Gene Symbol: S100a7a
Description: S100 calcium binding protein A7A
Alias: AY465109, Gm1020, S100A7L1, S100A7f, S100a15, S100a15a, S100a17l1, protein S100-A15A, S100 calcium binding protein A15, S100 calcium binding protein A7-like 1, S100 calcium-binding protein A15A
Species: mouse
Products:     S100a7a

Top Publications

  1. Webb M, Emberley E, Lizardo M, Alowami S, Qing G, Alfia ar A, et al. Expression analysis of the mouse S100A7/psoriasin gene in skin inflammation and mammary tumorigenesis. BMC Cancer. 2005;5:17 pubmed
  2. Wolf R, Voscopoulos C, FitzGerald P, Goldsmith P, Cataisson C, Gunsior M, et al. The mouse S100A15 ortholog parallels genomic organization, structure, gene expression, and protein-processing pattern of the human S100A7/A15 subfamily during epidermal maturation. J Invest Dermatol. 2006;126:1600-8 pubmed
    ..The hS100A7 (psoriasin) and S100A15 reside in a chromosomal cluster of highly similar paralogs...
  3. Wolf R, Mascia F, Dharamsi A, Howard O, Cataisson C, Bliskovski V, et al. Gene from a psoriasis susceptibility locus primes the skin for inflammation. Sci Transl Med. 2010;2:61ra90 pubmed publisher
    ..Inflammation-prone psoriatic skin constitutively expresses elevated concentrations of S100A7 (psoriasin) and S100A15 (koebnerisin) in the epidermis...
  4. Gui J, Gober M, Yang X, Katlinski K, Marshall C, Sharma M, et al. Therapeutic Elimination of the Type 1 Interferon Receptor for Treating Psoriatic Skin Inflammation. J Invest Dermatol. 2016;136:1990-2002 pubmed publisher
  5. Marenholz I, Heizmann C, Fritz G. S100 proteins in mouse and man: from evolution to function and pathology (including an update of the nomenclature). Biochem Biophys Res Commun. 2004;322:1111-22 pubmed
    ..An update of the S100 nomenclature is included, because some of the recently identified S100 genes and pseudogenes had to be renamed. ..
  6. Marenholz I, Lovering R, Heizmann C. An update of the S100 nomenclature. Biochim Biophys Acta. 2006;1763:1282-3 pubmed
    ..Here we present the official and updated nomenclature of this protein family, approved by the HGNC (HUGO gene nomenclature committee) and ECS (European Calcium Society). ..
  7. Nasser M, Qamri Z, Deol Y, Ravi J, Powell C, Trikha P, et al. S100A7 enhances mammary tumorigenesis through upregulation of inflammatory pathways. Cancer Res. 2012;72:604-15 pubmed publisher
    ..In summary, our work used a powerful new model system to show that S100A7 enhances breast tumor growth and metastasis by activating proinflammatory and metastatic pathways. ..
  8. Hau C, Kanda N, Noda S, Tatsuta A, Kamata M, Shibata S, et al. Visfatin enhances the production of cathelicidin antimicrobial peptide, human β-defensin-2, human β-defensin-3, and S100A7 in human keratinocytes and their orthologs in murine imiquimod-induced psoriatic skin. Am J Pathol. 2013;182:1705-17 pubmed publisher
    ..Visfatin may potentiate the development of psoriasis via antimicrobial peptides. ..
  9. Ravasi T, Hsu K, Goyette J, Schroder K, Yang Z, Rahimi F, et al. Probing the S100 protein family through genomic and functional analysis. Genomics. 2004;84:10-22 pubmed
    ..Evolution of the S100 proteins appears to have occurred in a modular fashion, also seen in other protein families such as the C2H2-type zinc-finger family. ..

More Information


  1. Mailleux A, Overholtzer M, Schmelzle T, Bouillet P, Strasser A, Brugge J. BIM regulates apoptosis during mammary ductal morphogenesis, and its absence reveals alternative cell death mechanisms. Dev Cell. 2007;12:221-34 pubmed
    ..These data provide important mechanistic information on the processes involved in sculpting the mammary gland and demonstrate that BIM is a critical regulator of apoptosis in vivo. ..
  2. Zhou G, Xie T, Zhao M, Jasser S, Younes M, Sano D, et al. Reciprocal negative regulation between S100A7/psoriasin and beta-catenin signaling plays an important role in tumor progression of squamous cell carcinoma of oral cavity. Oncogene. 2008;27:3527-38 pubmed publisher
    ..Downregulation of S100A7 in later stages of tumorigenesis increases beta-catenin signaling, leading to promotion of tumor growth and tumor progression. ..