Ryr3

Summary

Gene Symbol: Ryr3
Description: ryanodine receptor 3
Alias: AI851294, C230090H21, RYR-3, ryanodine receptor 3, brain ryanodine receptor-calcium release channel, brain-type ryanodine receptor, calcium release channel, type 3 ryanodine receptor
Species: mouse
Products:     Ryr3

Top Publications

  1. Ikemoto T, Komazaki S, Takeshima H, Nishi M, Noda T, Iino M, et al. Functional and morphological features of skeletal muscle from mutant mice lacking both type 1 and type 3 ryanodine receptors. J Physiol. 1997;501 ( Pt 2):305-12 pubmed
    ..RyR-3 may have a role in the normal morphogenesis of skeletal muscle cells, although functionally it can be replaced by RyR-1. ..
  2. Zhao M, Li P, Li X, Zhang L, Winkfein R, Chen S. Molecular identification of the ryanodine receptor pore-forming segment. J Biol Chem. 1999;274:25971-4 pubmed
    ..These data suggest that this conserved region constitutes an essential part of the ryanodine binding site and the channel conduction pathway of the ryanodine receptor. ..
  3. Giannini G, Conti A, Mammarella S, Scrobogna M, Sorrentino V. The ryanodine receptor/calcium channel genes are widely and differentially expressed in murine brain and peripheral tissues. J Cell Biol. 1995;128:893-904 pubmed
    ..In the uterus and vas deferens, expression of RyR3 was localized to the smooth muscle component of these organs...
  4. Bertocchini F, Ovitt C, Conti A, Barone V, Scholer H, Bottinelli R, et al. Requirement for the ryanodine receptor type 3 for efficient contraction in neonatal skeletal muscles. EMBO J. 1997;16:6956-63 pubmed
    ..Another isoform, RyR3, has been observed recently in some mammalian skeletal muscles, but whether it participates in regulating skeletal ..
  5. Wan K, Moriya T, Akiyama M, Takeshima H, Shibata S. Involvement of ryanodine receptor type 3 in dopamine release from the striatum: evidence from mutant mice lacking this receptor. Biochem Biophys Res Commun. 1999;266:588-92 pubmed
    ..Caffeine produced a similar hyper-motor activity in both wild and homozygous mice. The present results suggest the involvement of ryanodine receptor type 3 in dopamine release from the striatum. ..
  6. Tarroni P, Rossi D, Conti A, Sorrentino V. Expression of the ryanodine receptor type 3 calcium release channel during development and differentiation of mammalian skeletal muscle cells. J Biol Chem. 1997;272:19808-13 pubmed
    ..Recently, the presence of another RyR isoform, RyR3, has been detected in mammalian skeletal muscle cells, raising the question of the eventual relevance of RyR3 for ..
  7. Balschun D, Wolfer D, Bertocchini F, Barone V, Conti A, Zuschratter W, et al. Deletion of the ryanodine receptor type 3 (RyR3) impairs forms of synaptic plasticity and spatial learning. EMBO J. 1999;18:5264-73 pubmed
    Deletion of the ryanodine receptor type 3 (RyR3) results in specific changes in hippocampal synaptic plasticity, without affecting hippocampal morphology, basal synaptic transmission or presynaptic function...
  8. Takeshima H, Ikemoto T, Nishi M, Nishiyama N, Shimuta M, Sugitani Y, et al. Generation and characterization of mutant mice lacking ryanodine receptor type 3. J Biol Chem. 1996;271:19649-52 pubmed
    ..These results indicate that the loss of RyR-3 causes no gross abnormalities and suggest that the lack of RyR-3-mediated Ca2+ signaling results in abnormalities of certain neurons in the central nervous system. ..
  9. Lohn M, Jessner W, Furstenau M, Wellner M, Sorrentino V, Haller H, et al. Regulation of calcium sparks and spontaneous transient outward currents by RyR3 in arterial vascular smooth muscle cells. Circ Res. 2001;89:1051-7 pubmed
    ..To provide molecular information on RyR cluster function and assembly, we examined Ca(2+) sparks and STOCs in RyR3-deficient freshly isolated myocytes of resistance-sized cerebral arteries from knockout mice and compared them to ..

More Information

Publications69

  1. Shimuta M, Yoshikawa M, Fukaya M, Watanabe M, Takeshima H, Manabe T. Postsynaptic modulation of AMPA receptor-mediated synaptic responses and LTP by the type 3 ryanodine receptor. Mol Cell Neurosci. 2001;17:921-30 pubmed
    ..We examined the roleof RyRs in excitatory synaptic transmission in hippocampal slices, using type 3 RyR (RyR3)-deficient mice...
  2. Takeshima H, Yamazawa T, Ikemoto T, Takekura H, Nishi M, Noda T, et al. Ca(2+)-induced Ca2+ release in myocytes from dyspedic mice lacking the type-1 ryanodine receptor. EMBO J. 1995;14:2999-3006 pubmed
    ..Although RyR-3 does not mediate excitation-contraction coupling of the skeletal muscle type, we propose that RyR-3 may induce intracellular Ca2+ release in response to a Ca2+ rise with a high threshold. ..
  3. Kouzu Y, Moriya T, Takeshima H, Yoshioka T, Shibata S. Mutant mice lacking ryanodine receptor type 3 exhibit deficits of contextual fear conditioning and activation of calcium/calmodulin-dependent protein kinase II in the hippocampus. Brain Res Mol Brain Res. 2000;76:142-50 pubmed
  4. Futatsugi A, Kato K, Ogura H, Li S, Nagata E, Kuwajima G, et al. Facilitation of NMDAR-independent LTP and spatial learning in mutant mice lacking ryanodine receptor type 3. Neuron. 1999;24:701-13 pubmed
    To evaluate the role in synaptic plasticity of ryanodine receptor type 3 (RyR3), which is normally enriched in hippocampal area CA1, we generated RyR3-deficient mice...
  5. Mori F, Fukaya M, Abe H, Wakabayashi K, Watanabe M. Developmental changes in expression of the three ryanodine receptor mRNAs in the mouse brain. Neurosci Lett. 2000;285:57-60 pubmed
    ..During the embryonic stage, RyR1 mRNA levels were highest in the rostral cortical plate, whereas RyR3 mRNA was most prominent in the caudal cortical plate and hippocampus...
  6. Conti A, Gorza L, Sorrentino V. Differential distribution of ryanodine receptor type 3 (RyR3) gene product in mammalian skeletal muscles. Biochem J. 1996;316 ( Pt 1):19-23 pubmed
    ..In addition to RyR1, low levels of the mRNA of the RyR3 isoform have been recently detected in mammalian skeletal muscles...
  7. Wang Y, Zheng Y, Mei Q, Wang Q, Collier M, Fleischer S, et al. FKBP12.6 and cADPR regulation of Ca2+ release in smooth muscle cells. Am J Physiol Cell Physiol. 2004;286:C538-46 pubmed
    ..Taken together, these findings point to an important role of the FKBP12.6/RyR2 complex in stochastic (spontaneous) and receptor-mediated Ca2+ release in smooth muscle. ..
  8. Barone V, Bertocchini F, Bottinelli R, Protasi F, Allen P, Franzini Armstrong C, et al. Contractile impairment and structural alterations of skeletal muscles from knockout mice lacking type 1 and type 3 ryanodine receptors. FEBS Lett. 1998;422:160-4 pubmed
    ..Recently it has been shown that also the type 3 isoform of ryanodine receptor (RyR3), which is expressed in some mammalian skeletal muscles, may participate in the regulation of skeletal muscle ..
  9. Sonnleitner A, Conti A, Bertocchini F, Schindler H, Sorrentino V. Functional properties of the ryanodine receptor type 3 (RyR3) Ca2+ release channel. EMBO J. 1998;17:2790-8 pubmed
    ..analysis of sarcoplasmic reticulum vesicles prepared from diaphragm muscle, which contains both RyR1 and RyR3 isoforms, revealed the presence of two functionally distinct ryanodine receptor calcium release channels...
  10. Tiso N, Stephan D, Nava A, Bagattin A, Devaney J, Stanchi F, et al. Identification of mutations in the cardiac ryanodine receptor gene in families affected with arrhythmogenic right ventricular cardiomyopathy type 2 (ARVD2). Hum Mol Genet. 2001;10:189-94 pubmed
    ..The detection of RyR2 mutations causing ARVD2, reported in this paper, opens the way to pre-symptomatic detection of carriers of the disease in childhood, thus enabling early monitoring and treatment. ..
  11. Komazaki S, Ikemoto T, Takeshima H, Iino M, Endo M, Nakamura H. Morphological abnormalities of adrenal gland and hypertrophy of liver in mutant mice lacking ryanodine receptors. Cell Tissue Res. 1998;294:467-73 pubmed
    ..which form Ca2+ channels in the membrane of the endoplasmic reticulum, consist of three subtypes (RyR1, RyR2, and RyR3)...
  12. Fulceri R, Rossi R, Bottinelli R, Conti A, Intravaia E, Galione A, et al. Ca2+ release induced by cyclic ADP ribose in mice lacking type 3 ryanodine receptor. Biochem Biophys Res Commun. 2001;288:697-702 pubmed
    ..was studied on calcium release from sarcoplasmic reticulum of skeletal muscles of neonatal and adult wild-type and RyR3-deficient mice...
  13. Matsuo N, Tanda K, Nakanishi K, Yamasaki N, Toyama K, Takao K, et al. Comprehensive behavioral phenotyping of ryanodine receptor type 3 (RyR3) knockout mice: decreased social contact duration in two social interaction tests. Front Behav Neurosci. 2009;3:3 pubmed publisher
    ..Among the three RyR isoforms, RyR3 is preferentially expressed in the brain especially in the hippocampus and striatum...
  14. Legrand C, Giacomello E, Berthier C, Allard B, Sorrentino V, Jacquemond V. Spontaneous and voltage-activated Ca2+ release in adult mouse skeletal muscle fibres expressing the type 3 ryanodine receptor. J Physiol. 2008;586:441-57 pubmed
    The physiological properties and role of the type 3 ryanodine receptor (RyR3), a calcium release channel expressed in a wide variety of cell types, remain mysterious...
  15. Ponting C, Schultz J, Bork P. SPRY domains in ryanodine receptors (Ca(2+)-release channels). Trends Biochem Sci. 1997;22:193-4 pubmed
  16. Du W, Stiber J, Rosenberg P, Meissner G, Eu J. Ryanodine receptors in muscarinic receptor-mediated bronchoconstriction. J Biol Chem. 2005;280:26287-94 pubmed
    ..Here we report that mouse ASMCs also express the skeletal muscle and brain isoforms of RyRs (RyR1 and RyR3, respectively)...
  17. Zheng Y, Wang Q, Liu Q, Rathore R, Yadav V, Wang Y. Heterogeneous gene expression and functional activity of ryanodine receptors in resistance and conduit pulmonary as well as mesenteric artery smooth muscle cells. J Vasc Res. 2008;45:469-79 pubmed publisher
    ..All 3 RyR subtype (RyR1, RyR2 and RyR3) mRNAs are expressed in RPASMCs, CPASMCs and MASMCs, but their expression levels are different...
  18. Yamamori E, Iwasaki Y, Oki Y, Yoshida M, Asai M, Kambayashii M, et al. Possible involvement of ryanodine receptor-mediated intracellular calcium release in the effect of corticotropin-releasing factor on adrenocorticotropin secretion. Endocrinology. 2004;145:36-8 pubmed
    ..Expression of two ryanodine receptor subtypes (RyR1 and RyR3) was confirmed by RT-PCR...
  19. Tsai S, Chang E, Chang Y, Hee S, Tsai Y, Chang T, et al. Knockdown of RyR3 enhances adiponectin expression through an atf3-dependent pathway. Endocrinology. 2013;154:1117-29 pubmed publisher
    ..b>RyR3 was expressed in 3T3-L1 preadipocytes, and its level was decreased upon adipogenesis...
  20. Ji G, Feldman M, Greene K, Sorrentino V, Xin H, Kotlikoff M. RYR2 proteins contribute to the formation of Ca(2+) sparks in smooth muscle. J Gen Physiol. 2004;123:377-86 pubmed
    ..6(-/-), and RYR3(-/-) mouse bladders. Consistent with a role of FKBP12...
  21. Costa R, Varanda W, Franci C. A calcium-induced calcium release mechanism supports luteinizing hormone-induced testosterone secretion in mouse Leydig cells. Am J Physiol Cell Physiol. 2010;299:C316-23 pubmed publisher
    ..These results not only broaden our understanding of the role played by calcium in Leydig cells but also show, for the first time, that RyRs have an important role in determining testosterone secretion by the testis. ..
  22. Liu J, Supnet C, Sun S, Zhang H, Good L, Popugaeva E, et al. The role of ryanodine receptor type 3 in a mouse model of Alzheimer disease. Channels (Austin). 2014;8:230-42 pubmed
    ..Caffeine is an activator of RyanRs and our results may help to explain a complex epidemiological connection between coffee consumption in mid-life and risk of AD development in old age...
  23. Van de Vrede Y, Fossier P, Baux G, Joels M, Chameau P. Control of IsAHP in mouse hippocampus CA1 pyramidal neurons by RyR3-mediated calcium-induced calcium release. Pflugers Arch. 2007;455:297-308 pubmed
    ..Immunohistology, using an anti-RyR3 specific antibody, indicates that RyR3 expression is particularly enriched in the CA1 apical dendrites (considered ..
  24. Pouvreau S, Royer L, Yi J, Brum G, Meissner G, Rios E, et al. Ca(2+) sparks operated by membrane depolarization require isoform 3 ryanodine receptor channels in skeletal muscle. Proc Natl Acad Sci U S A. 2007;104:5235-40 pubmed
    ..Mammalian muscles instead lose postnatally the ability to produce sparks, and they also lose RyR3, an isoform abundant in spark-producing skeletal muscles...
  25. Miyatake R, Furukawa A, Matsushita M, Iwahashi K, Nakamura K, Ichikawa Y, et al. Tissue-specific alternative splicing of mouse brain type ryanodine receptor/calcium release channel mRNA. FEBS Lett. 1996;395:123-6 pubmed
    We detected alternative splicing of the mouse brain type ryanodine receptor (RyR3) mRNA. The splicing variant was located in the transmembrane segment...
  26. Shirokova N, Shirokov R, Rossi D, Gonzalez A, Kirsch W, Garcia J, et al. Spatially segregated control of Ca2+ release in developing skeletal muscle of mice. J Physiol. 1999;521 Pt 2:483-95 pubmed
    ..Ca2+ signals in primary-cultured myotubes, prepared from forelimbs of wild-type or ryanodine receptor type 3 (RyR3) knockout mice...
  27. Matyash M, Matyash V, Nolte C, Sorrentino V, Kettenmann H. Requirement of functional ryanodine receptor type 3 for astrocyte migration. FASEB J. 2002;16:84-6 pubmed
    ..These results indicate that astrocytes express only RyR type 3 and that this receptor is important for controlling astrocyte motility. ..
  28. Morel J, Rakotoarisoa L, Jeyakumar L, Fleischer S, Mironneau C, Mironneau J. Decreased expression of ryanodine receptors alters calcium-induced calcium release mechanism in mdx duodenal myocytes. J Biol Chem. 2004;279:21287-93 pubmed
    ..Taken together, our results suggest that inhibition of type 2 ryanodine receptor expression in mdx duodenal myocytes may account for the decreased calcium release from the sarcoplasmic reticulum and reduced mechanical activity. ..
  29. Faure A, Grunwald D, Moutin M, Hilly M, Mauger J, Marty I, et al. Developmental expression of the calcium release channels during early neurogenesis of the mouse cerebral cortex. Eur J Neurosci. 2001;14:1613-22 pubmed
    ..Altogether, they provide a molecular basis for analyzing the developmental modulation of calcium signals useful for neurogenesis progression. ..
  30. Luciani D, Gwiazda K, Yang T, Kalynyak T, Bychkivska Y, Frey M, et al. Roles of IP3R and RyR Ca2+ channels in endoplasmic reticulum stress and beta-cell death. Diabetes. 2009;58:422-32 pubmed publisher
    ..Our results also suggest the involvement of mitochondria in beta-cell apoptosis associated with dysfunctional beta-cell ER Ca(2+) homeostasis and ER stress. ..
  31. Clancy J, Takeshima H, Hamilton S, Reid M. Contractile function is unaltered in diaphragm from mice lacking calcium release channel isoform 3. Am J Physiol. 1999;277:R1205-9 pubmed
    Skeletal muscle expresses at least two isoforms of the calcium release channel in the sarcoplasmic reticulum (RyR1 and RyR3). Whereas the function of RyR1 is well defined, the physiological significance of RyR3 is unclear...
  32. Mattei M, Giannini G, Moscatelli F, Sorrentino V. Chromosomal localization of murine ryanodine receptor genes RYR1, RYR2, and RYR3 by in situ hybridization. Genomics. 1994;22:202-4 pubmed
    ..location on murine chromosomes of the three genes of the ryanodine receptor/Ca2+ channel family: RYR1, RYR2, and RYR3. The skeletal ryanodine receptor, or type 1 (Ryr1), maps to bands 7A2-7A3; the cardiac ryanodine receptor, or type ..
  33. Dabertrand F, Fritz N, Mironneau J, Macrez N, Morel J. Role of RYR3 splice variants in calcium signaling in mouse nonpregnant and pregnant myometrium. Am J Physiol Cell Physiol. 2007;293:C848-54 pubmed
    Alternative splicing of ryanodine receptor subtype 3 (RYR3) may generate a short isoform (RYR3S) without channel function and a functional full-length isoform (RYR3L)...
  34. Wada F, Nakata A, Tatsu Y, Ooashi N, Fukuda T, Nabetani T, et al. Myosin Va and Endoplasmic Reticulum Calcium Channel Complex Regulates Membrane Export during Axon Guidance. Cell Rep. 2016;15:1329-44 pubmed publisher
    ..MyoVa-Ca(2+) channel interactions are required for proper long-range axon growth in developing spinal cord in vivo. These findings reveal a peri-ER membrane export pathway for Ca(2+)-dependent attraction in axon guidance. ..
  35. Rossi D, Murayama T, Manini I, Franci D, Ogawa Y, Sorrentino V. Expression and functional activity of ryanodine receptors (RyRs) during skeletal muscle development. Cell Calcium. 2007;41:573-80 pubmed
    Two isoforms of ryanodine receptors are expressed in skeletal muscles, RyR1 and RyR3. We investigated the relative level of expression of RyRs in developing murine skeletal muscles using [3H]ryanodine binding and immunoprecipitation ..
  36. Pistocchi A, Gaudenzi G, Foglia E, Monteverde S, Moreno Fortuny A, Pianca A, et al. Conserved and divergent functions of Nfix in skeletal muscle development during vertebrate evolution. Development. 2013;140:1528-36 pubmed publisher
    ..We conclude that, during vertebrate evolution, the transcription factor Nfix lost some specific functions, probably as a consequence of the different environment in which teleosts and mammals develop. ..
  37. Ayabe T, Kopf G, Schultz R. Regulation of mouse egg activation: presence of ryanodine receptors and effects of microinjected ryanodine and cyclic ADP ribose on uninseminated and inseminated eggs. Development. 1995;121:2233-44 pubmed
    ..Results of these experiments suggest that although ryanodine receptors are present and functional, release of Ca2+ from this store is not essential for sperm-induced egg activation. ..
  38. Steullet P, Lavoie S, Kraftsik R, Guidi R, Gysin R, Cuenod M, et al. A glutathione deficit alters dopamine modulation of L-type calcium channels via D2 and ryanodine receptors in neurons. Free Radic Biol Med. 2008;44:1042-54 pubmed publisher
    ..This represents a mechanism by which dopaminergic systems could be dysfunctional under conditions of impaired glutathione synthesis as in schizophrenia. ..
  39. Galeotti N, Quattrone A, Vivoli E, Bartolini A, Ghelardini C. Type 1 and type 3 ryanodine receptors are selectively involved in muscarinic antinociception in mice: an antisense study. Neuroscience. 2008;153:814-22 pubmed publisher
    ..A selective involvement of RyR1 and RyR3 in supraspinal muscarinic analgesia was demonstrated whereas RyR2 appears not to play an essential role in acute ..
  40. Steck T. The organization of proteins in the human red blood cell membrane. A review. J Cell Biol. 1974;62:1-19 pubmed
  41. Liu Q, Zheng Y, Korde A, Li X, Ma J, Takeshima H, et al. Protein kinase C-epsilon regulates local calcium signaling in airway smooth muscle cells. Am J Respir Cell Mol Biol. 2009;40:663-71 pubmed publisher
    ..6 homozygous or RyR2 heterozygous gene deletion did not prevent the effect of PKCepsilon inhibition or activation. RyR3 homogenous gene deletion did not block the effect of PKCepsilon inhibition and activation, either...
  42. Weisleder N, Ferrante C, Hirata Y, Collet C, Chu Y, Cheng H, et al. Systemic ablation of RyR3 alters Ca2+ spark signaling in adult skeletal muscle. Cell Calcium. 2007;42:548-55 pubmed
    ..In mammalian skeletal muscle, RyR1 is the predominant isoform present in adult skeletal fibers, while some RyR3 is expressed during development...
  43. Liu Q, Zheng Y, Korde A, Yadav V, Rathore R, Wess J, et al. Membrane depolarization causes a direct activation of G protein-coupled receptors leading to local Ca2+ release in smooth muscle. Proc Natl Acad Sci U S A. 2009;106:11418-23 pubmed publisher
    ..These findings demonstrate an important mechanism for Ca(2+) signaling and attendant physiological function in SMCs. ..
  44. Pavel E, Zhao W, Powell K, Weinstein M, Kirschner L. Analysis of a new allele of limb deformity (ld) reveals tissue- and age-specific transcriptional effects of the Ld Global Control Region. Int J Dev Biol. 2007;51:273-81 pubmed
  45. Galeotti N, Vivoli E, Bartolini A, Ghelardini C. A gene-specific cerebral types 1, 2, and 3 RyR protein knockdown induces an antidepressant-like effect in mice. J Neurochem. 2008;106:2385-94 pubmed publisher
    ..These findings identify cerebral RyRs as critical targets underlying depressive states and should facilitate the comprehension of the pathophysiology of mood disorders and help developing of new therapeutical strategies. ..
  46. Sawada K, Hosoi E, Bando M, Sakata Haga H, Lee N, Jeong Y, et al. Differential alterations in expressions of ryanodine receptor subtypes in cerebellar cortical neurons of an ataxic mutant, rolling mouse Nagoya. Neuroscience. 2008;152:609-17 pubmed publisher
    ..study aimed to clarify changes in the spatial expressions of types 1, 2 and 3 ryanodine receptors (RyR1, RyR2 and RyR3) in the cerebellum of a Ca(2+) channel alpha(1A) subunit mutant, rolling mouse Nagoya...
  47. Gartz Hanson M, Niswander L. Rectification of muscle and nerve deficits in paralyzed ryanodine receptor type 1 mutant embryos. Dev Biol. 2015;404:76-87 pubmed publisher
    ..Moreover, we show the involvement of ryanodine receptors in presynaptic release at the NMJ. This data provides evidence of a role for RyR1 on both the pre- and postsynaptic sides of the NMJ. ..
  48. Yang D, Pan Z, Takeshima H, Wu C, Nagaraj R, Ma J, et al. RyR3 amplifies RyR1-mediated Ca(2+)-induced Ca(2+) release in neonatal mammalian skeletal muscle. J Biol Chem. 2001;276:40210-4 pubmed
    The neonatal mammalian skeletal muscle contains both type 1 and type 3 ryanodine receptors (RyR1 and RyR3) located in the sarcoplasmic reticulum membrane...
  49. Wang P, Tang M, Gao L, Luo H, Wang G, Ma X, et al. Roles of I(f) and intracellular Ca2+ release in spontaneous activity of ventricular cardiomyocytes during murine embryonic development. J Cell Biochem. 2013;114:1852-62 pubmed publisher
    ..Thus, we conclude that in murine embryonic ventricular cells I(f) regulates firing rate, while RyRs and IP3Rs (early stage) or RyRs (late stage)-mediated ICR determines the occurrence of APs. ..
  50. Nabhani T, Zhu X, Simeoni I, Sorrentino V, Valdivia H, Garcia J. Imperatoxin a enhances Ca(2+) release in developing skeletal muscle containing ryanodine receptor type 3. Biophys J. 2002;82:1319-28 pubmed
    ..contain only one isoform of ryanodine receptor (RyR1), whereas neonatal muscles contain two isoforms (RyR1 and RyR3)...
  51. Amador F, Stathopulos P, Enomoto M, Ikura M. Ryanodine receptor calcium release channels: lessons from structure-function studies. FEBS J. 2013;280:5456-70 pubmed publisher
    ..The functional insights provided by recent structural studies for both channels will aid in the development of rationale treatments for a myriad of Ca(2+)-signaled malignancies. ..
  52. Payne S, Burney M, McCue K, Popal N, Davidson S, Anderson R, et al. A critical role for the chromatin remodeller CHD7 in anterior mesoderm during cardiovascular development. Dev Biol. 2015;405:82-95 pubmed publisher
    ..This work therefore reveals the importance of CHD7 in the cardiogenic mesoderm for multiple processes during cardiovascular development. ..
  53. Wu B, Yamaguchi H, Lai F, Shen J. Presenilins regulate calcium homeostasis and presynaptic function via ryanodine receptors in hippocampal neurons. Proc Natl Acad Sci U S A. 2013;110:15091-6 pubmed publisher
  54. Takekura H, Flucher B, Franzini Armstrong C. Sequential docking, molecular differentiation, and positioning of T-Tubule/SR junctions in developing mouse skeletal muscle. Dev Biol. 2001;239:204-14 pubmed
    ..These sequential stages suggests an order of inductive processes for the molecular differentiation and structural organization of the CRUs in skeletal muscle development. ..
  55. Rederstorff M, Castets P, Arbogast S, Laine J, Vassilopoulos S, Beuvin M, et al. Increased muscle stress-sensitivity induced by selenoprotein N inactivation in mouse: a mammalian model for SEPN1-related myopathy. PLoS ONE. 2011;6:e23094 pubmed publisher
  56. Ikemoto T, Takeshima H, Iino M, Endo M. Effect of calmodulin on Ca2+-induced Ca2+ release of skeletal muscle from mutant mice expressing either ryanodine receptor type 1 or type 3. Pflugers Arch. 1998;437:43-8 pubmed
    ..These data suggest that multiple CaM-binding sites are involved in the differential effects on RyR-1 and RyR-3. These effects of CaM are important for the evaluation of the physiological roles of RyRs. ..
  57. Dabertrand F, Morel J, Sorrentino V, Mironneau J, Mironneau C, Macrez N. Modulation of calcium signalling by dominant negative splice variant of ryanodine receptor subtype 3 in native smooth muscle cells. Cell Calcium. 2006;40:11-21 pubmed
    The ryanodine receptor subtype 3 (RYR3) is expressed ubiquitously but its physiological function varies from cell to cell. Here, we investigated the role of a dominant negative RYR3 isoform in Ca2+ signalling in native smooth muscle cells...
  58. Stolk M, Leon Ponte M, Merrill M, Ahern G, O Connell P. IP3Rs are sufficient for dendritic cell Ca2+ signaling in the absence of RyR1. J Leukoc Biol. 2006;80:651-8 pubmed
    ..Moreover, the absence of RyR1 did not lead to de novo expression of RyR2 or RyR3. WT and RyR KO DC express all three isoforms of inositol 1,4,5-trisphosphate receptor (IP(3)R), although Type 3 IP(..
  59. Flucher B, Conti A, Takeshima H, Sorrentino V. Type 3 and type 1 ryanodine receptors are localized in triads of the same mammalian skeletal muscle fibers. J Cell Biol. 1999;146:621-30 pubmed
    The type 3 ryanodine receptor (RyR3) is a ubiquitous calcium release channel that has recently been found in mammalian skeletal muscles...
  60. Zhou Y, Ru Y, Wang C, Wang S, Zhou Z, Zhang Y. Tripeptidyl peptidase II regulates sperm function by modulating intracellular Ca(2+) stores via the ryanodine receptor. PLoS ONE. 2013;8:e66634 pubmed publisher
    ..with these results, indirect immunofluorescence assay using anti-RyR antibodies further validated the presence of RyR3 in the acrosomal region of mature sperm...