Sca-1

Summary

Gene Symbol: Sca-1
Description: lymphocyte antigen 6 complex, locus A
Alias: Ly-6A.2, Ly-6A/E, Ly-6E.1, Sca-1, Sca1, TAP, lymphocyte antigen 6A-2/6E-1, T-cell-activating protein, stem cell antigen 1
Species: mouse
Products:     Sca-1

Top Publications

  1. Welm B, Tepera S, Venezia T, Graubert T, Rosen J, Goodell M. Sca-1(pos) cells in the mouse mammary gland represent an enriched progenitor cell population. Dev Biol. 2002;245:42-56 pubmed
  2. Ito C, Li C, Bernstein A, Dick J, Stanford W. Hematopoietic stem cell and progenitor defects in Sca-1/Ly-6A-null mice. Blood. 2003;101:517-23 pubmed
    ..Thus, our studies conclusively demonstrate that Sca-1, in addition to being a marker of HSCs, regulates the developmental program of HSCs and specific progenitor populations. ..
  3. Mizobe T, Kidoguchi K, Tamaki M, Sasayama T, Kondoh T, Kohmura E. Sca-1 and Thy-1 accelerate neuron-like differentiation in bone marrow stromal cells. Kobe J Med Sci. 2006;52:119-25 pubmed
    ..Neuron-like differentiation of bone marrow cells can be enhanced by selection using cell surface proteins. ..
  4. Grange C, Lanzardo S, Cavallo F, Camussi G, Bussolati B. Sca-1 identifies the tumor-initiating cells in mammary tumors of BALB-neuT transgenic mice. Neoplasia. 2008;10:1433-43 pubmed
    ..The data of the present study indicate that a Sca-1(+) population derived from mammary BALB-neuT tumors is responsible for sphere generation in culture and for initiating tumors in vivo...
  5. Stanford W, Bruyns E, Snodgrass H. The isolation and sequence of the chromosomal gene and regulatory regions of Ly-6A.2. Immunogenetics. 1992;35:408-11 pubmed
  6. Holmes C, Khan T, Owen C, Ciliberti N, Grynpas M, Stanford W. Longitudinal analysis of mesenchymal progenitors and bone quality in the stem cell antigen-1-null osteoporotic mouse. J Bone Miner Res. 2007;22:1373-86 pubmed
    ..We previously showed that stem cell antigen 1 (Sca-1)-null mice undergo normal bone development but exhibit significantly decreased bone mass ..
  7. Mitchell P, Mills T, O Connor R, Kline E, Graubert T, Dzierzak E, et al. Sca-1 negatively regulates proliferation and differentiation of muscle cells. Dev Biol. 2005;283:240-52 pubmed
    ..These studies reveal a novel system that reversibly modulates the myogenic behavior of myoblasts. These studies provide evidence that, rather than being a fixed property, myoblast heterogeneity can be modulated by the microenvironment. ..
  8. Lee S, Su B, Maher S, Bothwell A. Ly-6A is required for T cell receptor expression and protein tyrosine kinase fyn activity. EMBO J. 1994;13:2167-76 pubmed
    ..These data demonstrate that Ly-6A may regulate TCR expression and may be involved in early events of T cell activation via regulation of fyn tyrosine kinase activity. ..
  9. Kim R, Kim S, Roh K, Park S, Park J, Kang K, et al. Ras activation contributes to the maintenance and expansion of Sca-1pos cells in a mouse model of breast cancer. Cancer Lett. 2010;287:172-81 pubmed publisher
    ..The Ras farnesylation inhibitor (FTI-277) suppressed the maintenance and expansion of CSCs. Therefore, selective inhibition of Ras activation may be useful for stem-specific cancer therapy. ..

More Information

Publications93

  1. Brachvogel B, Moch H, Pausch F, Schlötzer Schrehardt U, Hofmann C, Hallmann R, et al. Perivascular cells expressing annexin A5 define a novel mesenchymal stem cell-like population with the capacity to differentiate into multiple mesenchymal lineages. Development. 2005;132:2657-68 pubmed
    ..Hence, Anxa5 expression in perivascular cells from mouse defines a novel population of cells with a distinct developmental potential. ..
  2. Epting C, Lopez J, Shen X, Liu L, Bristow J, Bernstein H. Stem cell antigen-1 is necessary for cell-cycle withdrawal and myoblast differentiation in C2C12 cells. J Cell Sci. 2004;117:6185-95 pubmed
    ..These findings suggest that, beyond its role as a marker for muscle progenitors, Sca-1 may be an important therapeutic target for promoting muscle regeneration. ..
  3. Matsuura K, Nagai T, Nishigaki N, Oyama T, Nishi J, Wada H, et al. Adult cardiac Sca-1-positive cells differentiate into beating cardiomyocytes. J Biol Chem. 2004;279:11384-91 pubmed
    ..These results suggest that Sca-1+ cells in the adult murine heart have potential as stem cells and may contribute to the regeneration of injured hearts. ..
  4. Stanford W, Haque S, Alexander R, Liu X, Latour A, Snodgrass H, et al. Altered proliferative response by T lymphocytes of Ly-6A (Sca-1) null mice. J Exp Med. 1997;186:705-17 pubmed
    ..Moreover, T cells from Ly-6A-deficient animals exhibit a prolonged proliferative response to antigen stimulation, thereby suggesting that Ly-6A acts to downmodulate lymphocyte responses. ..
  5. Epting C, King F, Pedersen A, Zaman J, Ritner C, Bernstein H. Stem cell antigen-1 localizes to lipid microdomains and associates with insulin degrading enzyme in skeletal myoblasts. J Cell Physiol. 2008;217:250-60 pubmed publisher
    ..Future efforts to manipulate this pathway may lead to new strategies for augmenting the myogenic proliferative response, and ultimately muscle repair...
  6. Kafadar K, Yi L, Ahmad Y, So L, Rossi F, Pavlath G. Sca-1 expression is required for efficient remodeling of the extracellular matrix during skeletal muscle regeneration. Dev Biol. 2009;326:47-59 pubmed publisher
    ..Further elucidation of the role of Sca-1 in matrix remodeling may aid in the development of novel therapeutic strategies for the treatment of fibrotic diseases. ..
  7. LeClair K, Palfree R, Flood P, Hammerling U, Bothwell A. Isolation of a murine Ly-6 cDNA reveals a new multigene family. EMBO J. 1986;5:3227-34 pubmed
    ..Isolation of Ly-6 genomic clones may promote a further understanding of the complex tissue-specific expression patterns characteristic of Ly-6-linked genes. ..
  8. Bamezai A, Rock K. Overexpressed Ly-6A.2 mediates cell-cell adhesion by binding a ligand expressed on lymphoid cells. Proc Natl Acad Sci U S A. 1995;92:4294-8 pubmed
    ..2 binds a ligand that is expressed on thymocytes. Tg+ thymocytes also bind to nontransgenic thymocytes, B cells, and T cells, indicating that normal cells naturally express the Ly-6A.2 ligand. ..
  9. Luna G, Paez J, Cardier J. Expression of the hematopoietic stem cell antigen Sca-1 (LY-6A/E) in liver sinusoidal endothelial cells: possible function of Sca-1 in endothelial cells. Stem Cells Dev. 2004;13:528-35 pubmed
    ..These results suggest that Sca-1 may participate in several clinical conditions such as angiogenesis and inflammation. ..
  10. Tillman B, Kelly J, Richards T, Chen A, Donnenberg A, Donnenberg V, et al. A depleting antibody toward sca-1 mitigates a surge of CD34(+)/c-kit(+) progenitors and reduces vascular restenosis in a murine vascular injury model. J Vasc Surg. 2016;64:1084-92 pubmed publisher
    ..This suggests that circulating progenitors play an active role in restenotic disease. ..
  11. Zhang P, Nelson S, Bagby G, Siggins R, Shellito J, Welsh D. The lineage-c-Kit+Sca-1+ cell response to Escherichia coli bacteremia in Balb/c mice. Stem Cells. 2008;26:1778-86 pubmed publisher
    ..Functional modifications of these primitive hematopoietic precursors are critical for enhancing granulocyte production following bacterial infection. ..
  12. Kwon O, Zhang L, Xin L. Stem Cell Antigen-1 Identifies a Distinct Androgen-Independent Murine Prostatic Luminal Cell Lineage with Bipotent Potential. Stem Cells. 2016;34:191-202 pubmed publisher
    ..These cells may represent a putative luminal progenitor population and serve as a cellular origin for castration resistant prostate cancer. ..
  13. Valorani M, Germani A, Otto W, Harper L, Biddle A, Khoo C, et al. Hypoxia increases Sca-1/CD44 co-expression in murine mesenchymal stem cells and enhances their adipogenic differentiation potential. Cell Tissue Res. 2010;341:111-20 pubmed publisher
    ..In conclusion, pre-culturing MSCs under hypoxic culture conditions may represent a strategy to enhance MSC production, enrichment and adipogenic differentiation. ..
  14. Roos A, Berg T, Barton J, Didon L, Nord M. Airway epithelial cell differentiation during lung organogenesis requires C/EBP? and C/EBP?. Dev Dyn. 2012;241:911-23 pubmed publisher
    ..Our findings demonstrate that C/EBP? and C/EBP? play pivotal, and partly overlapping roles in determining airway epithelial differentiation, with possible implications for tissue regeneration in lung homeostasis and disease. ..
  15. Zhao X, Ren G, Liang L, Ai P, Zheng B, Tischfield J, et al. Brief report: interferon-gamma induces expansion of Lin(-)Sca-1(+)C-Kit(+) Cells. Stem Cells. 2010;28:122-6 pubmed publisher
    ..Therefore, our findings demonstrated a novel role of IFNgamma in activating hematopoietic progenitor cells and provide a new insight into the clinical application of interferon. ..
  16. Hu M, Deshpande A, Schlichting N, Hinds E, Mao C, Dose M, et al. CDK6 kinase activity is required for thymocyte development. Blood. 2011;117:6120-31 pubmed publisher
    ..This role of CDK6 as a downstream mediator of Notch identifies CDK6 kinase activity as a potential therapeutic target in human lymphoid malignancies. ..
  17. Drew E, Merkens H, Chelliah S, Doyonnas R, McNagny K. CD34 is a specific marker of mature murine mast cells. Exp Hematol. 2002;30:1211-8 pubmed
  18. Patterson J, Johnson M, Zimonjic D, Graubert T. Characterization of Ly-6M, a novel member of the Ly-6 family of hematopoietic proteins. Blood. 2000;95:3125-32 pubmed
    ..The identification and characterization of Ly-6M adds a new member to a complex family of homologous, tightly linked genes that have proven extremely useful reagents for defining populations within the hematopoietic system. ..
  19. Nemeth M, Curtis D, Kirby M, Garrett Beal L, Seidel N, Cline A, et al. Hmgb3: an HMG-box family member expressed in primitive hematopoietic cells that inhibits myeloid and B-cell differentiation. Blood. 2003;102:1298-306 pubmed
    ..We conclude that down-regulation of Hmgb3 protein levels is an important step for myeloid and B-cell differentiation. ..
  20. Upadhyay G, Yin Y, Yuan H, Li X, Derynck R, Glazer R. Stem cell antigen-1 enhances tumorigenicity by disruption of growth differentiation factor-10 (GDF10)-dependent TGF-beta signaling. Proc Natl Acad Sci U S A. 2011;108:7820-5 pubmed publisher
    ..These findings suggest a new functional role for Sca-1 in maintaining tumorigenicity, in part by acting as a potent suppressor of TGF-? signaling. ..
  21. Shi X, Siggins R, Stanford W, Melvan J, Basson M, Zhang P. Toll-like receptor 4/stem cell antigen 1 signaling promotes hematopoietic precursor cell commitment to granulocyte development during the granulopoietic response to Escherichia coli bacteremia. Infect Immun. 2013;81:2197-205 pubmed publisher
    ..These results demonstrate that TLR4/Sca-1 signaling plays an important role in the regulation of hematopoietic precursor cell programming and their enhancement of granulocyte lineage commitment in response to E. coli bacteremia...
  22. Di Rosa P, Villaescusa J, Longobardi E, Iotti G, Ferretti E, Diaz V, et al. The homeodomain transcription factor Prep1 (pKnox1) is required for hematopoietic stem and progenitor cell activity. Dev Biol. 2007;311:324-34 pubmed
    ..Indeed, wt embryonic expression of Prep1 in the aorta-gonad-mesonephros (AGM) region, fetal liver (FL), cKit(+)Sca1(+)Lin(-)AA4.1(+) (KSLA) cells and B-lymphocytes precursors agrees with the observed phenotype...
  23. Greene S, Gunaratne P, Hammond S, Rosen J. A putative role for microRNA-205 in mammary epithelial cell progenitors. J Cell Sci. 2010;123:606-18 pubmed publisher
    ..This cell line contains a heterogeneous subpopulation of progenitors characterized by the expression of stem cell antigen 1 (Sca-1; encoded by Ly6a)...
  24. de Jong S, Kas M, Kiernan J, de Mooij van Malsen A, Oppelaar H, Janson E, et al. Hippocampal gene expression analysis highlights Ly6a/Sca-1 as candidate gene for previously mapped novelty induced behaviors in mice. PLoS ONE. 2011;6:e20716 pubmed publisher
    ..This study shows that gene expression profiling can be used to narrow down a previously identified behavioral QTL in mice, providing support for Ly6a as a candidate gene for functional involvement in novelty responsiveness. ..
  25. Panizzi P, Swirski F, Figueiredo J, Waterman P, Sosnovik D, Aikawa E, et al. Impaired infarct healing in atherosclerotic mice with Ly-6C(hi) monocytosis. J Am Coll Cardiol. 2010;55:1629-38 pubmed publisher
    ..These findings position monocyte subsets as potential therapeutic targets to augment tissue repair after infarction and to prevent post-MI heart failure. ..
  26. Gamwell L, Collins O, Vanderhyden B. The mouse ovarian surface epithelium contains a population of LY6A (SCA-1) expressing progenitor cells that are regulated by ovulation-associated factors. Biol Reprod. 2012;87:80 pubmed publisher
    ..Our work has identified a population of LY6A+ MOSE progenitor cells on the surface of the ovary that may play a role in ovulatory wound healing...
  27. Le Grand F, Auda Boucher G, Levitsky D, Rouaud T, Fontaine Pérus J, Gardahaut M. Endothelial cells within embryonic skeletal muscles: a potential source of myogenic progenitors. Exp Cell Res. 2004;301:232-41 pubmed
    ..The marked ability of the embryonic muscle endothelial cells to activate myogenic program could be related to their somitic origin. ..
  28. Shikatani E, Chandy M, Besla R, Li C, Momen A, El Mounayri O, et al. c-Myb Regulates Proliferation and Differentiation of Adventitial Sca1+ Vascular Smooth Muscle Cell Progenitors by Transactivation of Myocardin. Arterioscler Thromb Vasc Biol. 2016;36:1367-76 pubmed publisher
    ..Our objective was to examine the role of c-Myb in the proliferation and differentiation of Sca1(+) adventitial VSMC progenitor cells...
  29. Hanson P, Mathews V, Marrus S, Graubert T. Enhanced green fluorescent protein targeted to the Sca-1 (Ly-6A) locus in transgenic mice results in efficient marking of hematopoietic stem cells in vivo. Exp Hematol. 2003;31:159-67 pubmed
    ..This system should be useful for studying the normal biology of hematopoietic stem cells and for targeting other genes to this cellular compartment. ..
  30. Zhou Q, Sun Q, Zhang Y, Teng F, Sun J. Up-Regulation of miRNA-21 Expression Promotes Migration and Proliferation of Sca-1+ Cardiac Stem Cells in Mice. Med Sci Monit. 2016;22:1724-32 pubmed
  31. Pina C, Fugazza C, Tipping A, Brown J, Soneji S, Teles J, et al. Inferring rules of lineage commitment in haematopoiesis. Nat Cell Biol. 2012;14:287-94 pubmed publisher
  32. Smeriglio P, Alonso Martin S, Masciarelli S, Madaro L, Iosue I, Marrocco V, et al. Phosphotyrosine phosphatase inhibitor bisperoxovanadium endows myogenic cells with enhanced muscle stem cell functions via epigenetic modulation of Sca-1 and Pw1 promoters. FASEB J. 2016;30:1404-15 pubmed publisher
    ..Fazi, F., Marazzi, G., Sassoon, D. A., Bouché, M. Phosphotyrosine phosphatase inhibitor bisperoxovanadium endows myogenic cells with enhanced muscle stem cell functionsviaepigenetic modulation of Sca-1 and Pw1 promoters. ..
  33. Gasco S, Rando A, Zaragoza P, García Redondo A, Calvo A, Osta R. Hematopoietic stem and progenitor cells as novel prognostic biomarkers of longevity in a murine model for amyotrophic lateral sclerosis. Am J Physiol Cell Physiol. 2016;311:C910-C919 pubmed publisher
    ..On the basis of these results, both CLPs and CMPs could be considered prognostic biomarkers of longevity in this animal model, opening the door to future studies in human patients for their potential clinical use. ..
  34. Staszkiewicz J, Gimble J, Manuel J, Gawronska Kozak B. IFATS collection: Stem cell antigen-1-positive ear mesenchymal stem cells display enhanced adipogenic potential. Stem Cells. 2008;26:2666-73 pubmed publisher
    ..b>Stem cell antigen 1 (Sca-1) has been used recently as a candidate marker in the search for tissue-resident stem cells...
  35. CAMARATA T, Weaver G, Vasilyev A, Arnaout M. Negative Regulation of TGFβ Signaling by Stem Cell Antigen-1 Protects against Ischemic Acute Kidney Injury. PLoS ONE. 2015;10:e0129561 pubmed publisher
    ..These studies demonstrate that by normally repressing TGFβ-mediated canonical Smad signaling, Sca-1 plays an important in renal epithelial cell homeostasis and in recovery of renal function following ischemic acute kidney injury. ..
  36. Kotton D, Summer R, Sun X, Ma B, Fine A. Stem cell antigen-1 expression in the pulmonary vascular endothelium. Am J Physiol Lung Cell Mol Physiol. 2003;284:L990-6 pubmed
    ..Overall, our data indicate that Sca-1 expression helps define the surface phenotype of endothelial cells throughout the pulmonary vasculature. ..
  37. Li W, Liu H, Liu P, Yin D, Zhang S, Zhao J. Sphingosylphosphorylcholine promotes the differentiation of resident Sca-1 positive cardiac stem cells to cardiomyocytes through lipid raft/JNK/STAT3 and ?-catenin signaling pathways. Biochim Biophys Acta. 2016;1863:1579-88 pubmed publisher
    ..We found no crosstalk between the lipid raft/JNK/STAT3 and ?-catenin pathway. Our study describes a lipid, SPC, as an endogenic inducer of myogenic conversion in Sca-1(+) stem cells with low toxicity and high efficiency for uptake. ..
  38. Cho S, Spangrude G. Enrichment of functionally distinct mouse hematopoietic progenitor cell populations using CD62L. J Immunol. 2011;187:5203-10 pubmed publisher
    ..These data establish CD62L as a useful tool in the study of early hematopoiesis and emphasize the power of trilineage-engraftment studies in establishing the lineage potential of MPP subsets. ..
  39. Jones M, DeWolf S, Vacharathit V, Yim M, Spencer S, Bamezai A. Investigating B Cell Development, Natural and Primary Antibody Responses in Ly-6A/Sca-1 Deficient Mice. PLoS ONE. 2016;11:e0157271 pubmed publisher
    ..In addition, we report significantly higher expression of the immunoglobulin ? light chain by B cells in lamina propria of Ly-6A/Sca-1deficient mice when compared to the wild-type control. ..
  40. Dou X, Zhang B, Liu R, Li J, Shi D, Lu C, et al. Expanding Sca-1(+) mammary stem cell in the presence of oestrogen and growth hormone. Clin Transl Oncol. 2012;14:444-51 pubmed publisher
    ..Our research demonstrates that Sca-1(+) mammary stem cells can be more easily isolated when cultured in the presence of oestrogen and GH. ..
  41. Gao Z, Tibbles L, Yilmaz S, Gao Y, MacDonald A. Prolonged skin allograft survival in Scid mice reconstituted with isogeneic bone marrow stem cell antigen-1-positive cells and thymus tissue. Transplant Proc. 2005;37:2300-2 pubmed
    ..The results suggest direct persistent contact of bone marrow Sca-1-positive cells with graft alloantigen may be a feasible approach to prolong allograft survival and induce tolerance in a small fraction of adult animals. ..
  42. Prevorsek Z, Gorjanc G, Paigen B, Horvat S. Congenic and bioinformatics analyses resolved a major-effect Fob3b QTL on mouse Chr 15 into two closely linked loci. Mamm Genome. 2010;21:172-85 pubmed publisher
    ..A high-resolution map along with prioritization of Fob3b1 candidates by bioinformatics represents an important step forward to final identification of the Chr 15 obesity QTL. ..
  43. Ewald A, Huebner R, Palsdottir H, Lee J, Perez M, Jorgens D, et al. Mammary collective cell migration involves transient loss of epithelial features and individual cell migration within the epithelium. J Cell Sci. 2012;125:2638-54 pubmed publisher
    ..Our data suggest that reductions in polarity and adhesion during breast cancer progression might reflect partial recapitulation of a normal developmental program. ..
  44. Pflugh D, Maher S, Bothwell A. Ly-6 superfamily members Ly-6A/E, Ly-6C, and Ly-6I recognize two potential ligands expressed by B lymphocytes. J Immunol. 2002;169:5130-6 pubmed
  45. Saravanakumar M, Devaraj H. Distribution and homing pattern of c-kit+ Sca-1+ CXCR4+ resident cardiac stem cells in neonatal, postnatal, and adult mouse heart. Cardiovasc Pathol. 2013;22:257-63 pubmed publisher
    ..Cardiac stem cells are higher in the atrium than in the ventricle, suggesting the atria as the source of cardiac stem cell. ..
  46. Park J, Park J, Park D, Kim D, Kim H. Stem Cells Antigen-1 Enriches for a Cancer Stem Cell-Like Subpopulation in Mouse Gastric Cancer. Stem Cells. 2016;34:1177-87 pubmed publisher
    ..Taken together, Sca-1 is a novel CSC enrichment marker that mediates TGF-β and Wnt/β-catenin signaling in mouse gastric cancer. Stem Cells 2016;34:1177-1187. ..
  47. Khan K, Lindwall G, Maher S, Bothwell A. Characterization of promoter elements of an interferon-inducible Ly-6E/A differentiation antigen, which is expressed on activated T cells and hematopoietic stem cells. Mol Cell Biol. 1990;10:5150-9 pubmed
    ..The Ly-6E gene may prove to be a novel system for the study of interferon induction. ..
  48. Azalea Romero M, González Mendoza M, Cáceres Pérez A, Lara Padilla E, Cáceres Cortés J. Low expression of stem cell antigen-1 on mouse haematopoietic precursors is associated with erythroid differentiation. Cell Immunol. 2012;279:187-95 pubmed publisher
    b>Sca1 is a surface marker of haematopoietic stem cell but its role in erythropoiesis is still largely unknown. In this work we evaluated the ability of Sca1? cells to differentiate into cells of the erythrocytic lineage...
  49. Nombela Arrieta C, Pivarnik G, Winkel B, Canty K, Harley B, Mahoney J, et al. Quantitative imaging of haematopoietic stem and progenitor cell localization and hypoxic status in the bone marrow microenvironment. Nat Cell Biol. 2013;15:533-43 pubmed publisher
    ..These studies argue that the characteristic hypoxic state of HSPCs is not solely the result of a minimally oxygenated niche but may be partially regulated by cell-specific mechanisms. ..
  50. Cusella De Angelis M, Balconi G, Bernasconi S, Zanetta L, Boratto R, Galli D, et al. Skeletal myogenic progenitors in the endothelium of lung and yolk sac. Exp Cell Res. 2003;290:207-16 pubmed
    ..The number (or potency to generate skeletal muscle) of these vessels associated cells decreases rapidly with age and is very low in mature animals, possibly correlating with reduced regenerative capacity of adult mammalian tissues. ..
  51. Passman J, Dong X, Wu S, Maguire C, Hogan K, Bautch V, et al. A sonic hedgehog signaling domain in the arterial adventitia supports resident Sca1+ smooth muscle progenitor cells. Proc Natl Acad Sci U S A. 2008;105:9349-54 pubmed publisher
    ..a sonic hedgehog (Shh) signaling domain restricted to the adventitial layer of artery wall that supports resident Sca1-positive vascular progenitor cells (AdvSca1)...
  52. Zhou H, Bian Z, Zong J, Deng W, Yan L, Shen D, et al. Stem cell antigen 1 protects against cardiac hypertrophy and fibrosis after pressure overload. Hypertension. 2012;60:802-9 pubmed publisher
    ..Our results suggest that Sca-1 protects against cardiac hypertrophy and fibrosis via regulation of multiple pathways in cardiomyocytes. ..
  53. Mitsuishi H, Kato T, Chen M, Cai L, Yako H, Higuchi M, et al. Characterization of a pituitary-tumor-derived cell line, TtT/GF, that expresses Hoechst efflux ABC transporter subfamily G2 and stem cell antigen 1. Cell Tissue Res. 2013;354:563-72 pubmed publisher
    ..The high and specific expression of stem cell antigen 1 (Sca1) in TtT/GF cells was confirmed by real-time PCR...
  54. Walter D, Lier A, Geiselhart A, Thalheimer F, Huntscha S, Sobotta M, et al. Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells. Nature. 2015;520:549-52 pubmed publisher
  55. Sherwood R, Maehr R, Mazzoni E, Melton D. Wnt signaling specifies and patterns intestinal endoderm. Mech Dev. 2011;128:387-400 pubmed publisher
    ..These findings shed light on the mechanism of embryonic intestinal induction and provide a method to manipulate intestinal development from embryonic stem cells. ..
  56. Tousoulis D, Briasoulis A, Vogiatzi G, Valatsou A, Kourkouti P, Pantopoulou A, et al. Infusion of lin-/sca-1+ and endothelial progenitor cells improves proinflammatory and oxidative stress markers in atherosclerotic mice. Int J Cardiol. 2013;167:1900-5 pubmed publisher
    ..The principal novelty of this work is that treatment with hematopoietic progenitors, EPCs or G-CSF may exert beneficial effects on vascular inflammation and atherosclerotic plaque development. ..
  57. Dominov J, Houlihan Kawamoto C, Swap C, Miller J. Pro- and anti-apoptotic members of the Bcl-2 family in skeletal muscle: a distinct role for Bcl-2 in later stages of myogenesis. Dev Dyn. 2001;220:18-26 pubmed
    ..Thus, Bcl-2 function is required for particular stages of fetal and postnatal myogenesis. ..
  58. Purwanti N, Tsuji D, Azlina A, Karabasil M, Javkhlan P, Hasegawa T, et al. Induction of Sca-1 in the duct cells of the mouse submandibular gland by obstruction of the main excretory duct. J Oral Pathol Med. 2011;40:651-8 pubmed publisher
    ..These results imply that Sca-1-positive cells may have a role in the duct cell proliferation in the regeneration step elicited by MED ligation-induced injury...
  59. Ma X, de Bruijn M, Robin C, Peeters M, Kong A San J, de Wit T, et al. Expression of the Ly-6A (Sca-1) lacZ transgene in mouse haematopoietic stem cells and embryos. Br J Haematol. 2002;116:401-8 pubmed
    ..Surprisingly, when compared with data from Ly-6E lacZ transgenic mice, our results suggest that the Ly-6A cassette does not improve lacZ marker gene expression in haematopoietic cells. ..
  60. Izzotti A, D Agostini F, Larghero P, Cartiglia C, Travaini G, Balansky R, et al. Upregulation of stem cell antigen-1 in the lung of neonatal mice exposed to environmental cigarette smoke. Oncol Rep. 2009;22:469-74 pubmed
    ..These findings may contribute to explain the high vulnerability of mouse lung early in life. ..
  61. Morikawa S, Mabuchi Y, Kubota Y, Nagai Y, Niibe K, Hiratsu E, et al. Prospective identification, isolation, and systemic transplantation of multipotent mesenchymal stem cells in murine bone marrow. J Exp Med. 2009;206:2483-96 pubmed publisher
    ..Naive MSCs resided in the perivascular region in a quiescent state. This study provides the useful method needed to identify MSCs as defined in vivo entities. ..
  62. van Solingen C, de Boer H, Bijkerk R, Monge M, van Oeveren Rietdijk A, Seghers L, et al. MicroRNA-126 modulates endothelial SDF-1 expression and mobilization of Sca-1(+)/Lin(-) progenitor cells in ischaemia. Cardiovasc Res. 2011;92:449-55 pubmed publisher
  63. Li N, Pasha Z, Ashraf M. Reversal of ischemic cardiomyopathy with Sca-1+ stem cells modified with multiple growth factors. PLoS ONE. 2014;9:e93645 pubmed publisher
    ..Infarct size was attenuated and the global heart function was improved in group-3 as compared to group-2. Administration of BM Sca-1+ transduced with multiple genes is a novel approach to treat infarcted heart for its regeneration. ..
  64. Moro K, Yamada T, Tanabe M, Takeuchi T, Ikawa T, Kawamoto H, et al. Innate production of T(H)2 cytokines by adipose tissue-associated c-Kit(+)Sca-1(+) lymphoid cells. Nature. 2010;463:540-4 pubmed publisher
    ..Thus, FALC Lin(-)c-Kit(+)Sca-1(+) cells are T(H)2-type innate lymphocytes, and we propose that these cells be called 'natural helper cells'. ..
  65. Ye J, Boyle A, Shih H, Sievers R, Zhang Y, Prasad M, et al. Sca-1+ cardiosphere-derived cells are enriched for Isl1-expressing cardiac precursors and improve cardiac function after myocardial injury. PLoS ONE. 2012;7:e30329 pubmed publisher
    ..e., Isl-1(+)) precursors that give rise to both myocardial and vascular tissues, and may be an appropriate source of progenitor cells for autologous cell-therapy post-MI. ..
  66. Tatsumi K, Higuchi T, Fujiwara H, Nakayama T, Fujii S, Fujita J. Expression of Ly-6A/E in the mouse uterus during implantation period. Mol Reprod Dev. 2001;58:159-65 pubmed
    ..These findings suggest that Ly-6A/E plays a role in embryo implantation. ..
  67. Iwasaki H, Arai F, Kubota Y, Dahl M, Suda T. Endothelial protein C receptor-expressing hematopoietic stem cells reside in the perisinusoidal niche in fetal liver. Blood. 2010;116:544-53 pubmed publisher
    ..In conclusion, EPCR(+) HSCs resided in the perisinusoidal niche in mouse FL. ..
  68. Okamoto M, Hayase S, Miyakoshi M, Murata T, Kimura S. Stem cell antigen 1-positive mesenchymal cells are the origin of follicular cells during thyroid regeneration. PLoS ONE. 2013;8:e80801 pubmed publisher
    ..thyroid regeneration, and bromodeoxyuridine (BrdU) long label-retaining cell analysis, we demonstrated that stem cell antigen 1 (Sca1) and BrdU-positive, but ?-gal and NKX2-1 negative cells were found in the non-follicular mesenchymal ..
  69. Liu Z, Wu L, Zhu J, Zhu X, Zhu J, Liu J, et al. Interleukin-27 signalling induces stem cell antigen-1 expression in T lymphocytes in vivo. Immunology. 2017;152:638-647 pubmed publisher
    ..Direct expansion of Sca-1+  CD62L+  CD44- T memory stem cells may explain why IL-27 enhances T-cell memory. ..
  70. Long K, Pavlath G, Montano M. Sca-1 influences the innate immune response during skeletal muscle regeneration. Am J Physiol Cell Physiol. 2011;300:C287-94 pubmed publisher
    ..Collectively, these data reveal a novel role for Sca-1 in innate immunity during muscle regeneration and indicate that further elucidation of immuno-myogenic processes will help to better understand and promote muscle regeneration. ..
  71. Noseda M, Harada M, McSweeney S, Leja T, Belian E, Stuckey D, et al. PDGFRα demarcates the cardiogenic clonogenic Sca1+ stem/progenitor cell in adult murine myocardium. Nat Commun. 2015;6:6930 pubmed publisher
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    ..Thus, the Sca-1-deficient mice may provide a useful model for metabolic studies. ..
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    ..We conclude that the HSC niche is composed of solitary cells and that adult bone marrow HSC are not clustered. ..
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    ..The results suggest the hypothesis that the more aggressive behavior of Ly6a/Sca-1 expressing leukemias is due at least in part to greater capacity to degrade microenvironmental stroma and invade tissues. ..
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    ..Herein, we show that these mice exhibit enrichment of Sca1(+)/cKit(-) progenitors and several mature immune cells, such as dendritic cells and macrophages...
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    ..Thus, Sca-1 might be an essential component to promote CSC proliferation and survival to directly facilitate early engraftment, and might indirectly exert the effects on late cardiovascular differentiation after CSC transplantation...
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