..Finally, behavioral tests show that Abcg4(-/-) mice have a general deficit in associative fear memory. Together, these data indicate that loss of ABCG1 and/or ABCG4 from the CNS results in changes in metabolic pathways and in behavior...
  41. Yokoyama S, Hosoi T, Ozawa K. Stearoyl-CoA Desaturase 1 (SCD1) is a key factor mediating diabetes in MyD88-deficient mice. Gene. 2012;497:340-3 pubmed publisher
    ..Stearoyl-CoA Desaturase 1 (SCD1) is the rate-limiting enzyme in the biosynthesis of monounsaturated fatty acids and known as a risk factor of ..
  42. Charalambous M, Ferron S, da Rocha S, Murray A, Rowland T, Ito M, et al. Imprinted gene dosage is critical for the transition to independent life. Cell Metab. 2012;15:209-21 pubmed publisher
    ..This shows that appropriate dosage control at imprinted loci can act as a critical determinant in postnatal survival during phases of physiological adaptation. ..
  43. Patra D, DeLassus E, Liang G, Sandell L. Cartilage-specific ablation of site-1 protease in mice results in the endoplasmic reticulum entrapment of type IIb procollagen and down-regulation of cholesterol and lipid homeostasis. PLoS ONE. 2014;9:e105674 pubmed publisher
    ..significantly down-regulated in S1Pcko chondrocytes, with maximal down-regulation of the stearoyl-CoA desaturase-1 (Scd1) gene...
  44. Nikonova L, Koza R, Mendoza T, Chao P, Curley J, Kozak L. Mesoderm-specific transcript is associated with fat mass expansion in response to a positive energy balance. FASEB J. 2008;22:3925-37 pubmed publisher
    ..hypothesis that MEST modulates fat mass expansion, its expression was compared to that of stearoyl CoA desaturase (Scd1) in B6 mice exposed to diets and environmental temperatures that generated conditions separating the effects of ..
  45. Hu C, Qing K, Chen Y. Diet-induced changes in stearoyl-CoA desaturase 1 expression in obesity-prone and -resistant mice. Obes Res. 2004;12:1264-70 pubmed
    ..SCD) 1 expression in obesity-prone C57BL/6 mice and in obesity-resistant FVB mice to explore the relationship of SCD1 expression and susceptibility to diet-induced obesity...
  46. Fehrenschild D, Galli U, Breiden B, Bloch W, Schettina P, Brodesser S, et al. TCF/Lef1-mediated control of lipid metabolism regulates skin barrier function. J Invest Dermatol. 2012;132:337-45 pubmed publisher
    ..signaling regulates expression of lipid-modifying enzymes, such as Elovl3 and stearoyl coenzyme A desaturase 1 (SCD1), which are key regulators of barrier function...
  47. Fonseca T, Fernandes G, McAninch E, Bocco B, Abdalla S, Ribeiro M, et al. Perinatal deiodinase 2 expression in hepatocytes defines epigenetic susceptibility to liver steatosis and obesity. Proc Natl Acad Sci U S A. 2015;112:14018-23 pubmed publisher
    ..The resulting phenotype of the adult ALB-D2KO mouse is dramatic, with greatly reduced susceptibility to diet-induced steatosis, hypertriglyceridemia, and obesity. ..
  48. Chen J, Li J, Yiu J, Lam J, Wong C, Dorweiler B, et al. TRIF-dependent Toll-like receptor signaling suppresses Scd1 transcription in hepatocytes and prevents diet-induced hepatic steatosis. Sci Signal. 2017;10: pubmed publisher
    ..mice was due to the increased hepatocyte transcription of the gene encoding stearoyl-coenzyme A (CoA) desaturase 1 (SCD1), the rate-limiting enzyme for lipogenesis...
  49. Yee J, Mao C, Hummel H, Lim S, Sugano S, Rehan V, et al. Compartmentalization of stearoyl-coenzyme A desaturase 1 activity in HepG2 cells. J Lipid Res. 2008;49:2124-34 pubmed publisher
    Stearoyl-coenzyme A desaturase 1 (SCD1) catalyzes the conversion of stearate (18:0) to oleate (18:1n-9) and of palmitate (16:0) to palmitoleate (16:1), which are key steps in triglyceride synthesis in the fatty acid metabolic network...
  50. Miyazaki M, Kim Y, Ntambi J. A lipogenic diet in mice with a disruption of the stearoyl-CoA desaturase 1 gene reveals a stringent requirement of endogenous monounsaturated fatty acids for triglyceride synthesis. J Lipid Res. 2001;42:1018-24 pubmed
    ..The lipogenic diet fed to mice with a null mutation in the SCD1 gene (SCD-/-) fails to induce the synthesis of triglycerides in liver, despite the induction of expression of SREBP-..
  51. Kim H, Miyazaki M, Ntambi J. Dietary cholesterol opposes PUFA-mediated repression of the stearoyl-CoA desaturase-1 gene by SREBP-1 independent mechanism. J Lipid Res. 2002;43:1750-7 pubmed
    ..The mouse expresses three well-characterized SCD genes (SCD1, 2, and 3). SCD1 is the main isoform expressed in the liver of mice...
  52. Yeoh B, Saha P, Singh V, Xiao X, Ying Y, Vanamala J, et al. Deficiency of stearoyl-CoA desaturase-1 aggravates colitogenic potential of adoptively transferred effector T cells. Am J Physiol Gastrointest Liver Physiol. 2016;311:G713-G723 pubmed publisher
    Stearoyl-CoA desaturase-1 (SCD1) is a lipogenic enzyme involved in the de novo biosynthesis of oleate (C18:1, n9), a major fatty acid in the phospholipids of lipid bilayers of cell membranes...
  53. Hyun C, Kim E, Flowers M, Liu X, Kim E, Strable M, et al. Adipose-specific deletion of stearoyl-CoA desaturase 1 up-regulates the glucose transporter GLUT1 in adipose tissue. Biochem Biophys Res Commun. 2010;399:480-6 pubmed publisher
    Stearoyl-CoA desaturase 1 (SCD1) deficiency protects mice from diet-induced obesity and insulin resistance...
  54. Mainieri D, Montani J, Seydoux J, Giacobino J, Boss O, Dulloo A. beta-Adrenergic control of stearoyl-CoA desaturase 1 repression in relation to sympathoadrenal regulation of thermogenesis. Int J Obes (Lond). 2007;31:378-81 pubmed
    ..show diminished thermogenesis and high susceptibility to obesity, whereas mice lacking stearoyl-CoA desaturase 1 (SCD1), which catalyzes the synthesis of monounsaturated fatty acids, show enhanced thermogenesis and high resistance to ..
  55. Paton C, Ntambi J. Loss of stearoyl-CoA desaturase activity leads to free cholesterol synthesis through increased Xbp-1 splicing. Am J Physiol Endocrinol Metab. 2010;299:E1066-75 pubmed publisher
    Stearoyl-CoA desaturase-1 (SCD-1) is the rate-limiting enzyme in the biosynthesis of monounsaturated fatty acids (MUFA), which are required for efficient neutral lipid esterification...
  56. Uryu S, Tokuhiro S, Oda T. beta-Amyloid-specific upregulation of stearoyl coenzyme A desaturase-1 in macrophages. Biochem Biophys Res Commun. 2003;303:302-5 pubmed
    ..002). We found that the gene for a well-characterized lipogenetic enzyme, stearoyl coenzyme A desaturase-1 (SCD-1), was specifically upregulated by A beta treatment and was suppressed to basal levels by RS-1178...
  57. Stoffel W, Schmidt Soltau I, Jenke B, Binczek E, Hammels I. Hair Growth Cycle Is Arrested in SCD1 Deficiency by Impaired Wnt3a-Palmitoleoylation and Retrieved by the Artificial Lipid Barrier. J Invest Dermatol. 2017;137:1424-1433 pubmed publisher
    Stearoyl-CoA desaturase 1 (SCD1) is the dominant member of the SCD-isozyme family, regarded as a major regulator of lipid and energy metabolism in liver and adipose tissue...
  58. Pan Y, Lin M, Tian X, Cheng H, Gridley T, Shen J, et al. gamma-secretase functions through Notch signaling to maintain skin appendages but is not required for their patterning or initial morphogenesis. Dev Cell. 2004;7:731-43 pubmed
  59. von Roemeling C, Marlow L, Pinkerton A, Crist A, Miller J, Tun H, et al. Aberrant lipid metabolism in anaplastic thyroid carcinoma reveals stearoyl CoA desaturase 1 as a novel therapeutic target. J Clin Endocrinol Metab. 2015;100:E697-709 pubmed publisher
    ..We investigated the effects of targeted inhibition of stearoyl-CoA desaturase 1 (SCD1), a constituent of fatty acid metabolism overexpressed in ATC...
  60. Chen L, Chen Q, Xie B, Quan C, Sheng Y, Zhu S, et al. Disruption of the AMPK-TBC1D1 nexus increases lipogenic gene expression and causes obesity in mice via promoting IGF1 secretion. Proc Natl Acad Sci U S A. 2016;113:7219-24 pubmed publisher
    ..These findings also have implications for drug discovery to combat obesity. ..
  61. Hashimoto K, Ishida E, Miura A, Ozawa A, Shibusawa N, Satoh T, et al. Human stearoyl-CoA desaturase 1 (SCD-1) gene expression is negatively regulated by thyroid hormone without direct binding of thyroid hormone receptor to the gene promoter. Endocrinology. 2013;154:537-49 pubmed publisher
    Stearoyl-CoA desaturase-1 (SCD-1) plays a pivotal role in an increase of triglyceride by an excess of dietary carbohydrate intake...
  62. Keller S, Jones J, Boyle A, Barrow L, Killen P, Green D, et al. Kidney and retinal defects (Krd), a transgene-induced mutation with a deletion of mouse chromosome 19 that includes the Pax2 locus. Genomics. 1994;23:309-20 pubmed
    ..molecular data are consistent with an approximately 7-cM deletion that includes the loci stearoyl CoA desaturase (Scd1), pale ear (ep), D19Mit17, D19Mit24, D19Mit27, D19Mit11, and Pax2...
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    Absence of stearoyl-CoA desaturase-1 (SCD1) in mice leads to chronic inflammation of the skin and increased susceptibility to atherosclerosis, while also increasing plasma inflammatory markers...
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    ..By haplotype analysis and direct sequencing of PCR products, we show that this mutation is a new allele of the asebia locus with a naturally occurring mutation in the Scd1 gene (a CCC insertion at nucleotide position 835 in exon 5), ..
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    ..Thus far, three isoforms of SCD (SCD1, SCD2, and SCD3) have been identified and characterized...
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    A cDNA sequence of stearoyl-CoA desaturase (SCD) was determined from zebrafish (Danio rerio) and compared to the corresponding genes in several teleosts...
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    ..would increase energy expenditure and further improve glucose tolerance in mice lacking stearoyl-coA desaturase-1 (SCD1)...
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    ..Reduced expression of SREBP-2 from the hypomorphic allele leads to early death in females and reduced cholesterol content in the liver, but not in adipose tissue. ..
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    ..reticulum (ER) homeostasis is regulated by a network of signaling pathways to which stearoyl-CoA desaturase (SCD)-1, p38 mitogen-activated protein kinase (MAPK) and the unfolded protein response (UPR) belong...
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    ..into monounsaturated FAs palmitoleate (16:1n-7) and oleate (18:1n-9) is catalyzed by stearoyl-CoA desaturase 1 (SCD1). These FAs represent the dominant constituents of adipocyte triacylglycerols (TAGs) and phospholipids (PLs)...
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    ..We found that the HG of the mice with a disruption in the gene for stearoyl-CoA desaturase 1 (SCD1) (SCD1-/-) is deficient in ADG...
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    ..The Acly knockout allele is useful for identifying cell types with a high demand for acetyl-CoA synthesis. ..
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    Stearoyl-CoA desaturase 1 (SCD1) deficiency partitions fatty acids away from lipid synthesis towards fatty acid oxidation in liver and skeletal muscle in part due to activation of AMP-activated protein kinase (AMPK) pathway...
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    ..Two mouse and rat SCD genes (SCD1 and SCD2) and a single human SCD gene have been cloned and characterized...