Rps6ka3

Summary

Gene Symbol: Rps6ka3
Description: ribosomal protein S6 kinase polypeptide 3
Alias: MAPKAPK-1b, MPK-9, Rsk2, S6K-alpha3, p90RSK3, pp90RSK2, ribosomal protein S6 kinase alpha-3, 90 kDa ribosomal protein S6 kinase 3, MAP kinase-activated protein kinase 1b, MAPK-activated protein kinase 1b, MAPKAP kinase 1b, ribosomal protein S6 kinase 2
Species: mouse
Products:     Rps6ka3

Top Publications

  1. Smith J, Poteet Smith C, Malarkey K, Sturgill T. Identification of an extracellular signal-regulated kinase (ERK) docking site in ribosomal S6 kinase, a sequence critical for activation by ERK in vivo. J Biol Chem. 1999;274:2893-8 pubmed
    ..GST)-fusion proteins containing the carboxyl-terminal tails of three p90 ribosomal S6 kinase (RSK) isozymes (RSK1, RSK2, and RSK3) interacted with extracellular signal-regulated kinase (ERK) but not c-Jun-NH2-kinase (JNK) or p38 ..
  2. Mehmood T, Schneider A, Sibille J, Sibillec J, Marques Pereira P, Pannetier S, et al. Transcriptome profile reveals AMPA receptor dysfunction in the hippocampus of the Rsk2-knockout mice, an animal model of Coffin-Lowry syndrome. Hum Genet. 2011;129:255-69 pubmed publisher
    ..syndrome (CLS) is a syndromic form of mental retardation caused by loss of function mutations in the X-linked RPS6KA3 gene, which encodes RSK2, a serine/threonine kinase acting in the MAPK/ERK pathway...
  3. Yang X, Matsuda K, Bialek P, Jacquot S, Masuoka H, Schinke T, et al. ATF4 is a substrate of RSK2 and an essential regulator of osteoblast biology; implication for Coffin-Lowry Syndrome. Cell. 2004;117:387-98 pubmed
    ..The gene mutated in CLS, RSK2, encodes a growth factor-regulated kinase...
  4. Schneider A, Mehmood T, Pannetier S, Hanauer A. Altered ERK/MAPK signaling in the hippocampus of the mrsk2_KO mouse model of Coffin-Lowry syndrome. J Neurochem. 2011;119:447-59 pubmed publisher
    Coffin-Lowry syndrome is a syndromic form of mental retardation caused by mutations of the Rps6ka3 gene encoding ribosomal s6 kinase (RSK)2. RSK2 belongs to a family containing four members in mammals: RSK1-4...
  5. Poirier R, Jacquot S, Vaillend C, Soutthiphong A, Libbey M, Davis S, et al. Deletion of the Coffin-Lowry syndrome gene Rsk2 in mice is associated with impaired spatial learning and reduced control of exploratory behavior. Behav Genet. 2007;37:31-50 pubmed
    ..It is caused by mutations of the Rsk2 gene, which encodes a growth factor regulated kinase...
  6. Cho Y, Yao K, Bode A, Bergen H, Madden B, Oh S, et al. RSK2 mediates muscle cell differentiation through regulation of NFAT3. J Biol Chem. 2007;282:8380-92 pubmed
    b>RSK2, an ERK downstream kinase, is a novel mediator of skeletal muscle cell differentiation through its regulation of NFAT3 activity...
  7. Kohn M, Hameister H, Vogel M, Kehrer Sawatzki H. Expression pattern of the Rsk2, Rsk4 and Pdk1 genes during murine embryogenesis. Gene Expr Patterns. 2003;3:173-7 pubmed
    The ribosomal S6 kinase family members RSK2 (RPS6KA3) and RSK4 (RPS6KA6) belong to the group of X chromosomal genes, in which defects cause unspecific mental retardation (MRX) in humans...
  8. Strachan R, Allen J, Sheffler D, Roth B. p90 Ribosomal S6 kinase 2, a novel GPCR kinase, is required for growth factor-mediated attenuation of GPCR signaling. Biochemistry. 2010;49:2657-71 pubmed publisher
    ..Recently, we discovered that the ERK/MAPK effector p90 ribosomal S6 kinase 2 (RSK2) phosphorylates the 5-HT(2A) receptor and attenuates 5-HT(2A) receptor signaling...
  9. Zeniou M, Ding T, Trivier E, Hanauer A. Expression analysis of RSK gene family members: the RSK2 gene, mutated in Coffin-Lowry syndrome, is prominently expressed in brain structures essential for cognitive function and learning. Hum Mol Genet. 2002;11:2929-40 pubmed
    ..The gene implicated in CLS encodes RSK2, a serine/threonine kinase acting in the Ras/MAPK signalling pathway...

More Information

Publications65

  1. Chrestensen C, Sturgill T. Characterization of the p90 ribosomal S6 kinase 2 carboxyl-terminal domain as a protein kinase. J Biol Chem. 2002;277:27733-41 pubmed
    ..GST-RSK2-(aa373-740) was phosphorylated in the P-loop (Thr(577)) by MAPK, accompanied by increased phosphorylation on the ..
  2. Jensen C, Buch M, Krag T, Hemmings B, Gammeltoft S, Frodin M. 90-kDa ribosomal S6 kinase is phosphorylated and activated by 3-phosphoinositide-dependent protein kinase-1. J Biol Chem. 1999;274:27168-76 pubmed
    90-kDa ribosomal S6 kinase-2 (RSK2) belongs to a family of growth factor-activated serine/threonine kinases composed of two kinase domains connected by a regulatory linker region...
  3. Dugani C, Paquin A, Kaplan D, Miller F. Coffin-Lowry syndrome: a role for RSK2 in mammalian neurogenesis. Dev Biol. 2010;347:348-59 pubmed publisher
    ..CLS patients present with loss-of-function mutations in the RPS6KA3 gene encoding the mitogen-activated protein kinase (MAPK)-activated kinase p90 ribosomal S6 kinase 2 (Rsk2)...
  4. Strachan R, Sciaky N, Cronan M, Kroeze W, Roth B. Genetic deletion of p90 ribosomal S6 kinase 2 alters patterns of 5-hydroxytryptamine 2A serotonin receptor functional selectivity. Mol Pharmacol. 2010;77:327-38 pubmed publisher
    ..We have uncovered a novel regulatory mechanism whereby p90 ribosomal S6 kinase 2 (RSK2) interacts with 5-hydroxytryptamine(2A) (5-HT(2A)) serotonin receptors and attenuates receptor signaling via direct ..
  5. Bakiri L, Reschke M, Gefroh H, Idarraga M, Polzer K, Zenz R, et al. Functions of Fos phosphorylation in bone homeostasis, cytokine response and tumourigenesis. Oncogene. 2011;30:1506-17 pubmed publisher
    ..Importantly, skin papilloma development was delayed in FosAA, Fos362A and Rsk2-deficient mice, accelerated in FosDD mice and unaffected in Fos374A mutants...
  6. Cho Y, Park S, Kim D, Lee S, Woo K, Lee K, et al. TPA-induced cell transformation provokes a complex formation between Pin1 and 90 kDa ribosomal protein S6 kinase 2. Mol Cell Biochem. 2012;367:85-92 pubmed publisher
    ..Here, we found that 90 kDa ribosomal protein S6 kinase 2 (RSK2) could form a physical complex with Pin1, leading to phosphorylation of Pin1 at Ser(16) ex vivo ..
  7. Peng C, Cho Y, Zhu F, Xu Y, Wen W, Ma W, et al. RSK2 mediates NF-{kappa}B activity through the phosphorylation of IkappaBalpha in the TNF-R1 pathway. FASEB J. 2010;24:3490-9 pubmed publisher
    The ribosomal S6 kinase 2 (RSK2) is a well-known serine/threonine kinase and a member of the p90 ribosomal S6 kinase (p90RSK) family of proteins. It is activated downstream of the MEK/ERKs cascade by mitogenic stimuli such as EGF or TPA...
  8. Marques Pereira P, Gruss M, Braun K, Foos N, Pannetier S, Hanauer A. Dopaminergic system dysregulation in the mrsk2_KO mouse, an animal model of the Coffin-Lowry syndrome. J Neurochem. 2008;107:1325-34 pubmed publisher
    ..a rare syndromic form of X-linked mental retardation, is caused by loss-of-function mutations in the hRSK2 (RPS6KA3) gene...
  9. Utepbergenov D, Hennig P, Derewenda U, Artamonov M, Somlyo A, Derewenda Z. Bacterial Expression, Purification and In Vitro Phosphorylation of Full-Length Ribosomal S6 Kinase 2 (RSK2). PLoS ONE. 2016;11:e0164343 pubmed publisher
    ..Here, we demonstrate that full-length RSK2-which is implicated in several types of cancer, and which is linked to the genetic Coffin-Lowry syndrome-can be ..
  10. Wang R, Jung S, Wu C, Qin J, Kobayashi R, Gallick G, et al. Direct roles of the signaling kinase RSK2 in Cdc25C activation during Xenopus oocyte maturation. Proc Natl Acad Sci U S A. 2010;107:19885-90 pubmed publisher
    ..In this study, we demonstrate that this missing kinase is RSK2, which phosphorylates three sites in Cdc25C and also partially activates Cdc25C...
  11. Morice E, Farley S, Poirier R, Dallérac G, Chagneau C, Pannetier S, et al. Defective synaptic transmission and structure in the dentate gyrus and selective fear memory impairment in the Rsk2 mutant mouse model of Coffin-Lowry syndrome. Neurobiol Dis. 2013;58:156-68 pubmed publisher
    The Coffin-Lowry syndrome (CLS) is a syndromic form of intellectual disability caused by loss-of-function of the RSK2 serine/threonine kinase encoded by the rsk2 gene...
  12. He Z, Ma W, Liu G, Zhang Y, Bode A, Dong Z. Arsenite-induced phosphorylation of histone H3 at serine 10 is mediated by Akt1, extracellular signal-regulated kinase 2, and p90 ribosomal S6 kinase 2 but not mitogen- and stress-activated protein kinase 1. J Biol Chem. 2003;278:10588-93 pubmed
    ..However, cells deficient in p90 ribosomal S6 kinase 2 (Rsk2(-/-)) totally block this phosphorylation in a dose- and time-dependent manner...
  13. Bruning J, Gillette J, Zhao Y, Bjorbaeck C, Kotzka J, Knebel B, et al. Ribosomal subunit kinase-2 is required for growth factor-stimulated transcription of the c-Fos gene. Proc Natl Acad Sci U S A. 2000;97:2462-7 pubmed
  14. Liu K, Cho Y, Yao K, Nadas J, Kim D, Cho E, et al. Eriodictyol inhibits RSK2-ATF1 signaling and suppresses EGF-induced neoplastic cell transformation. J Biol Chem. 2011;286:2057-66 pubmed publisher
    b>RSK2 is a widely expressed serine/threonine kinase, and its activation enhances cell proliferation...
  15. Abe Y, Yoon S, Kubota K, Mendoza M, Gygi S, Blenis J. p90 ribosomal S6 kinase and p70 ribosomal S6 kinase link phosphorylation of the eukaryotic chaperonin containing TCP-1 to growth factor, insulin, and nutrient signaling. J Biol Chem. 2009;284:14939-48 pubmed publisher
    ..Although the molecular mechanism of CCTbeta regulation remains unclear, our findings demonstrate a link between oncogene and growth factor signaling and chaperonin CCT-mediated cellular activities. ..
  16. Lee C, Lee M, Lee J, Song J, Lee H, Cho Y. RSK2-induced stress tolerance enhances cell survival signals mediated by inhibition of GSK3? activity. Biochem Biophys Res Commun. 2013;440:112-8 pubmed publisher
    Our previous studies demonstrated that RSK2 plays a key role in cell proliferation and transformation induced by tumor promoters such as epidermal growth factor (EGF) in mouse and human skin cells...
  17. Blair H, Gormally E, Uwechue I, Boyd Y. Mouse mutants carrying deletions that remove the genes mutated in Coffin-Lowry syndrome and lactic acidosis. Hum Mol Genet. 1998;7:549-55 pubmed
    ..7 cM of genetic material and includes the growth factor-regulated protein kinase gene, Rsk2. Stripey carries a larger deletion which removes approximately 2...
  18. Lin J, Spolski R, Leonard W. Critical role for Rsk2 in T-lymphocyte activation. Blood. 2008;111:525-33 pubmed
    ..report that interleukin 2 (IL-2) and IL-15, but not IL-7, rapidly activate the p90 ribosomal S6 kinases, Rsk1 and Rsk2, in human T lymphocytes...
  19. David J, Mehic D, Bakiri L, Schilling A, Mandic V, Priemel M, et al. Essential role of RSK2 in c-Fos-dependent osteosarcoma development. J Clin Invest. 2005;115:664-72 pubmed
    Inactivation of the growth factor-regulated S6 kinase RSK2 causes Coffin-Lowry syndrome in humans, an X-linked mental retardation condition associated with progressive skeletal abnormalities...
  20. Lim J, Catez F, Birger Y, West K, Prymakowska Bosak M, Postnikov Y, et al. Chromosomal protein HMGN1 modulates histone H3 phosphorylation. Mol Cell. 2004;15:573-84 pubmed
    ..Thus, the levels of posttranslational modifications in chromatin are modulated by nucleosome binding proteins that alter the ability of enzymatic complexes to access and modify their nucleosomal targets. ..
  21. Dufresne S, Bjørbaek C, El Haschimi K, Zhao Y, Aschenbach W, Moller D, et al. Altered extracellular signal-regulated kinase signaling and glycogen metabolism in skeletal muscle from p90 ribosomal S6 kinase 2 knockout mice. Mol Cell Biol. 2001;21:81-7 pubmed
    ..for the extracellular signal-regulated kinase (ERK), is involved in transcriptional regulation, and one isoform (RSK2) has been implicated in the activation of glycogen synthase by insulin...
  22. Zaru R, Matthews S, Edgar A, Prescott A, Gomez Nicola D, Hanauer A, et al. The PDK1-Rsk Signaling Pathway Controls Langerhans Cell Proliferation and Patterning. J Immunol. 2015;195:4264-72 pubmed publisher
    ..Deletion of the phosphoinositide-dependent kinase 1 target kinases, ribosomal S6 kinase 1 (Rsk1) and Rsk2, produced a striking perturbation in the LC network: LC density was reduced 2-fold, but LC size was increased by ..
  23. Fischer M, Pereira P, Holtmann B, Simon C, Hanauer A, Heisenberg M, et al. P90 Ribosomal s6 kinase 2 negatively regulates axon growth in motoneurons. Mol Cell Neurosci. 2009;42:134-41 pubmed publisher
    Mutations in Ribosomal s6 kinase 2 (Rsk2) are associated with severe neuronal dysfunction in Coffin-Lowry syndrome (CLS) patients, flies and mice...
  24. Godeny M, Sayeski P. ERK1/2 regulates ANG II-dependent cell proliferation via cytoplasmic activation of RSK2 and nuclear activation of elk1. Am J Physiol Cell Physiol. 2006;291:C1308-17 pubmed
    ..A loss of c-Src/Yes/Fyn blocked ANG II-dependent RSK2 activation, RSK2 nuclear translocation, serum-response factor (SRF) phosphorylation, a portion of c-fos ..
  25. Thomas G, Rumbaugh G, Harrar D, Huganir R. Ribosomal S6 kinase 2 interacts with and phosphorylates PDZ domain-containing proteins and regulates AMPA receptor transmission. Proc Natl Acad Sci U S A. 2005;102:15006-11 pubmed
    ..Mutation of the RSK2 PDZ ligand does not inhibit RSK2 activation in intact cells or phosphorylation of peptide substrates by RSK2 in ..
  26. Elf S, Blevins D, Jin L, Chung T, Williams I, Lee B, et al. p90RSK2 is essential for FLT3-ITD- but dispensable for BCR-ABL-induced myeloid leukemia. Blood. 2011;117:6885-94 pubmed publisher
    ..Interestingly, in a murine BM transplantation (BMT) model, genetic deficiency of RSK2 did not affect the pathogenesis or disease progression of BCR-ABL-induced myeloproliferative neoplasm (PN)...
  27. Kang S, Elf S, Dong S, Hitosugi T, Lythgoe K, Guo A, et al. Fibroblast growth factor receptor 3 associates with and tyrosine phosphorylates p90 RSK2, leading to RSK2 activation that mediates hematopoietic transformation. Mol Cell Biol. 2009;29:2105-17 pubmed publisher
    ..We recently reported that FGFR3 directly tyrosine phosphorylates RSK2 at Y529, which consequently regulates RSK2 activation...
  28. Takada I, Yogiashi Y, Makishima M. The ribosomal S6 kinase inhibitor BI-D1870 ameliorated experimental autoimmune encephalomyelitis in mice. Immunobiology. 2016;221:188-92 pubmed publisher
    ..Ribosomal S6 kinase 2 (RSK2; RPS6KA3) regulates TH17 differentiation by attenuating RORγt transcriptional activities and IL-17A production...
  29. Lu Z, Abe J, Taunton J, Lu Y, Shishido T, McClain C, et al. Reactive oxygen species-induced activation of p90 ribosomal S6 kinase prolongs cardiac repolarization through inhibiting outward K+ channel activity. Circ Res. 2008;103:269-78 pubmed publisher
    ..These findings indicate that p90RSK activation is critical for reactive oxygen species-mediated inhibition of voltage-gated K+ channel activity and leads to prolongation of cardiac repolarization. ..
  30. Yamaguchi N, Chakraborty A, Pasek D, Molkentin J, Meissner G. Dysfunctional ryanodine receptor and cardiac hypertrophy: role of signaling molecules. Am J Physiol Heart Circ Physiol. 2011;300:H2187-95 pubmed publisher
    ..5 hearts; rather increased Erk1/2 and p90RSK phosphorylation levels likely leading to reduced GSK-3? activity were found to precede development of cardiac hypertrophy in mice expressing dysfunctional ryanodine receptor ion channel. ..
  31. McMullen J, Shioi T, Zhang L, Tarnavski O, Sherwood M, Dorfman A, et al. Deletion of ribosomal S6 kinases does not attenuate pathological, physiological, or insulin-like growth factor 1 receptor-phosphoinositide 3-kinase-induced cardiac hypertrophy. Mol Cell Biol. 2004;24:6231-40 pubmed
    ..These studies suggest that S6Ks alone are not essential for the development of cardiac hypertrophy. ..
  32. Cordón Barris L, Pascual Guiral S, Yang S, Gimenez Llort L, Lope Piedrafita S, Niemeyer C, et al. Mutation of the 3-phosphoinositide-dependent protein kinase-1 (PDK1) substrate-docking site in the developing brain causes microcephaly with abnormal brain morphogenesis independently of Akt, leading to impaired cognition and disruptive behaviors. Mol Cell Biol. 2016;: pubmed
  33. Soulet F, Bailly K, Roga S, Lavigne A, Amalric F, Bouche G. Exogenously added fibroblast growth factor 2 (FGF-2) to NIH3T3 cells interacts with nuclear ribosomal S6 kinase 2 (RSK2) in a cell cycle-dependent manner. J Biol Chem. 2005;280:25604-10 pubmed
    ..exogenously to NIH3T3 cells enters the nucleus and interacts with the nuclear active 90-kDa ribosomal S6 kinase 2 (RSK2) in a cell cycle-dependent manner...
  34. Malakhova M, Kurinov I, Liu K, Zheng D, D Angelo I, Shim J, et al. Structural diversity of the active N-terminal kinase domain of p90 ribosomal S6 kinase 2. PLoS ONE. 2009;4:e8044 pubmed publisher
    The p90 ribosomal protein kinase 2 (RSK2) is a highly expressed Ser/Thr kinase activated by growth factors and is involved in cancer cell proliferation and tumor promoter-induced cell transformation...
  35. Paronetto M, Giorda E, Carsetti R, Rossi P, Geremia R, Sette C. Functional interaction between p90Rsk2 and Emi1 contributes to the metaphase arrest of mouse oocytes. EMBO J. 2004;23:4649-59 pubmed
  36. Roux P, Richards S, Blenis J. Phosphorylation of p90 ribosomal S6 kinase (RSK) regulates extracellular signal-regulated kinase docking and RSK activity. Mol Cell Biol. 2003;23:4796-804 pubmed
    ..Analysis of different RSK isoforms revealed that RSK1 and RSK2 readily dissociate from ERK1/2 following mitogen stimulation but that RSK3 remains associated with active ERK1/2...
  37. Saha M, Carriere A, Cheerathodi M, Zhang X, Lavoie G, Rush J, et al. RSK phosphorylates SOS1 creating 14-3-3-docking sites and negatively regulating MAPK activation. Biochem J. 2012;447:159-66 pubmed publisher
    ..Together these data suggest that one mechanism whereby RSK negatively regulates MAPK activation is via site-specific SOS1 phosphorylation. ..
  38. Merienne K, Pannetier S, Harel Bellan A, Sassone Corsi P. Mitogen-regulated RSK2-CBP interaction controls their kinase and acetylase activities. Mol Cell Biol. 2001;21:7089-96 pubmed
    The protein kinase ribosomal S6 kinase 2 (RSK2) has been implicated in phosphorylation of transcription factor CREB and histone H3 in response to mitogenic stimulation by epidermal growth factor...
  39. Elefteriou F, Benson M, Sowa H, Starbuck M, Liu X, Ron D, et al. ATF4 mediation of NF1 functions in osteoblast reveals a nutritional basis for congenital skeletal dysplasiae. Cell Metab. 2006;4:441-51 pubmed
    ..by favoring amino acid import and collagen synthesis in osteoblasts, a function requiring its phosphorylation by RSK2, the kinase inactivated in Coffin-Lowry Syndrome...
  40. Kim S, Kim M, Cho Y, Yao K, Kim D, Jeong C, et al. ERK1 phosphorylates Nanog to regulate protein stability and stem cell self-renewal. Stem Cell Res. 2014;13:1-11 pubmed publisher
    ..Overall, our results demonstrated that ERKs-mediated Nanog phosphorylation plays an important role in self-renewal of ES cells through FBXW8-mediated Nanog protein stability. ..
  41. Böhm C, Derer A, Axmann R, Hillienhoff U, Zaiss M, Luther J, et al. RSK2 protects mice against TNF-induced bone loss. J Cell Sci. 2012;125:2160-71 pubmed publisher
    ..Here, we demonstrate that inactivating the pro-osteoblastogenic ERK-activated ribosomal S6 kinase RSK2 leads to a drastically accelerated and amplified systemic bone loss in mice ectopically expressing TNF-? [human TNF ..
  42. Laugel Haushalter V, Paschaki M, Marangoni P, Pilgram C, Langer A, Kuntz T, et al. RSK2 is a modulator of craniofacial development. PLoS ONE. 2014;9:e84343 pubmed publisher
    The RSK2 gene is responsible for Coffin-Lowry syndrome, an X-linked dominant genetic disorder causing mental retardation, skeletal growth delays, with craniofacial and digital abnormalities typically associated with this syndrome...
  43. Mieulet V, Roceri M, Espeillac C, Sotiropoulos A, Ohanna M, Oorschot V, et al. S6 kinase inactivation impairs growth and translational target phosphorylation in muscle cells maintaining proper regulation of protein turnover. Am J Physiol Cell Physiol. 2007;293:C712-22 pubmed
    ..Our results do not support a role for global translational control in the growth defect due to S6K deletion, suggesting specific modes of growth control and translational target regulation downstream of mTOR. ..
  44. Darcq E, Koebel P, Del Boca C, Pannetier S, Kirstetter A, Garnier J, et al. RSK2 signaling in brain habenula contributes to place aversion learning. Learn Mem. 2011;18:574-8 pubmed publisher
    b>RSK2 is a Ser/Thr kinase acting in the Ras/MAPK pathway. Rsk2 gene deficiency leads to the Coffin-Lowry Syndrome, notably characterized by cognitive deficits...
  45. Alcorta D, Crews C, Sweet L, Bankston L, Jones S, Erikson R. Sequence and expression of chicken and mouse rsk: homologs of Xenopus laevis ribosomal S6 kinase. Mol Cell Biol. 1989;9:3850-9 pubmed
    ..We propose that this family of genes be named rsk, for ribosomal S6 kinase. ..
  46. Lim H, Xie L, Zhang W, Li R, Chen Z, Wu G, et al. Ribosomal S6 Kinase 2 (RSK2) maintains genomic stability by activating the Atm/p53-dependent DNA damage pathway. PLoS ONE. 2013;8:e74334 pubmed publisher
    ..Loss-of function mutations in the RPS6KA3 gene, which encodes the RSK2 protein, have been implicated in Coffin-Lowry Syndrome (CLS), an X-linked mental ..
  47. Zaru R, Ronkina N, Gaestel M, Arthur J, Watts C. The MAPK-activated kinase Rsk controls an acute Toll-like receptor signaling response in dendritic cells and is activated through two distinct pathways. Nat Immunol. 2007;8:1227-35 pubmed
    ..Thus, in DCs, p38 contributes to the activation of all known MK families. ..
  48. Wang Y, Wang F, Sun T, Trostinskaia A, Wygle D, Puscheck E, et al. Entire mitogen activated protein kinase (MAPK) pathway is present in preimplantation mouse embryos. Dev Dyn. 2004;231:72-87 pubmed
    ..2003] Development 130:4527-4537). This spatial and temporal expression study lays a foundation to plan and analyze perturbation studies aimed at understanding the role of the major mitogenic pathway in preimplantation mouse embryos. ..
  49. Ammar M, Humeau Y, Hanauer A, Nieswandt B, Bader M, Vitale N. The Coffin-Lowry syndrome-associated protein RSK2 regulates neurite outgrowth through phosphorylation of phospholipase D1 (PLD1) and synthesis of phosphatidic acid. J Neurosci. 2013;33:19470-9 pubmed publisher
    ..We show here that neurons cultured from mice lacking ribosomal S6 kinase 2 (Rsk2), a model for the Coffin-Lowry syndrome (CLS), exhibit a significant delay in growth in a similar way to that shown ..
  50. El Haschimi K, Dufresne S, Hirshman M, Flier J, Goodyear L, Bjørbaek C. Insulin resistance and lipodystrophy in mice lacking ribosomal S6 kinase 2. Diabetes. 2003;52:1340-6 pubmed
    The p90 ribosomal S6 kinase 2 (RSK2) is a serine/threonine kinase with high expression levels in adipose tissue...
  51. Xifro X, Anglada Huguet M, Rue L, Saavedra A, Pérez Navarro E, Alberch J. Increased 90-kDa ribosomal S6 kinase (Rsk) activity is protective against mutant huntingtin toxicity. Mol Neurodegener. 2011;6:74 pubmed publisher
    ..We observed increased protein levels of Rsk1 and Rsk2 in the striatum of Hdh(Q111/Q111) and R6/1 mice, STHdh(Q111/Q111) cells and striatal cells transfected with full-..
  52. Sheffler D, Kroeze W, Garcia B, Deutch A, Hufeisen S, Leahy P, et al. p90 ribosomal S6 kinase 2 exerts a tonic brake on G protein-coupled receptor signaling. Proc Natl Acad Sci U S A. 2006;103:4717-22 pubmed
    ..We report here that genetic deletion of p90 ribosomal S6 kinase 2 (RSK2) potentiates GPCR signaling...
  53. Sun C, Sun Y, Jiang D, Bao G, Zhu X, Xu D, et al. PDK1 promotes the inflammatory progress of fibroblast-like synoviocytes by phosphorylating RSK2. Cell Immunol. 2017;315:27-33 pubmed publisher
    ..role of PDK1 in inflammatory response which is initiated by TNF-α and analyzed the association between PDK1 and RSK2. TNF-α were added into MH7A cells to induce inflammation condition...
  54. Kim J, Heo Y, Lee K. Osajin Inhibits Solar UV-Induced Cyclooxygenase-2 Expression Through Direct Inhibition of RSK2. J Cell Biochem. 2017;118:4080-4087 pubmed publisher
    ..Osajin inhibited transactivation of these transcription factors. We identified RSK2 as an inhibitory target of osajin by screening against 68 kinases related to inflammation...
  55. Darcq E, Befort K, Koebel P, Pannetier S, Mahoney M, Gaveriaux Ruff C, et al. RSK2 signaling in medial habenula contributes to acute morphine analgesia. Neuropsychopharmacology. 2012;37:1288-96 pubmed publisher
    ..The Ser/Thr kinase RSK2 is a direct downstream effector of ERK1/2 and has a role in cellular signaling, cell survival growth, and ..
  56. Koehne T, Jeschke A, Petermann F, Seitz S, Neven M, Peters S, et al. Rsk2, the Kinase Mutated in Coffin-Lowry Syndrome, Controls Cementum Formation. J Dent Res. 2016;95:752-60 pubmed publisher
    The ribosomal S6 kinase RSK2 is essential for osteoblast function, and inactivating mutations of RSK2 cause osteopenia in humans with Coffin-Lowry syndrome (CLS)...