S100a4

Summary

Gene Symbol: S100a4
Description: S100 calcium binding protein A4
Alias: 18A2, 42a, Capl, FSp1, Mts1, PeL98, metastasin, pk9a, protein S100-A4, calvasculin, metastatic cell protein, placental calcium-binding protein, protein 18A2, protein Mts1
Species: mouse
Products:     S100a4

Top Publications

  1. Spiekerkoetter E, Alvira C, Kim Y, Bruneau A, Pricola K, Wang L, et al. Reactivation of gammaHV68 induces neointimal lesions in pulmonary arteries of S100A4/Mts1-overexpressing mice in association with degradation of elastin. Am J Physiol Lung Cell Mol Physiol. 2008;294:L276-89 pubmed
    b>S100A4/Mts-overexpressing mice have thick elastic laminae and mild pulmonary arterial hypertension (PAH), and the occasional older mouse develops occlusive neointimal lesions and perivascular inflammation...
  2. Grum Schwensen B, Klingelhofer J, Grigorian M, Almholt K, Nielsen B, Lukanidin E, et al. Lung metastasis fails in MMTV-PyMT oncomice lacking S100A4 due to a T-cell deficiency in primary tumors. Cancer Res. 2010;70:936-47 pubmed publisher
    ..The metastasis-stimulating protein S100A4 exerts its function as a stroma cell-derived factor...
  3. Kriajevska M, Cardenas M, Grigorian M, Ambartsumian N, Georgiev G, Lukanidin E. Non-muscle myosin heavy chain as a possible target for protein encoded by metastasis-related mts-1 gene. J Biol Chem. 1994;269:19679-82 pubmed
    ..The data suggest that the target for Mts-1 protein is a heavy chain of non-muscle myosin. ..
  4. Xue C, Plieth D, Venkov C, Xu C, Neilson E. The gatekeeper effect of epithelial-mesenchymal transition regulates the frequency of breast cancer metastasis. Cancer Res. 2003;63:3386-94 pubmed
    ..Cells making this switch selectively express S100A4, a p53-associated, calcium-binding protein known in the fibroblast literature as fibroblast-specific protein-1 (..
  5. Ambartsumian N, Grigorian M, Larsen I, Karlstrøm O, Sidenius N, Rygaard J, et al. Metastasis of mammary carcinomas in GRS/A hybrid mice transgenic for the mts1 gene. Oncogene. 1996;13:1621-30 pubmed
    Transgenic mice, carrying the mts1 gene, one of the genes involved in the acquisition of the metastatic phenotype, were generated...
  6. Grotterød I, Maelandsmo G, Boye K. Signal transduction mechanisms involved in S100A4-induced activation of the transcription factor NF-kappaB. BMC Cancer. 2010;10:241 pubmed publisher
    The metastasis-promoting protein S100A4 activates the transcription factor NF-kappaB through the classical NF-kappaB activation pathway...
  7. Zimmer D, Cornwall E, Landar A, Song W. The S100 protein family: history, function, and expression. Brain Res Bull. 1995;37:417-29 pubmed
  8. Ambartsumian N, Klingelhofer J, Grigorian M, Christensen C, Kriajevska M, Tulchinsky E, et al. The metastasis-associated Mts1(S100A4) protein could act as an angiogenic factor. Oncogene. 2001;20:4685-95 pubmed
    The involvement of Mts1(S100A4), a small Ca(2+)-binding protein in tumor progression and metastasis had been demonstrated. However, the mechanism by which mts1(S100A4) promoted metastasis had not been identified...
  9. Grigorian M, Tulchinsky E, Zain S, Ebralidze A, Kramerov D, Kriajevska M, et al. The mts1 gene and control of tumor metastasis. Gene. 1993;135:229-38 pubmed
    ..the data obtained on the detection, cloning, structure and transcription control of the mts1 gene, that encodes metastasin 1, a protein which seems to play an important role in the control of metastasis in mouse tumors...

More Information

Publications87

  1. Endo H, Takenaga K, Kanno T, Satoh H, Mori S. Methionine aminopeptidase 2 is a new target for the metastasis-associated protein, S100A4. J Biol Chem. 2002;277:26396-402 pubmed
    b>S100A4 is an EF-hand type calcium-binding protein that regulates tumor metastasis and a variety of cellular processes via interaction with different target proteins...
  2. Grigorian M, Ambartsumian N, Lykkesfeldt A, Bastholm L, Elling F, Georgiev G, et al. Effect of mts1 (S100A4) expression on the progression of human breast cancer cells. Int J Cancer. 1996;67:831-41 pubmed
    The mts1 (S100A4) gene, encoding a Ca(2+)-binding protein of the S-100 subfamily, is involved in the control of tumor metastasis in some murine tumor cell lines...
  3. Ebralidze A, Tulchinsky E, Grigorian M, Afanasyeva A, Senin V, Revazova E, et al. Isolation and characterization of a gene specifically expressed in different metastatic cells and whose deduced gene product has a high degree of homology to a Ca2+-binding protein family. Genes Dev. 1989;3:1086-93 pubmed
    The gene mts1, which is expressed specifically in metastatic cells, was isolated by molecular cloning coupled with differential DNA reassociation...
  4. Marenholz I, Heizmann C, Fritz G. S100 proteins in mouse and man: from evolution to function and pathology (including an update of the nomenclature). Biochem Biophys Res Commun. 2004;322:1111-22 pubmed
    ..An update of the S100 nomenclature is included, because some of the recently identified S100 genes and pseudogenes had to be renamed. ..
  5. Davies M, Rudland P, Robertson L, Parry E, Jolicoeur P, Barraclough R. Expression of the calcium-binding protein S100A4 (p9Ka) in MMTV-neu transgenic mice induces metastasis of mammary tumours. Oncogene. 1996;13:1631-7 pubmed
    Increased levels of S100A4 (p9Ka) confer metastatic ability on a normally non-metastatic epithelial cell line...
  6. Forst B, Hansen M, Klingelhöfer J, Møller H, Nielsen G, Grum Schwensen B, et al. Metastasis-inducing S100A4 and RANTES cooperate in promoting tumor progression in mice. PLoS ONE. 2010;5:e10374 pubmed publisher
    ..A pivotal role of metastasis-inducing S100A4 in the development of tumor stroma has been proven in animal models and verified in human breast cancer biopsies...
  7. O Connell J, Sugimoto H, Cooke V, Macdonald B, Mehta A, LeBleu V, et al. VEGF-A and Tenascin-C produced by S100A4+ stromal cells are important for metastatic colonization. Proc Natl Acad Sci U S A. 2011;108:16002-7 pubmed publisher
    Increased numbers of S100A4(+) cells are associated with poor prognosis in patients who have cancer...
  8. Schmidt Hansen B, Klingelhofer J, Grum Schwensen B, Christensen A, Andresen S, Kruse C, et al. Functional significance of metastasis-inducing S100A4(Mts1) in tumor-stroma interplay. J Biol Chem. 2004;279:24498-504 pubmed
    Causal implication of S100A4 in inducing metastases was convincingly shown previously. However, the mechanisms that associate S100A4 with tumor progression are not well understood...
  9. Strutz F, Okada H, Lo C, Danoff T, Carone R, Tomaszewski J, et al. Identification and characterization of a fibroblast marker: FSP1. J Cell Biol. 1995;130:393-405 pubmed
    ..One such gene encodes a filament-associated, calcium-binding protein, fibroblast-specific protein 1 (FSP1)...
  10. Barraclough R. Calcium-binding protein S100A4 in health and disease. Biochim Biophys Acta. 1998;1448:190-9 pubmed
    The S100 proteins contain two EF-hand motifs and are of generally unknown function. One of these proteins, S100A4, is an intracellular calcium-binding protein that is present in normal rodent and human cells...
  11. Takenaga K, Nakamura Y, Sakiyama S. Expression of antisense RNA to S100A4 gene encoding an S100-related calcium-binding protein suppresses metastatic potential of high-metastatic Lewis lung carcinoma cells. Oncogene. 1997;14:331-7 pubmed
    S100A4 (also known as pEL98/mts1/p9Ka/18A2/42A/calvasculin /FSP1/CAPL), a member of S100-related calcium-binding proteins, has been implicated to play a role in metastasis...
  12. Grum Schwensen B, Klingelhofer J, Berg C, EL Naaman C, Grigorian M, Lukanidin E, et al. Suppression of tumor development and metastasis formation in mice lacking the S100A4(mts1) gene. Cancer Res. 2005;65:3772-80 pubmed
    The S100A4(mts1) protein stimulates metastatic spread of tumor cells. An elevated expression of S100A4 is associated with poor prognosis in many human cancers...
  13. Kim H, Lee Y, Kim M, Kwon J, Song M, Lee Z, et al. Extracellular S100A4 negatively regulates osteoblast function by activating the NF-?B pathway. BMB Rep. 2017;50:97-102 pubmed
    ..The S100A4 protein is a member of the calcium-binding S100 protein family, which is abundantly expressed in inflammatory ..
  14. Tulchinsky E, Ford H, Kramerov D, Reshetnyak E, Grigorian M, Zain S, et al. Transcriptional analysis of the mts1 gene with specific reference to 5' flanking sequences. Proc Natl Acad Sci U S A. 1992;89:9146-50 pubmed
    The mts1 gene is specifically expressed in certain metastatic tumors but not in their nonmetastatic counterparts. It is also expressed in several normal cell and tissue types that exhibit the ability to be motile...
  15. Daub B, Schroeter M, Pfitzer G, Ganitkevich V. Expression of members of the S100 Ca2+-binding protein family in guinea-pig smooth muscle. Cell Calcium. 2003;33:1-10 pubmed
    ..Transcripts of cDNA of S100A1, S100A4, S100A6 and S100A10 were amplified from smooth muscle RNA of neonatal and adult urinary bladder, ileum, aorta and ..
  16. Marenholz I, Lovering R, Heizmann C. An update of the S100 nomenclature. Biochim Biophys Acta. 2006;1763:1282-3 pubmed
    ..Here we present the official and updated nomenclature of this protein family, approved by the HGNC (HUGO gene nomenclature committee) and ECS (European Calcium Society). ..
  17. Ojala J, Pikkarainen T, Elmberger G, Tryggvason K. Progressive reactive lymphoid connective tissue disease and development of autoantibodies in scavenger receptor A5-deficient mice. Am J Pathol. 2013;182:1681-95 pubmed publisher
    ..These disturbances are reminiscent of those found in many human autoimmune connective tissue disorders, which suggests that defects in fibroblast SCARA5 can underlie some forms of autoimmune disease. ..
  18. Dukhanina E, Lukyanova T, Romanova E, Dukhanin A, Sashchenko L. Comparative analysis of secretion of S100A4 metastatic marker by immune and tumor cells. Bull Exp Biol Med. 2008;145:78-80 pubmed
    b>S100A4 protein is present in low concentrations (2.1-15.7 ng/10(6) cells) in lymphocyte and neutrophil culture medium. Addition of stimulants to the cells did not lead to an appreciable increase in the content of this protein...
  19. Parker C, Sherbet G. Modulators of intracellular Ca2+ and the calmodulin inhibitor W-7 alter the expression of metastasis-associated genes MTS1 and NM23 in metastatic variants of the B16 murine melanoma. Melanoma Res. 1992;2:337-43 pubmed
    b>MTS1 is a metastasis-associated gene highly expressed in highly metastatic tumours. NM23 has been described as a putative metastasis suppressor gene...
  20. Ochiya T, Takenaga K, Endo H. Silencing of S100A4, a metastasis-associated protein, in endothelial cells inhibits tumor angiogenesis and growth. Angiogenesis. 2014;17:17-26 pubmed publisher
    Endothelial cells express S100A4, a metastasis-associated protein, but its role in angiogenesis remains to be elucidated...
  21. Tarabykina S, Kriajevska M, Scott D, Hill T, Lafitte D, Derrick P, et al. Heterocomplex formation between metastasis-related protein S100A4 (Mts1) and S100A1 as revealed by the yeast two-hybrid system. FEBS Lett. 2000;475:187-91 pubmed
    b>S100A4 (Mts1) is a Ca(2+)-binding protein of the S100 family. This protein plays an important role in promoting tumor metastasis...
  22. Dorin J, Emslie E, van Heyningen V. Related calcium-binding proteins map to the same subregion of chromosome 1q and to an extended region of synteny on mouse chromosome 3. Genomics. 1990;8:420-6 pubmed
    ..cDNA probes for the related genes calcyclin (CACY) and a mouse placental protein (18A2, suggested name Capl) enabled us to confirm and refine the in situ hybridization result assigning CACY to ..
  23. Herzog C, Wiseman R, You M. Deletion mapping of a putative tumor suppressor gene on chromosome 4 in mouse lung tumors. Cancer Res. 1994;54:4007-10 pubmed
    ..cancers has recently been found to contain a candidate tumor suppressor gene called multiple tumor suppressor-1 (MTS1); which was previously shown to encode an inhibitor of cyclin-dependent kinase 4...
  24. Nagahama Y, Sone M, Chen X, Okada Y, Yamamoto M, Xin B, et al. Contributions of hepatocytes and bile ductular cells in ductular reactions and remodeling of the biliary system after chronic liver injury. Am J Pathol. 2014;184:3001-12 pubmed publisher
    ..We conclude that hepatocytes and bile ducts or ductules are important sources of ductular reaction and that the intrahepatic biliary system undergoes remarkable remodeling in response to chronic liver injury. ..
  25. Lu K, Reddy R, Berika M, Warburton D, El Hashash A. Abrogation of Eya1/Six1 disrupts the saccular phase of lung morphogenesis and causes remodeling. Dev Biol. 2013;382:110-23 pubmed publisher
    ..These findings uncover novel functions for Six1-Eya1-SHH pathway during the saccular phase of lung morphogenesis, providing a conceptual framework for future mechanistic and translational studies in this area. ..
  26. Siddique H, Adhami V, Parray A, Johnson J, Siddiqui I, Shekhani M, et al. The S100A4 Oncoprotein Promotes Prostate Tumorigenesis in a Transgenic Mouse Model: Regulating NF?B through the RAGE Receptor. Genes Cancer. 2013;4:224-34 pubmed publisher
    b>S100A4, a calcium-binding protein, is known for its role in the metastatic spread of tumor cells, a late event of cancer disease...
  27. Atlasi Y, Noori R, Marolin I, Franken P, Brandao J, Biermann K, et al. The role of S100a4 (Mts1) in Apc- and Smad4-driven tumour onset and progression. Eur J Cancer. 2016;68:114-124 pubmed publisher
    b>S100a4 is a calcium-binding protein belonging to the family of S100-proteins, highly expressed in different stromal cell types...
  28. Jackson Grusby L, Swiergiel J, Linzer D. A growth-related mRNA in cultured mouse cells encodes a placental calcium binding protein. Nucleic Acids Res. 1987;15:6677-90 pubmed
    ..This mRNA, designated 18A2, encodes a predicted polypeptide of 101 amino acids with homology to known calcium binding proteins...
  29. Räsänen K, Sriswasdi S, Valiga A, Tang H, Zhang G, Perego M, et al. Comparative secretome analysis of epithelial and mesenchymal subpopulations of head and neck squamous cell carcinoma identifies S100A4 as a potential therapeutic target. Mol Cell Proteomics. 2013;12:3778-92 pubmed publisher
    ..These cells also exhibited a secretome profile resembling that of cancer-associated fibroblastic cells (CAF). S100A4, a commonly used marker for cancer-associated fibroblastic cells, was elevated more than 20-fold in the ..
  30. Dempsie Y, Nilsen M, White K, Mair K, Loughlin L, Ambartsumian N, et al. Development of pulmonary arterial hypertension in mice over-expressing S100A4/Mts1 is specific to females. Respir Res. 2011;12:159 pubmed publisher
    ..However, the reason for this remains unknown. Both the calcium binding protein S100A4/Mts1 (Mts1) and its endogenous receptor (receptor for advanced glycosylation end products; RAGE) have been ..
  31. Tulchinsky E, Prokhortchouk E, Georgiev G, Lukanidin E. A kappaB-related binding site is an integral part of the mts1 gene composite enhancer element located in the first intron of the gene. J Biol Chem. 1997;272:4828-35 pubmed
    The transcription of the mts1 gene correlates with the metastatic potential of mouse adenocarcinomas. Here we describe strong enhancer whose location coincides with the DNase I hypersensitivity area in the first intron of the mts1 gene...
  32. Duarte W, Shibata T, Takenaga K, Takahashi E, Kubota K, Ohya K, et al. S100A4: a novel negative regulator of mineralization and osteoblast differentiation. J Bone Miner Res. 2003;18:493-501 pubmed
    b>S100A4 is an intracellular calcium-binding protein expressed by osteoblastic cells. However, its roles in bone physiology are unknown...
  33. Cajone F, Debiasi S, Parker C, Lakshmi M, Sherbet G. Metastasis-associated mts1 gene expression is down-regulated by heat shock in variant cell lines of the B16 murine melanoma. Melanoma Res. 1994;4:143-50 pubmed
    ..we report that induction of heat shock proteins was associated with a down-regulation of the metastasis associated mts1 gene in BL6-B16 murine melanoma cells, and the heat-resistant HTG variant of the BL6 line...
  34. Davies M, Harris S, Rudland P, Barraclough R. Expression of the rat, S-100-related, calcium-binding protein gene, p9Ka, in transgenic mice demonstrates different patterns of expression between these two species. DNA Cell Biol. 1995;14:825-32 pubmed
    p9Ka (also known as mts1/18A2/calvasculin/CAPL) is a member of the S-100-related family of small, calcium-binding proteins...
  35. Xia H, Gilbertsen A, Herrera J, Racila E, Smith K, Peterson M, et al. Calcium-binding protein S100A4 confers mesenchymal progenitor cell fibrogenicity in idiopathic pulmonary fibrosis. J Clin Invest. 2017;127:2586-2597 pubmed publisher
    ..transcriptional analysis, we found that IPF MPCs displayed increased expression of S100 calcium-binding A4 (S100A4), a protein linked to cancer cell proliferation and invasiveness...
  36. Cheng G, Tian K, Zhang L, Yang N, Xing Y, He T. S100A4 gene silencing in oxygen-induced ischemic retinopathy inhibits retinal neovascularization via down-regulation of CREB expression. Graefes Arch Clin Exp Ophthalmol. 2016;254:97-108 pubmed publisher
    To investigate the possible role of S100A4 in retinal neovascularization (RNV), as well as the underlying mechanism, in a mouse model of oxygen-induced retinopathy (OIR)...
  37. Suemizu H, Monnai M, Ohnishi Y, Ito M, Tamaoki N, Nakamura M. Identification of a key molecular regulator of liver metastasis in human pancreatic carcinoma using a novel quantitative model of metastasis in NOD/SCID/gammacnull (NOG) mice. Int J Oncol. 2007;31:741-51 pubmed
    ..Only S100A4 expression correlated with the ability to form liver metastases, as evaluated in our quantitative model of ..
  38. Bruhn S, Fang Y, Barrenas F, Gustafsson M, Zhang H, Konstantinell A, et al. A generally applicable translational strategy identifies S100A4 as a candidate gene in allergy. Sci Transl Med. 2014;6:218ra4 pubmed publisher
    ..Functional studies of human TH2 cells as well as mouse models of allergy showed that deletion of one of the genes, S100A4, resulted in decreased signs of allergy including TH2 cell activation, humoral immunity, and infiltration of ..
  39. Andersen K, Mori H, Fata J, Bascom J, Oyjord T, Mælandsmo G, et al. The metastasis-promoting protein S100A4 regulates mammary branching morphogenesis. Dev Biol. 2011;352:181-90 pubmed publisher
    High levels of the S100 calcium binding protein S100A4 also called fibroblast specific protein 1 (FSP1) have been established as an inducer of metastasis and indicator of poor prognosis in breast cancer...
  40. Haase Kohn C, Wolf S, Herwig N, Mosch B, Pietzsch J. Metastatic potential of B16-F10 melanoma cells is enhanced by extracellular S100A4 derived from RAW264.7 macrophages. Biochem Biophys Res Commun. 2014;446:143-8 pubmed publisher
    b>S100A4, synthesized and secreted from both tumor and stroma cells, modulates an aggressive tumor phenotype in various cancers by intracellular and extracellular interactions which are not completely understood...
  41. Tulchinsky E, Kramerov D, Ford H, Reshetnyak E, Lukanidin E, Zain S. Characterization of a positive regulatory element in the mts1 gene. Oncogene. 1993;8:79-86 pubmed
    The first intron of the mts1 gene, a gene that is selectively expressed in metastatic cells and in normal cells that are motile, was found to be highly homologous to the CD3 delta enhancer element...
  42. Cano E, Carmona R, Muñoz Chápuli R. Wt1-expressing progenitors contribute to multiple tissues in the developing lung. Am J Physiol Lung Cell Mol Physiol. 2013;305:L322-32 pubmed publisher
    ..b>FSP1? fibroblast-like cells were always YFP?; they expressed the common leukocyte antigen CD45 and were apparently ..
  43. Philcox J, Coyle P, Michalska A, Choo K, Rofe A. Endotoxin-induced inflammation does not cause hepatic zinc accumulation in mice lacking metallothionein gene expression. Biochem J. 1995;308 ( Pt 2):543-6 pubmed
    ..This study confirms that MT synthesis is essential for endotoxin-induced liver Zn accumulation. ..
  44. Doroudgar S, Quijada P, Konstandin M, Ilves K, Broughton K, Khalafalla F, et al. S100A4 protects the myocardium against ischemic stress. J Mol Cell Cardiol. 2016;100:54-63 pubmed publisher
    ..b>S100A4 protein plays multiple roles in cellular survival, and tissue fibrosis, but the relative role of the S100A4 in the ..
  45. Fang Z, Duthoit N, Wicher G, Källskog O, Ambartsumian N, Lukanidin E, et al. Intracellular calcium-binding protein S100A4 influences injury-induced migration of white matter astrocytes. Acta Neuropathol. 2006;111:213-9 pubmed
    ..We previously showed that the calcium-binding protein S100A4 is exclusively expressed in white matter astrocytes and markedly up-regulated after injury...
  46. Grum Schwensen B, Klingelhöfer J, Beck M, Bonefeld C, Hamerlik P, Guldberg P, et al. S100A4-neutralizing antibody suppresses spontaneous tumor progression, pre-metastatic niche formation and alters T-cell polarization balance. BMC Cancer. 2015;15:44 pubmed publisher
    ..Among the known molecules that are engaged in stimulating the metastatic spread of tumor cells is the S100A4 protein...
  47. Erlandsson M, Svensson M, Jonsson I, Bian L, Ambartsumian N, Andersson S, et al. Expression of metastasin S100A4 is essential for bone resorption and regulates osteoclast function. Biochim Biophys Acta. 2013;1833:2653-2663 pubmed publisher
    b>S100A4 is a Ca-binding protein that regulates cell growth, survival, and motility. The abundant expression of S100A4 in rheumatiod arthritis contributes to the invasive growth of joint tissue and to bone damage...
  48. Li Z, Dulyaninova N, House R, Almo S, Bresnick A. S100A4 regulates macrophage chemotaxis. Mol Biol Cell. 2010;21:2598-610 pubmed publisher
    b>S100A4, a member of the S100 family of Ca(2+)-binding proteins, is directly involved in tumor metastasis...
  49. Tulchinsky E, Grigorian M, Ebralidze A, Milshina N, Lukanidin E. Structure of gene mts1, transcribed in metastatic mouse tumor cells. Gene. 1990;87:219-23 pubmed
    ..mouse lines, highly metastatic CSML-100 and nearly nonmetastatic CSML-0, we have cloned the cDNA of the gene, mts1, which is specifically expressed in different metastatic cells...
  50. Rivard C, Brown L, Almeida N, Maunsbach A, Pihakaski Maunsbach K, Andres Hernando A, et al. Expression of the calcium-binding protein S100A4 is markedly up-regulated by osmotic stress and is involved in the renal osmoadaptive response. J Biol Chem. 2007;282:6644-52 pubmed
    ..Of these proteins, one of the most robustly up-regulated (22-fold) was S100A4. The identity of the protein was verified by high pressure liquid chromatography-mass spectrometry...
  51. Tamaki Y, Iwanaga Y, Niizuma S, Kawashima T, Kato T, Inuzuka Y, et al. Metastasis-associated protein, S100A4 mediates cardiac fibrosis potentially through the modulation of p53 in cardiac fibroblasts. J Mol Cell Cardiol. 2013;57:72-81 pubmed publisher
    Metastasis-associated protein, S100A4 is suggested as a marker for fibrosis in several organs. It also modulates DNA binding of p53 and affects its function. However, the functional role of S100A4 in the myocardium has remained unclear...
  52. Parker C, Lakshmi M, Piura B, Sherbet G. Metastasis-associated mts1 gene expression correlates with increased p53 detection in the B16 murine melanoma. DNA Cell Biol. 1994;13:343-51 pubmed
    b>MTS1 is a metastasis-associated gene highly expressed in high-metastasis tumors. Here we show that the expression of the suppressor gene p53 protein correlates with mts1 expression...
  53. Tarabykina S, Ambartsumian N, Grigorian M, Georgiev G, Lukanidin E. Activation of mts1 transcription by insertion of a retrovirus-like IAP element. Gene. 1996;168:151-5 pubmed
    The mechanism of activation of mestatasis-associated mts1 gene transcription in the mouse myelomonocytic leukaemia WEHI-3 cell line is described...
  54. Vouyiouklis D, Anderson T, King H, Kirkham D, Karim S, Johnson K, et al. Mapping of the dysmyelinating murine Hindshaker mutation to a 1.2-cM interval on chromosome 3. Genomics. 2002;80:126-8 pubmed
    ..breeding strategy in conjunction with genotyping for microsatellites and a novel marker for the gene S100a4. We describe the genomic mapping of the hsh mutation to within a 1...
  55. Erlandsson M, Bian L, Jonsson I, Andersson K, Bokarewa M. Metastasin S100A4 is a mediator of sex hormone-dependent formation of the cortical bone. Mol Endocrinol. 2013;27:1311-21 pubmed publisher
    b>S100A4 is a Ca-binding protein participating in regulation of cell growth, survival, and motility. Here we studied the role of S100A4 protein in sex hormone-regulated bone formation...
  56. Simpson P, Shoker B, Barraclough R, Halliwell N, Rudland P, Sibson D, et al. Examination of tumour histopathology and gene expression in a neu/S100A4 transgenic model of metastatic breast cancer. Int J Exp Pathol. 2003;84:173-84 pubmed
    Elevated levels of the calcium-binding protein S100A4 have been causally linked to the metastatic spread of breast cancer cells in several in vitro and in vivo model systems and, more recently, correlated with patient death in a series of ..
  57. Trembley M, Velasquez L, de Mesy Bentley K, Small E. Myocardin-related transcription factors control the motility of epicardium-derived cells and the maturation of coronary vessels. Development. 2015;142:21-30 pubmed publisher
  58. Reimann S, Fink L, Wilhelm J, Hoffmann J, Bednorz M, Seimetz M, et al. Increased S100A4 expression in the vasculature of human COPD lungs and murine model of smoke-induced emphysema. Respir Res. 2015;16:127 pubmed publisher
    ..The Ca(2+) binding protein, S100A4 is known to play a role in non-COPD-driven vascular remodeling of intrapulmonary arteries...
  59. Sato F, Kohsaka A, Takahashi K, Otao S, Kitada Y, Iwasaki Y, et al. Smad3 and Bmal1 regulate p21 and S100A4 expression in myocardial stromal fibroblasts via TNF-?. Histochem Cell Biol. 2017;148:617-624 pubmed publisher
    ..Both Smad3 knockout and heart-specific Bmal1 knockout mice showed increases in p21, S100A4, CD206 and TNF-? expression in the myocardial stromal fibroblasts and macrophage compared to control mice...
  60. Otsubo K, Goto H, Nishio M, Kawamura K, Yanagi S, Nishie W, et al. MOB1-YAP1/TAZ-NKX2.1 axis controls bronchioalveolar cell differentiation, adhesion and tumour formation. Oncogene. 2017;36:4201-4211 pubmed publisher
    ..Thus, a MOB1-YAP1/TAZ-NKX2.1 axis is essential for normal lung homeostasis and expression of the collagen XVII protein necessary for alveolar stem cell maintenance in the lung niche. ..
  61. Ravasi T, Hsu K, Goyette J, Schroder K, Yang Z, Rahimi F, et al. Probing the S100 protein family through genomic and functional analysis. Genomics. 2004;84:10-22 pubmed
    ..Evolution of the S100 proteins appears to have occurred in a modular fashion, also seen in other protein families such as the C2H2-type zinc-finger family. ..
  62. Cox C, Dutta K, Basavappa R, Zain S, Pascal S. Sequence-specific chemical shift assignment of calcium-loaded murine S100A4. J Biomol NMR. 2002;23:153-4 pubmed
  63. Sun L, Sun C, Liang Z, Li H, Chen L, Luo H, et al. FSP1(+) fibroblast subpopulation is essential for the maintenance and regeneration of medullary thymic epithelial cells. Sci Rep. 2015;5:14871 pubmed publisher
    ..We herein found that thymic non-hematopoietic CD45(-)FSP1(+) cells represent a unique Fibroblast specific protein 1 (FSP1)(-)fibroblast-derived cell subset...
  64. Chow K, Park H, George J, Yamamoto K, Gallup A, Graber J, et al. S100A4 Is a Biomarker and Regulator of Glioma Stem Cells That Is Critical for Mesenchymal Transition in Glioblastoma. Cancer Res. 2017;77:5360-5373 pubmed publisher
    ..Here, we show that S100A4 is a novel biomarker of GSCs...
  65. Albertazzi E, Cajone F, Lakshmi M, Sherbet G. Heat shock modulates the expression of the metastasis associated gene MTS1 and proliferation of murine and human cancer cells. DNA Cell Biol. 1998;17:1-7 pubmed
    b>Mts1 is a metastasis-associated gene of the S-100 gene family and codes for a Ca2+-binding protein. It is highly expressed in murine and human cancers of high invasive and metastatic potential...
  66. Osterreicher C, Penz Osterreicher M, Grivennikov S, Guma M, Koltsova E, Datz C, et al. Fibroblast-specific protein 1 identifies an inflammatory subpopulation of macrophages in the liver. Proc Natl Acad Sci U S A. 2011;108:308-13 pubmed publisher
    ..Fibroblast-specific protein 1 (FSP1, also called S100A4) is considered a marker of fibroblasts in different organs undergoing tissue remodeling and is used to identify ..
  67. Andersen D, Laborda J, Baladron V, Kassem M, Sheikh S, Jensen C. Dual role of delta-like 1 homolog (DLK1) in skeletal muscle development and adult muscle regeneration. Development. 2013;140:3743-53 pubmed publisher
    ..Collectively, our results suggest a novel and surprising dual biological function of DLK1 as an enhancer of muscle development, but as an inhibitor of adult muscle regeneration. ..
  68. Jie Z, Liang Y, Yi P, Tang H, Soong L, Cong Y, et al. Retinoic Acid Regulates Immune Responses by Promoting IL-22 and Modulating S100 Proteins in Viral Hepatitis. J Immunol. 2017;198:3448-3460 pubmed publisher
    ..Furthermore, adoptive transfer of S100A4-repressed, virus-pulsed DCs into the hind foot of naive mice failed to prime T cell responses in draining lymph ..
  69. Teng Y, Kanasaki K, Bardeesy N, Sugimoto H, Kalluri R. Deletion of Smad4 in fibroblasts leads to defective chondrocyte maturation and cartilage production in a TGF? type II receptor independent manner. Biochem Biophys Res Commun. 2011;407:633-9 pubmed publisher
    ..We used Cre recombinase driven by the Fsp1/S100A4 promoter to delete the Smad4 gene in fibroblasts...
  70. Kanazawa T, Ichii O, Otsuka S, Namiki Y, Hashimoto Y, Kon Y. Hepatocyte nuclear factor 4 alpha is associated with mesenchymal-epithelial transition in developing kidneys of C57BL/6 mice. J Vet Med Sci. 2011;73:601-7 pubmed
    ..These results, and those of previous findings, indicate that Hnf4? protein is associated with the initiation of MET in early nephrogenesis. ..
  71. Ieda M, Tsuchihashi T, Ivey K, Ross R, Hong T, Shaw R, et al. Cardiac fibroblasts regulate myocardial proliferation through beta1 integrin signaling. Dev Cell. 2009;16:233-44 pubmed publisher
    ..These findings reveal a previously unrecognized paracrine function of embryonic cardiac fibroblasts in regulating cardiomyocyte proliferation. ..
  72. EL Naaman C, Grum Schwensen B, Mansouri A, Grigorian M, Santoni Rugiu E, Hansen T, et al. Cancer predisposition in mice deficient for the metastasis-associated Mts1(S100A4) gene. Oncogene. 2004;23:3670-80 pubmed
    Metastasis-promoting Mts1(S100A4) protein belongs to the S100 family of Ca(2+)-binding proteins. A mouse strain with a germ-line inactivation of the S100A4 gene was generated...
  73. Radestock Y, Hoang Vu C, Hombach Klonisch S. Relaxin reduces xenograft tumour growth of human MDA-MB-231 breast cancer cells. Breast Cancer Res. 2008;10:R71 pubmed publisher
    ..human breast cancer cells, relaxin was shown to down-regulate the metastasis-promoting protein S100A4 (metastasin), a highly significant prognostic factor for poor survival in breast cancer patients...
  74. Dutta K, Cox C, Huang H, Basavappa R, Pascal S. Calcium coordination studies of the metastatic Mts1 protein. Biochemistry. 2002;41:4239-45 pubmed
    Mts1, also known as S100A4, is an 11 kDa calcium-binding protein strongly linked to metastasis...
  75. Cheng J, Wang Y, Liang A, Jia L, Du J. FSP-1 silencing in bone marrow cells suppresses neointima formation in vein graft. Circ Res. 2012;110:230-40 pubmed publisher
    ..The Rac1 and ERK5 signaling cascade mediate FSP-1-induced responses in SMCs and BM cells. This novel pathophysiology suggests a new therapeutic target, FSP-1, for preventing the development of neointima in vein grafts. ..
  76. Bian L, Strzyz P, Jonsson I, Erlandsson M, Hellvard A, Brisslert M, et al. S100A4 deficiency is associated with efficient bacterial clearance and protects against joint destruction during Staphylococcal infection. J Infect Dis. 2011;204:722-30 pubmed publisher
    ..The aim of this study was to investigate the role of S100A4 in staphylococcal arthritis...
  77. Goto K, Endo H, Fujiyoshi T. Cloning of the sequences expressed abundantly in established cell lines: identification of a cDNA clone highly homologous to S-100, a calcium binding protein. J Biochem. 1988;103:48-53 pubmed
    ..One such clone, named pEL98, corresponding to mRNA of approximately 600 nucleotides, was further characterized...
  78. Kim Y, Haghighat L, Spiekerkoetter E, Sawada H, Alvira C, Wang L, et al. Neutrophil elastase is produced by pulmonary artery smooth muscle cells and is linked to neointimal lesions. Am J Pathol. 2011;179:1560-72 pubmed publisher
    ..we reported that murine gammaherpesvirus-68 (M1-MHV-68) induces pulmonary artery (PA) neointimal lesions in S100A4-overexpressing, but not in wild-type (C57), mice...