S1pr2

Summary

Gene Symbol: S1pr2
Description: sphingosine-1-phosphate receptor 2
Alias: 1100001A16Rik, Edg5, Gpcr13, H218, LPb2, S1P2, sphingosine 1-phosphate receptor 2, G-protein coupled receptor 13, S1P receptor 2, S1P receptor Edg-5, endothelial differentiation G-protein coupled receptor 5, endothelial differentiation, sphingolipid G-protein-coupled receptor, 5, lysophospholipid receptor B2, sphingosine 1-phosphate receptor Edg-5, sphingosine-1-phosphate receptor S1P(2)
Species: mouse
Products:     S1pr2

Top Publications

  1. Zhang G, Contos J, Weiner J, Fukushima N, Chun J. Comparative analysis of three murine G-protein coupled receptors activated by sphingosine-1-phosphate. Gene. 1999;227:89-99 pubmed
    ..Three murine genomic clones (designated lpB1, lpB2, and lpB3) were isolated, corresponding to human/rat Edg-1, rat H218/AGR16, and human edg-3, respectively...
  2. Ishii I, Ye X, Friedman B, Kawamura S, Contos J, Kingsbury M, et al. Marked perinatal lethality and cellular signaling deficits in mice null for the two sphingosine 1-phosphate (S1P) receptors, S1P(2)/LP(B2)/EDG-5 and S1P(3)/LP(B3)/EDG-3. J Biol Chem. 2002;277:25152-9 pubmed
    ..Although either receptor subtype supports embryonic development, deletion of both produces marked perinatal lethality, demonstrating an essential role for combined S1P signaling by these receptors. ..
  3. Wang X, Cho B, Suzuki K, Xu Y, Green J, An J, et al. Follicular dendritic cells help establish follicle identity and promote B cell retention in germinal centers. J Exp Med. 2011;208:2497-510 pubmed publisher
    ..These experiments indicate that FDCs help maintain primary follicles as a B cell exclusive niche and define a critical role for FDCs in cell retention within GCs...
  4. Wendler C, Rivkees S. Sphingosine-1-phosphate inhibits cell migration and endothelial to mesenchymal cell transformation during cardiac development. Dev Biol. 2006;291:264-77 pubmed
    ..These data indicate that S1P, locally maintained within a specific concentration range, is an important and necessary component of early heart development. ..
  5. Mizugishi K, Yamashita T, Olivera A, Miller G, Spiegel S, Proia R. Essential role for sphingosine kinases in neural and vascular development. Mol Cell Biol. 2005;25:11113-21 pubmed
    ..Our findings also suggest that exploitation of this potent neuronal survival pathway could lead to the development of novel therapeutic approaches for neurological diseases. ..
  6. Green J, Suzuki K, Cho B, Willison L, Palmer D, Allen C, et al. The sphingosine 1-phosphate receptor S1P? maintains the homeostasis of germinal center B cells and promotes niche confinement. Nat Immunol. 2011;12:672-80 pubmed publisher
    ..We suggest that by inhibiting Akt activation and migration, S1P(2) helps restrict GC B cell survival and localization to an S1P-low niche at the follicle center. ..
  7. Ohuchi H, Hamada A, Matsuda H, Takagi A, Tanaka M, Aoki J, et al. Expression patterns of the lysophospholipid receptor genes during mouse early development. Dev Dyn. 2008;237:3280-94 pubmed publisher
    ..These results suggest that multiple receptor systems for LPA/S1P lysophospholipids may be functioning during organogenesis. ..
  8. Cattoretti G, Mandelbaum J, Lee N, Chaves A, Mahler A, Chadburn A, et al. Targeted disruption of the S1P2 sphingosine 1-phosphate receptor gene leads to diffuse large B-cell lymphoma formation. Cancer Res. 2009;69:8686-92 pubmed publisher
    ..The high incidence of DLBCL in S1P(2)(-/-) mice, its onset at old age, and the relative lack of other neoplasms identify these mice as a novel, and potentially valuable, model for this highly prevalent and aggressive human malignancy. ..
  9. Du W, Takuwa N, Yoshioka K, Okamoto Y, Gonda K, Sugihara K, et al. S1P(2), the G protein-coupled receptor for sphingosine-1-phosphate, negatively regulates tumor angiogenesis and tumor growth in vivo in mice. Cancer Res. 2010;70:772-81 pubmed publisher

More Information

Publications62

  1. Olivera A, Eisner C, Kitamura Y, Dillahunt S, Allende L, Tuymetova G, et al. Sphingosine kinase 1 and sphingosine-1-phosphate receptor 2 are vital to recovery from anaphylactic shock in mice. J Clin Invest. 2010;120:1429-40 pubmed publisher
    ..Mice lacking the S1P receptor S1PR2 also showed a delay in plasma histamine clearance and a poor recovery from anaphylaxis...
  2. Medlin M, Staus D, Dubash A, Taylor J, Mack C. Sphingosine 1-phosphate receptor 2 signals through leukemia-associated RhoGEF (LARG), to promote smooth muscle cell differentiation. Arterioscler Thromb Vasc Biol. 2010;30:1779-86 pubmed publisher
    ..Using a combination of receptor-specific agonists and antagonists we identified S1P receptor 2 (S1PR2) as the major S1P receptor subtype that regulates SMC differentiation marker gene expression...
  3. Sanchez T, Thangada S, Wu M, Kontos C, Wu D, Wu H, et al. PTEN as an effector in the signaling of antimigratory G protein-coupled receptor. Proc Natl Acad Sci U S A. 2005;102:4312-7 pubmed
    ..Here, we show that the bioactive lipid sphingosine 1-phosphate (S1P), which acts through the S1P2 receptor (S1P2R) G protein-coupled receptor (GPCR) to inhibit cell migration, utilizes PTEN as a signaling ..
  4. Kono M, Mi Y, Liu Y, Sasaki T, Allende M, Wu Y, et al. The sphingosine-1-phosphate receptors S1P1, S1P2, and S1P3 function coordinately during embryonic angiogenesis. J Biol Chem. 2004;279:29367-73 pubmed
    ..Our results indicate that the S1P(1), S1P(2) and S1P(3) receptors have redundant or cooperative functions for the development of a stable and mature vascular system during embryonic development. ..
  5. Arikawa K, Takuwa N, Yamaguchi H, Sugimoto N, Kitayama J, Nagawa H, et al. Ligand-dependent inhibition of B16 melanoma cell migration and invasion via endogenous S1P2 G protein-coupled receptor. Requirement of inhibition of cellular RAC activity. J Biol Chem. 2003;278:32841-51 pubmed
    ..and sphingosylphosphorylcholine inhibited B16 cell migration and invasion with the relative potencies expected as S1P2 receptor agonists. The S1P2-selective antagonist JTE013 completely abolished the responses to these agonists...
  6. Michaud J, Im D, Hla T. Inhibitory role of sphingosine 1-phosphate receptor 2 in macrophage recruitment during inflammation. J Immunol. 2010;184:1475-83 pubmed publisher
    ..Our results suggest that S1P serves as a negative regulator of macrophage recruitment by inhibiting migration in these cells and identify an additional facet to the regulation of leukocyte trafficking by S1P. ..
  7. MacLennan A, Carney P, Zhu W, Chaves A, Garcia J, Grimes J, et al. An essential role for the H218/AGR16/Edg-5/LP(B2) sphingosine 1-phosphate receptor in neuronal excitability. Eur J Neurosci. 2001;14:203-9 pubmed
    A wealth of indirect data suggest that the H218/AGR16/Edg-5/LP(B2) sphingosine 1-phosphate (S1P) receptor plays important roles in development...
  8. Meng H, Lee V. Differential expression of sphingosine-1-phosphate receptors 1-5 in the developing nervous system. Dev Dyn. 2009;238:487-500 pubmed publisher
    ..We showed that S1pr2 was expressed in migrating cranial neural crest cells and enteric neurons...
  9. Studer E, Zhou X, Zhao R, Wang Y, Takabe K, Nagahashi M, et al. Conjugated bile acids activate the sphingosine-1-phosphate receptor 2 in primary rodent hepatocytes. Hepatology. 2012;55:267-76 pubmed publisher
    ..In summary, all these data support the hypothesis that conjugated bile acids activate the ERK1/2 and AKT signaling pathways primarily through S1P(2) in primary rodent hepatocytes. ..
  10. Calise S, Blescia S, Cencetti F, Bernacchioni C, Donati C, Bruni P. Sphingosine 1-phosphate stimulates proliferation and migration of satellite cells: role of S1P receptors. Biochim Biophys Acta. 2012;1823:439-50 pubmed publisher
    ..and silencing individual S1P receptors, the mitogenic action of S1P in satellite cells was shown to depend on S1P2 and S1P3...
  11. Tu Z, Argmann C, Wong K, Mitnaul L, Edwards S, Sach I, et al. Integrating siRNA and protein-protein interaction data to identify an expanded insulin signaling network. Genome Res. 2009;19:1057-67 pubmed publisher
    ..We experimentally validated one of the predictions, S1pr2, as a novel candidate gene for T2D.
  12. Kempf A, Boda E, Kwok J, Fritz R, Grande V, Kaelin A, et al. Control of Cell Shape, Neurite Outgrowth, and Migration by a Nogo-A/HSPG Interaction. Dev Cell. 2017;43:24-34.e5 pubmed publisher
    ..we show that Nogo-A-?20 can act via HSPGs independently of its receptor, Sphingosine-1-Phosphate receptor 2 (S1PR2). We thereby identify the HSPG family members syndecan-3 and syndecan-4 as functional receptors for Nogo-A-?20...
  13. Skoura A, Sanchez T, Claffey K, Mandala S, Proia R, Hla T. Essential role of sphingosine 1-phosphate receptor 2 in pathological angiogenesis of the mouse retina. J Clin Invest. 2007;117:2506-16 pubmed
    ..subjected to ischemia-driven retinopathy, pathologic neovascularization in the vitreous chamber was suppressed in S1p2-/- mice concomitant with reduction in endothelial gaps and inflammatory cell infiltration...
  14. Herr D, Grillet N, Schwander M, Rivera R, Muller U, Chun J. Sphingosine 1-phosphate (S1P) signaling is required for maintenance of hair cells mainly via activation of S1P2. J Neurosci. 2007;27:1474-8 pubmed
    ..We report here that sphingosine 1-phosphate (S1P) signaling, mainly via activation of its cognate receptor S1P2, is required for the maintenance of vestibular and cochlear hair cells in vivo...
  15. McGiffert C, Contos J, Friedman B, Chun J. Embryonic brain expression analysis of lysophospholipid receptor genes suggests roles for s1p(1) in neurogenesis and s1p(1-3) in angiogenesis. FEBS Lett. 2002;531:103-8 pubmed
    ..The punctate pattern colocalized with vascular endothelial markers. Together, these results suggest that s1p(1) influences neurogenesis and s1p(1-3) influence angiogenesis in the developing brain. ..
  16. Szczepaniak W, Pitt B, McVerry B. S1P2 receptor-dependent Rho-kinase activation mediates vasoconstriction in the murine pulmonary circulation induced by sphingosine 1-phosphate. Am J Physiol Lung Cell Mol Physiol. 2010;299:L137-45 pubmed publisher
    ..These results suggest that S1P is capable of altering pulmonary vascular tone in vivo and may play an important role in the modulation of pulmonary vascular tone both in the normal lung and under pathological conditions. ..
  17. Wang Z, Lai Y, Bernard J, MacLeod D, Cogen A, Moss B, et al. Skin mast cells protect mice against vaccinia virus by triggering mast cell receptor S1PR2 and releasing antimicrobial peptides. J Immunol. 2012;188:345-57 pubmed publisher
    ..mice from VV, neutralizing Ab to the L1 fusion entry protein of VV inhibits degranulation apparently by preventing S1PR2 activation by viral membrane lipids, and antimicrobial peptide release from MC granules is necessary to inactivate ..
  18. Catarzi S, Romagnoli C, Marcucci G, Favilli F, Iantomasi T, Vincenzini M. Redox regulation of ERK1/2 activation induced by sphingosine 1-phosphate in fibroblasts: involvement of NADPH oxidase and platelet-derived growth factor receptor. Biochim Biophys Acta. 2011;1810:446-56 pubmed publisher
  19. Sugimoto N, Takuwa N, Okamoto H, Sakurada S, Takuwa Y. Inhibitory and stimulatory regulation of Rac and cell motility by the G12/13-Rho and Gi pathways integrated downstream of a single G protein-coupled sphingosine-1-phosphate receptor isoform. Mol Cell Biol. 2003;23:1534-45 pubmed
    The G protein-coupled receptors S1P2/Edg5 and S1P3/Edg3 both mediate sphingosine-1-phosphate (S1P) stimulation of Rho, yet S1P2 but not S1P3 mediates downregulation of Rac activation, membrane ruffling, and cell migration in response to ..
  20. Higashi K, Matsuzaki E, Hashimoto Y, Takahashi Yanaga F, Takano A, Anan H, et al. Sphingosine-1-phosphate/S1PR2-mediated signaling triggers Smad1/5/8 phosphorylation and thereby induces Runx2 expression in osteoblasts. Bone. 2016;93:1-11 pubmed publisher
    ..Recently, we reported that the S1P receptors S1PR1 and S1PR2 were mainly expressed in osteoblast-like cells, and that the S1P/S1PR1 signaling pathway up-regulated ..
  21. Kim G, Yang L, Zhang G, Zhao H, Selim M, McCullough L, et al. Critical role of sphingosine-1-phosphate receptor-2 in the disruption of cerebrovascular integrity in experimental stroke. Nat Commun. 2015;6:7893 pubmed publisher
    ..By using genetic approaches and a S1PR2 antagonist (JTE013), here we show that S1PR2 plays a critical role in the induction of cerebrovascular ..
  22. Herr D, Lee C, Wang W, Ware A, Rivera R, Chun J. Sphingosine 1-phosphate receptors are essential mediators of eyelid closure during embryonic development. J Biol Chem. 2013;288:29882-9 pubmed publisher
    ..Here, we show that two S1P receptors, S1P2 and S1P3, are collectively essential mediators of eyelid closure during murine development...
  23. Olivera A, Dillahunt S, Rivera J. Interrogation of sphingosine-1-phosphate receptor 2 function in vivo reveals a prominent role in the recovery from IgE and IgG-mediated anaphylaxis with minimal effect on its onset. Immunol Lett. 2013;150:89-96 pubmed publisher
    Autocrine stimulation of S1PR2, a receptor for the lipid mediator sphingosine-1-phosphate (S1P), has been implicated in mast cell degranulation to IgE/antigen (Ag) although, paradoxically, its ligand cannot trigger substantial ..
  24. Germinario E, Peron S, Toniolo L, Betto R, Cencetti F, Donati C, et al. S1P2 receptor promotes mouse skeletal muscle regeneration. J Appl Physiol (1985). 2012;113:707-13 pubmed publisher
    ..The study indicates that S1P(2) receptor plays a key role in the early phases of muscle regeneration by sustaining differentiation and growth of new-forming myofibers. ..
  25. Kageyama Y, Ikeda H, Watanabe N, Nagamine M, Kusumoto Y, Yashiro M, et al. Antagonism of sphingosine 1-phosphate receptor 2 causes a selective reduction of portal vein pressure in bile duct-ligated rodents. Hepatology. 2012;56:1427-38 pubmed publisher
    ..of those cells and enhances portal vein pressure in isolated perfused rat livers with Rho activation by way of S1P receptor 2 (S1P(2) )...
  26. Takabatake M, Takuwa Y, Takuwa N, Yasuno H, Matsumoto S, Shibutani M, et al. A case report of a renal mixed epithelial and stromal tumor in a heterozygous S1P2 receptor deficient mouse. J Vet Med Sci. 2008;70:483-5 pubmed
    ..mixed epithelial and stromal tumor of the kidney (MESTK) in a 32-week-old heterozygous sphingosine 1-phosphate-2 (S1P2) receptor deficient female mouse...
  27. Grabski A, Shimizu T, Deou J, Mahoney W, Reidy M, Daum G. Sphingosine-1-phosphate receptor-2 regulates expression of smooth muscle alpha-actin after arterial injury. Arterioscler Thromb Vasc Biol. 2009;29:1644-50 pubmed publisher
    ..We further conclude that transcriptional regulation of SMA by S1P in vitro requires S1P2R-dependent activation of RhoA and mobilization of calcium from intracellular calcium stores. ..
  28. Sammani S, Moreno Vinasco L, Mirzapoiazova T, Singleton P, Chiang E, Evenoski C, et al. Differential effects of sphingosine 1-phosphate receptors on airway and vascular barrier function in the murine lung. Am J Respir Cell Mol Biol. 2010;43:394-402 pubmed publisher
  29. Chiba Y, Suzuki K, Uechi M, Kurihara E, Goto K, Sakai H, et al. Downregulation of sphingosine-1-phosphate receptors in bronchial smooth muscle of mouse experimental asthma. Pharmacol Res. 2010;62:357-63 pubmed publisher
    ..The S1P-mediated contraction was abolished by JTE-013, a selective S1P receptor 2 (S1PR2) antagonist, but not by W123, a selective S1PR1 antagonist, and BML-241, a selective S1PR3 antagonist...
  30. Cui H, Okamoto Y, Yoshioka K, Du W, Takuwa N, Zhang W, et al. Sphingosine-1-phosphate receptor 2 protects against anaphylactic shock through suppression of endothelial nitric oxide synthase in mice. J Allergy Clin Immunol. 2013;132:1205-1214.e9 pubmed publisher
    ..Analyses were performed to examine vascular permeability and the underlying mechanisms. S1pr2 deletion augmented vascular leakage and lethality after either antigen challenge or PAF injection...
  31. Hou J, Chen Q, Zhang K, Cheng B, Xie G, Wu X, et al. Sphingosine 1-phosphate Receptor 2 Signaling Suppresses Macrophage Phagocytosis and Impairs Host Defense against Sepsis. Anesthesiology. 2015;123:409-22 pubmed publisher
    ..Sphingosine 1-phosphate receptor 2 (S1PR2) modulates endotoxin-induced inflammation in endothelium...
  32. Nakajima C, Haffner P, Goerke S, Zurhove K, Adelmann G, Frotscher M, et al. The lipoprotein receptor LRP1 modulates sphingosine-1-phosphate signaling and is essential for vascular development. Development. 2014;141:4513-25 pubmed publisher
  33. Muppidi J, Schmitz R, Green J, Xiao W, Larsen A, Braun S, et al. Loss of signalling via Gα13 in germinal centre B-cell-derived lymphoma. Nature. 2014;516:254-8 pubmed publisher
    ..Work in mice showed that sphingosine-1-phosphate receptor-2 (S1PR2), a Gα12 and Gα13 coupled receptor, promotes growth regulation and local confinement of germinal centre B ..
  34. Edsbagge J, Johansson J, Esni F, Luo Y, Radice G, Semb H. Vascular function and sphingosine-1-phosphate regulate development of the dorsal pancreatic mesenchyme. Development. 2005;132:1085-92 pubmed
    ..Thus, we propose a new model where blood vessel-derived sphingosine-1-phosphate stimulates growth and budding of the dorsal pancreatic endoderm by induction of mesenchymal cell proliferation. ..
  35. Sand F, Hörnblad A, Johansson J, Lorén C, Edsbagge J, Ståhlberg A, et al. Growth-limiting role of endothelial cells in endoderm development. Dev Biol. 2011;352:267-77 pubmed publisher
    ..Altogether, our results show that endothelial cell hyperplasia negatively influences organ development in several foregut-derived organs. ..
  36. McQuiston T, Luberto C, Del Poeta M. Role of sphingosine-1-phosphate (S1P) and S1P receptor 2 in the phagocytosis of Cryptococcus neoformans by alveolar macrophages. Microbiology. 2011;157:1416-27 pubmed publisher
    ..neoformans by AMs through S1P receptor 2 (S1P2)...
  37. Lorenz J, Arend L, Robitz R, Paul R, MacLennan A. Vascular dysfunction in S1P2 sphingosine 1-phosphate receptor knockout mice. Am J Physiol Regul Integr Comp Physiol. 2007;292:R440-6 pubmed
    ..This is mediated, at least in part, through an effect on the endothelium, but direct effects on vascular smooth muscle cannot be ruled out and require further investigation. ..
  38. Kohno M, Momoi M, Oo M, Paik J, Lee Y, Venkataraman K, et al. Intracellular role for sphingosine kinase 1 in intestinal adenoma cell proliferation. Mol Cell Biol. 2006;26:7211-23 pubmed
    ..Our findings suggest that Sphk1 plays a critical role in intestinal tumor cell proliferation and that inhibitors of Sphk1 may be useful in the control of intestinal cancer. ..
  39. Kirby R, Jin Y, Fu J, Cubillos J, Swertfeger D, Arend L. Dynamic regulation of sphingosine-1-phosphate homeostasis during development of mouse metanephric kidney. Am J Physiol Renal Physiol. 2009;296:F634-41 pubmed publisher
    ..S1P1 and S1P2 were the predominant S1P receptors expressed in the embryonic kidney...
  40. Ingham N, Carlisle F, Pearson S, Lewis M, Buniello A, Chen J, et al. S1PR2 variants associated with auditory function in humans and endocochlear potential decline in mouse. Sci Rep. 2016;6:28964 pubmed publisher
    ..loss was detected and exome sequencing revealed a Thr289Arg substitution in Sphingosine-1-Phosphate Receptor-2 (S1pr2)...
  41. Kitada Y, Kajita K, Taguchi K, Mori I, Yamauchi M, Ikeda T, et al. Blockade of Sphingosine 1-Phosphate Receptor 2 Signaling Attenuates High-Fat Diet-Induced Adipocyte Hypertrophy and Systemic Glucose Intolerance in Mice. Endocrinology. 2016;157:1839-51 pubmed publisher
    ..its 5 cognate receptors (S1pr1-S1pr5), S1P seems to counteract insulin signaling and confer insulin resistance via S1pr2 in these cells...
  42. Hughes J, Srinivasan S, Lynch K, Proia R, Ferdek P, Hedrick C. Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages. Circ Res. 2008;102:950-8 pubmed publisher
    ..Studies using bone marrow-derived macrophages from S1P2-deficient mice revealed that the S1P2 receptor did not play a pivotal role in this process...
  43. Goparaju S, Jolly P, Watterson K, Bektas M, Alvarez S, Sarkar S, et al. The S1P2 receptor negatively regulates platelet-derived growth factor-induced motility and proliferation. Mol Cell Biol. 2005;25:4237-49 pubmed
    ..Thus, S1P(2) serves as a negative regulator of PDGF-induced migration and proliferation as well as SphK1 expression. Our results suggest that a complex interplay between PDGFR and S1P receptors determines their functions. ..
  44. Ishii M, Kikuta J, Shimazu Y, Meier Schellersheim M, Germain R. Chemorepulsion by blood S1P regulates osteoclast precursor mobilization and bone remodeling in vivo. J Exp Med. 2010;207:2793-8 pubmed publisher
    ..We show that OPs also express S1PR2, an S1P receptor which mediates negative chemotaxis (or chemorepulsion)...
  45. Means C, Xiao C, Li Z, Zhang T, Omens J, Ishii I, et al. Sphingosine 1-phosphate S1P2 and S1P3 receptor-mediated Akt activation protects against in vivo myocardial ischemia-reperfusion injury. Am J Physiol Heart Circ Physiol. 2007;292:H2944-51 pubmed
    ..Our data demonstrate that activation of S1P(2) and S1P(3) receptors plays a significant role in protecting cardiomyocytes from I/R damage in vivo and implicate the release of S1P and receptor-mediated Akt activation in this process. ..
  46. Japtok L, Schmitz E, Fayyaz S, Krämer S, Hsu L, Kleuser B. Sphingosine 1-phosphate counteracts insulin signaling in pancreatic β-cells via the sphingosine 1-phosphate receptor subtype 2. FASEB J. 2015;29:3357-69 pubmed publisher
    ..antagonizes insulin-mediated cell growth and survival via the sphingosine 1-phosphate receptor subtype 2 (S1P2) followed by an inhibition of Akt-signaling...
  47. Tanaka K, Hashizume M, Mihara M, Yoshida H, Suzuki M, Matsumoto Y. Anti-interleukin-6 receptor antibody prevents systemic bone mass loss via reducing the number of osteoclast precursors in bone marrow in a collagen-induced arthritis model. Clin Exp Immunol. 2014;175:172-80 pubmed publisher
    ..of osteoclast precursor cells (OCPs) between the blood and bone marrow, in part via S1P receptors (S1PR1 and S1PR2) expressed on the surface of OCPs...
  48. Muppidi J, Lu E, Cyster J. The G protein-coupled receptor P2RY8 and follicular dendritic cells promote germinal center confinement of B cells, whereas S1PR3 can contribute to their dissemination. J Exp Med. 2015;212:2213-22 pubmed publisher
  49. Santos Cortez R, Faridi R, Rehman A, Lee K, Ansar M, Wang X, et al. Autosomal-Recessive Hearing Impairment Due to Rare Missense Variants within S1PR2. Am J Hum Genet. 2016;98:331-8 pubmed publisher
    ..However, S1PRs have not been previously reported to be involved in the genetic etiology of human traits. S1PR2 lies within the autosomal-recessive nonsyndromic hearing impairment (ARNSHI) locus DFNB68 on 19p13.2...
  50. Shimizu T, Nakazawa T, Cho A, Dastvan F, Shilling D, Daum G, et al. Sphingosine 1-phosphate receptor 2 negatively regulates neointimal formation in mouse arteries. Circ Res. 2007;101:995-1000 pubmed
    Neointimal lesion formation was induced in sphingosine 1-phosphate (S1P) receptor 2 (S1P2)-null and wild-type mice by ligation of the left carotid artery...
  51. Poulsen R, McClaskey C, Rivkees S, Wendler C. The Sphingosine-1-phospate receptor 1 mediates S1P action during cardiac development. BMC Dev Biol. 2011;11:37 pubmed publisher
  52. Serafimidis I, Rodriguez Aznar E, Lesche M, Yoshioka K, Takuwa Y, Dahl A, et al. Pancreas lineage allocation and specification are regulated by sphingosine-1-phosphate signalling. PLoS Biol. 2017;15:e2000949 pubmed publisher
    ..genomics, we found that sphingosine-1-phosphate (S1p), signalling through the G protein coupled receptor (GPCR) S1pr2, plays a key role in pancreas development linking lineage allocation and specification...
  53. Roelofsen T, Akkers R, Beumer W, Apotheker M, Steeghs I, van de Ven J, et al. Sphingosine-1-phosphate acts as a developmental stage specific inhibitor of platelet-derived growth factor-induced chemotaxis of osteoblasts. J Cell Biochem. 2008;105:1128-38 pubmed publisher
    ..By RNA interference and overexpression experiments we showed that the expression level of the S1P2 receptor is the sole determinant controlling responsiveness to S1P...