Sall4

Summary

Gene Symbol: Sall4
Description: spalt like transcription factor 4
Alias: 5730441M18Rik, AA407717, AL022809, AW536104, C330011P20Rik, C78083, C78563, Tex20, sal-like protein 4, sal-like 4, zinc finger protein SALL4
Species: mouse
Products:     Sall4

Top Publications

  1. Lim C, Tam W, Zhang J, Ang H, Jia H, Lipovich L, et al. Sall4 regulates distinct transcription circuitries in different blastocyst-derived stem cell lineages. Cell Stem Cell. 2008;3:543-54 pubmed publisher
    ..The transcription factor Sall4 is required for early embryonic development and for ESC pluripotency...
  2. Kohlhase J, Heinrich M, Liebers M, Fröhlich Archangelo L, Reardon W, Kispert A. Cloning and expression analysis of SALL4, the murine homologue of the gene mutated in Okihiro syndrome. Cytogenet Genome Res. 2002;98:274-7 pubmed
    ..the chromosomal location of SALL4 on mouse chromosome 2H3 and suggested that a predicted testis expressed gene TEX20 at the very same locus is most likely not a gene on its own but part of the SALL4 3' UTR...
  3. Sweetman D, Munsterberg A. The vertebrate spalt genes in development and disease. Dev Biol. 2006;293:285-93 pubmed
    ..Here we review what is currently known about the role of spalt genes in vertebrate development and human disease. ..
  4. Tsubooka N, Ichisaka T, Okita K, Takahashi K, Nakagawa M, Yamanaka S. Roles of Sall4 in the generation of pluripotent stem cells from blastocysts and fibroblasts. Genes Cells. 2009;14:683-94 pubmed publisher
    ..is maintained by a network consisting of multiple transcription factors, including Oct3/4, Sox2, Nanog, Klf4 and Sall4. Among these factors, the forced expressions of Oct3/4, Sox2 and Klf4 are sufficient to reprogram fibroblasts into ..
  5. Elling U, Klasen C, Eisenberger T, Anlag K, Treier M. Murine inner cell mass-derived lineages depend on Sall4 function. Proc Natl Acad Sci U S A. 2006;103:16319-24 pubmed
    b>Sall4 is a mammalian Spalt transcription factor expressed by cells of the early embryo and germ cells, an expression pattern similar to that of both Oct4 and Sox2, which play essential roles during early murine development...
  6. Yang J, Aguila J, Alipio Z, Lai R, Fink L, Ma Y. Enhanced self-renewal of hematopoietic stem/progenitor cells mediated by the stem cell gene Sall4. J Hematol Oncol. 2011;4:38 pubmed publisher
    b>Sall4 is a key factor for the maintenance of pluripotency and self-renewal of embryonic stem cells (ESCs)...
  7. Ma Y, Cui W, Yang J, Qu J, Di C, Amin H, et al. SALL4, a novel oncogene, is constitutively expressed in human acute myeloid leukemia (AML) and induces AML in transgenic mice. Blood. 2006;108:2726-35 pubmed
    b>SALL4, a human homolog to Drosophila spalt, is a novel zinc finger transcriptional factor essential for development. We cloned SALL4 and its isoforms (SALL4A and SALL4B)...
  8. Yuri S, Fujimura S, Nimura K, Takeda N, Toyooka Y, Fujimura Y, et al. Sall4 is essential for stabilization, but not for pluripotency, of embryonic stem cells by repressing aberrant trophectoderm gene expression. Stem Cells. 2009;27:796-805 pubmed publisher
    b>Sall4 is a mouse homolog of a causative gene of the autosomal dominant disorder Okihiro syndrome...
  9. Böhm J, Kaiser F, Borozdin W, Depping R, Kohlhase J. Synergistic cooperation of Sall4 and Cyclin D1 in transcriptional repression. Biochem Biophys Res Commun. 2007;356:773-9 pubmed
    Loss of function mutations in SALL4 cause Okihiro syndrome, an autosomal dominant disorder characterised by radial ray malformations associated with Duane anomaly...

More Information

Publications63

  1. Yang J, Chai L, Fowles T, Alipio Z, Xu D, Fink L, et al. Genome-wide analysis reveals Sall4 to be a major regulator of pluripotency in murine-embryonic stem cells. Proc Natl Acad Sci U S A. 2008;105:19756-61 pubmed publisher
    Embryonic stem cells have potential utility in regenerative medicine because of their pluripotent characteristics. Sall4, a zinc-finger transcription factor, is expressed very early in embryonic development with Oct4 and Nanog, two well-..
  2. Warren M, Wang W, Spiden S, Chen Murchie D, Tannahill D, Steel K, et al. A Sall4 mutant mouse model useful for studying the role of Sall4 in early embryonic development and organogenesis. Genesis. 2007;45:51-8 pubmed
    b>SALL4 is a homologue of the Drosophila homeotic gene spalt, a zinc finger transcription factor, required for inner cell mass proliferation in early embryonic development...
  3. Koshiba Takeuchi K, Takeuchi J, Arruda E, Kathiriya I, Mo R, Hui C, et al. Cooperative and antagonistic interactions between Sall4 and Tbx5 pattern the mouse limb and heart. Nat Genet. 2006;38:175-83 pubmed
    Human mutations in TBX5, a gene encoding a T-box transcription factor, and SALL4, a gene encoding a zinc-finger transcription factor, cause similar upper limb and heart defects...
  4. Wu Q, Chen X, Zhang J, Loh Y, Low T, Zhang W, et al. Sall4 interacts with Nanog and co-occupies Nanog genomic sites in embryonic stem cells. J Biol Chem. 2006;281:24090-4 pubmed
    ..Using affinity purification coupled to liquid chromatography-tandem mass spectrometry analysis, we identified Sall4 as a Nanog co-purified protein...
  5. Zhang J, Tam W, Tong G, Wu Q, Chan H, Soh B, et al. Sall4 modulates embryonic stem cell pluripotency and early embryonic development by the transcriptional regulation of Pou5f1. Nat Cell Biol. 2006;8:1114-23 pubmed
    ..Here, we report that a spalt family member, Sall4, is required for the pluripotency of ES cells...
  6. Sakaki Yumoto M, Kobayashi C, Sato A, Fujimura S, Matsumoto Y, Takasato M, et al. The murine homolog of SALL4, a causative gene in Okihiro syndrome, is essential for embryonic stem cell proliferation, and cooperates with Sall1 in anorectal, heart, brain and kidney development. Development. 2006;133:3005-13 pubmed
    Mutations in SALL4, the human homolog of the Drosophila homeotic gene spalt (sal), cause the autosomal dominant disorder known as Okihiro syndrome...
  7. Eildermann K, Aeckerle N, Debowski K, Godmann M, Christiansen H, Heistermann M, et al. Developmental expression of the pluripotency factor sal-like protein 4 in the monkey, human and mouse testis: restriction to premeiotic germ cells. Cells Tissues Organs. 2012;196:206-20 pubmed publisher
    b>SALL4 (sal-like protein 4) is a pluripotency transcription factor, which is highly expressed in embryonic stem (ES) cells and which is essential for mouse preimplantation development...
  8. Kawakami Y, Uchiyama Y, Rodriguez Esteban C, Inenaga T, Koyano Nakagawa N, Kawakami H, et al. Sall genes regulate region-specific morphogenesis in the mouse limb by modulating Hox activities. Development. 2009;136:585-94 pubmed publisher
  9. Oikawa T, Kamiya A, Kakinuma S, Zeniya M, Nishinakamura R, Tajiri H, et al. Sall4 regulates cell fate decision in fetal hepatic stem/progenitor cells. Gastroenterology. 2009;136:1000-11 pubmed publisher
    ..The molecular mechanisms regulating this lineage segmentation process remain unknown. Sall4 has been shown to be among the regulators of organogenesis, embryogenesis, maintenance of pluripotency, and early ..
  10. Rao S, Zhen S, Roumiantsev S, McDonald L, Yuan G, Orkin S. Differential roles of Sall4 isoforms in embryonic stem cell pluripotency. Mol Cell Biol. 2010;30:5364-80 pubmed publisher
    ..b>Sall4, a transcription factor essential for pluripotency, exists as two isoforms (Sall4a and Sall4b)...
  11. Yang J, Gao C, Chai L, Ma Y. A novel SALL4/OCT4 transcriptional feedback network for pluripotency of embryonic stem cells. PLoS ONE. 2010;5:e10766 pubmed publisher
    b>SALL4 is a member of the SALL gene family that encodes a group of putative developmental transcription factors. Murine Sall4 plays a critical role in maintaining embryonic stem cell (ES cell) pluripotency and self-renewal...
  12. Hobbs R, Fagoonee S, Papa A, Webster K, Altruda F, Nishinakamura R, et al. Functional antagonism between Sall4 and Plzf defines germline progenitors. Cell Stem Cell. 2012;10:284-98 pubmed publisher
    ..Here we demonstrate critical and distinct roles for Sall4 in development of embryonic germ cells and differentiation of postnatal spermatogonial progenitor cells (SPCs)...
  13. Liang J, Wan M, Zhang Y, Gu P, Xin H, Jung S, et al. Nanog and Oct4 associate with unique transcriptional repression complexes in embryonic stem cells. Nat Cell Biol. 2008;10:731-9 pubmed publisher
    ..Our data collectively suggest that Nanog and Oct4 associate with unique repressor complexes on their target genes to control ES cell fate. ..
  14. Uez N, Lickert H, Kohlhase J, de Angelis M, Kühn R, Wurst W, et al. Sall4 isoforms act during proximal-distal and anterior-posterior axis formation in the mouse embryo. Genesis. 2008;46:463-77 pubmed publisher
    ..Here we have analyzed three gene trap mutations of Sall4, of which one (Sall4-1a) led to a hypomorphic and recessive phenotype, demonstrating that Sall4-1a has yet ..
  15. Yang J, Chai L, Liu F, Fink L, Lin P, Silberstein L, et al. Bmi-1 is a target gene for SALL4 in hematopoietic and leukemic cells. Proc Natl Acad Sci U S A. 2007;104:10494-9 pubmed
    Bmi-1 and SALL4 are putative oncogenes that modulate stem cell pluripotency and play a role in leukemogenesis...
  16. Wong C, Gaspar Maia A, Ramalho Santos M, Reijo Pera R. High-efficiency stem cell fusion-mediated assay reveals Sall4 as an enhancer of reprogramming. PLoS ONE. 2008;3:e1955 pubmed publisher
    ..Moreover, we demonstrate that overexpression of the Spalt transcription factor, Sall4, which was previously identified as a regulator of embryonic stem cell pluripotency and early mouse development, ..
  17. Tanimura N, Saito M, Ebisuya M, Nishida E, Ishikawa F. Stemness-related factor Sall4 interacts with transcription factors Oct-3/4 and Sox2 and occupies Oct-Sox elements in mouse embryonic stem cells. J Biol Chem. 2013;288:5027-38 pubmed publisher
    ..However, little is known regarding the components of the complex. In this study we show that Sall4, a member of the Spalt-like family of proteins, directly interacts with Sox2 and Oct-3/4...
  18. Fujii Y, Yoshihashi K, Suzuki H, Tsutsumi S, Mutoh H, Maeda S, et al. CDX1 confers intestinal phenotype on gastric epithelial cells via induction of stemness-associated reprogramming factors SALL4 and KLF5. Proc Natl Acad Sci U S A. 2012;109:20584-9 pubmed publisher
    ..directly activated by CDX1 in gastric epithelial cells and identified stemness-associated reprogramming factors SALL4 and KLF5...
  19. Yamaguchi Y, Tanaka S, Kumagai M, Fujimoto Y, Terabayashi T, Matsui Y, et al. Sall4 is essential for mouse primordial germ cell specification by suppressing somatic cell program genes. Stem Cells. 2015;33:289-300 pubmed publisher
    The Spalt-like 4 (Sall4) zinc finger protein is a critical transcription factor for pluripotency in embryonic stem cells (ESCs). It is also involved in the formation of a variety of organs, in mice, and humans...
  20. Sulaiman F, Nishimoto S, Murphy G, Kucharska A, Butterfield N, Newbury Ecob R, et al. Tbx5 Buffers Inherent Left/Right Asymmetry Ensuring Symmetric Forelimb Formation. PLoS Genet. 2016;12:e1006521 pubmed publisher
    ..Our data demonstrate an early, inherent asymmetry in the left and right limb-forming regions and that threshold levels of Tbx5 are required to overcome this asymmetry to ensure symmetric forelimb formation. ..
  21. Wang F, Gao C, Lu J, Tatetsu H, Williams D, Müller L, et al. Leukemic survival factor SALL4 contributes to defective DNA damage repair. Oncogene. 2016;35:6087-6095 pubmed publisher
    b>SALL4 is aberrantly expressed in human myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). We have generated a SALL4 transgenic (SALL4B Tg) mouse model with pre-leukemic MDS-like symptoms that transform to AML over time...
  22. Abboud N, Moore Morris T, Hiriart E, Yang H, Bezerra H, Gualazzi M, et al. A cohesin-OCT4 complex mediates Sox enhancers to prime an early embryonic lineage. Nat Commun. 2015;6:6749 pubmed publisher
    ..b>SALL4 concomitantly mobilizes the polycomb complexes at the Soxs loci...
  23. Yamashita K, Sato A, Asashima M, Wang P, Nishinakamura R. Mouse homolog of SALL1, a causative gene for Townes-Brocks syndrome, binds to A/T-rich sequences in pericentric heterochromatin via its C-terminal zinc finger domains. Genes Cells. 2007;12:171-82 pubmed
    ..Thus Sall1 may bind to A/T-rich sequences of the major satellite DNA via its C-terminal double zinc fingers, thereby mediating its localization to heterochromatin. ..
  24. Probst S, Kraemer C, Demougin P, Sheth R, Martin G, Shiratori H, et al. SHH propagates distal limb bud development by enhancing CYP26B1-mediated retinoic acid clearance via AER-FGF signalling. Development. 2011;138:1913-23 pubmed publisher
    ..In summary, SHH promotes distal progression of limb development by enhancing CYP26B1-mediated RA clearance as part of a signalling network linking the SHH/GREM1/AER-FGF feedback loop to the newly identified AER-FGF/CYP26B1/RA module. ..
  25. Iseki H, Nakachi Y, Hishida T, Yamashita Sugahara Y, Hirasaki M, Ueda A, et al. Combined Overexpression of JARID2, PRDM14, ESRRB, and SALL4A Dramatically Improves Efficiency and Kinetics of Reprogramming to Induced Pluripotent Stem Cells. Stem Cells. 2016;34:322-33 pubmed publisher
    ..Our findings provide an insight into the important roles of JARID2 during reprogramming and suggest that the JARID2-associated protein network contributes to overcoming reprogramming barriers. ..
  26. Gely Pernot A, Raverdeau M, Teletin M, Vernet N, Féret B, Klopfenstein M, et al. Retinoic Acid Receptors Control Spermatogonia Cell-Fate and Induce Expression of the SALL4A Transcription Factor. PLoS Genet. 2015;11:e1005501 pubmed publisher
  27. Hosako H, Martin G, Barrier M, Chen Y, Ivanov I, Mirkes P. Gene and microRNA expression in p53-deficient day 8.5 mouse embryos. Birth Defects Res A Clin Mol Teratol. 2009;85:546-55 pubmed publisher
    ..We also identified six genes (Csk, Itga3, Jarid2, Prkaca, Rarg, and Sall4), known to cause NTDs when deleted, that are also down-regulated in p53 -/- embryos...
  28. Kang E, Wu G, Ma H, Li Y, Tippner Hedges R, Tachibana M, et al. Nuclear reprogramming by interphase cytoplasm of two-cell mouse embryos. Nature. 2014;509:101-4 pubmed publisher
    ..The ability to use interphase cytoplasm in SCNT could aid efforts to generate autologous human ES cells for regenerative applications, as donated or discarded embryos are more accessible than unfertilized MII oocytes. ..
  29. Liu L, Souto J, Liao W, Jiang Y, Li Y, Nishinakamura R, et al. Histone lysine-specific demethylase 1 (LSD1) protein is involved in Sal-like protein 4 (SALL4)-mediated transcriptional repression in hematopoietic stem cells. J Biol Chem. 2013;288:34719-28 pubmed publisher
    The stem cell protein SALL4 plays a critical role in hematopoiesis by regulating the cell fate...
  30. Costa Y, Ding J, Theunissen T, Faiola F, Hore T, Shliaha P, et al. NANOG-dependent function of TET1 and TET2 in establishment of pluripotency. Nature. 2013;495:370-4 pubmed publisher
    ..These results provide an insight into the reprogramming mechanism of NANOG and uncover a new role for 5-methylcytosine hydroxylases in the establishment of naive pluripotency. ..
  31. Xu K, Chen X, Yang H, Xu Y, He Y, Wang C, et al. Maternal Sall4 Is Indispensable for Epigenetic Maturation of Mouse Oocytes. J Biol Chem. 2017;292:1798-1807 pubmed publisher
    b>Sall4 (Splat-like 4) plays important roles in maintaining pluripotency of embryonic stem cells and in various developmental processes. Here, we find that Sall4 is highly expressed in oocytes and early embryos...
  32. Kwon C, Arnold J, Hsiao E, Taketo M, Conklin B, Srivastava D. Canonical Wnt signaling is a positive regulator of mammalian cardiac progenitors. Proc Natl Acad Sci U S A. 2007;104:10894-9 pubmed
    ..Together, these data provide in vivo and in vitro evidence that canonical Wnt signaling promotes the expansion of cardiac progenitors and differentiation of cardiomyocytes. ..
  33. Böhm J, Buck A, Borozdin W, Mannan A, Matysiak Scholze U, Adham I, et al. Sall1, sall2, and sall4 are required for neural tube closure in mice. Am J Pathol. 2008;173:1455-63 pubmed publisher
    Four homologs to the Drosophila homeotic gene spalt (sal) exist in both humans and mice (SALL1 to SALL4/Sall1 to Sall4, respectively)...
  34. Toyoda D, Taguchi A, Chiga M, Ohmori T, Nishinakamura R. Sall4 Is Transiently Expressed in the Caudal Wolffian Duct and the Ureteric Bud, but Dispensable for Kidney Development. PLoS ONE. 2013;8:e68508 pubmed publisher
    ..Sall1 expressed in the metanephric mesenchyme is essential for ureteric bud attraction in kidney development. Sall4, another member of the Sall gene family, is required for maintenance of embryonic stem cells and establishment of ..
  35. Dai X, Jiang W, Zhang Q, Xu L, Geng P, Zhuang S, et al. Requirement for integrin-linked kinase in neural crest migration and differentiation and outflow tract morphogenesis. BMC Biol. 2013;11:107 pubmed publisher
    ..Changes in these pathways may collectively result in the unique neural crest and outflow tract phenotypes observed in ILK mutants. ..
  36. Cox J, Mallanna S, Luo X, Rizzino A. Sox2 uses multiple domains to associate with proteins present in Sox2-protein complexes. PLoS ONE. 2010;5:e15486 pubmed publisher
    ..we examined the size distribution of nuclear protein complexes containing Sox2 and its associated proteins HDAC1, Sall4 and Lin28...
  37. Tian Y, Yuan L, Goss A, Wang T, Yang J, Lepore J, et al. Characterization and in vivo pharmacological rescue of a Wnt2-Gata6 pathway required for cardiac inflow tract development. Dev Cell. 2010;18:275-87 pubmed publisher
    ..These data reveal a molecular pathway regulating the posterior cardiac mesoderm and demonstrate that cardiovascular defects caused by loss of Wnt signaling can be rescued pharmacologically in vivo. ..
  38. Gassei K, Orwig K. SALL4 expression in gonocytes and spermatogonial clones of postnatal mouse testes. PLoS ONE. 2013;8:e53976 pubmed publisher
    ..The pluripotency factor SALL4 (sal-like protein 4) is implicated in stem cell maintenance and patterning in many organs during embryonic ..
  39. Wu G, Han D, Gong Y, Sebastiano V, Gentile L, Singhal N, et al. Establishment of totipotency does not depend on Oct4A. Nat Cell Biol. 2013;15:1089-97 pubmed publisher
  40. Saito K, Abe H, Nakazawa M, Irokawa E, Watanabe M, Hosoi Y, et al. Cloning of complementary DNAs encoding structurally related homeoproteins from preimplantation mouse embryos: their involvement in the differentiation of embryonic stem cells. Biol Reprod. 2010;82:687-97 pubmed publisher
    ..Taken together, it was concluded that these transcripts encoding homeoproteins are capable of regulating the maintenance and/or differentiation of mouse ES cells and likely regulate that of preimplantation embryos. ..
  41. Kagey M, Newman J, Bilodeau S, Zhan Y, Orlando D, van Berkum N, et al. Mediator and cohesin connect gene expression and chromatin architecture. Nature. 2010;467:430-5 pubmed publisher
    ..Mediator and cohesin co-occupy different promoters in different cells, thus generating cell-type-specific DNA loops linked to the gene expression program of each cell. ..
  42. Milanovich S, Peterson J, Allred J, Stelloh C, Rajasekaran K, Fisher J, et al. Sall4 overexpression blocks murine hematopoiesis in a dose-dependent manner. Exp Hematol. 2015;43:53-64.e1-8 pubmed publisher
    Sal-like protein 4 (SALL4) is a transcription factor that exists in two splice isoforms, SALL4a and SALL4b, and regulates transcription in embryonic stem cells, hematopoiesis, and acute myeloid leukemia...
  43. Ewart Toland A, Briassouli P, de Koning J, Mao J, Yuan J, Chan F, et al. Identification of Stk6/STK15 as a candidate low-penetrance tumor-susceptibility gene in mouse and human. Nat Genet. 2003;34:403-12 pubmed
    ..This interaction results in colocalization of UBE2N with STK15 at the centrosomes during mitosis. These results are consistent with an important role for the Ile31 variant of STK15 in human cancer susceptibility. ..
  44. Jakobsen J, Braun M, Astorga J, Gustafson E, Sandmann T, Karzynski M, et al. Temporal ChIP-on-chip reveals Biniou as a universal regulator of the visceral muscle transcriptional network. Genes Dev. 2007;21:2448-60 pubmed
    ..The regulatory connection of a number of Biniou target genes is conserved in mice, suggesting an ancient wiring of this developmental program. ..
  45. Xu B, Hrycaj S, McIntyre D, Baker N, Takeuchi J, Jeannotte L, et al. Hox5 interacts with Plzf to restrict Shh expression in the developing forelimb. Proc Natl Acad Sci U S A. 2013;110:19438-43 pubmed publisher
    ..These findings, along with previous reports showing that point mutations in the Shh limb enhancer lead to similar anterior limb defects, highlight the importance of Shh repression for proper patterning of the vertebrate limb. ..
  46. Krentz A, Murphy M, Zhang T, Sarver A, Jain S, Griswold M, et al. Interaction between DMRT1 function and genetic background modulates signaling and pluripotency to control tumor susceptibility in the fetal germ line. Dev Biol. 2013;377:67-78 pubmed publisher
    ..Given the strong evidence for involvement of DMRT1 in human TGCT, the downstream genes and pathways identified in this study provide potentially useful candidates for roles in the human disease. ..
  47. Xiong J, Todorova D, Su N, Kim J, Lee P, Shen Z, et al. Stemness factor Sall4 is required for DNA damage response in embryonic stem cells. J Cell Biol. 2015;208:513-20 pubmed publisher
    ..The underlying mechanisms, however, remain largely unclear. In this paper, we show that the stemness factor Sall4 is required for activating the critical Ataxia Telangiectasia Mutated (ATM)-dependent cellular responses to DNA ..
  48. Akiyama R, Kawakami H, Wong J, Oishi I, Nishinakamura R, Kawakami Y. Sall4-Gli3 system in early limb progenitors is essential for the development of limb skeletal elements. Proc Natl Acad Sci U S A. 2015;112:5075-80 pubmed publisher
    ..Here we show that the zinc finger factors Sall4 and Gli3 cooperate for proper development of the anterior-proximal skeletal elements and also function upstream of ..
  49. Lovelace D, Gao Z, Mutoji K, Song Y, Ruan J, Hermann B. The regulatory repertoire of PLZF and SALL4 in undifferentiated spermatogonia. Development. 2016;143:1893-906 pubmed publisher
    ..The transcription factors Sal-like 4 (SALL4) and promyelocytic leukemia zinc finger (PLZF; also known as ZBTB16) are known to be required for normal SSC ..
  50. Chen Y, Ming Q, Zhu B. Exclusion of Sall 4 as the sex-determining gene in the Mandarin vole Microtus mandarinus mandarinus. Hereditas. 2011;148:93-7 pubmed publisher
    ..m. mandarinus is independent of the Sry gene. We amplified a 312 bp fragment within exon 2 of the Sall4 gene in the mouse and M. m...
  51. Wilson C, Crombie C, van der Weyden L, Poulogiannis G, Rust A, Pardo M, et al. Nuclear receptor binding protein 1 regulates intestinal progenitor cell homeostasis and tumour formation. EMBO J. 2012;31:2486-97 pubmed publisher
    ..components of the ubiquitination machinery and that loss of Nrbp1 in the intestine results in the accumulation of Sall4, a key mediator of stem cell fate, and of Tsc22d2...
  52. Nimura K, Ura K, Shiratori H, Ikawa M, Okabe M, Schwartz R, et al. A histone H3 lysine 36 trimethyltransferase links Nkx2-5 to Wolf-Hirschhorn syndrome. Nature. 2009;460:287-91 pubmed publisher
    ..governed H3K36me3 along euchromatin by associating with the cell-type-specific transcription factors Sall1, Sall4 and Nanog in embryonic stem cells, and Nkx2-5 in embryonic hearts, regulating the expression of their target genes...
  53. Miller A, Ralser M, Kloet S, Loos R, Nishinakamura R, Bertone P, et al. Sall4 controls differentiation of pluripotent cells independently of the Nucleosome Remodelling and Deacetylation (NuRD) complex. Development. 2016;143:3074-84 pubmed publisher
    b>Sall4 is an essential transcription factor for early mammalian development and is frequently overexpressed in cancer...
  54. Tan M, Au K, Leong D, Foygel K, Wong W, Yao M. An Oct4-Sall4-Nanog network controls developmental progression in the pre-implantation mouse embryo. Mol Syst Biol. 2013;9:632 pubmed publisher
    ..We delineated the regulons of Oct4, Sall4, and Nanog and identified a set of metabolism- and transport-related genes that were controlled by these ..