scavenger receptor

Summary

Gene Symbol: scavenger receptor
Description: macrophage scavenger receptor 1
Alias: MRS-A, MSR, MSR-A, SR-AI, SR-AII, Scara1, Scvr, macrophage scavenger receptor types I and II, SR-A, macrophage acetylated LDL receptor I and II, scavenger receptor type A
Species: mouse
Products:     scavenger receptor

Top Publications

  1. Jozefowski S, Kobzik L. Scavenger receptor A mediates H2O2 production and suppression of IL-12 release in murine macrophages. J Leukoc Biol. 2004;76:1066-74 pubmed
    Although class A type I/II scavenger receptor (SR-A) is involved in numerous macrophage functions, its signaling ability remains uncertain...
  2. Elomaa O, Kangas M, Sahlberg C, Tuukkanen J, Sormunen R, Liakka A, et al. Cloning of a novel bacteria-binding receptor structurally related to scavenger receptors and expressed in a subset of macrophages. Cell. 1995;80:603-9 pubmed
  3. Hughes D, Fraser I, Gordon S. Murine macrophage scavenger receptor: in vivo expression and function as receptor for macrophage adhesion in lymphoid and non-lymphoid organs. Eur J Immunol. 1995;25:466-73 pubmed
    ..In this study we have used a recently defined monoclonal antibody (2F8) which recognizes murine macrophage scavenger receptor, to explore its expression in lymphoid and non-lymphoid organs of the normal adult...
  4. Frenkel D, Wilkinson K, Zhao L, Hickman S, Means T, Puckett L, et al. Scara1 deficiency impairs clearance of soluble amyloid-? by mononuclear phagocytes and accelerates Alzheimer's-like disease progression. Nat Commun. 2013;4:2030 pubmed publisher
    ..Here we use short hairpin RNA screening and identify the scavenger receptor Scara1 as a receptor for soluble amyloid-? expressed on myeloid cells...
  5. Kuchibhotla S, Vanegas D, Kennedy D, Guy E, Nimako G, Morton R, et al. Absence of CD36 protects against atherosclerosis in ApoE knock-out mice with no additional protection provided by absence of scavenger receptor A I/II. Cardiovasc Res. 2008;78:185-96 pubmed
    ..in atherogenesis is controversial as a result of conflicting reports and a recent hypothesis suggesting that scavenger receptor absence would enhance the pro-inflammatory, pro-atherogenic milieu...
  6. Manning Tobin J, Moore K, Seimon T, Bell S, Sharuk M, Alvarez Leite J, et al. Loss of SR-A and CD36 activity reduces atherosclerotic lesion complexity without abrogating foam cell formation in hyperlipidemic mice. Arterioscler Thromb Vasc Biol. 2009;29:19-26 pubmed publisher
    ..These data suggest that targeted inhibition of these pathways in vivo may reduce lesional inflammation and promote plaque stability. ..
  7. Mukhopadhyay S, Varin A, Chen Y, Liu B, Tryggvason K, Gordon S. SR-A/MARCO-mediated ligand delivery enhances intracellular TLR and NLR function, but ligand scavenging from cell surface limits TLR4 response to pathogens. Blood. 2011;117:1319-28 pubmed publisher
    ..The class-A scavenger receptors SR-A (scavenger receptor A) and MARCO (macrophage receptor with collagenous structure) are 2 well-characterized phagocytic receptors ..
  8. Plüddemann A, Hoe J, Makepeace K, Moxon E, Gordon S. The macrophage scavenger receptor A is host-protective in experimental meningococcal septicaemia. PLoS Pathog. 2009;5:e1000297 pubmed publisher
    Macrophage Scavenger Receptor A (SR-A) is a major non-opsonic receptor for Neisseria meningitidis on mononuclear phagocytes in vitro, and the surface proteins NMB0278, NMB0667, and NMB1220 have been identified as ligands for SR-A...
  9. Thomas C, Li Y, Kodama T, Suzuki H, Silverstein S, El Khoury J. Protection from lethal gram-positive infection by macrophage scavenger receptor-dependent phagocytosis. J Exp Med. 2000;191:147-56 pubmed
    ..Here, we show that SR-AI/II-deficient mice (MSR-A(-/-)) are more susceptible to intraperitoneal infection with a prototypic gram-positive pathogen, Staphylococcus ..

More Information

Publications75

  1. Peiser L, Makepeace K, Plüddemann A, Savino S, Wright J, Pizza M, et al. Identification of Neisseria meningitidis nonlipopolysaccharide ligands for class A macrophage scavenger receptor by using a novel assay. Infect Immun. 2006;74:5191-9 pubmed
    ..Previously, we have shown that the class A Mphi scavenger receptor (SR-A) is a major nonopsonic receptor for Neisseria meningitidis on Mphi...
  2. Bieghs V, Wouters K, van Gorp P, Gijbels M, de Winther M, Binder C, et al. Role of scavenger receptor A and CD36 in diet-induced nonalcoholic steatohepatitis in hyperlipidemic mice. Gastroenterology. 2010;138:2477-86, 2486.e1-3 pubmed publisher
    ..Scavenging of modified lipoproteins mainly depends on CD36 and macrophage scavenger receptor 1...
  3. Raycroft M, Harvey B, Bruck M, Mamula M. Inhibition of antigen trafficking through scavenger receptor A. J Biol Chem. 2012;287:5310-6 pubmed publisher
    ..We previously identified scavenger receptor A (SR-A) as an early target in altering B cell-mediated autoimmunity...
  4. Bieghs V, Verheyen F, van Gorp P, Hendrikx T, Wouters K, Lutjohann D, et al. Internalization of modified lipids by CD36 and SR-A leads to hepatic inflammation and lysosomal cholesterol storage in Kupffer cells. PLoS ONE. 2012;7:e34378 pubmed publisher
    ..Recently, we demonstrated that combined deletion of the two main scavenger receptors, CD36 and macrophage scavenger receptor 1 (MSR1), which are important for modified cholesterol-rich lipoprotein uptake, reduced NASH...
  5. Becker M, Cotena A, Gordon S, Platt N. Expression of the class A macrophage scavenger receptor on specific subpopulations of murine dendritic cells limits their endotoxin response. Eur J Immunol. 2006;36:950-60 pubmed
    ..Here, we describe the expression of the murine class A macrophage scavenger receptor (SR-A) and show that it is restricted to specific subpopulations of bone marrow-derived and splenic DC...
  6. Amiel E, Alonso A, Uematsu S, Akira S, Poynter M, Berwin B. Pivotal Advance: Toll-like receptor regulation of scavenger receptor-A-mediated phagocytosis. J Leukoc Biol. 2009;85:595-605 pubmed publisher
  7. Suzuki H, Kurihara Y, Takeya M, Kamada N, Kataoka M, Jishage K, et al. A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infection. Nature. 1997;386:292-6 pubmed
    Macrophage type-I and type-II class-A scavenger receptors (MSR-A) are implicated in the pathological deposition of cholesterol during atherogenesis as a result of receptor-mediated uptake of modified low-density lipoproteins (mLDL)...
  8. Guest C, Hartman M, O Connor J, Chakour K, Sovari A, Freund G. Phagocytosis of cholesteryl ester is amplified in diabetic mouse macrophages and is largely mediated by CD36 and SR-A. PLoS ONE. 2007;2:e511 pubmed
    ..these data indicate that direct cholesteryl ester accumulation in mouse macrophages is mediated by CD36 and SR-A, and the magnitude of accumulation is increased in db/db macrophages due to increased scavenger receptor expression.
  9. Chen Y, Pikkarainen T, Elomaa O, Soininen R, Kodama T, Kraal G, et al. Defective microarchitecture of the spleen marginal zone and impaired response to a thymus-independent type 2 antigen in mice lacking scavenger receptors MARCO and SR-A. J Immunol. 2005;175:8173-80 pubmed
    The macrophage scavenger receptor macrophage receptor with a collagenous structure (MARCO) is expressed in mice by the marginal zone macrophages of the spleen and by macrophages of the medullary cords of lymph nodes, as well as the ..
  10. Jozefowski S, Arredouani M, Sulahian T, Kobzik L. Disparate regulation and function of the class A scavenger receptors SR-AI/II and MARCO. J Immunol. 2005;175:8032-41 pubmed
    ..class A scavenger receptors, macrophage receptor with a collagenous structure (MARCO) and type I/II class A scavenger receptor (SR-AI/II), share structural features and roles in host defense, but little is known about their regulation ..
  11. Kobayashi Y, Miyaji C, Watanabe H, Umezu H, Hasegawa G, Abo T, et al. Role of macrophage scavenger receptor in endotoxin shock. J Pathol. 2000;192:263-72 pubmed
    Lipopolysaccharide (LPS) is known to bind to several receptors on macrophages, including CD14 and macrophage scavenger receptor class A types I and II (MSR-A), and stimulates macrophages to release various inflammatory mediators...
  12. Ono K, Nishitani C, Mitsuzawa H, Shimizu T, Sano H, Suzuki H, et al. Mannose-binding lectin augments the uptake of lipid A, Staphylococcus aureus, and Escherichia coli by Kupffer cells through increased cell surface expression of scavenger receptor A. J Immunol. 2006;177:5517-23 pubmed
    We investigated roles of scavenger receptor A (SR-A) and mannose-binding lectin (MBL) in the uptake of endotoxin and bacteria by Kupffer cells...
  13. Cotena A, Gordon S, Platt N. The class A macrophage scavenger receptor attenuates CXC chemokine production and the early infiltration of neutrophils in sterile peritonitis. J Immunol. 2004;173:6427-32 pubmed
    The macrophage scavenger receptor (SR-A) is a multifunctional receptor that is associated with several important pathological conditions, including atherosclerosis...
  14. Hollifield M, Bou Ghanem E, de Villiers W, Garvy B. Scavenger receptor A dampens induction of inflammation in response to the fungal pathogen Pneumocystis carinii. Infect Immun. 2007;75:3999-4005 pubmed
    ..carinii, mice deficient in the expression of scavenger receptor A (SRA) were infected with P. carinii, and clearance of organisms was monitored over time...
  15. Yi H, Yu X, Gao P, Wang Y, Baek S, Chen X, et al. Pattern recognition scavenger receptor SRA/CD204 down-regulates Toll-like receptor 4 signaling-dependent CD8 T-cell activation. Blood. 2009;113:5819-28 pubmed publisher
    Class A scavenger receptor (SRA), also known as CD204, has been shown to participate in the pathogenesis of atherosclerosis and the pattern recognition of pathogen infection...
  16. Dahl M, Bauer A, Arredouani M, Soininen R, Tryggvason K, Kleeberger S, et al. Protection against inhaled oxidants through scavenging of oxidized lipids by macrophage receptors MARCO and SR-AI/II. J Clin Invest. 2007;117:757-64 pubmed
    ..express the class A scavenger receptors (SRAs) macrophage receptor with collagenous structure (MARCO) and scavenger receptor AI/II (SRA-I/II), which recognize oxidized lipids and provide innate defense against inhaled pathogens and ..
  17. Freeman M, Ashkenas J, Rees D, Kingsley D, Copeland N, Jenkins N, et al. An ancient, highly conserved family of cysteine-rich protein domains revealed by cloning type I and type II murine macrophage scavenger receptors. Proc Natl Acad Sci U S A. 1990;87:8810-4 pubmed
    ..The type I-specific scavenger receptor cysteine-rich (SRCR) domain helps define a previously unrecognized family of remarkably well-conserved ..
  18. Tsujita K, Kaikita K, Hayasaki T, Honda T, Kobayashi H, Sakashita N, et al. Targeted deletion of class A macrophage scavenger receptor increases the risk of cardiac rupture after experimental myocardial infarction. Circulation. 2007;115:1904-11 pubmed
    Class A macrophage scavenger receptor (SR-A) is a macrophage-restricted multifunctional molecule that optimizes the inflammatory response by modulation of the activity of inflammatory cytokines...
  19. Brown J, Swindle E, Kushnir Sukhov N, Holian A, Metcalfe D. Silica-directed mast cell activation is enhanced by scavenger receptors. Am J Respir Cell Mol Biol. 2007;36:43-52 pubmed
    ..These findings demonstrate that silica directs mast cell production of inflammatory mediators, in part through SRs, providing insight into critical events in the pathogenesis and potential therapeutic targets in silicosis. ..
  20. Mäkinen P, Lappalainen J, Heinonen S, Leppänen P, Lähteenvuo M, Aarnio J, et al. Silencing of either SR-A or CD36 reduces atherosclerosis in hyperlipidaemic mice and reveals reciprocal upregulation of these receptors. Cardiovasc Res. 2010;88:530-8 pubmed publisher
    Macrophage scavenger receptor A (SR-A) and class B scavenger receptor CD36 (CD36) contribute to foam cell formation and atherogenesis via uptake of modified lipoproteins...
  21. Nicoletti A, Caligiuri G, Törnberg I, Kodama T, Stemme S, Hansson G. The macrophage scavenger receptor type A directs modified proteins to antigen presentation. Eur J Immunol. 1999;29:512-21 pubmed
    ..They were recently proposed to play a role in antigen presentation but the type of scavenger receptor involved in this process has not been known...
  22. Fraser I, Hughes D, Gordon S. Divalent cation-independent macrophage adhesion inhibited by monoclonal antibody to murine scavenger receptor. Nature. 1993;364:343-6 pubmed
    ..hamster ovary cells revealed that the antigen recognized by monoclonal 2F8 is identical to murine macrophage scavenger receptor. We propose a novel function for this molecule, previously described as an endocytic receptor, thus ..
  23. Kamada N, Kodama T, Suzuki H. Macrophage scavenger receptor (SR-A I/II) deficiency reduced diet-induced atherosclerosis in C57BL/6J mice. J Atheroscler Thromb. 2001;8:1-6 pubmed
    ..These results indicate that SR-A I/II has a crucial role in atherosclerotic lesion formation with uptake of oxidized-LDL in this mouse model. ..
  24. Yu X, Yi H, Guo C, Zuo D, Wang Y, Kim H, et al. Pattern recognition scavenger receptor CD204 attenuates Toll-like receptor 4-induced NF-kappaB activation by directly inhibiting ubiquitination of tumor necrosis factor (TNF) receptor-associated factor 6. J Biol Chem. 2011;286:18795-806 pubmed publisher
    ..Here we report a previously unrecognized role of scavenger receptor A (SRA; also known as CD204) as a signaling regulator in the context of Toll-like receptor 4 (TLR4) ..
  25. DeVries Seimon T, Li Y, Yao P, Stone E, Wang Y, Davis R, et al. Cholesterol-induced macrophage apoptosis requires ER stress pathways and engagement of the type A scavenger receptor. J Cell Biol. 2005;171:61-73 pubmed
    ..One involves the type A scavenger receptor (SRA)...
  26. Haworth R, Platt N, Keshav S, Hughes D, Darley E, Suzuki H, et al. The macrophage scavenger receptor type A is expressed by activated macrophages and protects the host against lethal endotoxic shock. J Exp Med. 1997;186:1431-9 pubmed
    ..Several different receptors on Mphi have been shown to bind LPS, including the type A scavenger receptor (SR-A)...
  27. Haasken S, Auger J, Taylor J, Hobday P, Goudy B, Titcombe P, et al. Macrophage scavenger receptor 1 (Msr1, SR-A) influences B cell autoimmunity by regulating soluble autoantigen concentration. J Immunol. 2013;191:1055-62 pubmed publisher
    The class A macrophage scavenger receptor Msr1 (SR-A, CD204) has been reported to participate in the maintenance of immunological tolerance. We investigated the role of Msr1 in a mouse model of autoantibody-dependent arthritis...
  28. Levy Barazany H, Frenkel D. Expression of scavenger receptor A on antigen presenting cells is important for CD4+ T-cells proliferation in EAE mouse model. J Neuroinflammation. 2012;9:120 pubmed publisher
    ..One of the key effectors for inflammatory injury is the antigen-presenting cell (APC). The class A scavenger receptor (SRA), constitutively expressed by APCs, such as macrophages and dendritic cells in peripheral tissues and ..
  29. Seimon T, Obstfeld A, Moore K, Golenbock D, Tabas I. Combinatorial pattern recognition receptor signaling alters the balance of life and death in macrophages. Proc Natl Acad Sci U S A. 2006;103:19794-9 pubmed
    ..We recently showed that engagement of the type A scavenger receptor (SRA), a PRR, triggers JNK-dependent apoptosis in endoplasmic reticulum (ER)-stressed macrophages...
  30. Takemura K, Sakashita N, Fujiwara Y, Komohara Y, Lei X, Ohnishi K, et al. Class A scavenger receptor promotes osteoclast differentiation via the enhanced expression of receptor activator of NF-kappaB (RANK). Biochem Biophys Res Commun. 2010;391:1675-80 pubmed publisher
    ..Class A scavenger receptor (SR-A) is one of the principal functional molecules of macrophages, and its level of expression declines ..
  31. Inoue M, Xuan X, Fujisaki K, Igarashi I, Suzuki H. Short report: role of type I/II scavenger receptors in malarial infection in C57BL/6J mice. Am J Trop Med Hyg. 2006;75:178-81 pubmed
  32. Ozeki Y, Tsutsui H, Kawada N, Suzuki H, Kataoka M, Kodama T, et al. Macrophage scavenger receptor down-regulates mycobacterial cord factor-induced proinflammatory cytokine production by alveolar and hepatic macrophages. Microb Pathog. 2006;40:171-6 pubmed
    We aimed to reveal the regulatory function of macrophage scavenger receptor-A (MSR-A) in proinflammatory cytokine production by macrophages stimulated with mycobacterial cord factor (CF)...
  33. Ricci R, Sumara G, Sumara I, Rozenberg I, Kurrer M, Akhmedov A, et al. Requirement of JNK2 for scavenger receptor A-mediated foam cell formation in atherogenesis. Science. 2004;306:1558-61 pubmed
    ..of modified lipoproteins and showed increased amounts of the modified lipoprotein-binding and -internalizing scavenger receptor A (SR-A), whose phosphorylation was markedly decreased...
  34. Kobayashi H, Sakashita N, Okuma T, Terasaki Y, Tsujita K, Suzuki H, et al. Class A scavenger receptor (CD204) attenuates hyperoxia-induced lung injury by reducing oxidative stress. J Pathol. 2007;212:38-46 pubmed
    ..Together these results suggest that SR-A expression attenuates hyperoxia-induced lung injury by reducing macrophage activation. ..
  35. Todt J, Hu B, Curtis J. The scavenger receptor SR-A I/II (CD204) signals via the receptor tyrosine kinase Mertk during apoptotic cell uptake by murine macrophages. J Leukoc Biol. 2008;84:510-8 pubmed publisher
    Apoptotic cells (AC) must be cleared by macrophages (Mø) to resolve inflammation effectively. Mertk and scavenger receptor A (SR-A) are two of many receptors involved in AC clearance...
  36. Peiser L, de Winther M, Makepeace K, Hollinshead M, Coull P, Plested J, et al. The class A macrophage scavenger receptor is a major pattern recognition receptor for Neisseria meningitidis which is independent of lipopolysaccharide and not required for secretory responses. Infect Immun. 2002;70:5346-54 pubmed
    ..The roles of two pattern recognition molecules, the Mphi scavenger receptor (SR-A) and Toll-like receptor 4 (TLR-4), have been investigated using bone marrow culture-derived Mphi (..
  37. Usui H, Shikata K, Sasaki M, Okada S, Matsuda M, Shikata Y, et al. Macrophage scavenger receptor-a-deficient mice are resistant against diabetic nephropathy through amelioration of microinflammation. Diabetes. 2007;56:363-72 pubmed
    ..Macrophage scavenger receptor-A (SR-A) is a multifunctional receptor expressed on macrophages...
  38. Chen Y, Wermeling F, Sundqvist J, Jonsson A, Tryggvason K, Pikkarainen T, et al. A regulatory role for macrophage class A scavenger receptors in TLR4-mediated LPS responses. Eur J Immunol. 2010;40:1451-60 pubmed publisher
    ..This regulation could also be important in maintaining tolerance since these receptors have been shown to be involved in regulation of self-reactivity. ..
  39. Arredouani M, Yang Z, Imrich A, Ning Y, Qin G, Kobzik L. The macrophage scavenger receptor SR-AI/II and lung defense against pneumococci and particles. Am J Respir Cell Mol Biol. 2006;35:474-8 pubmed
    The class A macrophage scavenger receptor SR-AI/II is implicated as a pattern recognition receptor for innate immunity, but its functional role in lung defense has not been studied...
  40. Zhu X, Zhuang Y, Ben J, Qian L, Huang H, Bai H, et al. Caveolae-dependent endocytosis is required for class A macrophage scavenger receptor-mediated apoptosis in macrophages. J Biol Chem. 2011;286:8231-9 pubmed publisher
    SR-A (class A macrophage scavenger receptor) is a transmembrane receptor that can bind many different ligands, including modified lipoproteins that are relevant to the development of vascular diseases...
  41. Wang M, Kiss R, Franklin V, McBride H, Whitman S, Marcel Y. Different cellular traffic of LDL-cholesterol and acetylated LDL-cholesterol leads to distinct reverse cholesterol transport pathways. J Lipid Res. 2007;48:633-45 pubmed
    ..This indicates a greater efficiency of HDL than lipid-poor apoA-I in interstitial fluid in controlling in vivo RCT. These assays, taken together, emphasize the importance of mediators of diffusional cholesterol efflux in RCT...
  42. Ozment T, Ha T, Breuel K, Ford T, Ferguson D, Kalbfleisch J, et al. Scavenger receptor class a plays a central role in mediating mortality and the development of the pro-inflammatory phenotype in polymicrobial sepsis. PLoS Pathog. 2012;8:e1002967 pubmed publisher
    ..The mechanisms that are involved in initiation and propagation of the disease are not well understood. Scavenger receptor A (SRA) is a membrane receptor that binds multiple polyanions such as oxidized LDL and endotoxin...
  43. Ganesan S, Faris A, Comstock A, Sonstein J, Curtis J, Sajjan U. Elastase/LPS-exposed mice exhibit impaired innate immune responses to bacterial challenge: role of scavenger receptor A. Am J Pathol. 2012;180:61-72 pubmed publisher
    ..bacterial phagocytosis, reduced expression of MARCO and of mannose receptor, and absent expression of scavenger receptor-A (SR-A). Neutralization of SR-A significantly decreased phagocytosis of NTHi by normal alveolar macrophages...
  44. Peruń A, Biedroń R, Konopinski M, Białecka A, Marcinkiewicz J, Jozefowski S. Phagocytosis of live versus killed or fluorescently labeled bacteria by macrophages differ in both magnitude and receptor specificity. Immunol Cell Biol. 2017;95:424-435 pubmed publisher
    b>Scavenger receptor (SR)-mediated opsonin-independent phagocytosis of bacteria by macrophages has been suggested to represent an important, early mechanism of anti-bacterial host defense...
  45. Varin A, Mukhopadhyay S, Herbein G, Gordon S. Alternative activation of macrophages by IL-4 impairs phagocytosis of pathogens but potentiates microbial-induced signalling and cytokine secretion. Blood. 2010;115:353-62 pubmed publisher
    ..uptake of N meningitidis was markedly reduced, depending on the common IL-4Ralpha chain, but independent of Scavenger receptor A and macrophage receptor with collagenous structure (MARCO), 2 known receptors for N meningitidis...
  46. Daugherty A, Whitman S, Block A, Rateri D. Polymorphism of class A scavenger receptors in C57BL/6 mice. J Lipid Res. 2000;41:1568-77 pubmed
    ..Differing reactivities toward a commonly used monoclonal antibody were used to identify polymorphism of SR-A in C57BL/6 mice. ..
  47. Vadali S, Post S. Lipid rafts couple class A scavenger receptors to phospholipase A2 activation during macrophage adhesion. J Leukoc Biol. 2014;96:873-81 pubmed publisher
    ..Overall, our results demonstrate an important role for LRs in selectively coupling SR-A with PLA2 activation during macrophage adhesion. ..
  48. Chen Y, Sullivan C, Peng C, Shan Y, Hu Y, Li D, et al. A tumor suppressor function of the Msr1 gene in leukemia stem cells of chronic myeloid leukemia. Blood. 2011;118:390-400 pubmed publisher
    ..Together, these results demonstrate that Msr1 suppresses LSCs and CML development. The enhancement of the tumor suppressor function of Msr1 may be of significance in the development of novel therapeutic strategies for CML. ..
  49. Shirato K, Kizaki T, Sakurai T, Ogasawara J, Ishibashi Y, Iijima T, et al. Hypoxia-inducible factor-1alpha suppresses the expression of macrophage scavenger receptor 1. Pflugers Arch. 2009;459:93-103 pubmed publisher
    ..immune defenses against bacterial infection by phagocytosis of bacterial pathogens through the macrophage scavenger receptor 1 (MSR1)...
  50. Sever Chroneos Z, Tvinnereim A, Hunter R, Chroneos Z. Prolonged survival of scavenger receptor class A-deficient mice from pulmonary Mycobacterium tuberculosis infection. Tuberculosis (Edinb). 2011;91 Suppl 1:S69-74 pubmed publisher
    The present study tested the hypothesis that the scavenger receptor SR-A modulates granuloma formation in response to pulmonary infection with Mycobacterium tuberculosis (MTB)...
  51. Platt N, Suzuki H, Kodama T, Gordon S. Apoptotic thymocyte clearance in scavenger receptor class A-deficient mice is apparently normal. J Immunol. 2000;164:4861-7 pubmed
    ..Previously, we have shown by the use of a blocking mAb against the class A scavenger receptor (SR-A) and thymic macrophages prepared from SR-A null mice, that this receptor is responsible for ..
  52. Makranz C, Cohen G, Baron A, Levidor L, Kodama T, Reichert F, et al. Phosphatidylinositol 3-kinase, phosphoinositide-specific phospholipase-Cgamma and protein kinase-C signal myelin phagocytosis mediated by complement receptor-3 alone and combined with scavenger receptor-AI/II in macrophages. Neurobiol Dis. 2004;15:279-86 pubmed
    ..This pathway may thus be targeted for in vivo modulation, which may explain differences in the efficiency of CR3/MAC-1-mediated myelin phagocytosis in different pathological conditions. ..
  53. Domingo Gonzalez R, Katz S, Serezani C, Moore T, LeVine A, Moore B. Prostaglandin E2-induced changes in alveolar macrophage scavenger receptor profiles differentially alter phagocytosis of Pseudomonas aeruginosa and Staphylococcus aureus post-bone marrow transplant. J Immunol. 2013;190:5809-17 pubmed publisher
    ..We hypothesized that the difference in phagocytosis was due to an altered scavenger receptor (SR) profile. Interestingly, MARCO expression was decreased, whereas SR-AI/II was increased...
  54. Qian L, Zong G, Ma K, Zhu X, Zhang H, Li N, et al. Class A scavenger receptor promotes cerebral ischemic injury by pivoting microglia/macrophage polarization. Neuroscience. 2012;218:35-48 pubmed publisher
    Class A scavenger receptor (SR-A) is primarily expressed in microglia/macrophages and plays an important role in immune responses...
  55. Qian L, Li X, Fang R, Wang Z, Xu Y, Zhang H, et al. Class A scavenger receptor deficiency augments angiotensin II-induced vascular remodeling. Biochem Pharmacol. 2014;90:254-64 pubmed publisher
    Class A scavenger receptor (SR-A) is a multifunctional molecule that participates in macrophage-mediated inflammation. Here we evaluated the role of SR-A in angiotensin II (Ang II)-induced hypertensive vascular remodeling...
  56. Drummond R, Cauvi D, Hawisher D, Song D, Nino D, Coimbra R, et al. Deletion of scavenger receptor A gene in mice resulted in protection from septic shock and modulation of TLR4 signaling in isolated peritoneal macrophages. Innate Immun. 2013;19:30-41 pubmed publisher
    b>Scavenger receptor A (Sra), also known as macrophage scavenger receptor 1 (Msr1), is a surface glycoprotein preferentially present in macrophages that plays a primary role in innate immunity...
  57. Kabamoto S, Bhagat N, Suzuki H, You M, Kamio T, Tsuji N, et al. Comparison of macrophage scavenger receptor-A knockout mice with wild type ones in the immune response against repeated infestation with Haemaphysalis longicornis. J Vet Med Sci. 2002;64:355-9 pubmed
    Using macrophage scavenger receptor-A knockout (SRKO) mice, we examined the role of macrophage class A scavenger receptors (MRS-A) on the immune response and acquisition of host resistance against repeated infestation with Haemaphysalis ..
  58. Husemann J, Loike J, Kodama T, Silverstein S. Scavenger receptor class B type I (SR-BI) mediates adhesion of neonatal murine microglia to fibrillar beta-amyloid. J Neuroimmunol. 2001;114:142-50 pubmed
    ..Thus SR-BI and SR-A mediate similar effector functions in neonatal microglia, which suggests that SR-BI plays as important a role as SR-A, and can maintain the wildtype phenotype in SR-A-/- microglia. ..
  59. Tao J, Liu C, Yang J, Xie Z, Ma M, Li X, et al. ClC-3 deficiency prevents atherosclerotic lesion development in ApoE-/- mice. J Mol Cell Cardiol. 2015;87:237-47 pubmed publisher
    ..Moreover, the expression of scavenger receptor SR-A, but not CD36, was significantly decreased in both ClC-3(-/-) peritoneal macrophages and aortic lesions ..
  60. Wang Z, DiDonato J, Buffa J, Comhair S, Aronica M, Dweik R, et al. Eosinophil Peroxidase Catalyzed Protein Carbamylation Participates in Asthma. J Biol Chem. 2016;291:22118-22135 pubmed
    ..Studies with scavenger receptor-A1 null mice reveal reduced IL-13 generation following exposure to aerosolized carbamylated protein, but no ..
  61. Czerkies M, Borzęcka K, Zdioruk M, Płóciennikowska A, Sobota A, Kwiatkowska K. An interplay between scavenger receptor A and CD14 during activation of J774 cells by high concentrations of LPS. Immunobiology. 2013;218:1217-26 pubmed publisher
    ..The binding and internalization of high amounts of LPS was mediated by scavenger receptor A (SR-A) with participation of CD14 without an engagement of TLR4...
  62. Leyva F, Pershouse M, Holian A. Modified low density lipoproteins binding requires a lysine cluster region in the murine macrophage scavenger receptor class A type II. Mol Biol Rep. 2010;37:2847-52 pubmed publisher
    Atherosclerosis is a consequence of lipid deposition and foam cell formation in the arterial wall. Macrophage scavenger receptor A II is involved in the uptake of modified low density lipoproteins...
  63. Court N, Vasseur V, Vacher R, Fremond C, Shebzukhov Y, Yeremeev V, et al. Partial redundancy of the pattern recognition receptors, scavenger receptors, and C-type lectins for the long-term control of Mycobacterium tuberculosis infection. J Immunol. 2010;184:7057-70 pubmed publisher
    ..tuberculosis infection, in sharp contrast with the nonredundant, essential role of the TNF, IL-1, or IFN-gamma pathway for host resistance to M. tuberculosis. ..
  64. de Winther M, Gijbels M, van Dijk K, van Gorp P, Suzuki H, Kodama T, et al. Scavenger receptor deficiency leads to more complex atherosclerotic lesions in APOE3Leiden transgenic mice. Atherosclerosis. 1999;144:315-21 pubmed
    ..To investigate the role of the macrophage scavenger receptor type I and II (MSR-A) in this process, APOE3Leiden transgenic mice were crossed onto a MSR-A deficient ..
  65. Chicheportiche Y, Vassalli P. Cloning and expression of a mouse macrophage cDNA coding for a membrane glycoprotein of the scavenger receptor cysteine-rich domain family. J Biol Chem. 1994;269:5512-7 pubmed
    We have cloned from murine macrophages a cDNA coding for a new protein of the scavenger receptor family whose mRNA is increased very strongly by adherence and moderately by exposure to tumor necrosis factor and interferon-gamma...
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