Runx3

Summary

Gene Symbol: Runx3
Description: runt related transcription factor 3
Alias: AML2, Cbfa3, Pebp2a3, runt-related transcription factor 3, CBF-alpha-3, PEA2-alpha C, PEBP2-alpha C, SL3-3 enhancer factor 1 alpha C subunit, SL3/AKV core-binding factor alpha C subunit, acute myeloid leukemia 2 protein, core binding factor alpha 3, core-binding factor subunit alpha-3, oncogene AML-2, polyomavirus enhancer-binding protein 2 alpha C subunit, runt domain, alpha subunit 3, transcription factor AML2/CBFA3
Species: mouse
Products:     Runx3

Top Publications

  1. Yarmus M, Woolf E, Bernstein Y, Fainaru O, Negreanu V, Levanon D, et al. Groucho/transducin-like Enhancer-of-split (TLE)-dependent and -independent transcriptional regulation by Runx3. Proc Natl Acad Sci U S A. 2006;103:7384-9 pubmed
    ..b>Runx3, a runt-domain transcription factor, regulates cell-intrinsic functions by activating and repressing gene ..
  2. Egawa T, Littman D. ThPOK acts late in specification of the helper T cell lineage and suppresses Runx-mediated commitment to the cytotoxic T cell lineage. Nat Immunol. 2008;9:1131-9 pubmed publisher
    ..Distal promoter-driven expression of the gene encoding the transcription factor Runx3 was restricted to major histocompatibility complex (MHC) class I-selected thymocytes...
  3. Levanon D, Negreanu V, Bernstein Y, Bar Am I, Avivi L, Groner Y. AML1, AML2, and AML3, the human members of the runt domain gene-family: cDNA structure, expression, and chromosomal localization. Genomics. 1994;23:425-32 pubmed
    cDNAs corresponding to three human runt domain containing genes, AML1, AML2, and AML3, were isolated and characterized...
  4. Telfer J, Hedblom E, Anderson M, Laurent M, Rothenberg E. Localization of the domains in Runx transcription factors required for the repression of CD4 in thymocytes. J Immunol. 2004;172:4359-70 pubmed
    The runt family transcription factors Runx1 and Runx3 are expressed in developing murine thymocytes...
  5. Setoguchi R, Tachibana M, Naoe Y, Muroi S, Akiyama K, Tezuka C, et al. Repression of the transcription factor Th-POK by Runx complexes in cytotoxic T cell development. Science. 2008;319:822-5 pubmed publisher
    ..Identification of the transcription factors network in CD4 and CD8 lineage choice provides insight into how distinct T cell subsets are developed for regulating the adaptive immune system. ..
  6. Levanon D, Bettoun D, Harris Cerruti C, Woolf E, Negreanu V, Eilam R, et al. The Runx3 transcription factor regulates development and survival of TrkC dorsal root ganglia neurons. EMBO J. 2002;21:3454-63 pubmed
    ..Recently, we demonstrated that Runx3 is highly expressed in developing cranial and dorsal root ganglia (DRGs)...
  7. Inoue K, Ozaki S, Shiga T, Ito K, Masuda T, Okado N, et al. Runx3 controls the axonal projection of proprioceptive dorsal root ganglion neurons. Nat Neurosci. 2002;5:946-54 pubmed
    ..The Runt-related genes Runx1 and Runx3 are expressed in DRG neuronal subpopulations, suggesting that they may regulate the trajectories of specific axons...
  8. Hassan H, Sakaguchi S, Tenno M, Kopf A, Boucheron N, Carpenter A, et al. Cd8 enhancer E8I and Runx factors regulate CD8? expression in activated CD8+ T cells. Proc Natl Acad Sci U S A. 2011;108:18330-5 pubmed publisher
    ..factor-? (CBF?) complexes were required for the establishment of this regulatory circuit, because E8(I)-, Runx3-, or CBF?-deficient CD8(+) T cells down-regulated CD8? expression during activation...
  9. Yamashiro T, Aberg T, Levanon D, Groner Y, Thesleff I. Expression of Runx1, -2 and -3 during tooth, palate and craniofacial bone development. Gene Expr Patterns. 2002;2:109-12 pubmed
    We describe the expression of three Runt-related RUNX genes (previously termed AML, Cbfa, or Pebp2alpha) Runx1 and Runx3 during the development of teeth and other craniofacial tissues and compare them to Runx2 expression reported earlier...

More Information

Publications75

  1. Kohu K, Ohmori H, Wong W, Onda D, Wakoh T, Kon S, et al. The Runx3 transcription factor augments Th1 and down-modulates Th2 phenotypes by interacting with and attenuating GATA3. J Immunol. 2009;183:7817-24 pubmed publisher
    Recently, it was reported that the expression of Runt-related transcription factor 3 (Runx3) is up-regulated in CD4(+) helper T cells during Th1 cell differentiation, and that Runx3 functions in a positive feed-forward manner with the T-..
  2. Ito K, Lim A, Salto Tellez M, Motoda L, Osato M, Chuang L, et al. RUNX3 attenuates beta-catenin/T cell factors in intestinal tumorigenesis. Cancer Cell. 2008;14:226-37 pubmed publisher
    ..However, other alterations may be involved in intestinal tumorigenesis. Here we found that RUNX3, a gastric tumor suppressor, forms a ternary complex with beta-catenin/TCF4 and attenuates Wnt signaling activity...
  3. Nakamura S, Senzaki K, Yoshikawa M, Nishimura M, Inoue K, Ito Y, et al. Dynamic regulation of the expression of neurotrophin receptors by Runx3. Development. 2008;135:1703-11 pubmed publisher
    ..The Runt-related transcription factors, Runx1 and Runx3, are expressed in DRG neuronal subpopulations, suggesting that they might regulate the cell specification and the ..
  4. Brenner O, Levanon D, Negreanu V, Golubkov O, Fainaru O, Woolf E, et al. Loss of Runx3 function in leukocytes is associated with spontaneously developed colitis and gastric mucosal hyperplasia. Proc Natl Acad Sci U S A. 2004;101:16016-21 pubmed
    ..b>Runx3 plays a role during the development of sensory neurons and T cells and regulates transforming growth factor beta (..
  5. Levanon D, Groner Y. Runx3-deficient mouse strains circa 2008: resemblance and dissimilarity. Blood Cells Mol Dis. 2009;43:1-5 pubmed publisher
    b>Runx3 is one of the three mammalian Runt domain transcription factors comprising the deeply conserved RUNX gene family...
  6. Bruno L, Mazzarella L, Hoogenkamp M, Hertweck A, Cobb B, Sauer S, et al. Runx proteins regulate Foxp3 expression. J Exp Med. 2009;206:2329-37 pubmed publisher
    ..Our data show that Runx and Foxp3 are components of a feed-forward loop in which Runx proteins contribute to the expression of Foxp3 and cooperate with Foxp3 proteins to regulate the expression of downstream target genes. ..
  7. Ehlers M, Laule Kilian K, Petter M, Aldrian C, Grueter B, Würch A, et al. Morpholino antisense oligonucleotide-mediated gene knockdown during thymocyte development reveals role for Runx3 transcription factor in CD4 silencing during development of CD4-/CD8+ thymocytes. J Immunol. 2003;171:3594-604 pubmed
    ..Using this approach, we show here that the transcription factor Runx3 is involved in silencing of CD4 expression during CD8 T cell differentiation...
  8. Woolf E, Xiao C, Fainaru O, Lotem J, Rosen D, Negreanu V, et al. Runx3 and Runx1 are required for CD8 T cell development during thymopoiesis. Proc Natl Acad Sci U S A. 2003;100:7731-6 pubmed
    ..Recently, we have demonstrated that Runx3 is a neurogenic transcription factor, which regulates development and survival of proprioceptive neurons in dorsal ..
  9. Grueter B, Petter M, Egawa T, Laule Kilian K, Aldrian C, Wuerch A, et al. Runx3 regulates integrin alpha E/CD103 and CD4 expression during development of CD4-/CD8+ T cells. J Immunol. 2005;175:1694-705 pubmed
    ..The transcription factor Runx3/AML-2 Runx, runt [corrected] dominant factor; AML, acute myeloid leukemia is expressed specifically during the ..
  10. Bangsow C, Rubins N, Glusman G, Bernstein Y, Negreanu V, Goldenberg D, et al. The RUNX3 gene--sequence, structure and regulated expression. Gene. 2001;279:221-32 pubmed
    The RUNX3 gene belongs to the runt domain family of transcription factors that act as master regulators of gene expression in major developmental pathways. In mammals the family includes three genes, RUNX1, RUNX2 and RUNX3...
  11. Yu L, Liu H, Yan M, Yang J, Long F, Muneoka K, et al. Shox2 is required for chondrocyte proliferation and maturation in proximal limb skeleton. Dev Biol. 2007;306:549-59 pubmed
    ..A dramatic down-regulation of Runx2 and Runx3 could account for the lack of chondrocyte hypertrophy, while a down-regulation of Ihh expression may be ..
  12. Djuretic I, Levanon D, Negreanu V, Groner Y, Rao A, Ansel K. Transcription factors T-bet and Runx3 cooperate to activate Ifng and silence Il4 in T helper type 1 cells. Nat Immunol. 2007;8:145-53 pubmed
    ..Here we show that the transcription factor Runx3 is induced in T helper type 1 (T(H)1) cells in a T-bet-dependent manner, and that both transcription factors T-bet ..
  13. Klunker S, Chong M, Mantel P, Palomares O, Bassin C, Ziegler M, et al. Transcription factors RUNX1 and RUNX3 in the induction and suppressive function of Foxp3+ inducible regulatory T cells. J Exp Med. 2009;206:2701-15 pubmed publisher
    ..growth factor-beta (TGF-beta) induces the expression of the Runt-related transcription factors RUNX1 and RUNX3 in CD4(+) T cells...
  14. Taniuchi I, Osato M, Egawa T, Sunshine M, Bae S, Komori T, et al. Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development. Cell. 2002;111:621-33 pubmed
    ..Runx1 is required for active repression in CD4(-)CD8(-) thymocytes whereas Runx3 is required for establishing epigenetic silencing in cytotoxic lineage thymocytes...
  15. Adoro S, McCaughtry T, Erman B, Alag A, Van Laethem F, Park J, et al. Coreceptor gene imprinting governs thymocyte lineage fate. EMBO J. 2012;31:366-77 pubmed publisher
    ..co-opts any coreceptor protein encoded within it to induce thymocytes to express the cytotoxic-lineage factor Runx3 and to adopt the cytotoxic-lineage fate, findings we refer to as 'coreceptor gene imprinting'...
  16. Levanon D, Brenner O, Negreanu V, Bettoun D, Woolf E, Eilam R, et al. Spatial and temporal expression pattern of Runx3 (Aml2) and Runx1 (Aml1) indicates non-redundant functions during mouse embryogenesis. Mech Dev. 2001;109:413-7 pubmed
    The human RUNX3/AML2 gene belongs to the 'runt domain' family of transcription factors that act as gene expression regulators in major developmental pathways...
  17. Avraham K, Levanon D, Negreanu V, Bernstein Y, Groner Y, Copeland N, et al. Mapping of the mouse homolog of the human runt domain gene, AML2, to the distal region of mouse chromosome 4. Genomics. 1995;25:603-5 pubmed
  18. Cruz Guilloty F, Pipkin M, Djuretic I, Levanon D, Lotem J, Lichtenheld M, et al. Runx3 and T-box proteins cooperate to establish the transcriptional program of effector CTLs. J Exp Med. 2009;206:51-9 pubmed publisher
    ..In addition, we demonstrate a critical role for the transcription factor Runx3 in CTL differentiation...
  19. Egawa T, Tillman R, Naoe Y, Taniuchi I, Littman D. The role of the Runx transcription factors in thymocyte differentiation and in homeostasis of naive T cells. J Exp Med. 2007;204:1945-57 pubmed
    ..We used a strategy to conditionally inactivate the genes encoding Runx1 or Runx3 at different stages of thymocyte development, demonstrating that Runx1 regulates the transitions of developing ..
  20. Zamisch M, Tian L, Grenningloh R, Xiong Y, Wildt K, Ehlers M, et al. The transcription factor Ets1 is important for CD4 repression and Runx3 up-regulation during CD8 T cell differentiation in the thymus. J Exp Med. 2009;206:2685-99 pubmed publisher
    ..We further show that Ets1 promotes expression of Runx3, a transcription factor important for CD8 T cell differentiation and the cessation of Cd4 gene expression...
  21. Naoe Y, Setoguchi R, Akiyama K, Muroi S, Kuroda M, Hatam F, et al. Repression of interleukin-4 in T helper type 1 cells by Runx/Cbf beta binding to the Il4 silencer. J Exp Med. 2007;204:1749-55 pubmed
    ..Using Cbf beta- or Runx3-deficient T cells, we show that loss of Runx complex function results in derepression of IL-4 in Th1 cells...
  22. Lotem J, Levanon D, Negreanu V, Leshkowitz D, Friedlander G, Groner Y. Runx3-mediated transcriptional program in cytotoxic lymphocytes. PLoS ONE. 2013;8:e80467 pubmed publisher
    The transcription factor Runx3 is highly expressed in CD8(+) T and NK cytotoxic lymphocytes and is required for their effective activation and proliferation but molecular insights into the transcription program regulated by Runx3 in ..
  23. Yano T, Ito K, Fukamachi H, Chi X, Wee H, Inoue K, et al. The RUNX3 tumor suppressor upregulates Bim in gastric epithelial cells undergoing transforming growth factor beta-induced apoptosis. Mol Cell Biol. 2006;26:4474-88 pubmed
    ..TGF-beta) signaling pathway are frequently altered in several types of cancers, and a gastric tumor suppressor RUNX3 appears to be an integral component of this pathway...
  24. Yamamura Y, Lee W, Inoue K, Ida H, Ito Y. RUNX3 cooperates with FoxO3a to induce apoptosis in gastric cancer cells. J Biol Chem. 2006;281:5267-76 pubmed
    The transcription factor RUNX3, which mediates apoptosis and cell growth inhibition in gastric epithelial cells, is a candidate tumor suppressor that is frequently lost in gastric cancer cells...
  25. Stricker S, Fundele R, Vortkamp A, Mundlos S. Role of Runx genes in chondrocyte differentiation. Dev Biol. 2002;245:95-108 pubmed
    ..To analyze the role of runx genes in skeletal development, we performed in situ hybridization with Runx2- and Runx3-specific probes...
  26. Komine O, Hayashi K, Natsume W, Watanabe T, Seki Y, Seki N, et al. The Runx1 transcription factor inhibits the differentiation of naive CD4+ T cells into the Th2 lineage by repressing GATA3 expression. J Exp Med. 2003;198:51-61 pubmed
    ..We conclude that Runx1 plays a novel role as a negative regulator of GATA3 expression, thereby inhibiting the Th2 cell differentiation. ..
  27. Li Q, Ito K, Sakakura C, Fukamachi H, Inoue K, Chi X, et al. Causal relationship between the loss of RUNX3 expression and gastric cancer. Cell. 2002;109:113-24 pubmed
    b>Runx3/Pebp2alphaC null mouse gastric mucosa exhibits hyperplasias due to stimulated proliferation and suppressed apoptosis in epithelial cells, and the cells are resistant to growth-inhibitory and apoptosis-inducing action of TGF-beta, ..
  28. Chung D, Honda K, Cafuir L, McDuffie M, Wotton D. The Runx3 distal transcript encodes an additional transcriptional activation domain. FEBS J. 2007;274:3429-39 pubmed
    The runt family transcriptional regulator, Runx3, is upregulated during the differentiation of CD8 single-positive thymocytes and is expressed in peripheral CD8(+) T cells...
  29. Inoue K, Ito K, Osato M, Lee B, Bae S, Ito Y. The transcription factor Runx3 represses the neurotrophin receptor TrkB during lineage commitment of dorsal root ganglion neurons. J Biol Chem. 2007;282:24175-84 pubmed
    b>Runx3, a Runt domain transcription factor, determines neurotrophin receptor phenotype in dorsal root ganglion (DRG) neurons. Molecular mechanisms by which Runx3 controls distinct neurotrophin receptors are largely unknown...
  30. Kramer I, Sigrist M, de Nooij J, Taniuchi I, Jessell T, Arber S. A role for Runx transcription factor signaling in dorsal root ganglion sensory neuron diversification. Neuron. 2006;49:379-93 pubmed
    ..b>Runx3 acts to diversify an Ngn1-independent neuronal cohort by promoting the differentiation of proprioceptive sensory ..
  31. Bae S, Takahashi E, Zhang Y, Ogawa E, Shigesada K, Namba Y, et al. Cloning, mapping and expression of PEBP2 alpha C, a third gene encoding the mammalian Runt domain. Gene. 1995;159:245-8 pubmed
    ..In this study, we identified the third Runt-domain-encoding gene, PEBP2 alpha C, which maps to 1p36.11-p36.13 in the human chromosome and encodes a 415-aa protein...
  32. Xiong Y, Castro E, Yagi R, Zhu J, Lesourne R, Love P, et al. Thpok-independent repression of Runx3 by Gata3 during CD4+ T-cell differentiation in the thymus. Eur J Immunol. 2013;43:918-28 pubmed publisher
    ..The transcription factor Runx3 inhibits CD4(+) T-cell differentiation by repressing Cd4 gene expression; accordingly, Runx3 is not expressed in ..
  33. Fainaru O, Shseyov D, Hantisteanu S, Groner Y. Accelerated chemokine receptor 7-mediated dendritic cell migration in Runx3 knockout mice and the spontaneous development of asthma-like disease. Proc Natl Acad Sci U S A. 2005;102:10598-603 pubmed
    The Runx3 transcription factor is a key regulator of lineage-specific gene expression in several developmental pathways and could also be involved in autoimmunity...
  34. Yagi R, Junttila I, Wei G, Urban J, Zhao K, Paul W, et al. The transcription factor GATA3 actively represses RUNX3 protein-regulated production of interferon-gamma. Immunity. 2010;32:507-17 pubmed publisher
    ..both in GATA3-deficient CD4(+) T cells differentiated under Th2 cell conditions and in Th2 cells with enforced Runx3 expression, contributing to IFN-gamma production...
  35. Yoshida C, Yamamoto H, Fujita T, Furuichi T, Ito K, Inoue K, et al. Runx2 and Runx3 are essential for chondrocyte maturation, and Runx2 regulates limb growth through induction of Indian hedgehog. Genes Dev. 2004;18:952-63 pubmed
    ..We investigated the involvement of Runx3 in chondrocyte differentiation by generating Runx2-and-Runx3-deficient (Runx2(-/-)3(-/-)) mice...
  36. Fainaru O, Woolf E, Lotem J, Yarmus M, Brenner O, Goldenberg D, et al. Runx3 regulates mouse TGF-beta-mediated dendritic cell function and its absence results in airway inflammation. EMBO J. 2004;23:969-79 pubmed
    b>Runx3 transcription factor regulates cell lineage decisions in thymopoiesis and neurogenesis...
  37. McCaughtry T, Etzensperger R, Alag A, Tai X, Kurtulus S, Park J, et al. Conditional deletion of cytokine receptor chains reveals that IL-7 and IL-15 specify CD8 cytotoxic lineage fate in the thymus. J Exp Med. 2012;209:2263-76 pubmed publisher
    ..Thus, ?(c)-transduced cytokine signals are required for cytotoxic lineage specification in the thymus and for inducing the differentiation of MHC-I-selected thymocytes into functionally mature T cells. ..
  38. Milner J, Toma C, Yu B, Zhang K, Omilusik K, Phan A, et al. Runx3 programs CD8+ T cell residency in non-lymphoid tissues and tumours. Nature. 2017;552:253-257 pubmed publisher
    ..Using computational and pooled in vivo RNA interference screens, we identify the transcription factor Runx3 as a key regulator of TRM cell differentiation and homeostasis...
  39. Juuri E, Saito K, Lefebvre S, Michon F. Establishment of crown-root domain borders in mouse incisor. Gene Expr Patterns. 2013;13:255-64 pubmed publisher
    ..We discovered that Barx2, En1, Wnt11, and Runx3 were exclusively expressed on the mesial crown-root border...
  40. Hippenmeyer S, Vrieseling E, Sigrist M, Portmann T, Laengle C, Ladle D, et al. A developmental switch in the response of DRG neurons to ETS transcription factor signaling. PLoS Biol. 2005;3:e159 pubmed
    ..Together, our findings indicate that DRG sensory neurons exhibit a temporal developmental switch that can be revealed by distinct responses to ETS transcription factor signaling at sequential steps of neuronal maturation. ..
  41. Islam M, Itoh S, Yanagita T, Sumiyoshi K, Hayano S, Kuremoto K, et al. Runx/Cbfb signaling regulates postnatal development of granular convoluted tubule in the mouse submandibular gland. Dev Dyn. 2015;244:488-96 pubmed publisher
    ..Runx signaling is important in the postnatal development of androgen-dependent GCT in the SMG. ..
  42. Ebihara T, Song C, Ryu S, Plougastel Douglas B, Yang L, Levanon D, et al. Runx3 specifies lineage commitment of innate lymphoid cells. Nat Immunol. 2015;16:1124-33 pubmed publisher
    ..Here we report that the transcription factor Runx3 was essential for the normal development of ILC1 and ILC3 cells but not of ILC2 cells...
  43. Levanon D, Bernstein Y, Negreanu V, Bone K, Pozner A, Eilam R, et al. Absence of Runx3 expression in normal gastrointestinal epithelium calls into question its tumour suppressor function. EMBO Mol Med. 2011;3:593-604 pubmed publisher
    The Runx3 transcription factor regulates cell fate decisions during embryonic development and in adults...
  44. Seo W, Tanaka H, Miyamoto C, Levanon D, Groner Y, Taniuchi I. Roles of VWRPY motif-mediated gene repression by Runx proteins during T-cell development. Immunol Cell Biol. 2012;90:827-30 pubmed publisher
    ..By examining mice lacking VWRPY motifs in both Runx1 and Runx3 proteins, here, we show a full and partial derepression of Cd4 and ThPOK in CD8-linegae T cells, respectively...
  45. Hesse E, Saito H, Kiviranta R, Correa D, Yamana K, Neff L, et al. Zfp521 controls bone mass by HDAC3-dependent attenuation of Runx2 activity. J Cell Biol. 2010;191:1271-83 pubmed publisher
    ..Thus, the balance and molecular interplay between Zfp521 and Runx2 contribute to the control of osteoblast differentiation, skeletal development, and bone homeostasis. ..
  46. Inoue K, Ozaki S, Ito K, Iseda T, Kawaguchi S, Ogawa M, et al. Runx3 is essential for the target-specific axon pathfinding of trkc-expressing dorsal root ganglion neurons. Blood Cells Mol Dis. 2003;30:157-60 pubmed
    ..Here we show that Runx3-/- mice display severe limb ataxia and abnormal posture and that most of them die shortly after birth...
  47. Zhang L, Li Z, Yan J, Pradhan P, Corpora T, Cheney M, et al. Mutagenesis of the Runt domain defines two energetic hot spots for heterodimerization with the core binding factor beta subunit. J Biol Chem. 2003;278:33097-104 pubmed
    ..CBFs consist of a DNA-binding CBF alpha subunit (Runx1, Runx2, or Runx3) and a non-DNA-binding CBF beta subunit...
  48. Ben Zvi A, Manor O, Schachner M, Yaron A, Tessier Lavigne M, Behar O. The Semaphorin receptor PlexinA3 mediates neuronal apoptosis during dorsal root ganglia development. J Neurosci. 2008;28:12427-32 pubmed publisher
    ..The results also support the idea that naturally occurring neuronal cell death reflects not only competition for target-derived trophic factors, but also the action of proapoptotic signaling via a Semaphorin/Plexin pathway. ..
  49. Bone K, Gruper Y, Goldenberg D, Levanon D, Groner Y. Translation regulation of Runx3. Blood Cells Mol Dis. 2010;45:112-6 pubmed publisher
    b>Runx3 protein products that are translated from the distal (P1)- and proximal (P2)-promoter transcripts appear on Western blots as a 47-46kDa doublet corresponding to full-length proteins bearing the P1- and P2-N-termini respectively...
  50. Afaloniati H, Karagiannis G, Hardas A, Poutahidis T, Angelopoulou K. Inflammation-driven colon neoplasmatogenesis in uPA-deficient mice is associated with an increased expression of Runx transcriptional regulators. Exp Cell Res. 2017;361:257-264 pubmed publisher
    ..These findings suggest that the absence of uPA correlates with increased levels of Runx transcriptional regulators in a way that promotes inflammation-associated carcinogenesis...
  51. Jiang Q, Qin X, Kawane T, Komori H, Matsuo Y, Taniuchi I, et al. Cbfb2 Isoform Dominates More Potent Cbfb1 and Is Required for Skeletal Development. J Bone Miner Res. 2016;31:1391-404 pubmed publisher
    Cbfb is a cotranscription factor that forms a heterodimer with Runx proteins Runx1, Runx2, and Runx3. It is required for fetal liver hematopoiesis and skeletal development...
  52. Zhou G, Zheng Q, Engin F, Munivez E, Chen Y, Sebald E, et al. Dominance of SOX9 function over RUNX2 during skeletogenesis. Proc Natl Acad Sci U S A. 2006;103:19004-9 pubmed
    ..In summary, SOX9 is dominant over RUNX2 function in mesenchymal precursors that are destined for a chondrogenic lineage during endochondral ossification...
  53. Reis B, Hoytema van Konijnenburg D, Grivennikov S, Mucida D. Transcription factor T-bet regulates intraepithelial lymphocyte functional maturation. Immunity. 2014;41:244-56 pubmed publisher
    ..strategies, as well as reporter approaches, we showed that cooperation between the transcription factors T-bet and Runx3 resulted in suppression of conventional CD4(+) T helper functions and induction of an intraepithelial lymphocyte (..
  54. Levanon D, Negreanu V, Lotem J, Bone K, Brenner O, Leshkowitz D, et al. Transcription factor Runx3 regulates interleukin-15-dependent natural killer cell activation. Mol Cell Biol. 2014;34:1158-69 pubmed publisher
    ..However, very little is known about the transcription program driving this process. The transcription factor Runx3 is highly expressed in natural killer cells, but its function in these cells is largely unknown...
  55. Woolf E, Brenner O, Goldenberg D, Levanon D, Groner Y. Runx3 regulates dendritic epidermal T cell development. Dev Biol. 2007;303:703-14 pubmed
    The Runx3 transcription factor regulates development of T cells during thymopoiesis and TrkC sensory neurons during dorsal root ganglia neurogenesis...
  56. Zhang M, Xie R, Hou W, Wang B, Shen R, Wang X, et al. PTHrP prevents chondrocyte premature hypertrophy by inducing cyclin-D1-dependent Runx2 and Runx3 phosphorylation, ubiquitylation and proteasomal degradation. J Cell Sci. 2009;122:1382-9 pubmed publisher
    ..The mechanism by which PTHrP does this is not fully understood. Both Runx2 and Runx3 are required for chondrocyte maturation...
  57. Kim E, Cho S, Shin J, Lee M, Kim K, Jung H. Ihh and Runx2/Runx3 signaling interact to coordinate early chondrogenesis: a mouse model. PLoS ONE. 2013;8:e55296 pubmed publisher
    ..The transfer of 5E1 decreased the expression of Runx2 and Runx3, whereas an exogenous recombinant IHH protein increased Runx2 and Runx3 expression...
  58. Ohno S, Sato T, Kohu K, Takeda K, Okumura K, Satake M, et al. Runx proteins are involved in regulation of CD122, Ly49 family and IFN-gamma expression during NK cell differentiation. Int Immunol. 2008;20:71-9 pubmed
    ..However, their function in NK cells is still uncertain. We found that NK cells and CD8 T cells dominantly express Runx3 protein, whereas NKT cells and CD4 T cells express Runx1...
  59. Gross S, Krause Y, Wuelling M, Vortkamp A. Hoxa11 and Hoxd11 regulate chondrocyte differentiation upstream of Runx2 and Shox2 in mice. PLoS ONE. 2012;7:e43553 pubmed publisher
    ..These results give insight into mechanisms by which positional information might be translated into a specific bone pattern. ..
  60. Wang X, Aberg T, James M, Levanon D, Groner Y, Thesleff I. Runx2 (Cbfa1) inhibits Shh signaling in the lower but not upper molars of mouse embryos and prevents the budding of putative successional teeth. J Dent Res. 2005;84:138-43 pubmed
    ..We have proposed that compensation by Runx3 may be involved...
  61. Guo W, Weng L, Ito K, Chen L, Nakanishi H, Tatematsu M, et al. Inhibition of growth of mouse gastric cancer cells by Runx3, a novel tumor suppressor. Oncogene. 2002;21:8351-5 pubmed
    We reported recently that the silencing of RUNX3 is causally related to gastric cancer in humans...
  62. Lambrecht B, Hammad H. Lung dendritic cells: targets for therapy in allergic disease. Chem Immunol Allergy. 2008;94:189-200 pubmed publisher
    ..A careful study of DC biology and of the receptors expressed by lung DCs has provided a framework for the discovery of novel antiallergic compounds. ..
  63. Yamashiro T, Aberg T, Levanon D, Groner Y, Thesleff I. Expression of Runx1, -2 and -3 during tooth, palate and craniofacial bone development. Mech Dev. 2002;119 Suppl 1:S107-10 pubmed
    We describe the expression of three Runt-related RUNX genes (previously termed AML, Cbfa, or Pebp2alpha) Runx1 and Runx3 during the development of teeth and other craniofacial tissues and compare them to Runx2 expression reported earlier...
  64. Kitoh A, Ono M, Naoe Y, Ohkura N, Yamaguchi T, Yaguchi H, et al. Indispensable role of the Runx1-Cbfbeta transcription complex for in vivo-suppressive function of FoxP3+ regulatory T cells. Immunity. 2009;31:609-20 pubmed publisher
    ..showed that Treg cell-specific deficiency of Cbfbeta, a cofactor for all Runx proteins, or that of Runx1, but not Runx3, induced lymphoproliferation, autoimmune disease, and hyperproduction of IgE...
  65. Lee Y, Lee J, Jang J, Chi X, Kim J, Li Y, et al. Runx3 inactivation is a crucial early event in the development of lung adenocarcinoma. Cancer Cell. 2013;24:603-16 pubmed publisher
    Targeted inactivation of Runx3 in mouse lung induced mucinous and nonmucinous adenomas and markedly shortened latency of adenocarcinoma formation induced by oncogenic K-Ras...
  66. Karamitros D, Patmanidi A, Kotantaki P, Potocnik A, Bähr Ivacevic T, Benes V, et al. Geminin deletion increases the number of fetal hematopoietic stem cells by affecting the expression of key transcription factors. Development. 2015;142:70-81 pubmed publisher
    ..Our data suggest that geminin is indispensable for fetal hematopoiesis and regulates the generation of a physiological pool of stem and progenitor cells in the fetal hematopoietic system. ..