Scd1

Summary

Gene Symbol: Scd1
Description: stearoyl-Coenzyme A desaturase 1
Alias: AA589638, AI265570, Scd, Scd-1, acyl-CoA desaturase 1, asebia, delta(9)-desaturase 1, fatty acid desaturase 1, stearoyl-CoA desaturase 1
Species: mouse

Top Publications

  1. ncbi Mice fed a lipogenic methionine-choline-deficient diet develop hypermetabolism coincident with hepatic suppression of SCD-1
    Gizem Rizki
    Department of Medicine, University of California, San Francisco, San Francisco, CA, USA
    J Lipid Res 47:2280-90. 2006
  2. ncbi Dietary regulation of stearoyl-CoA desaturase 1 gene expression in mouse liver
    J M Ntambi
    Department of Biochemistry and Molecular Biology, Georgetown University School of Medicine, Washington, D C 20007
    J Biol Chem 267:10925-30. 1992
  3. ncbi Scd1ab-Xyk: a new asebia allele characterized by a CCC trinucleotide insertion in exon 5 of the stearoyl-CoA desaturase 1 gene in mouse
    Y Lu
    Health Science Center, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Shanghai Second Medical University, 200025, Shanghai, People s Republic of China
    Mol Genet Genomics 272:129-37. 2004
  4. pmc Compartmentalization of stearoyl-coenzyme A desaturase 1 activity in HepG2 cells
    Jennifer K Yee
    Department of Pediatrics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA
    J Lipid Res 49:2124-34. 2008
  5. ncbi Regulation of gene expression by insulin and tumor necrosis factor alpha in 3T3-L1 cells. Modulation of the transcription of genes encoding acyl-CoA synthetase and stearoyl-CoA desaturase-1
    F R Weiner
    Department of Medicine, Atran Laboratories, Albert Einstein College of Medicine, Bronx, New York 10461
    J Biol Chem 266:23525-8. 1991
  6. pmc Peroxisome proliferators induce mouse liver stearoyl-CoA desaturase 1 gene expression
    C W Miller
    Department of Biochemistry, University of Wisconsin, Madison 53706, USA
    Proc Natl Acad Sci U S A 93:9443-8. 1996
  7. ncbi A lipogenic diet in mice with a disruption of the stearoyl-CoA desaturase 1 gene reveals a stringent requirement of endogenous monounsaturated fatty acids for triglyceride synthesis
    M Miyazaki
    Department of Biochemistry, University of Wisconsin, 433 Babcock Drive, Madison, WI 53706, USA
    J Lipid Res 42:1018-24. 2001
  8. ncbi Role for stearoyl-CoA desaturase-1 in leptin-mediated weight loss
    Paul Cohen
    Laboratory of Molecular Genetics, Center for Studies in Physics and Biology, Rogosin Institute, Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Science 297:240-3. 2002
  9. ncbi Lack of stearoyl-CoA desaturase-1 function induces a palmitoyl-CoA Delta6 desaturase and represses the stearoyl-CoA desaturase-3 gene in the preputial glands of the mouse
    Makoto Miyazaki
    Departments of Biochemistry, University of Wisconsin, Madison, Wisconsin Nutritional Sciences, University of Wisconsin, Madison, Wisconsin, USA
    J Lipid Res 43:2146-54. 2002
  10. ncbi Diet-induced changes in stearoyl-CoA desaturase 1 expression in obesity-prone and -resistant mice
    Charlie C Hu
    Division of Endocrinology, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA
    Obes Res 12:1264-70. 2004

Research Grants

  1. Regulation of Apolipoprotein B Secretion
    ALAN ATTIE; Fiscal Year: 2006
  2. 2006 Genes & Behavior Conference
    Robert Hitzemann; Fiscal Year: 2006
  3. Role of Stearoyl-CoA Desaturase in Metabolism
    James M Ntambi; Fiscal Year: 2010

Scientific Experts

  • Jessica C Ralston
  • Andreas Koeberle
  • Zhen An Zhu
  • Yan Xu
  • Matthew T Flowers
  • Melissa B Glier
  • Karine H Hellemans
  • J E Gudjonsson
  • Marika Charalambous
  • John P Sundberg
  • ALAN ATTIE
  • Makoto Miyazaki
  • Kristofer Thorn
  • Robert J Hitzemann
  • James Ntambi
  • Anne Beigneux
  • Pawel Dobrzyn
  • Agnieszka Dobrzyn
  • Harini Sampath
  • Chad M Paton
  • Paul Cohen
  • Kiki Chu
  • Marcia L E MacDonald
  • Seong Ho Lee
  • Shaikh Mizanoor Rahman
  • Jeffrey M Friedman
  • C Ronald Kahn
  • Sudha B Biddinger
  • Xueqing Liu
  • Esra Asilmaz
  • Hui Wang
  • Weng Chi Man
  • Yuta Ogasawara
  • Yadi Huang
  • R W Schwenk
  • Jonas Sieber
  • Haojian Zhang
  • Nicolas Lachance
  • Rong Rong Cui
  • Dagmar Fehrenschild
  • Shota Yokoyama
  • K Ganesh Kumar
  • Matthew D Hirschey
  • Helena Maier
  • Alexander S Banks
  • Michelle M Angrish
  • Y Zheng
  • Minghui Zhao
  • Dechun Feng
  • Nagat Bissada
  • Michael R Hayden
  • Jennifer K Yee
  • Abdel M Hebbachi
  • Robert Brommage
  • Chi Chen
  • Jon E Wergedal
  • Tuija J Huusko
  • Yuzhen Zhang
  • D Mainieri
  • Jessica B Flowers
  • Erika Binczek
  • Yahua Zhang
  • Gizem Rizki
  • S K Pinnamaneni
  • Philippe Georgel
  • Lorin E Olson
  • D Grahame Hardie
  • Charlie C Hu
  • Y Lu
  • Yonghua Pan
  • Nicholas D Socci
  • Alexander A Soukas
  • Shigeko Uryu
  • Joachim W Fluhr
  • Kichoon Lee
  • S L Hsieh
  • F Scott Heinemann
  • Michael G Klein
  • Bi Ching Sang
  • Gyorgy Snell
  • Irena Levin
  • Weston Lane
  • Hua Zou
  • Ke Li
  • Hyoun ju Kim
  • Eisuke Itakura
  • Nozomu Kono
  • F Stefania Falvella
  • Akitsugu Yamamoto
  • Noboru Mizushima

Detail Information

Publications115 found, 100 shown here

  1. ncbi Mice fed a lipogenic methionine-choline-deficient diet develop hypermetabolism coincident with hepatic suppression of SCD-1
    Gizem Rizki
    Department of Medicine, University of California, San Francisco, San Francisco, CA, USA
    J Lipid Res 47:2280-90. 2006
    ..found that MCD feeding causes profound hepatic suppression of the gene encoding stearoyl-coenzyme A desaturase-1 (SCD-1), an enzyme whose regulation has significant effects on metabolic rate...
  2. ncbi Dietary regulation of stearoyl-CoA desaturase 1 gene expression in mouse liver
    J M Ntambi
    Department of Biochemistry and Molecular Biology, Georgetown University School of Medicine, Washington, D C 20007
    J Biol Chem 267:10925-30. 1992
    Expression of the murine liver stearoyl-CoA desaturase gene (SCD1) is induced upon feeding fasted mice a fat-free, high carbohydrate diet (Ntambi, J. M., Buhrow, S. A., Kaestner, K. H., Christy, R. J., Sibley, E., Kelly, T. J...
  3. ncbi Scd1ab-Xyk: a new asebia allele characterized by a CCC trinucleotide insertion in exon 5 of the stearoyl-CoA desaturase 1 gene in mouse
    Y Lu
    Health Science Center, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Shanghai Second Medical University, 200025, Shanghai, People s Republic of China
    Mol Genet Genomics 272:129-37. 2004
    ..By haplotype analysis and direct sequencing of PCR products, we show that this mutation is a new allele of the asebia locus with a naturally occurring mutation in the Scd1 gene (a CCC insertion at nucleotide position 835 in exon 5), ..
  4. pmc Compartmentalization of stearoyl-coenzyme A desaturase 1 activity in HepG2 cells
    Jennifer K Yee
    Department of Pediatrics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA
    J Lipid Res 49:2124-34. 2008
    Stearoyl-coenzyme A desaturase 1 (SCD1) catalyzes the conversion of stearate (18:0) to oleate (18:1n-9) and of palmitate (16:0) to palmitoleate (16:1), which are key steps in triglyceride synthesis in the fatty acid metabolic network...
  5. ncbi Regulation of gene expression by insulin and tumor necrosis factor alpha in 3T3-L1 cells. Modulation of the transcription of genes encoding acyl-CoA synthetase and stearoyl-CoA desaturase-1
    F R Weiner
    Department of Medicine, Atran Laboratories, Albert Einstein College of Medicine, Bronx, New York 10461
    J Biol Chem 266:23525-8. 1991
    ..the regulation of the expression of genes encoding acyl-CoA synthetase (ACS), and stearoyl CoA desaturase-1 (SCD-1), two enzymes that play key roles in the metabolism of long chain fatty acids...
  6. pmc Peroxisome proliferators induce mouse liver stearoyl-CoA desaturase 1 gene expression
    C W Miller
    Department of Biochemistry, University of Wisconsin, Madison 53706, USA
    Proc Natl Acad Sci U S A 93:9443-8. 1996
    ..1983) Biochim. Biophys. Acta 752, 259-264]. We analyzed the changes in stearoyl-CoA desaturase 1 (SCD1) mRNA to further define the molecular mechanism for the induction of stearoyl-CoA desaturase by peroxisome ..
  7. ncbi A lipogenic diet in mice with a disruption of the stearoyl-CoA desaturase 1 gene reveals a stringent requirement of endogenous monounsaturated fatty acids for triglyceride synthesis
    M Miyazaki
    Department of Biochemistry, University of Wisconsin, 433 Babcock Drive, Madison, WI 53706, USA
    J Lipid Res 42:1018-24. 2001
    ..The lipogenic diet fed to mice with a null mutation in the SCD1 gene (SCD-/-) fails to induce the synthesis of triglycerides in liver, despite the induction of expression of SREBP-..
  8. ncbi Role for stearoyl-CoA desaturase-1 in leptin-mediated weight loss
    Paul Cohen
    Laboratory of Molecular Genetics, Center for Studies in Physics and Biology, Rogosin Institute, Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Science 297:240-3. 2002
    ..Leptin was found to specifically repress RNA levels and enzymatic activity of hepatic stearoyl-CoA desaturase-1 (SCD-1), which catalyzes the biosynthesis of monounsaturated fatty acids...
  9. ncbi Lack of stearoyl-CoA desaturase-1 function induces a palmitoyl-CoA Delta6 desaturase and represses the stearoyl-CoA desaturase-3 gene in the preputial glands of the mouse
    Makoto Miyazaki
    Departments of Biochemistry, University of Wisconsin, Madison, Wisconsin Nutritional Sciences, University of Wisconsin, Madison, Wisconsin, USA
    J Lipid Res 43:2146-54. 2002
    ..We have found that the mouse PG expresses the three gene isoforms (SCD1, SCD2, and SCD3) of the Delta9 stearoyl-CoA desaturase enzyme that catalyzes the biosynthesis of monounsaturated ..
  10. ncbi Diet-induced changes in stearoyl-CoA desaturase 1 expression in obesity-prone and -resistant mice
    Charlie C Hu
    Division of Endocrinology, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA
    Obes Res 12:1264-70. 2004
    To investigate stearoyl-coenzyme A desaturase (SCD) 1 expression in obesity-prone C57BL/6 mice and in obesity-resistant FVB mice to explore the relationship of SCD1 expression and susceptibility to diet-induced obesity.
  11. ncbi Differentiation-induced gene expression in 3T3-L1 preadipocytes. Characterization of a differentially expressed gene encoding stearoyl-CoA desaturase
    J M Ntambi
    Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
    J Biol Chem 263:17291-300. 1988
    ..acid sequences of both cDNA and genomic clones revealed that the gene encodes the mouse stearoyl-CoA desaturase (SCD), an enzyme known to be expressed upon differentiation of 3T3-L1 preadipocytes...
  12. ncbi Cyclosporin inhibits intercellular adhesion molecule-1 expression and reduces mast cell numbers in the asebia mouse model of chronic skin inflammation
    A Oran
    Division of Dermatology, University of Toronto, Sunnybrook Health Sciences Centre, Ontario, Canada
    Br J Dermatol 136:519-26. 1997
    The asebia mouse represents a spontaneous mutation in BALB/c mice leading to hyperplasia of the epidermis and chronic inflammatory dermal changes including enhanced cellularity, oedema and elevated mast cell numbers...
  13. ncbi Scd1 is expressed in sebaceous glands and is disrupted in the asebia mouse
    Y Zheng
    Nat Genet 23:268-70. 1999
  14. pmc Asebia-2J (Scd1(ab2J)): a new allele and a model for scarring alopecia
    J P Sundberg
    Jackson Laboratory, Bar Harbor, Maine 04609 1500, USA
    Am J Pathol 156:2067-75. 2000
    ..Because this mutant mouse showed genetic, anatomical, and laboratory similarities to the asebia mutation, crosses were done between the new mutant and mice carrying the asebia-J allele...
  15. ncbi The biosynthesis of hepatic cholesterol esters and triglycerides is impaired in mice with a disruption of the gene for stearoyl-CoA desaturase 1
    M Miyazaki
    Departments of Biochemistry and Nutritional Sciences, University of Wisconsin, Madison, Wisconsin 53706, USA
    J Biol Chem 275:30132-8. 2000
    ..We found that asebia mice homozygous for a natural mutation of the gene for SCD1 (SCD-/-) are deficient in hepatic cholesterol esters ..
  16. pmc Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta
    J J Repa
    Howard Hughes Medical Institute and Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Genes Dev 14:2819-30. 2000
    ..Because this active form of SREBP-1c controls the transcription of genes involved in fatty acid biosynthesis, our results reveal a unique regulatory interplay between cholesterol and fatty acid metabolism...
  17. ncbi Scd3--a novel gene of the stearoyl-CoA desaturase family with restricted expression in skin
    Y Zheng
    Johnson and Johnson Skin Biology TRC, Grandview Road, Skillman, New Jersey 08558, USA
    Genomics 71:182-91. 2001
    ..Scd3 is expressed in the skin of young asebia mutant mice (Scd1(ab2J)/Scd1(ab2J)) in the absence of Scd1...
  18. ncbi Targeted disruption of stearoyl-CoA desaturase1 gene in mice causes atrophy of sebaceous and meibomian glands and depletion of wax esters in the eyelid
    M Miyazaki
    Departments of Biochemistry, University of Wisconsin, Madison, 53706, USA
    J Nutr 131:2260-8. 2001
    ..Three well-characterized isoforms of SCD, SCD1, SCD2 and SCD3, exist in mice...
  19. pmc Loss of stearoyl-CoA desaturase-1 function protects mice against adiposity
    James M Ntambi
    Department of Biochemistry, University of Wisconsin, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 99:11482-6. 2002
    ..Several SCD isoforms (SCD1-3) exist in the mouse...
  20. ncbi Relationship between stearoyl-CoA desaturase activity and plasma triglycerides in human and mouse hypertriglyceridemia
    Alan D Attie
    Department of Biochemistry, University of Wisconsin Madison, Madison, WI, USA
    J Lipid Res 43:1899-907. 2002
    ..Mice with a targeted disruption of the SCD1 gene have very low levels of VLDL and impaired triglyceride and cholesterol ester biosynthesis...
  21. ncbi Glycerol regulates stratum corneum hydration in sebaceous gland deficient (asebia) mice
    Joachim W Fluhr
    Dermatology Services, Veterans Administration Medical Center, and Department of Dermatology University of California, San Francisco, California, USA
    J Invest Dermatol 120:728-37. 2003
    ..We assessed here whether sebum influences stratum corneum hydration or permeability barrier function in asebia J1 and 2 J mice, with profound sebaceous gland hypoplasia...
  22. pmc Stearoyl-CoA desaturase 1 deficiency elevates insulin-signaling components and down-regulates protein-tyrosine phosphatase 1B in muscle
    Shaikh Mizanoor Rahman
    Department of Biochemistry, University of Wisconsin, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 100:11110-5. 2003
    We have shown previously that mice with a targeted disruption in the stearoyl-CoA desaturase 1 gene (SCD1-/-) have increased insulin sensitivity compared with control mice...
  23. ncbi Stearoyl-CoA desaturase 1 gene expression is necessary for fructose-mediated induction of lipogenic gene expression by sterol regulatory element-binding protein-1c-dependent and -independent mechanisms
    Makoto Miyazaki
    Department of Biochemistry, University of Wisconsin, Madison, Wisconsin 53706, USA
    J Biol Chem 279:25164-71. 2004
    ..Mice with a targeted disruption of the SCD1 gene are deficient in tissue oleate and have reduced expression of the sterol regulatory element-binding protein (..
  24. ncbi Lack of stearoyl-CoA desaturase 1 upregulates basal thermogenesis but causes hypothermia in a cold environment
    Seong Ho Lee
    Department of Biochemistry, University of Wisconsin, Madison, WI 53706, USA
    J Lipid Res 45:1674-82. 2004
    ..Mice with a targeted disruption of the SCD1 isoform (SCD1-/-) exhibit reduced adiposity and increased energy expenditure...
  25. ncbi Stearoyl-CoA desaturase 1 deficiency increases insulin signaling and glycogen accumulation in brown adipose tissue
    Shaikh Mizanoor Rahman
    Dept of Biochemistry, University of Wisconsin, 433 Babcock Drive, Madison, WI 53706, USA
    Am J Physiol Endocrinol Metab 288:E381-7. 2005
    ..Previously, we showed that SCD1 deficiency elevates insulin-signaling components and downregulates protein-tyrosine phosphatase-1B (PTP-1B) in ..
  26. ncbi Stearoyl-CoA desaturase-1 deficiency reduces ceramide synthesis by downregulating serine palmitoyltransferase and increasing beta-oxidation in skeletal muscle
    Agnieszka Dobrzyn
    Dept of Biochemistry, Univ of Wisconsin, 433 Babcock Dr, Madison, WI 53706, USA
    Am J Physiol Endocrinol Metab 288:E599-607. 2005
    ..Lack of SCD1 function significantly increases insulin sensitivity in skeletal muscles and corrects the hypometabolic phenotype ..
  27. ncbi Effects of diet and genetic background on sterol regulatory element-binding protein-1c, stearoyl-CoA desaturase 1, and the development of the metabolic syndrome
    Sudha B Biddinger
    Research Division, Joslin Diabetes Center, and Department of Medicine, Harvard Medical School, Boston, MA 02215, USA
    Diabetes 54:1314-23. 2005
    ..Stearoyl-CoA desaturase 1 (SCD1), an enzyme that regulates monounsaturated fatty acid (MUFA) synthesis, was also increased at the mRNA and enzyme ..
  28. ncbi Liver X receptor agonist TO-901317 upregulates SCD1 expression in renal proximal straight tubule
    Yahua Zhang
    Division of Nephrology, S 3223 MCN, Vanderbilt Univ Medical Center, Nashville, TN 37232 2372, USA
    Am J Physiol Renal Physiol 290:F1065-73. 2006
    ..Among them, the stearoyl-CoA desaturase-1 (SCD1) was upregulated most dramatically...
  29. ncbi Identification of mouse palmitoyl-coenzyme A Delta9-desaturase
    Makoto Miyazaki
    Department of Biochemistry, University of Wisconsin, Madison, WI 53706, USA
    J Lipid Res 47:700-4. 2006
    ..Currently, there are four known enzymatic isoforms (SCD1-SCD4) in the mouse genome...
  30. ncbi Leptin suppresses stearoyl-CoA desaturase 1 by mechanisms independent of insulin and sterol regulatory element-binding protein-1c
    Sudha B Biddinger
    Research Division, Joslin Diabetes Center, One Joslin Pl, Boston, MA 02215, USA
    Diabetes 55:2032-41. 2006
    ..b>SCD1 is suppressed by leptin but induced by insulin...
  31. pmc Stearoyl-coenzyme A desaturase 1 deficiency protects against hypertriglyceridemia and increases plasma high-density lipoprotein cholesterol induced by liver X receptor activation
    Kiki Chu
    Department of Biochemistry, University of Wisconsin Madison, 433 Babcock Drive, Madison, WI 53706, USA
    Mol Cell Biol 26:6786-98. 2006
    ..In this study, we investigated the regulation of mouse SCD1 by liver X receptor (LXR) and its role in plasma lipoprotein metabolism upon LXR activation...
  32. ncbi Stearoyl CoA desaturase 1 is elevated in obesity but protects against fatty acid-induced skeletal muscle insulin resistance in vitro
    S K Pinnamaneni
    Cellular and Molecular Metabolism Laboratory, School of Medical Sciences, RMIT University, Melbourne, Victoria, Australia
    Diabetologia 49:3027-37. 2006
    b>Stearoyl CoA desaturase 1 (SCD1) is implicated in mediating obesity and insulin resistance. Paradoxically, SCD1 converts saturated fatty acids, the lipid species implicated in mediating insulin resistance, to monounsaturated fatty acids...
  33. ncbi Stearoyl-CoA desaturase-1 mediates the pro-lipogenic effects of dietary saturated fat
    Harini Sampath
    Department of Nutritional Sciences, University of Wisconsin, Madison, Wisconsin 53706, USA
    J Biol Chem 282:2483-93. 2007
    ..that a diet high in the saturated fat stearate induces lipogenic genes in wild-type mice, with the induction of the Scd1 (stearoyl-CoA desaturase-1) gene preceding that of other lipogenic genes...
  34. ncbi Loss of stearoyl-CoA desaturase 1 inhibits fatty acid oxidation and increases glucose utilization in the heart
    Pawel Dobrzyn
    Department of Biochemistry, University of Wisconsin, 433 Babcock Drive, Madison, WI 53706, USA
    Am J Physiol Endocrinol Metab 294:E357-64. 2008
    ..Stearoyl-CoA desaturase (SCD) is a lipogenic enzyme that catalyzes the synthesis of monounsaturated fatty acids (FA). SCD1 deficiency activates metabolic pathways that promote FA beta-oxidation and decrease lipogenesis in liver...
  35. ncbi Hepatic stearoyl-CoA desaturase-1 deficiency protects mice from carbohydrate-induced adiposity and hepatic steatosis
    Makoto Miyazaki
    Department of Biochemistry, University of Wisconsin Madison, 433 Babcock Drive, Madison, WI 53706, USA
    Cell Metab 6:484-96. 2007
    Stearoyl-CoA desaturase-1 (SCD1), a critical regulator of energy metabolism, catalyzes the synthesis of monounsaturated fats...
  36. pmc Metabolomics reveals that hepatic stearoyl-CoA desaturase 1 downregulation exacerbates inflammation and acute colitis
    Chi Chen
    Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Cell Metab 7:135-47. 2008
    ..mice compared to controls led to the identification of DSS-elicited inhibition of stearoyl-CoA desaturase 1 (SCD1) expression in liver...
  37. doi Liver gene expression analysis reveals endoplasmic reticulum stress and metabolic dysfunction in SCD1-deficient mice fed a very low-fat diet
    Matthew T Flowers
    Department of Biochemistry, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    Physiol Genomics 33:361-72. 2008
    We previously reported that mice deficient in stearoyl-CoA desaturase-1 (Scd1) and maintained on a very low-fat (VLF) diet for 10 days developed severe loss of body weight, hypoglycemia, hypercholesterolemia, and many cholestasis-like ..
  38. pmc Biochemical and physiological function of stearoyl-CoA desaturase
    Chad M Paton
    Department of Biochemistry, University of Wisconsin, 433 Babcock Dr, Madison, WI 53706, USA
    Am J Physiol Endocrinol Metab 297:E28-37. 2009
    ..regulated enzyme that is required for the biosynthesis of monounsaturated fatty acids is stearoyl-CoA desaturase (SCD), which catalyzes the D(9)-cis desaturation of a range of fatty acyl-CoA substrates...
  39. pmc Stearoyl-CoA desaturase-1 deficiency attenuates obesity and insulin resistance in leptin-resistant obese mice
    Makoto Miyazaki
    Department of Biochemistry, University of Wisconsin Madison, 433, Babcock Drive, Madison, WI 53706, USA
    Biochem Biophys Res Commun 380:818-22. 2009
    ..Mice deficient in the enzyme stearoyl-CoA desaturase-1 (SCD1) are lean and protected from diet-induced obesity and insulin resistance...
  40. pmc Loss of Stearoyl-CoA desaturase-1 attenuates adipocyte inflammation: effects of adipocyte-derived oleate
    Xueqing Liu
    Department of Biochemistry, University of Wisconsin, Madison, 433 Babcock Dr, Madison, WI 53706, USA
    Arterioscler Thromb Vasc Biol 30:31-8. 2010
    ..This study aimed at identify the effects of stearoyl-CoA desaturase-1 (SCD1) on the inflammatory response of a paracrine network involving adipocytes, macrophages, and endothelial cells.
  41. pmc Loss of stearoyl-CoA desaturase 1 rescues cardiac function in obese leptin-deficient mice
    Pawel Dobrzyn
    Laboratory of Cell Signaling and Metabolic Disorders, Nencki Institute of Experimental Biology, Warsaw, Poland
    J Lipid Res 51:2202-10. 2010
    ..In the present study, using an ob/ob;SCD1(-/-) mouse model, we tested the hypothesis that lack of SCD1 could improve steatosis and left ventricle (LV) ..
  42. pmc Role of stearoyl-CoA desaturase-1 in skin integrity and whole body energy balance
    Harini Sampath
    From the Oregon Institute of Occupational Health Sciences, Oregon Health and Science University, Portland, Oregon 97239 and
    J Biol Chem 289:2482-8. 2014
    ..Mice with a deletion of the Δ(9)-desaturase-1 isoform (SCD1) either globally (Scd1(-/-)) or specifically in the skin (skin-specific Scd1-knockout; SKO) present with marked ..
  43. pmc Stearoyl-CoA desaturase 1 deficiency increases fatty acid oxidation by activating AMP-activated protein kinase in liver
    Pawel Dobrzyn
    Department of Biochemistry, University of Wisconsin, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 101:6409-14. 2004
    ..Mice with a targeted disruption of the SCD1 isoform have reduced body adiposity, increased energy expenditure, and up-regulated expression of several genes ..
  44. ncbi Loss of stearoyl-CoA desaturase-1 improves insulin sensitivity in lean mice but worsens diabetes in leptin-deficient obese mice
    Jessica B Flowers
    Department of Nutritional Sciences, University of Wisconsin Madison, Madison, WI 537606, USA
    Diabetes 56:1228-39. 2007
    ..we determined that insulin sensitivity was improved in heart, soleus muscle, adipose tissue, and liver of BTBR SCD1-deficient mice. We next determined whether SCD1 deficiency could prevent diabetes in leptin-deficient BTBR mice...
  45. pmc Skin-specific deletion of stearoyl-CoA desaturase-1 alters skin lipid composition and protects mice from high fat diet-induced obesity
    Harini Sampath
    Department of Nutritional Sciences, University of Wisconsin, Madison, Wisconsin 53706, USA
    J Biol Chem 284:19961-73. 2009
    Stearoyl-CoA desaturase-1 (SCD1) catalyzes the synthesis of monounsaturated fatty acids and is an important regulator of whole body energy homeostasis...
  46. ncbi Obesity resistance of the stearoyl-CoA desaturase-deficient (scd1-/-) mouse results from disruption of the epidermal lipid barrier and adaptive thermoregulation
    Erika Binczek
    Laboratory of Molecular Neurosciences, Center of Molecular Medicine CMMC, Center of Biochemistry, Faculty of Medicine, University of Cologne, Joseph Stelzmann Str 52, D 50931 Köln, Germany
    Biol Chem 388:405-18. 2007
    Targeted deletion of the stearoyl-CoA desaturase 1 gene (scd1) in mouse causes obesity resistance and a severe skin phenotype...
  47. ncbi Raf-1 activates MAP kinase-kinase
    J M Kyriakis
    Diabetes Unit, Medical Services, Massachusetts General Hospital, Charlestown 02129
    Nature 358:417-21. 1992
    ..These results indicate that c-Raf-1 is an immediate upstream activator of MAPK-K in vivo. To our knowledge, MAPK-K is the first physiological substrate of the c-raf-1 protooncogene product to be identified...
  48. ncbi Osteosclerosis, a recessive skeletal mutation on chromosome 19 in the mouse
    S C Marks
    J Hered 76:171-6. 1985
    ..Extensive extramedullary hemopoiesis occurs in the liver and spleen of mutants. This unique constellation of features suggests that the oc mutation is a valuable model in which to investigate the pathogenesis of osteopetrosis...
  49. ncbi Nuclear factor 1 is essential for the expression of stearoyl-CoA desaturase 1 gene during preadipocyte differentiation
    M V Singh
    Department of Biochemistry, University of Wisconsin Madison 53706, USA
    Biochim Biophys Acta 1398:148-56. 1998
    Stearoyl CoA desaturase gene 1 (SCD1) is a delta 9 desaturase that is transcriptionally activated during the differentiation of 3T3-L1 preadipocytes into adipocytes...
  50. ncbi Mouse Wnt8B is expressed in the developing forebrain and maps to chromosome 19
    M Richardson
    Centre for Genome Research, Roger Land Building, University of Edinburgh, Edinburgh EH9 3JQ, UK
    Mamm Genome 10:923-5. 1999
  51. pmc HSF1 is required for extra-embryonic development, postnatal growth and protection during inflammatory responses in mice
    X Xiao
    Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, TX 75235 8573, USA
    EMBO J 18:5943-52. 1999
    ....
  52. ncbi Membrane topology of mouse stearoyl-CoA desaturase 1
    Weng Chi Man
    Biochemistry andNutritional Sciences, University of Wisconsin Madison, 53706, USA
    J Biol Chem 281:1251-60. 2006
    ..Four mouse isoforms of SCD (SCD1-4) and two human isoforms have been characterized...
  53. pmc Dissociation of the glucose and lipid regulatory functions of FoxO1 by targeted knockin of acetylation-defective alleles in mice
    Alexander S Banks
    Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Cell Metab 14:587-97. 2011
    ..Thus, acetylation inactivates FoxO1 during nutrient excess whereas deacetylation selectively potentiates FoxO1 activity, protecting against excessive catabolism during nutrient deprivation...
  54. doi Discovery of potent and liver-selective stearoyl-CoA desaturase (SCD) inhibitors in an acyclic linker series
    Nicolas Lachance
    Department of Medicinal Chemistry, Merck Frosst Centre for Therapeutic Research, 16711 Transcanada Hwy, Kirkland, Quebec, Canada H9H 3L1
    Bioorg Med Chem Lett 22:623-7. 2012
    Elevated levels of stearoyl-CoA desaturase (SCD) activity have been implicated in metabolic disorders such as obesity and type II diabetes...
  55. pmc Adropin deficiency is associated with increased adiposity and insulin resistance
    K Ganesh Kumar
    Department of Metabolism and Aging, The Scripps Research Institute, Jupiter, FL, USA
    Obesity (Silver Spring) 20:1394-402. 2012
    ..Adropin is not required for regulating food intake, however, its functions impact on adiposity and are involved in preventing insulin resistance, dyslipidemia, and impaired glucose tolerance...
  56. doi Stearoyl-CoA Desaturase 1 (SCD1) is a key factor mediating diabetes in MyD88-deficient mice
    Shota Yokoyama
    Department of Pharmacotherapy, Hiroshima University, Hiroshima, Japan
    Gene 497:340-3. 2012
    ..Stearoyl-CoA Desaturase 1 (SCD1) is the rate-limiting enzyme in the biosynthesis of monounsaturated fatty acids and known as a risk factor of ..
  57. doi MicroRNA-204 regulates vascular smooth muscle cell calcification in vitro and in vivo
    Rong Rong Cui
    Department of Pediatrics, The Second Xiang Ya Hospital, Central South University, 139 Middle Renmin Road, 410011, Changsha, Hunan, People s Republic of China
    Cardiovasc Res 96:320-9. 2012
    ..In this study, we aimed to investigate whether miR-204 participates in the regulation of VSMC calcification...
  58. doi Diet-dependent alterations of hepatic Scd1 expression are accompanied by differences in promoter methylation
    R W Schwenk
    Department of Experimental Diabetology, German Institute of Human Nutrition Potsdam Rehbruecke, Nuthetal, Germany
    Horm Metab Res 45:786-94. 2013
    ..Expression of stearoyl-CoA desaturase 1 (Scd1) was lower in livers from HFD-fed C57BL/6 J mice compared to HCD-fed animals and correlated inversely with the ..
  59. pmc Susceptibility of podocytes to palmitic acid is regulated by stearoyl-CoA desaturases 1 and 2
    Jonas Sieber
    Laboratory of Molecular Nephrology, Department of Biomedicine, University Hospital, Basel, Switzerland
    Am J Pathol 183:735-44. 2013
    ..gene expression of enzymes involved in fatty acid metabolism, including induction of stearoyl-CoA desaturase (SCD)-1, which converts saturated to monounsaturated FFAs...
  60. doi Inhibition of stearoyl-CoA desaturase-1 in differentiating 3T3-L1 preadipocytes upregulates elongase 6 and downregulates genes affecting triacylglycerol synthesis
    J C Ralston
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, Canada
    Int J Obes (Lond) 38:1449-56. 2014
    Stearoyl-CoA desaturase-1 (SCD1) is rate limiting for the conversion of saturated fatty acids palmitate (16:0) and stearate (18:0) to monounsaturated fatty acids palmitoleate (16:1n7) and oleate (18:1n9), respectively...
  61. pmc Stearoyl-CoA desaturase 1 activity is required for autophagosome formation
    Yuta Ogasawara
    From the Nagahama Institute of Bio Science and Technology, 1266 Tamura, Nagahama, Shiga 526 0829
    J Biol Chem 289:23938-50. 2014
    ..To determine whether SCD1 inhibition influences autophagy, we examined the effects of the SCD1 inhibitor 28c...
  62. doi Crystal structure of human stearoyl-coenzyme A desaturase in complex with substrate
    Hui Wang
    Department of Structural Biology and Core Sciences and Technology, Takeda California, San Diego, California, USA
    Nat Struct Mol Biol 22:581-5. 2015
    Stearoyl-coenzyme A desaturase-1 (SCD1) has an important role in lipid metabolism, and SCD1 inhibitors are potential therapeutic agents for the treatment of metabolic diseases and cancers. Here we report the 3...
  63. ncbi Oleoyl-CoA is the major de novo product of stearoyl-CoA desaturase 1 gene isoform and substrate for the biosynthesis of the Harderian gland 1-alkyl-2,3-diacylglycerol
    M Miyazaki
    Department of Biochemistry and Nutritional Sciences, University of Wisconsin, Madison, Wisconsin 53706, USA
    J Biol Chem 276:39455-61. 2001
    ..We found that the HG of the mice with a disruption in the gene for stearoyl-CoA desaturase 1 (SCD1) (SCD1-/-) is deficient in ADG...
  64. ncbi Stearoyl-CoA desaturase 1 (Scd1) gene overexpression is associated with genetic predisposition to hepatocarcinogenesis in mice and rats
    F Stefania Falvella
    Department of Experimental Oncology, Istituto Nazionale Tumori, Via G Venezian 1, 20133 Milan, Italy
    Carcinogenesis 23:1933-6. 2002
    The stearoyl-CoA desaturase 1 (Scd1) gene is involved in the synthesis and regulation of unsaturated fatty acids...
  65. pmc Inhibition of adipogenesis and development of glucose intolerance by soluble preadipocyte factor-1 (Pref-1)
    Kichoon Lee
    Department of Nutritional Sciences and Toxicology, and Cancer Research Laboratory, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California 94720, USA
    J Clin Invest 111:453-61. 2003
    ..These findings demonstrate the inhibition of adipogenesis by Pref-1 in vivo and the resulting impairment of adipocyte function that leads to the development of metabolic abnormalities...
  66. ncbi beta-Amyloid-specific upregulation of stearoyl coenzyme A desaturase-1 in macrophages
    Shigeko Uryu
    Lead Discovery Research Laboratories, Sankyo, 2 58, Hiromachi 1 Chome, Shinagawa ku, Tokyo 140 8710, Japan
    Biochem Biophys Res Commun 303:302-5. 2003
    ..002). We found that the gene for a well-characterized lipogenetic enzyme, stearoyl coenzyme A desaturase-1 (SCD-1), was specifically upregulated by A beta treatment and was suppressed to basal levels by RS-1178...
  67. pmc Barx2 functions through distinct corepressor classes to regulate hair follicle remodeling
    Lorin E Olson
    Howard Hughes Medical Institute, Biomedical Sciences Graduate Program, University of California at San Diego School of Medicine, La Jolla, CA 92093 0648, USA
    Proc Natl Acad Sci U S A 102:3708-13. 2005
    ..Together, our data suggest that the hair-remodeling defect of Barx2 mutant mice could be explained, in part, by failure to repress one or more critical target genes...
  68. pmc Absence of stearoyl-CoA desaturase-1 ameliorates features of the metabolic syndrome in LDLR-deficient mice
    Marcia L E MacDonald
    Centre for Molecular Medicine and Therapeutics, Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada
    J Lipid Res 49:217-29. 2008
    ..Here, we show that absence of the Scd1 gene product reduces plasma triglycerides and reduces weight gain in severely hyperlipidemic low density ..
  69. doi High-throughput screening of mouse knockout lines identifies true lean and obese phenotypes
    Robert Brommage
    Lexicon Pharmaceuticals, Inc, The Woodlands, Texas, USA
    Obesity (Silver Spring) 16:2362-7. 2008
    ..d. below the mean for seven (perilipin, SCD1, CB1, MCH1R, PTP1B, GPAT1, PIP5K2B) but close to the mean for NPY Y4R...
  70. pmc The metabolic phenotype of SCD1-deficient mice is independent of melanin-concentrating hormone
    Melissa B Glier
    Department of Medical Genetics, Child and Family Research Institute, University of British Columbia, Canada
    Peptides 31:123-9. 2010
    ..would increase energy expenditure and further improve glucose tolerance in mice lacking stearoyl-coA desaturase-1 (SCD1)...
  71. pmc Metabolic changes in skin caused by Scd1 deficiency: a focus on retinol metabolism
    Matthew T Flowers
    Department of Biochemistry, University of Wisconsin Madison, Madison, Wisconsin, United States of America
    PLoS ONE 6:e19734. 2011
    We previously reported that mice with skin-specific deletion of stearoyl-CoA desaturase-1 (Scd1) recapitulated the skin phenotype and hypermetabolism observed in mice with a whole-body deletion of Scd1...
  72. pmc Normal fur development and sebum production depends on fatty acid 2-hydroxylase expression in sebaceous glands
    Helena Maier
    Institute of Biochemistry and Molecular Biology, Germany
    J Biol Chem 286:25922-34. 2011
    ..These results underline the importance of the sebaceous glands and suggest a role of specific sebaceous gland or sebum lipids, synthesized by FA2H, in the hair follicle homeostasis...
  73. pmc SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome
    Matthew D Hirschey
    Gladstone Institute of Virology and Immunology, San Francisco, CA 94158, USA
    Mol Cell 44:177-90. 2011
    ..Our findings show that loss of SIRT3 and dysregulation of mitochondrial protein acetylation contribute to the metabolic syndrome...
  74. pmc Aryl hydrocarbon receptor-mediated induction of Stearoyl-CoA desaturase 1 alters hepatic fatty acid composition in TCDD-elicited steatosis
    Michelle M Angrish
    Genetics Program, Michigan State University, East Lansing, Michigan 48824, USA
    Toxicol Sci 124:299-310. 2011
    ..Stearoyl-CoA desaturase 1 (Scd1) performs the rate-limiting step in monounsaturated fatty acid (MUFA) synthesis, desaturating 16:0 and 18:0 into 16:..
  75. doi TCF/Lef1-mediated control of lipid metabolism regulates skin barrier function
    Dagmar Fehrenschild
    Center for Molecular Medicine Cologne CMMC, University of Cologne, Cologne, Germany
    J Invest Dermatol 132:337-45. 2012
    ..signaling regulates expression of lipid-modifying enzymes, such as Elovl3 and stearoyl coenzyme A desaturase 1 (SCD1), which are key regulators of barrier function...
  76. pmc Scd1 plays a tumor-suppressive role in survival of leukemia stem cells and the development of chronic myeloid leukemia
    Haojian Zhang
    Division of Hematology Oncology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Mol Cell Biol 32:1776-87. 2012
    ..Using BCR-ABL-induced CML mouse model, here we show that expression of the stearoyl-CoA desaturase 1 (Scd1) gene is downregulated in LSCs and that Scd1 plays a tumor-suppressive role in LSCs with no effect on the function ..
  77. pmc Combined deletion of SCD1 from adipose tissue and liver does not protect mice from obesity
    Matthew T Flowers
    Department of Biochemistry University of Wisconsin Madison, Madison, WI 53706, USA
    J Lipid Res 53:1646-53. 2012
    Stearoyl-CoA desaturase 1 (SCD1) catalyzes the synthesis of monounsaturated fatty acids (MUFA) from saturated FA. Mice with whole-body or skin-specific deletion of SCD1 are resistant to obesity...
  78. pmc Transcriptional programs controlling perinatal lung maturation
    Yan Xu
    The Perinatal Institute and Section of Neonatology, Perinatal and Pulmonary Biology, University of Cincinnati, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
    PLoS ONE 7:e37046. 2012
    ..The present study systemically mapped key regulators, bioprocesses, and transcriptional networks controlling lung maturation, providing the basis for new therapeutic strategies to enhance lung function in preterm infants...
  79. pmc Hypoxia inducible factor 3α plays a critical role in alveolarization and distal epithelial cell differentiation during mouse lung development
    Yadi Huang
    Department of Pediatric Surgery, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
    PLoS ONE 8:e57695. 2013
    ..Moreover, Hif3α affected the expression of genes not typically involved in the hypoxia response, providing evidence for a novel function of Hif3α beyond the hypoxia response...
  80. ncbi Osteochondrodystrophy (ocd): a new autosomal recessive mutation in the mouse
    H O Sweet
    Jackson Laboratory, Bar Harbor, ME 04609
    J Hered 82:140-4. 1991
    ..Osteochondrodystrophy has been mapped to a position near the centromere of mouse chromosome (Chr) 19...
  81. pmc Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a
    H Shimano
    Department of Molecular Genetics, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas 75235, USA
    J Clin Invest 98:1575-84. 1996
    ..The amount of white adipose tissue decreased progressively as the liver enlarged. These studies indicate that the NH2-terminal domain of SREBP-1a can produce major effects on lipid synthesis and storage in the liver...
  82. ncbi Differential expression of hepatic stearoyl-CoA desaturase gene 1 in male and female mice
    K N Lee
    Department of Nutritional Sciences, University of Wisconsin Madison 53706, USA
    Biochim Biophys Acta 1304:85-8. 1996
    The expression of hepatic stearoyl-CoA desaturase (SCD1) mRNA abundance and the fatty acid profile in male and female mice were compared...
  83. ncbi Comparison of chemical carcinogen skin tumor induction efficacy in inbred, mutant, and hybrid strains of mice: morphologic variations of induced tumors and absence of a papillomavirus cocarcinogen
    J P Sundberg
    The Jackson Laboratory, Bar Harbor, Maine 04609 1500, USA
    Mol Carcinog 20:19-32. 1997
    ..These observations indicate that numerous modifier genes but not papillomaviruses are involved in cutaneous chemical carcinogenesis...
  84. ncbi A plasminogen-like protein selectively degrades stearoyl-CoA desaturase in liver microsomes
    F Scott Heinemann
    Department of Pathology, Hoag Memorial Hospital Presbyterian, Newport Beach, California 92663, USA
    J Biol Chem 278:42966-75. 2003
    Stearoyl-CoA desaturase (SCD) is an integral membrane protein of the endoplasmic reticulum that is rapidly and selectively degraded when isolated liver microsomes are incubated at 37 degrees C...
  85. ncbi Stearoyl-CoA desaturase-1 and the metabolic syndrome
    Paul Cohen
    Laboratory of Molecular Genetics, The Rockefeller University, New York, NY 10021, USA
    Curr Drug Targets Immune Endocr Metabol Disord 3:271-80. 2003
    ..The identification and role of one such component, stearoyl-CoA desaturase-1 (SCD-1), is reviewed here. Leptin's actions are not due to its anorectic effects alone...
  86. ncbi gamma-secretase functions through Notch signaling to maintain skin appendages but is not required for their patterning or initial morphogenesis
    Yonghua Pan
    Department of Molecular Biology and Pharmacology, Division of Dermatology, Washington University School of Medicine, Box 8103, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Dev Cell 7:731-43. 2004
    ....
  87. ncbi Polyunsaturated fatty acids do not activate AMP-activated protein kinase in mouse tissues
    Agnieszka Dobrzyn
    Department of Biochemistry, University of Wisconsin Madison, Madison, WI 53706, USA
    Biochem Biophys Res Commun 332:892-6. 2005
    Stearoyl-CoA desaturase 1 (SCD1) deficiency partitions fatty acids away from lipid synthesis towards fatty acid oxidation in liver and skeletal muscle in part due to activation of AMP-activated protein kinase (AMPK) pathway...
  88. ncbi beta-Adrenergic control of stearoyl-CoA desaturase 1 repression in relation to sympathoadrenal regulation of thermogenesis
    D Mainieri
    Department of Medicine Physiology, University of Fribourg, Fribourg, Switzerland
    Int J Obes (Lond) 31:378-81. 2007
    ..show diminished thermogenesis and high susceptibility to obesity, whereas mice lacking stearoyl-CoA desaturase 1 (SCD1), which catalyzes the synthesis of monounsaturated fatty acids, show enhanced thermogenesis and high resistance to ..
  89. ncbi GATA and Nkx factors synergistically regulate tissue-specific gene expression and development in vivo
    Yuzhen Zhang
    Department of Medicine and University of Pennsylvania, Philadelphia, PA 19104, USA
    Development 134:189-98. 2007
    ....
  90. ncbi Effects of phosphatidylethanol on mouse adipocyte differentiation and expression of stearoyl-CoA desaturase 1
    Tuija J Huusko
    Department of Internal Medicine, Clinical Research Center, University of Oulu, Oulu, Finland
    Alcohol Clin Exp Res 31:376-82. 2007
    ..In this study we tested whether lipoprotein-associated PEth affects stearoyl-CoA desaturase 1 (SCD1) which plays a major role in lipid-mediated signaling in the differentiation of adipocytes.
  91. ncbi Mouse models of psoriasis
    Johann E Gudjonsson
    Department of Dermatology, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
    J Invest Dermatol 127:1292-308. 2007
    ..In this review, we describe various animal models, detail the immunologic and intracellular pathways that mediate these phenotypes and assess the utility of these models to better understand this disease...
  92. pmc Absence of stearoyl-CoA desaturase-1 does not promote DSS-induced acute colitis
    Marcia L E MacDonald
    Centre for Molecular Medicine and Therapeutics, Department of Medical Genetics, University of British Columbia, BC, Canada V5Z 4H4
    Biochim Biophys Acta 1791:1166-72. 2009
    Absence of stearoyl-CoA desaturase-1 (SCD1) in mice leads to chronic inflammation of the skin and increased susceptibility to atherosclerosis, while also increasing plasma inflammatory markers...
  93. pmc Reduced levels of SCD1 accentuate palmitate-induced stress in insulin-producing β-cells
    Kristofer Thorn
    Department of Medical Cell Biology, Uppsala University, BMC Box 571, 75123 Uppsala, Sweden
    Lipids Health Dis 9:108. 2010
    Stearoyl-CoA desaturase 1 (SCD1) is an ER resident enzyme introducing a double-bond in saturated fatty acids...
  94. pmc Loss of stearoyl-CoA desaturase activity leads to free cholesterol synthesis through increased Xbp-1 splicing
    Chad M Paton
    Department of Biochemistry, University of Wisconsin, Madison, WI, USA
    Am J Physiol Endocrinol Metab 299:E1066-75. 2010
    Stearoyl-CoA desaturase-1 (SCD-1) is the rate-limiting enzyme in the biosynthesis of monounsaturated fatty acids (MUFA), which are required for efficient neutral lipid esterification...
  95. ncbi Chromosomal localization of the murine genes for the alpha- and beta-subunits of calcium/calmodulin-dependent protein kinase II
    M Danciger
    Jules Stein Eye Institute, UCLA School of Medicine 90024
    Mamm Genome 3:122-5. 1992
  96. ncbi Hereditary defect of the pilosebaceous unit in a new double mutant mouse
    A H Gates
    J Invest Dermatol 52:115-8. 1969
  97. ncbi Skin lipids of a normal and mutant (asebic) mouse strain
    D I Wilkinson
    J Invest Dermatol 47:449-55. 1966
  98. ncbi Defects of pelage hairs in 20 mouse mutations
    M E Hogan
    Jackson Laboratory, Bar Harbor, ME 04609 1500, USA
    J Invest Dermatol 104:31S-32S. 1995
  99. ncbi Nucleotide sequence of mouse spermidine synthase cDNA
    S Myöhänen
    Department of Biochemistry and Biotechnology, University of Kuopio, Finland
    DNA Seq 4:343-6. 1994
    ..The open reading frame encoded a polypeptide of 302 amino acids, displaying 95% similarity to human and 33% similarity to E. coli spermidine synthase. The 3' flanking region contained an unusual polyadenylation signal AATACA...
  100. ncbi Kidney and retinal defects (Krd), a transgene-induced mutation with a deletion of mouse chromosome 19 that includes the Pax2 locus
    S A Keller
    Department of Human Genetics, University of Michigan, Ann Arbor 48109 0618
    Genomics 23:309-20. 1994
    ..molecular data are consistent with an approximately 7-cM deletion that includes the loci stearoyl CoA desaturase (Scd1), pale ear (ep), D19Mit17, D19Mit24, D19Mit27, D19Mit11, and Pax2...
  101. ncbi Clofibrate treatment increases stearoyl-CoA desaturase mRNA level and enzyme activity in mouse liver
    U Diczfalusy
    Department of Medical Laboratory Sciences and Technology, Karolinska Institutet, Huddinge University Hospital, Sweden
    Biochim Biophys Acta 1259:313-6. 1995
    Stearoyl-CoA desaturase activity is encoded by two highly homologous genes, SCD1 and SCD2, which show tissue-specific expression and regulation...

Research Grants3

  1. Regulation of Apolipoprotein B Secretion
    ALAN ATTIE; Fiscal Year: 2006
    ..This will enable us to differentiate between an interaction with apoB early in the secretory pathway and an interaction that occurs after apoB secretion leading to re-uptake of the lipoprotein particles. ..
  2. 2006 Genes & Behavior Conference
    Robert Hitzemann; Fiscal Year: 2006
    ..We believe the second conference will be even more successful than the first. [unreadable] [unreadable] [unreadable]..
  3. Role of Stearoyl-CoA Desaturase in Metabolism
    James M Ntambi; Fiscal Year: 2010
    ..Studies in the previous grant application demonstrated that mice with a targeted disruption of SCD1 isoform (SCD1-/-) have reduced lipogenic gene expression, increased fatty acid oxidation and enhanced insulin ..